Click here to switch to the map view.

The map label for this gene is hisC2 [H]

Identifier: 118478282

GI number: 118478282

Start: 2800518

End: 2801618

Strand: Reverse

Name: hisC2 [H]

Synonym: BALH_2643

Alternate gene names: 118478282

Gene position: 2801618-2800518 (Counterclockwise)

Preceding gene: 118478283

Following gene: 118478281

Centisome position: 53.29

GC content: 37.6

Gene sequence:

>1101_bases
ATGCAAGTAAAAGATCAACTATCAACATTACAACCATATAAACCAGGTAAATCACCTGAACAAATGAAAGAAGTGTACGG
AGATCATTCGTTTGTTAAATTAGCATCGAATGAAAATCCATTCGGCTGTTCGCCACGAGTTTTAGATGAGTTGCAAAAAT
CGTGGTTGGATCATGCTTTATACCCTGACGGAGGTGCTACAACGCTCCGTCAAACAATTGCAAATAAGTTACATGTGAAA
ATGGAACAAGTACTTTGCGGTAGTGGTTTAGATGAAGTCATTCAAATGATAAGCAGAGCAGTACTTAAAGCAGGAGATAA
CATCGTAACGGCTGGGGCAACATTCCCGCAGTATCGTCATCATGCAATTATAGAAGGTTGCGAAGTGAAGGAAGTTGCGT
TAAATAACGGTGTATACGACTTAGACGAAATTTCTTCAGTAGTAGATAACGATACAAAAATTGTATGGATTTGTAACCCG
AACAATCCAACAGGCACATATGTGAATGACCGAAAATTGACTCAATTCATTGAAGGTATTAGTGAAAATACGTTAATTGT
CATTGATGAAGCGTACTATGAATACGTAACAGCAAAAGATTTCCCAGAGACATTACCGCTTTTAGAAAAACATAAAAATA
TTCTTGTGCTTAGAACATTTTCTAAAGCGTACGGATTAGCTTCTTTCCGCGTTGGATATGCGGTTGGACATGAAGAATTA
ATCGAAAAATTAAATGTCGTTCGTTTGCCATTTAACGTATCTTCATTAGCGCAAAAAGCAGCGACGATTGCTTTTGGTGA
TGACGAGTTTATTGAAGAAATAGTTCGTGTGAATACAGAAGGTTTACGACAATACGAAAGTTTCTGTAAGGAAAATGAAA
TTCCATTTTATCAGTCACAAACAAATTTCATTTTCTTGCCAGTAGAAAATGGTGGAGAGATTTATGAAGCTTGCGCACAC
GCAGGGTTTATTATTCGTCCGTTCCCGAATGGTGTCCGCATCACAGTCGGAACAAGGGAGCAAAATGAAGGAGTGATTTC
AGTGTTACAACAACACTTTGAAAATAAAAAAAGAAAGTCTCGAGATGAGGCAAATGCGTAA

Upstream 100 bases:

>100_bases
AGTCGAACAATTCGGAAAAGATCGTATGGAATTAATTCAACAAAACATTACGCAACATAATAAATACGCAAAAGAATTTT
AATAAAAAGGTGGTTTTAAC

Downstream 100 bases:

>100_bases
AAAGGTAGTTTTAATTGGAACGGGTTTAATCGGAGGTTCTCTCGCATTAGCAATTAAGAAGGACCACGATGTAACGATAA
CAGGTTATGATATATTTCAA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2 [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MQVKDQLSTLQPYKPGKSPEQMKEVYGDHSFVKLASNENPFGCSPRVLDELQKSWLDHALYPDGGATTLRQTIANKLHVK
MEQVLCGSGLDEVIQMISRAVLKAGDNIVTAGATFPQYRHHAIIEGCEVKEVALNNGVYDLDEISSVVDNDTKIVWICNP
NNPTGTYVNDRKLTQFIEGISENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGHEEL
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLRQYESFCKENEIPFYQSQTNFIFLPVENGGEIYEACAH
AGFIIRPFPNGVRITVGTREQNEGVISVLQQHFENKKRKSRDEANA

Sequences:

>Translated_366_residues
MQVKDQLSTLQPYKPGKSPEQMKEVYGDHSFVKLASNENPFGCSPRVLDELQKSWLDHALYPDGGATTLRQTIANKLHVK
MEQVLCGSGLDEVIQMISRAVLKAGDNIVTAGATFPQYRHHAIIEGCEVKEVALNNGVYDLDEISSVVDNDTKIVWICNP
NNPTGTYVNDRKLTQFIEGISENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGHEEL
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLRQYESFCKENEIPFYQSQTNFIFLPVENGGEIYEACAH
AGFIIRPFPNGVRITVGTREQNEGVISVLQQHFENKKRKSRDEANA
>Mature_366_residues
MQVKDQLSTLQPYKPGKSPEQMKEVYGDHSFVKLASNENPFGCSPRVLDELQKSWLDHALYPDGGATTLRQTIANKLHVK
MEQVLCGSGLDEVIQMISRAVLKAGDNIVTAGATFPQYRHHAIIEGCEVKEVALNNGVYDLDEISSVVDNDTKIVWICNP
NNPTGTYVNDRKLTQFIEGISENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGHEEL
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLRQYESFCKENEIPFYQSQTNFIFLPVENGGEIYEACAH
AGFIIRPFPNGVRITVGTREQNEGVISVLQQHFENKKRKSRDEANA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=348, Percent_Identity=30.1724137931034, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788627, Length=229, Percent_Identity=27.0742358078603, Blast_Score=72, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322075, Length=390, Percent_Identity=27.1794871794872, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41126; Mature: 41126

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVKDQLSTLQPYKPGKSPEQMKEVYGDHSFVKLASNENPFGCSPRVLDELQKSWLDHAL
CCCHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
YPDGGATTLRQTIANKLHVKMEQVLCGSGLDEVIQMISRAVLKAGDNIVTAGATFPQYRH
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHH
HAIIEGCEVKEVALNNGVYDLDEISSVVDNDTKIVWICNPNNPTGTYVNDRKLTQFIEGI
HHHHCCCCEEEHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEECHHHHHHHHHCC
SENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGHEEL
CCCEEEEEEHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECHHHHCCHHHHHHHHCCHHHH
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLRQYESFCKENEIPFYQSQ
HHHHCEEECCCCHHHHHHHHHEEEECCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEECC
TNFIFLPVENGGEIYEACAHAGFIIRPFPNGVRITVGTREQNEGVISVLQQHFENKKRKS
CCEEEEEECCCCHHHHHHHHCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHC
RDEANA
CCCCCC
>Mature Secondary Structure
MQVKDQLSTLQPYKPGKSPEQMKEVYGDHSFVKLASNENPFGCSPRVLDELQKSWLDHAL
CCCHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
YPDGGATTLRQTIANKLHVKMEQVLCGSGLDEVIQMISRAVLKAGDNIVTAGATFPQYRH
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHH
HAIIEGCEVKEVALNNGVYDLDEISSVVDNDTKIVWICNPNNPTGTYVNDRKLTQFIEGI
HHHHCCCCEEEHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEECHHHHHHHHHCC
SENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGHEEL
CCCEEEEEEHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECHHHHCCHHHHHHHHCCHHHH
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLRQYESFCKENEIPFYQSQ
HHHHCEEECCCCHHHHHHHHHEEEECCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEECC
TNFIFLPVENGGEIYEACAHAGFIIRPFPNGVRITVGTREQNEGVISVLQQHFENKKRKS
CCEEEEEECCCCHHHHHHHHCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHC
RDEANA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]