Click here to switch to the map view.

The map label for this gene is coaW [H]

Identifier: 118478243

GI number: 118478243

Start: 2759631

End: 2760461

Strand: Direct

Name: coaW [H]

Synonym: BALH_2604

Alternate gene names: 118478243

Gene position: 2759631-2760461 (Clockwise)

Preceding gene: 118478242

Following gene: 118478249

Centisome position: 52.49

GC content: 32.49

Gene sequence:

>831_bases
ATGGAAAGTACGATCGGTATCGATGCTGGAGGAACATTAACGAAAATTGCTTATTTGAACGAAAAAAAGCAATTAGCCTT
TGAAAAATTTTATTCAAATGAACAAGATAACATAATAGATTGGCTTAAGAACCGAACTGGTATAAAACAAATATGTATTA
CTGGTGGTAAAGCGAAACAATTACAACAACTACTTTTAGACTCATATAAAATAGTTGAACTAAACGAATTTGAAGCTACT
CTTGTAGGTGTCCGTTACATATTAAAAAAAGAAAAATATGATATAAACAACTTTGTTTTAACAAATATCGGTACAGGTAC
TTCCATTCATTACGTTTATAATGACAAATATATTCGCGCTGGTGGAACCGGTGTTGGCGGCGGTACTATTATGGGGCTTT
CAAAATTGTTAACAAATATAGCTCATTTTGAAGATGTGATTCCTTTAACAAAAGTAGGATCTAGAAAAGAACTTGATATT
ACGGTTGGAGATATTTATGGTGGTATTCTCTCTCCTATTGATAATAGTTTAACTGCAAGCAATTTTGGTAAAGTCGCTAT
TACAGACTCAAATTATAATAGCTCAGATATACTTGCTACTGTACAAGGACTTGTCGGTGAAGTCGTTACTGCATTAAGCC
TTCAATTCGCCGAAACAAAAAACATTGACCATATTATTTATATTGGTTCGACTCTATGTAATAACATACATCTTCAAAAT
ATTATTAGTAGCTACACAAAATACCAAAATAAAACACCCATCTTTTTACGAGATGGTGGTAATAGCGGTGCAATTGGTGC
TTTACTTCATGCTACGAATAAAAAAAGCTGA

Upstream 100 bases:

>100_bases
CAGAATAGAGACGTTTTCATTCACTAGGGTATCTATCTCCTACAAATTCGTCTCATCAACATGAACAGAGTAAACAAATT
ACTTAGTTAGGGGCAGAAAA

Downstream 100 bases:

>100_bases
CTTTTGTCAGCTTTTTTGCAACGGTACTTCAAATTCAATAATCGATTCCCCCTTTTCTCCAATTCGCTCTACACTAATTC
TATCAATTACACATTGTAAC

Product: pantothenate kinase

Products: NA

Alternate protein names: PanK-II; Pantothenic acid kinase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MESTIGIDAGGTLTKIAYLNEKKQLAFEKFYSNEQDNIIDWLKNRTGIKQICITGGKAKQLQQLLLDSYKIVELNEFEAT
LVGVRYILKKEKYDINNFVLTNIGTGTSIHYVYNDKYIRAGGTGVGGGTIMGLSKLLTNIAHFEDVIPLTKVGSRKELDI
TVGDIYGGILSPIDNSLTASNFGKVAITDSNYNSSDILATVQGLVGEVVTALSLQFAETKNIDHIIYIGSTLCNNIHLQN
IISSYTKYQNKTPIFLRDGGNSGAIGALLHATNKKS

Sequences:

>Translated_276_residues
MESTIGIDAGGTLTKIAYLNEKKQLAFEKFYSNEQDNIIDWLKNRTGIKQICITGGKAKQLQQLLLDSYKIVELNEFEAT
LVGVRYILKKEKYDINNFVLTNIGTGTSIHYVYNDKYIRAGGTGVGGGTIMGLSKLLTNIAHFEDVIPLTKVGSRKELDI
TVGDIYGGILSPIDNSLTASNFGKVAITDSNYNSSDILATVQGLVGEVVTALSLQFAETKNIDHIIYIGSTLCNNIHLQN
IISSYTKYQNKTPIFLRDGGNSGAIGALLHATNKKS
>Mature_276_residues
MESTIGIDAGGTLTKIAYLNEKKQLAFEKFYSNEQDNIIDWLKNRTGIKQICITGGKAKQLQQLLLDSYKIVELNEFEAT
LVGVRYILKKEKYDINNFVLTNIGTGTSIHYVYNDKYIRAGGTGVGGGTIMGLSKLLTNIAHFEDVIPLTKVGSRKELDI
TVGDIYGGILSPIDNSLTASNFGKVAITDSNYNSSDILATVQGLVGEVVTALSLQFAETKNIDHIIYIGSTLCNNIHLQN
IISSYTKYQNKTPIFLRDGGNSGAIGALLHATNKKS

Specific function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis [H]

COG id: COG5146

COG function: function code H; Pantothenate kinase, acetyl-CoA regulated

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II pantothenate kinase family [H]

Homologues:

Organism=Homo sapiens, GI8922665, Length=330, Percent_Identity=25.4545454545455, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI23510402, Length=300, Percent_Identity=26.3333333333333, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI24430175, Length=259, Percent_Identity=27.7992277992278, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI24430167, Length=259, Percent_Identity=27.7992277992278, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI85838513, Length=301, Percent_Identity=26.2458471760797, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI23510400, Length=300, Percent_Identity=26.3333333333333, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI13375789, Length=303, Percent_Identity=24.0924092409241, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32565377, Length=335, Percent_Identity=24.4776119402985, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25144310, Length=335, Percent_Identity=24.4776119402985, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25144312, Length=219, Percent_Identity=28.310502283105, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20544156, Length=290, Percent_Identity=29.3103448275862, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24667450, Length=290, Percent_Identity=29.3103448275862, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24667454, Length=290, Percent_Identity=29.3103448275862, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI20544160, Length=290, Percent_Identity=29.3103448275862, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17864532, Length=290, Percent_Identity=29.3103448275862, Blast_Score=100, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011602
- InterPro:   IPR014642
- InterPro:   IPR004567 [H]

Pfam domain/function: PF03630 Fumble [H]

EC number: =2.7.1.33 [H]

Molecular weight: Translated: 30122; Mature: 30122

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESTIGIDAGGTLTKIAYLNEKKQLAFEKFYSNEQDNIIDWLKNRTGIKQICITGGKAKQ
CCCCEECCCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHCCCCCHHEEECCCCHHH
LQQLLLDSYKIVELNEFEATLVGVRYILKKEKYDINNFVLTNIGTGTSIHYVYNDKYIRA
HHHHHHCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCEEEEC
GGTGVGGGTIMGLSKLLTNIAHFEDVIPLTKVGSRKELDITVGDIYGGILSPIDNSLTAS
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCEEEEEEHHHHHHHHHHCCCCCCCC
NFGKVAITDSNYNSSDILATVQGLVGEVVTALSLQFAETKNIDHIIYIGSTLCNNIHLQN
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCHHHHH
IISSYTKYQNKTPIFLRDGGNSGAIGALLHATNKKS
HHHHHHHHCCCCCEEEEECCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MESTIGIDAGGTLTKIAYLNEKKQLAFEKFYSNEQDNIIDWLKNRTGIKQICITGGKAKQ
CCCCEECCCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHCCCCCHHEEECCCCHHH
LQQLLLDSYKIVELNEFEATLVGVRYILKKEKYDINNFVLTNIGTGTSIHYVYNDKYIRA
HHHHHHCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCEEEEC
GGTGVGGGTIMGLSKLLTNIAHFEDVIPLTKVGSRKELDITVGDIYGGILSPIDNSLTAS
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCEEEEEEHHHHHHHHHHCCCCCCCC
NFGKVAITDSNYNSSDILATVQGLVGEVVTALSLQFAETKNIDHIIYIGSTLCNNIHLQN
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCHHHHH
IISSYTKYQNKTPIFLRDGGNSGAIGALLHATNKKS
HHHHHHHHCCCCCEEEEECCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]