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The map label for this gene is yrhP [H]

Identifier: 118477761

GI number: 118477761

Start: 2247124

End: 2247813

Strand: Reverse

Name: yrhP [H]

Synonym: BALH_2099

Alternate gene names: 118477761

Gene position: 2247813-2247124 (Counterclockwise)

Preceding gene: 118477762

Following gene: 118477751

Centisome position: 42.76

GC content: 32.17

Gene sequence:

>690_bases
ATGTGTGCTACACTATTTTTAATCAAATATTCTAAAAATAAAAAAGGAGGAGCGACTATGATTGAAAATTTTTTTCTTTT
CATCATTATGTCTATTTGTCTTATTATTTTACCCGGTCCAGATACAGCAATGGCTACGAAAAACACATTAGTTGCTGGTA
AGGTAGGCGGGGTGAAAACAGTGTTCGGTACATGTATTGCACTATTGATCCATACTTTAGCAGCGGTAATCGGCCTTTCT
GCACTTATTGTAAAGTCAGCTCTTTTATTTTCTATTTTCAAGTACGTTGGAGCTCTATATTTAATTTATATTGGTATTAA
AGCCCTTTTAGCAGTAAGAAATAAAGAAGGCGTCGATACGAACGATATTTCTTTGCATAATGAAGACGAACACACTTCTT
GCTTTCGTCAAGGGTTTCTTACGAATTTATTAAACCCTAAAGTTGCAGTCTTCTTTTTAACATTTTTACCGCAATTTTTA
AATCCAAATCATAATACGTTTATCCAACTTCTCATAATGGGCCTTACTTACCTCATTTTAACAGTTATATGGTTCGCTTT
TTATATATTTTTAATTGATAAAATTAGTGCTTTTATGAAAAAACCGAAGACGCAACGTTATATTCAAGGGTTAACGGGAA
TCGTCTTAATTGGTTTTGGCATTAAACTTGCTTTTGAAAAAAGTAATTAA

Upstream 100 bases:

>100_bases
TTGGGATAAACCTGAGGCTATATAGTCGTGTAATTCCATGACTATATAGCCTCTTTTCTATTTAATATTTTTTAATAAAA
TTTAATTTTATTAAATCGAA

Downstream 100 bases:

>100_bases
CAAAACGAAAACCACCACTATTTCTAGTGGTGGTTTTCATTTAATAACTGATTTGACTGTTTACTCTTTATTAAAACCAG
CGCTCAGTTACAACTTTTTT

Product: homoserine/threonine efflux protein

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MCATLFLIKYSKNKKGGATMIENFFLFIIMSICLIILPGPDTAMATKNTLVAGKVGGVKTVFGTCIALLIHTLAAVIGLS
ALIVKSALLFSIFKYVGALYLIYIGIKALLAVRNKEGVDTNDISLHNEDEHTSCFRQGFLTNLLNPKVAVFFLTFLPQFL
NPNHNTFIQLLIMGLTYLILTVIWFAFYIFLIDKISAFMKKPKTQRYIQGLTGIVLIGFGIKLAFEKSN

Sequences:

>Translated_229_residues
MCATLFLIKYSKNKKGGATMIENFFLFIIMSICLIILPGPDTAMATKNTLVAGKVGGVKTVFGTCIALLIHTLAAVIGLS
ALIVKSALLFSIFKYVGALYLIYIGIKALLAVRNKEGVDTNDISLHNEDEHTSCFRQGFLTNLLNPKVAVFFLTFLPQFL
NPNHNTFIQLLIMGLTYLILTVIWFAFYIFLIDKISAFMKKPKTQRYIQGLTGIVLIGFGIKLAFEKSN
>Mature_229_residues
MCATLFLIKYSKNKKGGATMIENFFLFIIMSICLIILPGPDTAMATKNTLVAGKVGGVKTVFGTCIALLIHTLAAVIGLS
ALIVKSALLFSIFKYVGALYLIYIGIKALLAVRNKEGVDTNDISLHNEDEHTSCFRQGFLTNLLNPKVAVFFLTFLPQFL
NPNHNTFIQLLIMGLTYLILTVIWFAFYIFLIDKISAFMKKPKTQRYIQGLTGIVLIGFGIKLAFEKSN

Specific function: Conducts The Efflux Of Homoserine And Homoserine Lactone. [C]

COG id: COG1280

COG function: function code E; Putative threonine efflux protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=207, Percent_Identity=27.536231884058, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788099, Length=208, Percent_Identity=27.4038461538462, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI48994978, Length=208, Percent_Identity=25.4807692307692, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004778
- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 25387; Mature: 25387

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCATLFLIKYSKNKKGGATMIENFFLFIIMSICLIILPGPDTAMATKNTLVAGKVGGVKT
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHCCCEEECCCCCHHH
VFGTCIALLIHTLAAVIGLSALIVKSALLFSIFKYVGALYLIYIGIKALLAVRNKEGVDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
NDISLHNEDEHTSCFRQGFLTNLLNPKVAVFFLTFLPQFLNPNHNTFIQLLIMGLTYLIL
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
TVIWFAFYIFLIDKISAFMKKPKTQRYIQGLTGIVLIGFGIKLAFEKSN
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCC
>Mature Secondary Structure
MCATLFLIKYSKNKKGGATMIENFFLFIIMSICLIILPGPDTAMATKNTLVAGKVGGVKT
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHCCCEEECCCCCHHH
VFGTCIALLIHTLAAVIGLSALIVKSALLFSIFKYVGALYLIYIGIKALLAVRNKEGVDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
NDISLHNEDEHTSCFRQGFLTNLLNPKVAVFFLTFLPQFLNPNHNTFIQLLIMGLTYLIL
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
TVIWFAFYIFLIDKISAFMKKPKTQRYIQGLTGIVLIGFGIKLAFEKSN
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 9308178 [H]