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The map label for this gene is 118477781

Identifier: 118477781

GI number: 118477781

Start: 2274597

End: 2275790

Strand: Reverse

Name: 118477781

Synonym: BALH_2119

Alternate gene names: NA

Gene position: 2275790-2274597 (Counterclockwise)

Preceding gene: 118477782

Following gene: 118477778

Centisome position: 43.29

GC content: 36.77

Gene sequence:

>1194_bases
TTGAAAAACAAAATCATTGTTTTCCTATCTGTTTTGTCATTTATTATTGGTGGTTTCTTCTTTAACACAAATACTTCAAG
TGCTGAAACATCATCTACTGATTACGTTCCTAACCAATTGATCGTTAAGTTCAAACAAAATGCATCTTTAAGTAATGTGC
AATCTTTTCATAAGTCTGTTGGTGCTACTGTTTTATCTAAAGATGATAAGTTAGGTTTTGAAGTCGTTCAATTTTCGAAA
GGTACTGTAAAAGAAAAGATAAAAAGCTATAAAAACAATCCAGATGTGGAATATGCAGAGCCGAATTACTACGTTCACTC
CTTTTGGACTCCGAACGATCCATATTATAAAAATCAATATGGATTACAAAAAATTCAAGCTCCACTAGCTTGGGATAGTC
AACGAAGTGATTCTAGTATAAAAGTAGCTATTATTGATACAGGAGTACAAGGTTCACACCCTGATTTATCTTCGAAAGTA
ATTTACGGGCATGATTATGTTGATAACGATAATGTTTCTGATGACGGTAATGGTCATGGTACACATTGCGCTGGAATTAC
TGGAGCACTTACGAATAACAGCGTCGGAATTGCTGGTGTTGCCCCACAAACTTCAATTTATGCTGTCCGCGTATTAGATA
ATCAAGGAAGTGGGACTCTTGATGCTGTAGCGCAAGGTATTCGAGAAGCTGCTGATTCAGGTGCAAAAGTAATTAGTTTA
AGTTTAGGAGCTCCAAATGGTGGGACTGCATTACAACAAGCTGTTCAATATGCATGGAATAAAGGCTCTGTTATTGTTGC
GGCTGCTGGAAATGCTGGAAATACAAAAGCTAATTACCCTGCTTATTACAGCGAAGTAATTGCAGTTGCTTCTACAGATC
AATCAGATAGAAAATCTTCATTTTCTACTTATGGTAGCTGGGTAGATGTTGCAGCACCAGGTTCAAATATATATTCCACA
TATAAAGGAAGCACGTATCAATCATTAAGTGGTACATCTATGGCAACACCCCACGTTGCAGGAGTCGCTGCTCTTTTAGC
AAATCAAGGATATAGCAATACTCAAATCCGCCAAATTATTGAGTCAACTACTGATAAAATTAGTGGTACAGGTACGTACT
GGAAAAACGGTAGAGTCAATGCATATAAGGCTGTACAATATGCTAAGCAATTACAAGAAAAGAAAGCCTCTTAA

Upstream 100 bases:

>100_bases
TAAATGACATAAATCGTATGGTCTAACTATATAGTTGAAAAGGAATGCGACATTAAAGCGTCGCTGAAAAACTTATCCAA
GAAAAGGGAGGAAAAATCTT

Downstream 100 bases:

>100_bases
GAAATCAAGTGAAATTATAATCTGTCGTTCTACCATTCATGCAGGATAAAATAGAAGGAGAGACTTTTACAATGAAAGCC
TCTCCTTCTTACAAATAATA

Product: thermitase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MKNKIIVFLSVLSFIIGGFFFNTNTSSAETSSTDYVPNQLIVKFKQNASLSNVQSFHKSVGATVLSKDDKLGFEVVQFSK
GTVKEKIKSYKNNPDVEYAEPNYYVHSFWTPNDPYYKNQYGLQKIQAPLAWDSQRSDSSIKVAIIDTGVQGSHPDLSSKV
IYGHDYVDNDNVSDDGNGHGTHCAGITGALTNNSVGIAGVAPQTSIYAVRVLDNQGSGTLDAVAQGIREAADSGAKVISL
SLGAPNGGTALQQAVQYAWNKGSVIVAAAGNAGNTKANYPAYYSEVIAVASTDQSDRKSSFSTYGSWVDVAAPGSNIYST
YKGSTYQSLSGTSMATPHVAGVAALLANQGYSNTQIRQIIESTTDKISGTGTYWKNGRVNAYKAVQYAKQLQEKKAS

Sequences:

>Translated_397_residues
MKNKIIVFLSVLSFIIGGFFFNTNTSSAETSSTDYVPNQLIVKFKQNASLSNVQSFHKSVGATVLSKDDKLGFEVVQFSK
GTVKEKIKSYKNNPDVEYAEPNYYVHSFWTPNDPYYKNQYGLQKIQAPLAWDSQRSDSSIKVAIIDTGVQGSHPDLSSKV
IYGHDYVDNDNVSDDGNGHGTHCAGITGALTNNSVGIAGVAPQTSIYAVRVLDNQGSGTLDAVAQGIREAADSGAKVISL
SLGAPNGGTALQQAVQYAWNKGSVIVAAAGNAGNTKANYPAYYSEVIAVASTDQSDRKSSFSTYGSWVDVAAPGSNIYST
YKGSTYQSLSGTSMATPHVAGVAALLANQGYSNTQIRQIIESTTDKISGTGTYWKNGRVNAYKAVQYAKQLQEKKAS
>Mature_397_residues
MKNKIIVFLSVLSFIIGGFFFNTNTSSAETSSTDYVPNQLIVKFKQNASLSNVQSFHKSVGATVLSKDDKLGFEVVQFSK
GTVKEKIKSYKNNPDVEYAEPNYYVHSFWTPNDPYYKNQYGLQKIQAPLAWDSQRSDSSIKVAIIDTGVQGSHPDLSSKV
IYGHDYVDNDNVSDDGNGHGTHCAGITGALTNNSVGIAGVAPQTSIYAVRVLDNQGSGTLDAVAQGIREAADSGAKVISL
SLGAPNGGTALQQAVQYAWNKGSVIVAAAGNAGNTKANYPAYYSEVIAVASTDQSDRKSSFSTYGSWVDVAAPGSNIYST
YKGSTYQSLSGTSMATPHVAGVAALLANQGYSNTQIRQIIESTTDKISGTGTYWKNGRVNAYKAVQYAKQLQEKKAS

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=265, Percent_Identity=29.4339622641509, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI31317307, Length=273, Percent_Identity=30.7692307692308, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI27894285, Length=363, Percent_Identity=24.5179063360882, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI20336188, Length=362, Percent_Identity=24.3093922651934, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI20336190, Length=362, Percent_Identity=24.3093922651934, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI20336180, Length=362, Percent_Identity=24.3093922651934, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI20336186, Length=362, Percent_Identity=24.3093922651934, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4505577, Length=362, Percent_Identity=24.3093922651934, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI20336184, Length=361, Percent_Identity=24.3767313019391, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI20336182, Length=361, Percent_Identity=24.3767313019391, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4505579, Length=300, Percent_Identity=25, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71983555, Length=395, Percent_Identity=22.7848101265823, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25141268, Length=395, Percent_Identity=22.7848101265823, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71988308, Length=272, Percent_Identity=27.9411764705882, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71988301, Length=272, Percent_Identity=27.9411764705882, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71988315, Length=272, Percent_Identity=27.9411764705882, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320775, Length=234, Percent_Identity=38.8888888888889, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324576, Length=214, Percent_Identity=40.6542056074766, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319893, Length=232, Percent_Identity=37.0689655172414, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45550681, Length=289, Percent_Identity=25.2595155709343, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24642494, Length=306, Percent_Identity=27.1241830065359, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642490, Length=306, Percent_Identity=27.1241830065359, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45555723, Length=306, Percent_Identity=27.1241830065359, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642492, Length=306, Percent_Identity=27.1241830065359, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281360987, Length=286, Percent_Identity=27.6223776223776, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24642488, Length=309, Percent_Identity=26.8608414239482, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24642484, Length=309, Percent_Identity=26.8608414239482, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24642486, Length=309, Percent_Identity=26.8608414239482, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: =3.4.21.66 [H]

Molecular weight: Translated: 42414; Mature: 42414

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00136 SUBTILASE_ASP ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKIIVFLSVLSFIIGGFFFNTNTSSAETSSTDYVPNQLIVKFKQNASLSNVQSFHKSV
CCCCEEEHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
GATVLSKDDKLGFEVVQFSKGTVKEKIKSYKNNPDVEYAEPNYYVHSFWTPNDPYYKNQY
CCEEECCCCCCCEEEEECCCCHHHHHHHHHCCCCCCEEECCCEEEEEEECCCCCCCCCCC
GLQKIQAPLAWDSQRSDSSIKVAIIDTGVQGSHPDLSSKVIYGHDYVDNDNVSDDGNGHG
CHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
THCAGITGALTNNSVGIAGVAPQTSIYAVRVLDNQGSGTLDAVAQGIREAADSGAKVISL
CEECCEEEEECCCCCEEEECCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEE
SLGAPNGGTALQQAVQYAWNKGSVIVAAAGNAGNTKANYPAYYSEVIAVASTDQSDRKSS
EECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHEEEEECCCCHHHHHH
FSTYGSWVDVAAPGSNIYSTYKGSTYQSLSGTSMATPHVAGVAALLANQGYSNTQIRQII
HHHCCCEEEEECCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
ESTTDKISGTGTYWKNGRVNAYKAVQYAKQLQEKKAS
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNKIIVFLSVLSFIIGGFFFNTNTSSAETSSTDYVPNQLIVKFKQNASLSNVQSFHKSV
CCCCEEEHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
GATVLSKDDKLGFEVVQFSKGTVKEKIKSYKNNPDVEYAEPNYYVHSFWTPNDPYYKNQY
CCEEECCCCCCCEEEEECCCCHHHHHHHHHCCCCCCEEECCCEEEEEEECCCCCCCCCCC
GLQKIQAPLAWDSQRSDSSIKVAIIDTGVQGSHPDLSSKVIYGHDYVDNDNVSDDGNGHG
CHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
THCAGITGALTNNSVGIAGVAPQTSIYAVRVLDNQGSGTLDAVAQGIREAADSGAKVISL
CEECCEEEEECCCCCEEEECCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEE
SLGAPNGGTALQQAVQYAWNKGSVIVAAAGNAGNTKANYPAYYSEVIAVASTDQSDRKSS
EECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHEEEEECCCCHHHHHH
FSTYGSWVDVAAPGSNIYSTYKGSTYQSLSGTSMATPHVAGVAALLANQGYSNTQIRQII
HHHCCCEEEEECCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
ESTTDKISGTGTYWKNGRVNAYKAVQYAKQLQEKKAS
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2647518; 2689655; 2196375; 1993669 [H]