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The map label for this gene is nhaC [H]

Identifier: 118476993

GI number: 118476993

Start: 1435859

End: 1437235

Strand: Direct

Name: nhaC [H]

Synonym: BALH_1291

Alternate gene names: 118476993

Gene position: 1435859-1437235 (Clockwise)

Preceding gene: 118476992

Following gene: 118476994

Centisome position: 27.31

GC content: 36.89

Gene sequence:

>1377_bases
TTGGAAGAGGTCTTTTGTTATTCATTAGAAAAAAGGTTGAAACTAGGGAGAGATGGTACTTTGAAAGAAACGAGAGGAAA
TGGTTTAGCTTTATTACCACTTGGGATATTTTTGGCGCTATTTATAGGTTCTGGAATTATTACAGGTGATTTTTATAAAT
TGCCGATACTTGTAGCGATTTCCATTGCTGTAGGAGTCGCTTTAGCGATGAATCGTAAAGAAAGCTTTCATGTAAAAGTA
GAAAGATTTGCTAAAGGTGCAGGAAACCCGGATATTATGATTATGGTTCTGATCTTTGTACTTGCAGGAGCATTTTCTGA
AACGGCAAAAGGGATGGGCGGCGTTGATTCTACAGTTAACTTAGCGTTATCAATTTTACCGCAAGGATTTATTATAGCTG
GGATTTTTGTTATAGGGGCATTTATTTCATTAGCAATGGGAACTTCAATGGGAACAATTGCCGCATTAGCACCGATTGCT
GTAGGGATTAGTGGGCAAACTGATATCTCAATTGCGCTTGCAATGGCTACCGTTGTTGGCGGGGCGATGTTTGGTGATAA
TTTATCATTTATTTCAGATACAACAATCGCAGCTGTACGTTCACAAGGAACAGAAATGAAAGATAAGTTTAAAACGAACT
TTTTAATTGTATTACCAGCAGCTATTATTACAATTGTACTATTAGTAATTCTTACTTTAGGAAGCGACACGCAAGTTAAA
GCGCATAGCTTTGACTTGATAAAGATTTTACCGTATGCAGGAGTACTTATTACAGCGCTACTTGGTTGGAATGTACTTAT
TGTATTAACTGGTGGAACTGTACTATCTGGGGTTATCGGTCTTTTAGATGGAAGTTACACGTTAGAGAGCTTCTTTAAAA
GTGTAACGACTGGAATGGGCGGCATGATGGAGTTAGTATTACTCGCTATTTTAATTGGCGGTATGGTTGAATTGATCCAA
TATAATGGTGGTATTCAATATTTAATGAATCTTTTAACGCGTAACATTCGTTCTAAAAAAGGAGCAGAGTTCGGTATCGC
TGGTTTAGTAGGGATGACGAATATGTGTACAGCAAATAATACAATTTCTATTATCTTTACAGGTCCACTTGCAAAAAACA
TTGCAGATCAATATGAAATTGATCCTCGTAAATCAGCGAGTGTATTAGATCTTTTCTCATGCTGTGTGCAAGGATTAATT
CCGTATGGTGCACAAATGTTAACGGCAGCAGGATTTGCGGCGTTATCTCCAATTGAATTGTTACCATATGCGTTTTATCC
GATTTTAGTTGGAGTATGTGGAATCATTTCTATATTAATTGGTTTCCCGAGGTTTTCTAAAGTAACGGAAAAGAAAGAGT
ATCATAAAACAGCATAA

Upstream 100 bases:

>100_bases
CGGCAGCGGACTCGATTTTAGAGTGCTGTGCCAAATCCAGCAAGCATGTGCTTGAAAGATGAGAAGAGCGTTTCTTATAG
ATGTATAAGACCTCTTCTCG

Downstream 100 bases:

>100_bases
TGAAAATGAAGTTTATTAAAAGTAACGAAAGCCGTTCAGAGAATGTTCTCTGTGCGGCTTTTTTGTGCGATAAAAGAGTG
AATAATCTCATGCTACCTTA

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MEEVFCYSLEKRLKLGRDGTLKETRGNGLALLPLGIFLALFIGSGIITGDFYKLPILVAISIAVGVALAMNRKESFHVKV
ERFAKGAGNPDIMIMVLIFVLAGAFSETAKGMGGVDSTVNLALSILPQGFIIAGIFVIGAFISLAMGTSMGTIAALAPIA
VGISGQTDISIALAMATVVGGAMFGDNLSFISDTTIAAVRSQGTEMKDKFKTNFLIVLPAAIITIVLLVILTLGSDTQVK
AHSFDLIKILPYAGVLITALLGWNVLIVLTGGTVLSGVIGLLDGSYTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQ
YNGGIQYLMNLLTRNIRSKKGAEFGIAGLVGMTNMCTANNTISIIFTGPLAKNIADQYEIDPRKSASVLDLFSCCVQGLI
PYGAQMLTAAGFAALSPIELLPYAFYPILVGVCGIISILIGFPRFSKVTEKKEYHKTA

Sequences:

>Translated_458_residues
MEEVFCYSLEKRLKLGRDGTLKETRGNGLALLPLGIFLALFIGSGIITGDFYKLPILVAISIAVGVALAMNRKESFHVKV
ERFAKGAGNPDIMIMVLIFVLAGAFSETAKGMGGVDSTVNLALSILPQGFIIAGIFVIGAFISLAMGTSMGTIAALAPIA
VGISGQTDISIALAMATVVGGAMFGDNLSFISDTTIAAVRSQGTEMKDKFKTNFLIVLPAAIITIVLLVILTLGSDTQVK
AHSFDLIKILPYAGVLITALLGWNVLIVLTGGTVLSGVIGLLDGSYTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQ
YNGGIQYLMNLLTRNIRSKKGAEFGIAGLVGMTNMCTANNTISIIFTGPLAKNIADQYEIDPRKSASVLDLFSCCVQGLI
PYGAQMLTAAGFAALSPIELLPYAFYPILVGVCGIISILIGFPRFSKVTEKKEYHKTA
>Mature_458_residues
MEEVFCYSLEKRLKLGRDGTLKETRGNGLALLPLGIFLALFIGSGIITGDFYKLPILVAISIAVGVALAMNRKESFHVKV
ERFAKGAGNPDIMIMVLIFVLAGAFSETAKGMGGVDSTVNLALSILPQGFIIAGIFVIGAFISLAMGTSMGTIAALAPIA
VGISGQTDISIALAMATVVGGAMFGDNLSFISDTTIAAVRSQGTEMKDKFKTNFLIVLPAAIITIVLLVILTLGSDTQVK
AHSFDLIKILPYAGVLITALLGWNVLIVLTGGTVLSGVIGLLDGSYTLESFFKSVTTGMGGMMELVLLAILIGGMVELIQ
YNGGIQYLMNLLTRNIRSKKGAEFGIAGLVGMTNMCTANNTISIIFTGPLAKNIADQYEIDPRKSASVLDLFSCCVQGLI
PYGAQMLTAAGFAALSPIELLPYAFYPILVGVCGIISILIGFPRFSKVTEKKEYHKTA

Specific function: Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on g

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 48308; Mature: 48308

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: PS00133 CARBOXYPEPT_ZN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEVFCYSLEKRLKLGRDGTLKETRGNGLALLPLGIFLALFIGSGIITGDFYKLPILVAI
CCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCEECCHHHHHHHHHH
SIAVGVALAMNRKESFHVKVERFAKGAGNPDIMIMVLIFVLAGAFSETAKGMGGVDSTVN
HHHHHHHHHHCCCCHHEEHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCHHHH
LALSILPQGFIIAGIFVIGAFISLAMGTSMGTIAALAPIAVGISGQTDISIALAMATVVG
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GAMFGDNLSFISDTTIAAVRSQGTEMKDKFKTNFLIVLPAAIITIVLLVILTLGSDTQVK
HHHHCCCCCHHHHHHHHHHHHCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCEEE
AHSFDLIKILPYAGVLITALLGWNVLIVLTGGTVLSGVIGLLDGSYTLESFFKSVTTGMG
ECCCHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHCCC
GMMELVLLAILIGGMVELIQYNGGIQYLMNLLTRNIRSKKGAEFGIAGLVGMTNMCTANN
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEECCC
TISIIFTGPLAKNIADQYEIDPRKSASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPIEL
EEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHH
LPYAFYPILVGVCGIISILIGFPRFSKVTEKKEYHKTA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MEEVFCYSLEKRLKLGRDGTLKETRGNGLALLPLGIFLALFIGSGIITGDFYKLPILVAI
CCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCEECCHHHHHHHHHH
SIAVGVALAMNRKESFHVKVERFAKGAGNPDIMIMVLIFVLAGAFSETAKGMGGVDSTVN
HHHHHHHHHHCCCCHHEEHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCHHHH
LALSILPQGFIIAGIFVIGAFISLAMGTSMGTIAALAPIAVGISGQTDISIALAMATVVG
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GAMFGDNLSFISDTTIAAVRSQGTEMKDKFKTNFLIVLPAAIITIVLLVILTLGSDTQVK
HHHHCCCCCHHHHHHHHHHHHCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCEEE
AHSFDLIKILPYAGVLITALLGWNVLIVLTGGTVLSGVIGLLDGSYTLESFFKSVTTGMG
ECCCHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHCCC
GMMELVLLAILIGGMVELIQYNGGIQYLMNLLTRNIRSKKGAEFGIAGLVGMTNMCTANN
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEECCC
TISIIFTGPLAKNIADQYEIDPRKSASVLDLFSCCVQGLIPYGAQMLTAAGFAALSPIEL
EEEEEEECHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHH
LPYAFYPILVGVCGIISILIGFPRFSKVTEKKEYHKTA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10903309; 11274110 [H]