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The map label for this gene is ndh [H]

Identifier: 118476439

GI number: 118476439

Start: 812525

End: 814189

Strand: Direct

Name: ndh [H]

Synonym: BALH_0703

Alternate gene names: 118476439

Gene position: 812525-814189 (Clockwise)

Preceding gene: 118476438

Following gene: 118476440

Centisome position: 15.46

GC content: 37.72

Gene sequence:

>1665_bases
ATGTCCAGAAAAATAGTTGTAGTAGGCGGAGTTGCCGGTGGAGCCTCAGTAGCTGCAAGGCTTCGTCGATTAAGTGAAGA
AGATGAAATTATTATGGTGGAGCGCGGTGAATATATTTCATTCGCAAATTGTGGCTTACCATACTATATTGGCGATGTCA
TTACAGAAAGACAAAAATTATTAGTACAAACTGTTGAAAGAATGTCGAAGCGTTTTAATTTAGATATACGTGTATTGAGT
GAAGTAGTACAGATTAATAAAGAAGAAAAAACAATTACGATAAAGAATGTAACGACAAATGAAACATATAACGAGGCATA
CGATGTGTTAATTCTTTCACCAGGGGCAAAACCAATTGTTCCATCTATTCCAGGGATTGAAGAAGCGAAAGCACTGTTTA
CGTTACGAAATGTACCGGATACTGATCGTATGAAAGCGTATATTGATGAGAAGAAACCACGTCATGCGACGGTGATTGGT
GGCGGATTTATTGGAGTGGAAATGGTTGAAAACTTAAGAGAACGAGGAATTGATGTTACTCTCGTAGAGATGGCGAATCA
AGTAATGCCACCAATCGATTATGAAATGGCAGCATATGTGCATGAGCATATGAAAAATCACGATGTTGAGCTTGTTTTTG
AAGATGGTGTAGATGCGTTAGAAGAGAGCGGGGCTGTTGTACGTTTAAAAAGTGGCTCAGTTATACAAACAGATATGCTT
ATTTTAGCAATTGGTGTACAACCAGAGAGTAGTTTAGCGAAGGATGCAGGGTTAGCACTAGGAGTTAGAGGAACGATAAA
GGTAAATGAGAAATTTCAAACGTCTGACCCACATATATATGCAATTGGTGATGCGATTGAAGTAAAAGATTTTGTTACTG
AAACAGAAACGATGATTCCTTTAGCGTGGCCGGCTAATCGTCAAGGTCGTATGTTAGCAGATATTATTCATGGTCATACG
GATTCTTTATATAAAGGTACGCTCGGAACTTCTGTAGCTAAAGTTTTTGATCTAACAGTTGCTTCGACTGGAGTAAATGA
GAAAATATTAAAACGATTAAATATACCCTATGAGGTAGTACATGTGCAGGCAAATTCTCATGCGGGATACTACCCGAATG
CTACGCCAGTGCTAATAAAATTAATTTTTAATAAAGATAGCGGAAAAATTTATGGAGCACAGGCGTTAGGACGTGACGGT
GTAGATAAGCGTATGGATGTTATCGCAACGGCAATAAAAGCAAATTTAACTGTACTTGATTTGCCAGATTTAGAATTATC
ATATGCCCCGCCATATTCTTCTGCAAAAGACCCAGTAAACATGGTAGGGTATGCAGCAAGTAATATAGTAGATGGTTTTG
TGGACACAGTACAATGGCATGAGATAGATCATATTGTTGAAAATGGTGGATATCTTATTGATGTTCGAGAGCCTAATGAA
CTAAAGCAAGGAATGATTAAAGGCTCTATTAATATTCCGTTAGATGAATTACGTGATCGTTTGGATGAAGTGCCAGTAGA
TAAAGATATATATATTACTTGCCAACTCGGTATGAGAGGGTATGTTGCAGCACGCATGTTAATGGAAAAAGGATATAAGG
TAAAGAATGTAGATGGTGGTTTTAAATTGTATGGGACAGTATTACCAGAACGTATTGCATATTGA

Upstream 100 bases:

>100_bases
ATTAAATTTTTTATAATTTATTATATACCCATACAGGTATAAGTTTTTCGCATGTGATACATGAGAAAATTAAATAATAA
ATAATATGGAGGTTTAAAAT

Downstream 100 bases:

>100_bases
TATTTTTTCATCTTCCACTTCAAAATTTGGTGGAAGATGAAAGCCTATAGATGAAGGTTTCGCTTTGTGTTTTGTGAATG
TATAAAATAAAATTTTAAAA

Product: NADH dehydrogenase

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MSRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGDVITERQKLLVQTVERMSKRFNLDIRVLS
EVVQINKEEKTITIKNVTTNETYNEAYDVLILSPGAKPIVPSIPGIEEAKALFTLRNVPDTDRMKAYIDEKKPRHATVIG
GGFIGVEMVENLRERGIDVTLVEMANQVMPPIDYEMAAYVHEHMKNHDVELVFEDGVDALEESGAVVRLKSGSVIQTDML
ILAIGVQPESSLAKDAGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIPLAWPANRQGRMLADIIHGHT
DSLYKGTLGTSVAKVFDLTVASTGVNEKILKRLNIPYEVVHVQANSHAGYYPNATPVLIKLIFNKDSGKIYGAQALGRDG
VDKRMDVIATAIKANLTVLDLPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVDTVQWHEIDHIVENGGYLIDVREPNE
LKQGMIKGSINIPLDELRDRLDEVPVDKDIYITCQLGMRGYVAARMLMEKGYKVKNVDGGFKLYGTVLPERIAY

Sequences:

>Translated_554_residues
MSRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGDVITERQKLLVQTVERMSKRFNLDIRVLS
EVVQINKEEKTITIKNVTTNETYNEAYDVLILSPGAKPIVPSIPGIEEAKALFTLRNVPDTDRMKAYIDEKKPRHATVIG
GGFIGVEMVENLRERGIDVTLVEMANQVMPPIDYEMAAYVHEHMKNHDVELVFEDGVDALEESGAVVRLKSGSVIQTDML
ILAIGVQPESSLAKDAGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIPLAWPANRQGRMLADIIHGHT
DSLYKGTLGTSVAKVFDLTVASTGVNEKILKRLNIPYEVVHVQANSHAGYYPNATPVLIKLIFNKDSGKIYGAQALGRDG
VDKRMDVIATAIKANLTVLDLPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVDTVQWHEIDHIVENGGYLIDVREPNE
LKQGMIKGSINIPLDELRDRLDEVPVDKDIYITCQLGMRGYVAARMLMEKGYKVKNVDGGFKLYGTVLPERIAY
>Mature_553_residues
SRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGDVITERQKLLVQTVERMSKRFNLDIRVLSE
VVQINKEEKTITIKNVTTNETYNEAYDVLILSPGAKPIVPSIPGIEEAKALFTLRNVPDTDRMKAYIDEKKPRHATVIGG
GFIGVEMVENLRERGIDVTLVEMANQVMPPIDYEMAAYVHEHMKNHDVELVFEDGVDALEESGAVVRLKSGSVIQTDMLI
LAIGVQPESSLAKDAGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIPLAWPANRQGRMLADIIHGHTD
SLYKGTLGTSVAKVFDLTVASTGVNEKILKRLNIPYEVVHVQANSHAGYYPNATPVLIKLIFNKDSGKIYGAQALGRDGV
DKRMDVIATAIKANLTVLDLPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVDTVQWHEIDHIVENGGYLIDVREPNEL
KQGMIKGSINIPLDELRDRLDEVPVDKDIYITCQLGMRGYVAARMLMEKGYKVKNVDGGFKLYGTVLPERIAY

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI65787454, Length=311, Percent_Identity=25.7234726688103, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI226437568, Length=311, Percent_Identity=25.7234726688103, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI21389617, Length=311, Percent_Identity=25.7234726688103, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI1789065, Length=332, Percent_Identity=26.2048192771084, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI87082354, Length=294, Percent_Identity=26.8707482993197, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786307, Length=304, Percent_Identity=27.9605263157895, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1789765, Length=289, Percent_Identity=25.2595155709343, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1788892, Length=196, Percent_Identity=28.0612244897959, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787352, Length=240, Percent_Identity=26.25, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17559934, Length=219, Percent_Identity=25.5707762557078, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585130, Length=300, Percent_Identity=25.3333333333333, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 61165; Mature: 61034

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGDVITERQKL
CCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHH
LVQTVERMSKRFNLDIRVLSEVVQINKEEKTITIKNVTTNETYNEAYDVLILSPGAKPIV
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCEEEEEECCCCCCCC
PSIPGIEEAKALFTLRNVPDTDRMKAYIDEKKPRHATVIGGGFIGVEMVENLRERGIDVT
CCCCCHHHHHHHEEECCCCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEE
LVEMANQVMPPIDYEMAAYVHEHMKNHDVELVFEDGVDALEESGAVVRLKSGSVIQTDML
EHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHCCCCEEEECCCCEEEEEEE
ILAIGVQPESSLAKDAGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIP
EEEEECCCCHHHHHHCCEEEEEEEEEEECCCCCCCCCEEEEECCCEEHHHHHHCCCCEEE
LAWPANRQGRMLADIIHGHTDSLYKGTLGTSVAKVFDLTVASTGVNEKILKRLNIPYEVV
EECCCCCCCCCHHHHHCCCCCCHHCCCHHHHHHHHHHHHEECCCCCHHHHHHHCCCEEEE
HVQANSHAGYYPNATPVLIKLIFNKDSGKIYGAQALGRDGVDKRMDVIATAIKANLTVLD
EEEECCCCCCCCCCCCEEEEEEEECCCCCEEEEHHCCCCCCHHHHHHHHHHHHCCEEEEE
LPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVDTVQWHEIDHIVENGGYLIDVREPNE
CCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
LKQGMIKGSINIPLDELRDRLDEVPVDKDIYITCQLGMRGYVAARMLMEKGYKVKNVDGG
HHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEECCCC
FKLYGTVLPERIAY
EEEEEEHHHHHHCC
>Mature Secondary Structure 
SRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGDVITERQKL
CCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHH
LVQTVERMSKRFNLDIRVLSEVVQINKEEKTITIKNVTTNETYNEAYDVLILSPGAKPIV
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCEEEEEECCCCCCCC
PSIPGIEEAKALFTLRNVPDTDRMKAYIDEKKPRHATVIGGGFIGVEMVENLRERGIDVT
CCCCCHHHHHHHEEECCCCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEE
LVEMANQVMPPIDYEMAAYVHEHMKNHDVELVFEDGVDALEESGAVVRLKSGSVIQTDML
EHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHCCCCEEEECCCCEEEEEEE
ILAIGVQPESSLAKDAGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIP
EEEEECCCCHHHHHHCCEEEEEEEEEEECCCCCCCCCEEEEECCCEEHHHHHHCCCCEEE
LAWPANRQGRMLADIIHGHTDSLYKGTLGTSVAKVFDLTVASTGVNEKILKRLNIPYEVV
EECCCCCCCCCHHHHHCCCCCCHHCCCHHHHHHHHHHHHEECCCCCHHHHHHHCCCEEEE
HVQANSHAGYYPNATPVLIKLIFNKDSGKIYGAQALGRDGVDKRMDVIATAIKANLTVLD
EEEECCCCCCCCCCCCEEEEEEEECCCCCEEEEHHCCCCCCHHHHHHHHHHHHCCEEEEE
LPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVDTVQWHEIDHIVENGGYLIDVREPNE
CCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
LKQGMIKGSINIPLDELRDRLDEVPVDKDIYITCQLGMRGYVAARMLMEKGYKVKNVDGG
HHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEECCCC
FKLYGTVLPERIAY
EEEEEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA