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The map label for this gene is ykwA [H]

Identifier: 118477272

GI number: 118477272

Start: 1725384

End: 1727126

Strand: Direct

Name: ykwA [H]

Synonym: BALH_1583

Alternate gene names: 118477272

Gene position: 1725384-1727126 (Clockwise)

Preceding gene: 118477271

Following gene: 118477273

Centisome position: 32.82

GC content: 39.59

Gene sequence:

>1743_bases
ATGCTATATATGAATAGAGGTAGGGATGTTATGAGCAAGTTTACAGTAGCTTCTAATGGTTCATTAGAAACGATATTAAG
AGGAGTAGAAGTATTATCAACACCACTTTTAAATAAAGGGGTCGCTTTCACGCAAGAAGAAAGAGAAGAATTAGGTTTAA
AAGGGTTATTACCGCCAGCAGTTTTAACATTGGAAGAACAAGCACGCCGAGCATACGAACAATTTTGTTCTCAGCCGGAT
GATTTATTAAAGAATGTATACTTAACAGCGTTACATGATCGAAATGAAGTGTTATTTTATCGCATTTTAACAGATCATTT
ACGCGAAATGTTACCAATCGTATATACACCAACTGTTGGTGTAGCAATCCAAAGATATAGTCATGAATACCGTAAACCAC
GTGGTGTGTATTTATCAATTAACGATCCGTCAGGTATTGAAGAAGCATTCGCCAATATCGGTGCAACAGCAGAAAATATT
GATTTAGTCGTTGTTACAGATGGAGAAGGCATACTTGGAATTGGTGACTGGGGCGTTGGTGGCATTAACATCGCAATCGG
AAAATTAGCTGTTTATACGGCAGCAGTTGGAATCGATCCTAGCCGCGTATTACCGGTAATTTTAGACGTAGGTACAAATC
GTGAGGAACTATTAAATAATCCATTTTATATTGGAAATCGTCACCCTCGTATAACAGGTGAAGCTTACGATGAATTTATT
GATACATTTGTACAAGCGGTAAATAAACAATTCCCGAAAGCACTTTTACATTGGGAAGACTTTAGCTCTCGAAATGCACG
AAAAATTTTAGATAAATATCGTCATGATATTTGTACGTTTAATGATGATATTCAAGGAACAGGTGCAGTTTCACTTGCTG
CTGTATTATCTGCAGTGAAAGCTTCTGGTGTACCGCTAAGTGAACACCGCGTTGTTGTGTTTGGTGCTGGTACGGCTGGA
ATCGGTATCGCAGATCAAGTTAGAGATGCGATGGTACGCGTCGGCGTATCAGAAGAAGAATCATATAAGCGCTTCTGGTG
TATTGATCGTAACGGATTAGTTACAGATAATATGGAAGATCTTCTTGATTTCCAAATTCCGTATGCAAGAAAAGAAGCGG
AAGTAAGTGAGTGGAAAGAAAATGGTGTGATTGGACTTGCTGAAGTTGTGAAACATGTGAAACCGACAATTTTAATTGGT
ACATCAACTGTTGCAGGCGCATTTAAAGAAGAAATTATTAAAGAAATGGCTTCTCACGTAGAAAGACCAATCATTTTACC
AATGTCGAATCCGACGCCACTTGCTGAAGCGAAACCAGCCGATTTAATCGAGTGGACAGAAGGAAGAGCACTAGTTGCAA
CAGGAAGTCCATTTGAACCAGTTACATATAACGGTGTAACGTATGTAATTGGGCAATCAAATAATGCACTTATTTTCCCA
GGTCTTGGTCTTGGAACAATTGTCGTACGTGCAAGCGTCATGACAGATGGAATGTTCGCAGCAGCAGCTGAAGCAGTTGC
AAGCATGGTGGACACAAGTCAGCCAGGAGCACCTATTTTGCCAGAAGTTGAAGAGTTACGTAATATCTCGGAAATGGTAG
CAATTGAAGTAGCGAAAGTTGCTGTTGCAGAAGGTGTTGCTAGAGAGAACTTAAGTGATAACGATATCAAGATTGCAGTG
AAAGAAGCAATCTGGGAGCCTGAGTATCGCCAAATAAAAGCGGTAGAAAAGGTTACAATATAG

Upstream 100 bases:

>100_bases
CATTTGAAATGACACACCCAGGGATTGCAGGAGCAACTCTTTTAAAGAAAAATTAAAAGAAGAGGGGGACAAGCCCCTCT
TTTTTGTTTACAATATAGAA

Downstream 100 bases:

>100_bases
AAATAAAGCCCGTTTATAATATAAGCGGGCTTTCACTTTTATTACTGAAAAAAAGAGTATAGGAAGTGGCACCTTTGAAT
TGGAATCAATTATGGAAGAA

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME 3 [H]

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MLYMNRGRDVMSKFTVASNGSLETILRGVEVLSTPLLNKGVAFTQEEREELGLKGLLPPAVLTLEEQARRAYEQFCSQPD
DLLKNVYLTALHDRNEVLFYRILTDHLREMLPIVYTPTVGVAIQRYSHEYRKPRGVYLSINDPSGIEEAFANIGATAENI
DLVVVTDGEGILGIGDWGVGGINIAIGKLAVYTAAVGIDPSRVLPVILDVGTNREELLNNPFYIGNRHPRITGEAYDEFI
DTFVQAVNKQFPKALLHWEDFSSRNARKILDKYRHDICTFNDDIQGTGAVSLAAVLSAVKASGVPLSEHRVVVFGAGTAG
IGIADQVRDAMVRVGVSEEESYKRFWCIDRNGLVTDNMEDLLDFQIPYARKEAEVSEWKENGVIGLAEVVKHVKPTILIG
TSTVAGAFKEEIIKEMASHVERPIILPMSNPTPLAEAKPADLIEWTEGRALVATGSPFEPVTYNGVTYVIGQSNNALIFP
GLGLGTIVVRASVMTDGMFAAAAEAVASMVDTSQPGAPILPEVEELRNISEMVAIEVAKVAVAEGVARENLSDNDIKIAV
KEAIWEPEYRQIKAVEKVTI

Sequences:

>Translated_580_residues
MLYMNRGRDVMSKFTVASNGSLETILRGVEVLSTPLLNKGVAFTQEEREELGLKGLLPPAVLTLEEQARRAYEQFCSQPD
DLLKNVYLTALHDRNEVLFYRILTDHLREMLPIVYTPTVGVAIQRYSHEYRKPRGVYLSINDPSGIEEAFANIGATAENI
DLVVVTDGEGILGIGDWGVGGINIAIGKLAVYTAAVGIDPSRVLPVILDVGTNREELLNNPFYIGNRHPRITGEAYDEFI
DTFVQAVNKQFPKALLHWEDFSSRNARKILDKYRHDICTFNDDIQGTGAVSLAAVLSAVKASGVPLSEHRVVVFGAGTAG
IGIADQVRDAMVRVGVSEEESYKRFWCIDRNGLVTDNMEDLLDFQIPYARKEAEVSEWKENGVIGLAEVVKHVKPTILIG
TSTVAGAFKEEIIKEMASHVERPIILPMSNPTPLAEAKPADLIEWTEGRALVATGSPFEPVTYNGVTYVIGQSNNALIFP
GLGLGTIVVRASVMTDGMFAAAAEAVASMVDTSQPGAPILPEVEELRNISEMVAIEVAKVAVAEGVARENLSDNDIKIAV
KEAIWEPEYRQIKAVEKVTI
>Mature_580_residues
MLYMNRGRDVMSKFTVASNGSLETILRGVEVLSTPLLNKGVAFTQEEREELGLKGLLPPAVLTLEEQARRAYEQFCSQPD
DLLKNVYLTALHDRNEVLFYRILTDHLREMLPIVYTPTVGVAIQRYSHEYRKPRGVYLSINDPSGIEEAFANIGATAENI
DLVVVTDGEGILGIGDWGVGGINIAIGKLAVYTAAVGIDPSRVLPVILDVGTNREELLNNPFYIGNRHPRITGEAYDEFI
DTFVQAVNKQFPKALLHWEDFSSRNARKILDKYRHDICTFNDDIQGTGAVSLAAVLSAVKASGVPLSEHRVVVFGAGTAG
IGIADQVRDAMVRVGVSEEESYKRFWCIDRNGLVTDNMEDLLDFQIPYARKEAEVSEWKENGVIGLAEVVKHVKPTILIG
TSTVAGAFKEEIIKEMASHVERPIILPMSNPTPLAEAKPADLIEWTEGRALVATGSPFEPVTYNGVTYVIGQSNNALIFP
GLGLGTIVVRASVMTDGMFAAAAEAVASMVDTSQPGAPILPEVEELRNISEMVAIEVAKVAVAEGVARENLSDNDIKIAV
KEAIWEPEYRQIKAVEKVTI

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=546, Percent_Identity=42.1245421245421, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI62420880, Length=546, Percent_Identity=42.1245421245421, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI239049447, Length=546, Percent_Identity=42.1245421245421, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI4505143, Length=554, Percent_Identity=40.6137184115523, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI4505145, Length=571, Percent_Identity=39.2294220665499, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI270265879, Length=482, Percent_Identity=41.701244813278, Blast_Score=361, Evalue=1e-99,
Organism=Escherichia coli, GI87081919, Length=548, Percent_Identity=47.2627737226277, Blast_Score=509, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17537199, Length=552, Percent_Identity=43.2971014492754, Blast_Score=436, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6322823, Length=578, Percent_Identity=45.3287197231834, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI281362674, Length=548, Percent_Identity=40.6934306569343, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI21356279, Length=548, Percent_Identity=40.6934306569343, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI281362672, Length=548, Percent_Identity=40.6934306569343, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24646388, Length=526, Percent_Identity=39.9239543726236, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24646386, Length=526, Percent_Identity=39.9239543726236, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI78707242, Length=556, Percent_Identity=35.431654676259, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI78707238, Length=556, Percent_Identity=35.431654676259, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI281363505, Length=538, Percent_Identity=34.7583643122677, Blast_Score=358, Evalue=7e-99,
Organism=Drosophila melanogaster, GI78707236, Length=538, Percent_Identity=34.7583643122677, Blast_Score=358, Evalue=7e-99,
Organism=Drosophila melanogaster, GI78707240, Length=529, Percent_Identity=36.2948960302458, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI281363503, Length=536, Percent_Identity=34.5149253731343, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI78707232, Length=512, Percent_Identity=35.546875, Blast_Score=352, Evalue=4e-97,
Organism=Drosophila melanogaster, GI19922384, Length=574, Percent_Identity=28.9198606271777, Blast_Score=256, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 63461; Mature: 63461

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYMNRGRDVMSKFTVASNGSLETILRGVEVLSTPLLNKGVAFTQEEREELGLKGLLPPA
CCEECCCHHHHHHHEECCCCCHHHHHHHHHHHHCCHHCCCCCCCHHHHHHCCCCCCCCHH
VLTLEEQARRAYEQFCSQPDDLLKNVYLTALHDRNEVLFYRILTDHLREMLPIVYTPTVG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCEEEHHHHHHHHHHHCCEEECCCHH
VAIQRYSHEYRKPRGVYLSINDPSGIEEAFANIGATAENIDLVVVTDGEGILGIGDWGVG
HHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCCEEEEEEECCCCEEEECCCCCC
GINIAIGKLAVYTAAVGIDPSRVLPVILDVGTNREELLNNPFYIGNRHPRITGEAYDEFI
CEEEEHHHHEEHHHHCCCCHHHCEEEEEECCCCHHHHCCCCEEECCCCCCCCHHHHHHHH
DTFVQAVNKQFPKALLHWEDFSSRNARKILDKYRHDICTFNDDIQGTGAVSLAAVLSAVK
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
ASGVPLSEHRVVVFGAGTAGIGIADQVRDAMVRVGVSEEESYKRFWCIDRNGLVTDNMED
HCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHH
LLDFQIPYARKEAEVSEWKENGVIGLAEVVKHVKPTILIGTSTVAGAFKEEIIKEMASHV
HHHCCCCCCCCCCHHHHHHHCCCEEHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHC
ERPIILPMSNPTPLAEAKPADLIEWTEGRALVATGSPFEPVTYNGVTYVIGQSNNALIFP
CCCEEEECCCCCCCCCCCCCCCEEECCCCEEEECCCCCCCEEECCEEEEEECCCCEEEEC
GLGLGTIVVRASVMTDGMFAAAAEAVASMVDTSQPGAPILPEVEELRNISEMVAIEVAKV
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AVAEGVARENLSDNDIKIAVKEAIWEPEYRQIKAVEKVTI
HHHHHHHHCCCCCCCEEEEEHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MLYMNRGRDVMSKFTVASNGSLETILRGVEVLSTPLLNKGVAFTQEEREELGLKGLLPPA
CCEECCCHHHHHHHEECCCCCHHHHHHHHHHHHCCHHCCCCCCCHHHHHHCCCCCCCCHH
VLTLEEQARRAYEQFCSQPDDLLKNVYLTALHDRNEVLFYRILTDHLREMLPIVYTPTVG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCEEEHHHHHHHHHHHCCEEECCCHH
VAIQRYSHEYRKPRGVYLSINDPSGIEEAFANIGATAENIDLVVVTDGEGILGIGDWGVG
HHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCCEEEEEEECCCCEEEECCCCCC
GINIAIGKLAVYTAAVGIDPSRVLPVILDVGTNREELLNNPFYIGNRHPRITGEAYDEFI
CEEEEHHHHEEHHHHCCCCHHHCEEEEEECCCCHHHHCCCCEEECCCCCCCCHHHHHHHH
DTFVQAVNKQFPKALLHWEDFSSRNARKILDKYRHDICTFNDDIQGTGAVSLAAVLSAVK
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
ASGVPLSEHRVVVFGAGTAGIGIADQVRDAMVRVGVSEEESYKRFWCIDRNGLVTDNMED
HCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHH
LLDFQIPYARKEAEVSEWKENGVIGLAEVVKHVKPTILIGTSTVAGAFKEEIIKEMASHV
HHHCCCCCCCCCCHHHHHHHCCCEEHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHC
ERPIILPMSNPTPLAEAKPADLIEWTEGRALVATGSPFEPVTYNGVTYVIGQSNNALIFP
CCCEEEECCCCCCCCCCCCCCCEEECCCCEEEECCCCCCCEEECCEEEEEECCCCEEEEC
GLGLGTIVVRASVMTDGMFAAAAEAVASMVDTSQPGAPILPEVEELRNISEMVAIEVAKV
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AVAEGVARENLSDNDIKIAVKEAIWEPEYRQIKAVEKVTI
HHHHHHHHCCCCCCCEEEEEHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]