Click here to switch to the map view.

The map label for this gene is bioA [H]

Identifier: 118477144

GI number: 118477144

Start: 1598977

End: 1600413

Strand: Direct

Name: bioA [H]

Synonym: BALH_1448

Alternate gene names: 118477144

Gene position: 1598977-1600413 (Clockwise)

Preceding gene: 118477143

Following gene: 118477145

Centisome position: 30.42

GC content: 37.86

Gene sequence:

>1437_bases
ATGAAAATAGCAGGGAGAAATTTAAATCATCATGGCACCAGCGCAGCTTTTGTGAAAAATAAGTTGTTATGGAAGGTGGA
AGAAATGATGAAAACGAAACAGACTGATGAATTATTAGCAAAAGATGAGCAATATGTTTGGCACGGAATGCGTCCCTTTA
GTCCAAATAGTACAATGGTAGGGGCAAAAGCAGAAGGGTGCTGGGTTGAAGATATACAGGGAAAAAGATATTTAGATGGT
ATGAGTGGTCTTTGGTGTGTGAATAGTGGATATGGAAGAAAAGAACTCGCAGAGGCGGCATATAAGCAATTACAAACATT
ATCATACTTTCCGATGTCACAATCGCATGAACCCGCTATAAAGCTTGCAGAAAAATTAAATGAGTGGCTTGGAGGGGAGT
ATGTTATTTTCTTCTCTAATAGTGGTTCGGAAGCGAACGAAACAGCTTTTAAAATAGCAAGACAATACTATGCTCAAAAA
GGTGAACCACATCGTTATAAATTTATGTCACGTTACCGCGGGTATCATGGGAATACAATGGCAACGATGGCAGCGACGGG
ACAAGCACAGCGTAGATATCAATATGAGCCATTTGCTTCAGGATTTTTACATGTAACGCCGCCAGATTGTTATCGTATGC
CTGGAATAGAAAGAGAGAACATTTATGATGTCGAATGTGTAAAAGAAGTAGATCGGGTCATGACATGGGAATTAAGTGAA
ACGATTGCAGCTTTTATTATGGAACCAATTATTACGGGCGGAGGCATTTTGATGCCGCCACAAGACTATATGAAAGCTGT
TCATGAAACGTGTCAAAAACATGGTGCCTTGCTCATTAGCGATGAAGTAATTTGCGGTTTTGGACGTACAGGAAAGGCAT
TTGGATTTATGAATTATGATGTGAAACCAGATATTATTACAATGGCAAAAGGTATTACGAGTGCGTATTTACCATTATCA
GCAACAGCTGTGAAAAAAGAAATATATGAAGCATTTAAAGGAAAAGGAGAATATGAATTCTTCCGTCATATTAATACATT
TGGTGGAAATCCTGCGGCTTGTGCATTAGCACTTAAAAACTTAGAAATTATGGAAAATGAAAATTTAATTGAGCGATCTG
CACAAATGGGTTCGCTTTTATTAGAGCAATTAAAAGAAGAAATTGGAGAACATCCACTTGTAGGGGATATTAGAGGAAAA
GGTCTACTAGTTGGAATCGAACTAGTAAATGATAAAGAGACGAAAGAGCCAATTGATAACGACAAAATTGCAAGTGTCGT
AAATGCTTGTAAAGAAAAAGGTTTAATTATAGGGCGGAACGGTATGACAACAGCAGGATATAATAACGTCTTGACTTTAG
CACCACCGCTTGTTATTTCAAGTGAAGAAATTGCCTTTGTTATTGGAACGTTGAAGACAGCGATGGAACGTATTTAA

Upstream 100 bases:

>100_bases
AAGAGGAGCTTTTCGATAGATAAGAAAAGCTCCTTTTTCTTTTGTCCTTTTCTTGTAAATAATACTGCTTTGTAAGTAGG
ATTTGTCTTAATTTTGTGGA

Downstream 100 bases:

>100_bases
TGAATGAAGCGAGCTGTACTATACAGCTCGCTTTTGTTTATGAGGTGAAATATGATAAATTTTCAAAGGGAGGGGAATTA
TTATGAAGAAATATGATTCT

Product: aminotransferase

Products: S-adenosyl-4-methylthio-2-oxobutanoate; 7,8-diaminononanoate

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MKIAGRNLNHHGTSAAFVKNKLLWKVEEMMKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDG
MSGLWCVNSGYGRKELAEAAYKQLQTLSYFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQK
GEPHRYKFMSRYRGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPPDCYRMPGIERENIYDVECVKEVDRVMTWELSE
TIAAFIMEPIITGGGILMPPQDYMKAVHETCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLS
ATAVKKEIYEAFKGKGEYEFFRHINTFGGNPAACALALKNLEIMENENLIERSAQMGSLLLEQLKEEIGEHPLVGDIRGK
GLLVGIELVNDKETKEPIDNDKIASVVNACKEKGLIIGRNGMTTAGYNNVLTLAPPLVISSEEIAFVIGTLKTAMERI

Sequences:

>Translated_478_residues
MKIAGRNLNHHGTSAAFVKNKLLWKVEEMMKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDG
MSGLWCVNSGYGRKELAEAAYKQLQTLSYFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQK
GEPHRYKFMSRYRGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPPDCYRMPGIERENIYDVECVKEVDRVMTWELSE
TIAAFIMEPIITGGGILMPPQDYMKAVHETCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLS
ATAVKKEIYEAFKGKGEYEFFRHINTFGGNPAACALALKNLEIMENENLIERSAQMGSLLLEQLKEEIGEHPLVGDIRGK
GLLVGIELVNDKETKEPIDNDKIASVVNACKEKGLIIGRNGMTTAGYNNVLTLAPPLVISSEEIAFVIGTLKTAMERI
>Mature_478_residues
MKIAGRNLNHHGTSAAFVKNKLLWKVEEMMKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDG
MSGLWCVNSGYGRKELAEAAYKQLQTLSYFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQK
GEPHRYKFMSRYRGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPPDCYRMPGIERENIYDVECVKEVDRVMTWELSE
TIAAFIMEPIITGGGILMPPQDYMKAVHETCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLS
ATAVKKEIYEAFKGKGEYEFFRHINTFGGNPAACALALKNLEIMENENLIERSAQMGSLLLEQLKEEIGEHPLVGDIRGK
GLLVGIELVNDKETKEPIDNDKIASVVNACKEKGLIIGRNGMTTAGYNNVLTLAPPLVISSEEIAFVIGTLKTAMERI

Specific function: Essential for glycerol catabolism [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=430, Percent_Identity=32.093023255814, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI24119277, Length=446, Percent_Identity=30.9417040358744, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI37574042, Length=423, Percent_Identity=33.806146572104, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI226442705, Length=424, Percent_Identity=33.9622641509434, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI226442709, Length=396, Percent_Identity=34.3434343434343, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI4557809, Length=432, Percent_Identity=27.3148148148148, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI284507298, Length=327, Percent_Identity=30.5810397553517, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI188536080, Length=428, Percent_Identity=24.0654205607477, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI38679950, Length=428, Percent_Identity=24.0654205607477, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI38679946, Length=428, Percent_Identity=24.0654205607477, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1789016, Length=433, Percent_Identity=30.4849884526559, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1789759, Length=413, Percent_Identity=30.7506053268765, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI145693181, Length=407, Percent_Identity=30.7125307125307, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=31.1904761904762, Blast_Score=178, Evalue=9e-46,
Organism=Escherichia coli, GI1786991, Length=447, Percent_Identity=31.0961968680089, Blast_Score=172, Evalue=6e-44,
Organism=Escherichia coli, GI1788044, Length=429, Percent_Identity=27.972027972028, Blast_Score=165, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI32564660, Length=463, Percent_Identity=31.9654427645788, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71992977, Length=466, Percent_Identity=30.0429184549356, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI25144271, Length=437, Percent_Identity=28.1464530892449, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI25144274, Length=291, Percent_Identity=30.5841924398625, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=383, Percent_Identity=23.7597911227154, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=462, Percent_Identity=30.0865800865801, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324432, Length=398, Percent_Identity=27.6381909547739, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6324386, Length=477, Percent_Identity=27.0440251572327, Blast_Score=144, Evalue=4e-35,
Organism=Drosophila melanogaster, GI161085790, Length=431, Percent_Identity=32.0185614849188, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI28574759, Length=430, Percent_Identity=31.6279069767442, Blast_Score=208, Evalue=7e-54,
Organism=Drosophila melanogaster, GI21356575, Length=473, Percent_Identity=30.2325581395349, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI21357415, Length=478, Percent_Identity=26.7782426778243, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI281366494, Length=385, Percent_Identity=22.5974025974026, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24667139, Length=385, Percent_Identity=22.5974025974026, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24667143, Length=385, Percent_Identity=22.5974025974026, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.62

Molecular weight: Translated: 53437; Mature: 53437

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAGRNLNHHGTSAAFVKNKLLWKVEEMMKTKQTDELLAKDEQYVWHGMRPFSPNSTMV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEE
GAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLSYFPMSQSHEPAI
CCCCCCCCCCCCCCCHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
KLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQKGEPHRYKFMSRYRGYHGNTM
HHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEE
ATMAATGQAQRRYQYEPFASGFLHVTPPDCYRMPGIERENIYDVECVKEVDRVMTWELSE
EEEECCCHHHHCCCCCCHHCCEEECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TIAAFIMEPIITGGGILMPPQDYMKAVHETCQKHGALLISDEVICGFGRTGKAFGFMNYD
HHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHCCCEEEECCEEECCCCCCCEEEEECCC
VKPDIITMAKGITSAYLPLSATAVKKEIYEAFKGKGEYEFFRHINTFGGNPAACALALKN
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHH
LEIMENENLIERSAQMGSLLLEQLKEEIGEHPLVGDIRGKGLLVGIELVNDKETKEPIDN
HHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEEEEECCCCCCCCCCC
DKIASVVNACKEKGLIIGRNGMTTAGYNNVLTLAPPLVISSEEIAFVIGTLKTAMERI
HHHHHHHHHHHHCCEEEECCCCCCCCCCCEEEECCCEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIAGRNLNHHGTSAAFVKNKLLWKVEEMMKTKQTDELLAKDEQYVWHGMRPFSPNSTMV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEE
GAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLSYFPMSQSHEPAI
CCCCCCCCCCCCCCCHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
KLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQKGEPHRYKFMSRYRGYHGNTM
HHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEE
ATMAATGQAQRRYQYEPFASGFLHVTPPDCYRMPGIERENIYDVECVKEVDRVMTWELSE
EEEECCCHHHHCCCCCCHHCCEEECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TIAAFIMEPIITGGGILMPPQDYMKAVHETCQKHGALLISDEVICGFGRTGKAFGFMNYD
HHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHCCCEEEECCEEECCCCCCCEEEEECCC
VKPDIITMAKGITSAYLPLSATAVKKEIYEAFKGKGEYEFFRHINTFGGNPAACALALKN
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHH
LEIMENENLIERSAQMGSLLLEQLKEEIGEHPLVGDIRGKGLLVGIELVNDKETKEPIDN
HHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEEEEECCCCCCCCCCC
DKIASVVNACKEKGLIIGRNGMTTAGYNNVLTLAPPLVISSEEIAFVIGTLKTAMERI
HHHHHHHHHHHHCCEEEECCCCCCCCCCCEEEECCCEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-adenosyl-L-methionine; 8-amino-7-oxononanoate

Specific reaction: S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 8969498; 8436953 [H]