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The map label for this gene is bioA [H]

Identifier: 118476835

GI number: 118476835

Start: 1275709

End: 1276944

Strand: Direct

Name: bioA [H]

Synonym: BALH_1122

Alternate gene names: 118476835

Gene position: 1275709-1276944 (Clockwise)

Preceding gene: 118476834

Following gene: 118476836

Centisome position: 24.27

GC content: 31.07

Gene sequence:

>1236_bases
GTGAAGAATAATACCTATGTTGTTCCAATGGGGGATATTACGCAATCCCCTTTTTATAATATGATAATCGAAGAAGCTAA
AGATAGTTTTTTACTAGATACAAATGGAAAAAAATATTTAGATCTTAGAAGCGGTTTATGGAATGTTTCATTGGGATACA
AGGAAGAGTTATACCAAAGAATTTCATCTCAATTTAATGAGTATTTACAAAAATCATTAACTTTTTTAGATATCCATGCA
TACAATCATCCTTTGTATAATGATTATAGTAATGCCTTGCTACAGTTTATTAATGAAAAAGATTCTGCGTATACTAAAGT
CTTTTTCACAAATAGCGGTTCGGAAGGAACAGAGTTAGCAACAAAGGTTGTAAGACATTTAAACAACAAAGATAAAAAAA
TTATTACGTATGATAAAAGTTATCATGGTACCTTTTTTGCAGGGGTATCAGCTAGTGGATTAGATGAGAAGATTACGGAA
GATTATCAACCAAAACTAGATGGATTCTTAAGTGTAAAAACTCCTCAAAATCGTGATGATGAAGATCATGTGTTGAATTT
TATAGAGGAAAATCATCAAAATATATCTGCTTTTTTATTTGAACCTATTATTGGTTCAGGCGGAGTGTATATTTTTAATA
AAGAATTTATTAAAAAACTACACAGCACATTAAAAAAATTCAACATACTACTAATTTTTGATGAGGTGGCAACAGGTTTT
TATAGAACGGGCAATCGCTTTTTCTTTAAAGAATTAGGGGTGACTCCAGATATTTTAATTTTGAGTAAATCGATTAACAA
TGGAATTCTCCCATTTGGAGCAGTCGTAATTTCAAAAGAAATTGAAGACGCTCTCAAAGGTAAGCATATCGAGCATTTCT
CTACTCAAAACGGAAATCTGCTAGGGGTACTATCAGCAAAGATTACATTAGAATACATTTTAGAAAATGAGACAAGTATT
ATTAGCAATGTTCGAGAAATCGAAAATATAGTAACAAATACGTTTAAGATGAAAAATATTGCTTACACGGGTGTCGGGGG
GATGTATTCGATCCCTGTGAATGATCCAATTAAAACTATGGAAATAGTTAACGGATTAAAAGAACTCGGTATTTTAGTCT
ATCATTACATGGATAATGATGAAGGTAATGGCATTACACTATTTCCTACCCTTTTAATAGATACGAAGGCATTTTCAAAA
GCTATGAAAATAATTGCAAAGAGGGTATTAGTTTGA

Upstream 100 bases:

>100_bases
CACACTATTGAATATTTTGAGAAAGTCTCTGAAGAGTTACATTATAAATTAAATATATTATATAGCGGAGAAAATATATA
TTTCTTGGAGTTGGAAAATT

Downstream 100 bases:

>100_bases
AAGAAGTAAATAACTTAAATGTTTGCAATGTAAATCTTGAATACCACATAGACGACTATGTTTATATATATAACCCTAAG
AATGAGAGAATGATACAAGC

Product: aminotransferase

Products: L-Glutamate; L-Glutamate 5-semialdehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MKNNTYVVPMGDITQSPFYNMIIEEAKDSFLLDTNGKKYLDLRSGLWNVSLGYKEELYQRISSQFNEYLQKSLTFLDIHA
YNHPLYNDYSNALLQFINEKDSAYTKVFFTNSGSEGTELATKVVRHLNNKDKKIITYDKSYHGTFFAGVSASGLDEKITE
DYQPKLDGFLSVKTPQNRDDEDHVLNFIEENHQNISAFLFEPIIGSGGVYIFNKEFIKKLHSTLKKFNILLIFDEVATGF
YRTGNRFFFKELGVTPDILILSKSINNGILPFGAVVISKEIEDALKGKHIEHFSTQNGNLLGVLSAKITLEYILENETSI
ISNVREIENIVTNTFKMKNIAYTGVGGMYSIPVNDPIKTMEIVNGLKELGILVYHYMDNDEGNGITLFPTLLIDTKAFSK
AMKIIAKRVLV

Sequences:

>Translated_411_residues
MKNNTYVVPMGDITQSPFYNMIIEEAKDSFLLDTNGKKYLDLRSGLWNVSLGYKEELYQRISSQFNEYLQKSLTFLDIHA
YNHPLYNDYSNALLQFINEKDSAYTKVFFTNSGSEGTELATKVVRHLNNKDKKIITYDKSYHGTFFAGVSASGLDEKITE
DYQPKLDGFLSVKTPQNRDDEDHVLNFIEENHQNISAFLFEPIIGSGGVYIFNKEFIKKLHSTLKKFNILLIFDEVATGF
YRTGNRFFFKELGVTPDILILSKSINNGILPFGAVVISKEIEDALKGKHIEHFSTQNGNLLGVLSAKITLEYILENETSI
ISNVREIENIVTNTFKMKNIAYTGVGGMYSIPVNDPIKTMEIVNGLKELGILVYHYMDNDEGNGITLFPTLLIDTKAFSK
AMKIIAKRVLV
>Mature_411_residues
MKNNTYVVPMGDITQSPFYNMIIEEAKDSFLLDTNGKKYLDLRSGLWNVSLGYKEELYQRISSQFNEYLQKSLTFLDIHA
YNHPLYNDYSNALLQFINEKDSAYTKVFFTNSGSEGTELATKVVRHLNNKDKKIITYDKSYHGTFFAGVSASGLDEKITE
DYQPKLDGFLSVKTPQNRDDEDHVLNFIEENHQNISAFLFEPIIGSGGVYIFNKEFIKKLHSTLKKFNILLIFDEVATGF
YRTGNRFFFKELGVTPDILILSKSINNGILPFGAVVISKEIEDALKGKHIEHFSTQNGNLLGVLSAKITLEYILENETSI
ISNVREIENIVTNTFKMKNIAYTGVGGMYSIPVNDPIKTMEIVNGLKELGILVYHYMDNDEGNGITLFPTLLIDTKAFSK
AMKIIAKRVLV

Specific function: Essential for glycerol catabolism [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=328, Percent_Identity=28.0487804878049, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI4557809, Length=404, Percent_Identity=26.980198019802, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI37574042, Length=349, Percent_Identity=28.080229226361, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI226442705, Length=349, Percent_Identity=28.3667621776504, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI226442709, Length=284, Percent_Identity=29.2253521126761, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI284507298, Length=315, Percent_Identity=27.3015873015873, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI24119277, Length=314, Percent_Identity=24.5222929936306, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI145693181, Length=289, Percent_Identity=27.681660899654, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786991, Length=286, Percent_Identity=26.2237762237762, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1788044, Length=330, Percent_Identity=27.2727272727273, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1789759, Length=295, Percent_Identity=29.8305084745763, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789016, Length=322, Percent_Identity=25.4658385093168, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787560, Length=421, Percent_Identity=22.5653206650831, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786349, Length=277, Percent_Identity=27.7978339350181, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI32564660, Length=460, Percent_Identity=28.695652173913, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=403, Percent_Identity=27.0471464019851, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=287, Percent_Identity=28.2229965156794, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71992977, Length=331, Percent_Identity=27.190332326284, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323470, Length=419, Percent_Identity=25.5369928400955, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324386, Length=350, Percent_Identity=25.4285714285714, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324432, Length=409, Percent_Identity=23.7163814180929, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21357415, Length=404, Percent_Identity=28.4653465346535, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.13 [C]

Molecular weight: Translated: 46633; Mature: 46633

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNNTYVVPMGDITQSPFYNMIIEEAKDSFLLDTNGKKYLDLRSGLWNVSLGYKEELYQR
CCCCEEEEECCCCCCCCHHHHHHHHCCCCEEEECCCCEEEEECCCCEEECCCHHHHHHHH
ISSQFNEYLQKSLTFLDIHAYNHPLYNDYSNALLQFINEKDSAYTKVFFTNSGSEGTELA
HHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHH
TKVVRHLNNKDKKIITYDKSYHGTFFAGVSASGLDEKITEDYQPKLDGFLSVKTPQNRDD
HHHHHHCCCCCCEEEEECCCCCCEEEECCCCCCCCHHHHHCCCCCCCCEEEECCCCCCCC
EDHVLNFIEENHQNISAFLFEPIIGSGGVYIFNKEFIKKLHSTLKKFNILLIFDEVATGF
HHHHHHHHHHCCCCEEHHEEHHHHCCCCEEEECHHHHHHHHHHHHHCEEEEEEHHHHCCH
YRTGNRFFFKELGVTPDILILSKSINNGILPFGAVVISKEIEDALKGKHIEHFSTQNGNL
HHCCCEEEHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCE
LGVLSAKITLEYILENETSIISNVREIENIVTNTFKMKNIAYTGVGGMYSIPVNDPIKTM
EEEEEHHEEEEEECCCCHHHHHHHHHHHHHHHHHEEECCEEEECCCCEEECCCCCCHHHH
EIVNGLKELGILVYHYMDNDEGNGITLFPTLLIDTKAFSKAMKIIAKRVLV
HHHHHHHHHCEEEEEEECCCCCCCEEEEHEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNNTYVVPMGDITQSPFYNMIIEEAKDSFLLDTNGKKYLDLRSGLWNVSLGYKEELYQR
CCCCEEEEECCCCCCCCHHHHHHHHCCCCEEEECCCCEEEEECCCCEEECCCHHHHHHHH
ISSQFNEYLQKSLTFLDIHAYNHPLYNDYSNALLQFINEKDSAYTKVFFTNSGSEGTELA
HHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHH
TKVVRHLNNKDKKIITYDKSYHGTFFAGVSASGLDEKITEDYQPKLDGFLSVKTPQNRDD
HHHHHHCCCCCCEEEEECCCCCCEEEECCCCCCCCHHHHHCCCCCCCCEEEECCCCCCCC
EDHVLNFIEENHQNISAFLFEPIIGSGGVYIFNKEFIKKLHSTLKKFNILLIFDEVATGF
HHHHHHHHHHCCCCEEHHEEHHHHCCCCEEEECHHHHHHHHHHHHHCEEEEEEHHHHCCH
YRTGNRFFFKELGVTPDILILSKSINNGILPFGAVVISKEIEDALKGKHIEHFSTQNGNL
HHCCCEEEHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCE
LGVLSAKITLEYILENETSIISNVREIENIVTNTFKMKNIAYTGVGGMYSIPVNDPIKTM
EEEEEHHEEEEEECCCCHHHHHHHHHHHHHHHHHEEECCEEEECCCCEEECCCCCCHHHH
EIVNGLKELGILVYHYMDNDEGNGITLFPTLLIDTKAFSKAMKIIAKRVLV
HHHHHHHHHCEEEEEEECCCCCCCEEEEHEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Oxoglutarate; Ornithine [C]

Specific reaction: 2-Oxoglutarate + Ornithine --> L-Glutamate + L-Glutamate 5-semialdehyde [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 8969498; 8436953 [H]