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The map label for this gene is proA [H]

Identifier: 118478315

GI number: 118478315

Start: 2840443

End: 2841759

Strand: Reverse

Name: proA [H]

Synonym: BALH_2678

Alternate gene names: 118478315

Gene position: 2841759-2840443 (Counterclockwise)

Preceding gene: 118478316

Following gene: 118478312

Centisome position: 54.06

GC content: 37.74

Gene sequence:

>1317_bases
ATGAAGTTATTCATAGAGATTATTGGGTTTCACTTTAAGAATAGTGATGTTAAAAAGGAGGAAACAAAAATGAATGAAGT
GTTGGCAAAGGGGAAAAAAGCGAAAGAAATTGCTAGAGAACTTGTACTAAAATCTACAAGTCAAAAAAATGAAGCACTTG
CTGCCATTGCTGATCAGTTAATAGTAGAAGCAGCTTATATTTTAGAGGAAAACAAACGGGATATAGAAGAAGGTAAGGCG
AAAGGATTTTCTGATTCACTCCTAGATCGTCTAATGTTGAATGAACAGCGTATTATTGATATGGCAGAGGGAATTAAGCA
GTTAATTGAATTACGTAATCCTGTAGGAGAATGTGTAAGTAAATGGGAGCGACCAAATGGACTATTTATTCAGGAGATGC
GTGTACCACTTGGTGTTGTTGGTATGATTTATGAGGCAAGGCCAAATGTAACAGTAGATGCTGCTACAATTTGTTTGAAG
ACAGGAAACGCAGTCATATTACGTGGTAGTTCTTCTGCTATTCATTCTAATAAAGCCATCGTTGCCGTTATTCACAGAGC
GCTTAAACAAACAAGCTTACCTCAAGAAAGTGTACAGCTTATAGAAGATACAACGCGAGATAGCGCAAAGCAGTTGTTTA
CAATGAATGATTATCTAGACGTTCTTATTCCAAGAGGTGGCAAGCAATTAATCGATACTGTTGTGAGGGAAGCGTCTGTC
CCAGTACTTGAAACAGGTGCGGGAAATTGTCATGTTTTCATTGATGAAACAGCGGATAAACAAATGGCATTTGATATTAT
TATAAATGCAAAAACGCAGCGTCCATCTGTATGTAATGCAATTGAAACGATTGTACTTCATGAGAAGTGGGCAGAGCAAT
ATGGTAGCGAGTTGTTTTCTTCTTTGAAGAAAAGAGGCGTGGAGCTACGTGGTGATCAAAAAGCATTGGCAATGGATTCA
TCAATTGTACTTGCTTCAGAAGAAGACTGGTGGACAGAATTTTTATCTCTCACGCTAGCAGTTAAATTAGTTTCTTCTAT
AGAAGAAGCGATTCATCACATAAATACGTATGGATCTATGCATTCTGAAGCGATTATTTCAGAAAACGAGGAAAACGTCA
GCAAATTTTTCGTATCTGTTGATGCGGCTGCACTGTATCATAATGCATCAACTCGTTTTACTGATGGATCTGAATTCGGA
TTTGGAGCAGAAATTGGTATCAGTACACAAAAGCTACACGTAAGAGGACCAATGGGGCTTCCTGCATTAACTTCTACAAA
ATACGTCATTCGTGGAAATGGACAAATTCGAAAATAA

Upstream 100 bases:

>100_bases
GTGATTGGAAAAGGACAATGCACATATAGTGCAGAGGAGCTAAGGGATGTAAAAGGTATGCAAAGCCAACATATTCAAGC
AAGAGGCGAAAGACATAATT

Downstream 100 bases:

>100_bases
AAATAAAAGACACTCAATTCGTTTGGGTGTCTTTTATTTTAAAAATTATTTACCATACAAAAAGCCCAACAAGCATAGCG
CTTAATAAGGAAACAGCCAT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MKLFIEIIGFHFKNSDVKKEETKMNEVLAKGKKAKEIARELVLKSTSQKNEALAAIADQLIVEAAYILEENKRDIEEGKA
KGFSDSLLDRLMLNEQRIIDMAEGIKQLIELRNPVGECVSKWERPNGLFIQEMRVPLGVVGMIYEARPNVTVDAATICLK
TGNAVILRGSSSAIHSNKAIVAVIHRALKQTSLPQESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASV
PVLETGAGNCHVFIDETADKQMAFDIIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDS
SIVLASEEDWWTEFLSLTLAVKLVSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAAALYHNASTRFTDGSEFG
FGAEIGISTQKLHVRGPMGLPALTSTKYVIRGNGQIRK

Sequences:

>Translated_438_residues
MKLFIEIIGFHFKNSDVKKEETKMNEVLAKGKKAKEIARELVLKSTSQKNEALAAIADQLIVEAAYILEENKRDIEEGKA
KGFSDSLLDRLMLNEQRIIDMAEGIKQLIELRNPVGECVSKWERPNGLFIQEMRVPLGVVGMIYEARPNVTVDAATICLK
TGNAVILRGSSSAIHSNKAIVAVIHRALKQTSLPQESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASV
PVLETGAGNCHVFIDETADKQMAFDIIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDS
SIVLASEEDWWTEFLSLTLAVKLVSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAAALYHNASTRFTDGSEFG
FGAEIGISTQKLHVRGPMGLPALTSTKYVIRGNGQIRK
>Mature_438_residues
MKLFIEIIGFHFKNSDVKKEETKMNEVLAKGKKAKEIARELVLKSTSQKNEALAAIADQLIVEAAYILEENKRDIEEGKA
KGFSDSLLDRLMLNEQRIIDMAEGIKQLIELRNPVGECVSKWERPNGLFIQEMRVPLGVVGMIYEARPNVTVDAATICLK
TGNAVILRGSSSAIHSNKAIVAVIHRALKQTSLPQESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASV
PVLETGAGNCHVFIDETADKQMAFDIIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDS
SIVLASEEDWWTEFLSLTLAVKLVSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAAALYHNASTRFTDGSEFG
FGAEIGISTQKLHVRGPMGLPALTSTKYVIRGNGQIRK

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=412, Percent_Identity=31.3106796116505, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI62912457, Length=412, Percent_Identity=31.3106796116505, Blast_Score=230, Evalue=2e-60,
Organism=Escherichia coli, GI1786438, Length=411, Percent_Identity=43.7956204379562, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17569969, Length=433, Percent_Identity=34.4110854503464, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17569967, Length=433, Percent_Identity=34.4110854503464, Blast_Score=260, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6324899, Length=427, Percent_Identity=36.768149882904, Blast_Score=276, Evalue=5e-75,
Organism=Drosophila melanogaster, GI21357643, Length=411, Percent_Identity=33.8199513381995, Blast_Score=261, Evalue=5e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 48517; Mature: 48517

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFIEIIGFHFKNSDVKKEETKMNEVLAKGKKAKEIARELVLKSTSQKNEALAAIADQL
CEEEEEEHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IVEAAYILEENKRDIEEGKAKGFSDSLLDRLMLNEQRIIDMAEGIKQLIELRNPVGECVS
HHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCHHHHHHH
KWERPNGLFIQEMRVPLGVVGMIYEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAI
HHCCCCCCEEEHHHCCHHHHHHHEECCCCCEEEHEEEEEECCCEEEEECCCCCHHCCCHH
VAVIHRALKQTSLPQESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCC
PVLETGAGNCHVFIDETADKQMAFDIIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFS
CEEECCCCCEEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SLKKRGVELRGDQKALAMDSSIVLASEEDWWTEFLSLTLAVKLVSSIEEAIHHINTYGSM
HHHHCCCCCCCCCHHEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
HSEAIISENEENVSKFFVSVDAAALYHNASTRFTDGSEFGFGAEIGISTQKLHVRGPMGL
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCEEEEEEECCCCC
PALTSTKYVIRGNGQIRK
CCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MKLFIEIIGFHFKNSDVKKEETKMNEVLAKGKKAKEIARELVLKSTSQKNEALAAIADQL
CEEEEEEHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IVEAAYILEENKRDIEEGKAKGFSDSLLDRLMLNEQRIIDMAEGIKQLIELRNPVGECVS
HHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCHHHHHHH
KWERPNGLFIQEMRVPLGVVGMIYEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAI
HHCCCCCCEEEHHHCCHHHHHHHEECCCCCEEEHEEEEEECCCEEEEECCCCCHHCCCHH
VAVIHRALKQTSLPQESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCC
PVLETGAGNCHVFIDETADKQMAFDIIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFS
CEEECCCCCEEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SLKKRGVELRGDQKALAMDSSIVLASEEDWWTEFLSLTLAVKLVSSIEEAIHHINTYGSM
HHHHCCCCCCCCCHHEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
HSEAIISENEENVSKFFVSVDAAALYHNASTRFTDGSEFGFGAEIGISTQKLHVRGPMGL
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCEEEEEEECCCCC
PALTSTKYVIRGNGQIRK
CCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA