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The map label for this gene is fhuB [H]

Identifier: 118476098

GI number: 118476098

Start: 393235

End: 394275

Strand: Reverse

Name: fhuB [H]

Synonym: BALH_0341

Alternate gene names: 118476098

Gene position: 394275-393235 (Counterclockwise)

Preceding gene: 118476099

Following gene: 118476097

Centisome position: 7.5

GC content: 39.48

Gene sequence:

>1041_bases
ATGAAAAGAAAAGATGTGAAACGAATGACAAAAGAACATGACAATACGCGTTCTATAGCTTTTACATACAAATTAATTTT
AAGCATAATTGCATTCTTTCTTATTTTTATGGTGGCAATGGTATTAGGTGCTGCAGATACTTCAATAAAAGACGTATGGT
TAGCGCTCACTTCCTCCGCTAAAGGGGACAAAATATCTATTATTCGCGAAATACGTTTGCCACGTGAAGTTGCTGCTATT
TTTGTAGGAGCTGGACTTGCCGTTTCTGGAGCAATTATGCAAGGATTAACACGAAATCCACTTGCTGATCCTGGATTACT
CGGGCTATCTGGTGGAGCAAATGCTGCGCTTGCACTAACACTTGCTTTCAACCCTTCCATAAGCTATCTTTACTTAACAT
TAGCTTGCTTTATCGGTGCTGCAGTTGGTGCAATTATGGTATTTGGAATTGGTATGGTGAAAAAAGGCGGTCTCTCCCCT
CTTCGAATTGTATTAGCTGGTGCTGCAGTTTCAGCATTTCTACTCGCAATTTCAGAAGGAGTCGGCATTTACTTCAAAAT
TTCACAAGATGTATCACTTTGGACTGCTGGAGGCGTAATTGGAACTACTTGGAGCCAATTGAAAGTTATTATTCCAGTCA
TTTCAATTAGTATCTTTATCGCTATCTTACTAGCCAAAAAGTTGACAGTTCTTAGTTTCAGTGAAGAAGTAGCTATTGGA
CTCGGTCAAAAAATTATTGTTATTAAAACCATTCTATTTATCATTATCATTTTACTTGCAGGTGCGTCTGTAGCACTTGT
CGGAAATATGGCATTTATCGGTTTAATGGTACCTCACATGGTACGTCCAATTGTCGGTCCAGATTACCGATTTGTTATAC
CGATGTCAGCAATTGCCGGGGCTTCCTTTATGCTACTTGCAGATACAATCGGACGTACGATTAACGCTCCGTACGAAACA
CCAGTTGCCGCTATTGTCGCAATTGTAGGATTACCATTCTTCCTATTCATTGTACGTAAAGGAGGAAAAACGTTCTCATG
A

Upstream 100 bases:

>100_bases
TACATTAGATTTCCAACTAGACTTCTTCAAGAAGAGCTTTCTTGGTAAATAATACAAACATGAGGAATTCTTAATTTAAG
AATTCCTCTTCCTTTATTCT

Downstream 100 bases:

>100_bases
TACCATCTATTCTAAGAAAACAACGTCTTATCATACTCGCTTTACTTATACTAACCATTACAACCATTGTAATTGGAATG
GGGCTCGGTTCAGCATCTTT

Product: ferrichrome transport system, permease

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKRKDVKRMTKEHDNTRSIAFTYKLILSIIAFFLIFMVAMVLGAADTSIKDVWLALTSSAKGDKISIIREIRLPREVAAI
FVGAGLAVSGAIMQGLTRNPLADPGLLGLSGGANAALALTLAFNPSISYLYLTLACFIGAAVGAIMVFGIGMVKKGGLSP
LRIVLAGAAVSAFLLAISEGVGIYFKISQDVSLWTAGGVIGTTWSQLKVIIPVISISIFIAILLAKKLTVLSFSEEVAIG
LGQKIIVIKTILFIIIILLAGASVALVGNMAFIGLMVPHMVRPIVGPDYRFVIPMSAIAGASFMLLADTIGRTINAPYET
PVAAIVAIVGLPFFLFIVRKGGKTFS

Sequences:

>Translated_346_residues
MKRKDVKRMTKEHDNTRSIAFTYKLILSIIAFFLIFMVAMVLGAADTSIKDVWLALTSSAKGDKISIIREIRLPREVAAI
FVGAGLAVSGAIMQGLTRNPLADPGLLGLSGGANAALALTLAFNPSISYLYLTLACFIGAAVGAIMVFGIGMVKKGGLSP
LRIVLAGAAVSAFLLAISEGVGIYFKISQDVSLWTAGGVIGTTWSQLKVIIPVISISIFIAILLAKKLTVLSFSEEVAIG
LGQKIIVIKTILFIIIILLAGASVALVGNMAFIGLMVPHMVRPIVGPDYRFVIPMSAIAGASFMLLADTIGRTINAPYET
PVAAIVAIVGLPFFLFIVRKGGKTFS
>Mature_346_residues
MKRKDVKRMTKEHDNTRSIAFTYKLILSIIAFFLIFMVAMVLGAADTSIKDVWLALTSSAKGDKISIIREIRLPREVAAI
FVGAGLAVSGAIMQGLTRNPLADPGLLGLSGGANAALALTLAFNPSISYLYLTLACFIGAAVGAIMVFGIGMVKKGGLSP
LRIVLAGAAVSAFLLAISEGVGIYFKISQDVSLWTAGGVIGTTWSQLKVIIPVISISIFIAILLAKKLTVLSFSEEVAIG
LGQKIIVIKTILFIIIILLAGASVALVGNMAFIGLMVPHMVRPIVGPDYRFVIPMSAIAGASFMLLADTIGRTINAPYET
PVAAIVAIVGLPFFLFIVRKGGKTFS

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786805, Length=304, Percent_Identity=36.5131578947368, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1790741, Length=282, Percent_Identity=35.1063829787234, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1790740, Length=295, Percent_Identity=33.5593220338983, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788004, Length=280, Percent_Identity=35, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786347, Length=292, Percent_Identity=30.1369863013699, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1786804, Length=307, Percent_Identity=28.6644951140065, Blast_Score=99, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36486; Mature: 36486

Theoretical pI: Translated: 10.63; Mature: 10.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKDVKRMTKEHDNTRSIAFTYKLILSIIAFFLIFMVAMVLGAADTSIKDVWLALTSSA
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
KGDKISIIREIRLPREVAAIFVGAGLAVSGAIMQGLTRNPLADPGLLGLSGGANAALALT
CCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCEEEEEE
LAFNPSISYLYLTLACFIGAAVGAIMVFGIGMVKKGGLSPLRIVLAGAAVSAFLLAISEG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
VGIYFKISQDVSLWTAGGVIGTTWSQLKVIIPVISISIFIAILLAKKLTVLSFSEEVAIG
CEEEEEEECCCEEEECCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHC
LGQKIIVIKTILFIIIILLAGASVALVGNMAFIGLMVPHMVRPIVGPDYRFVIPMSAIAG
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCC
ASFMLLADTIGRTINAPYETPVAAIVAIVGLPFFLFIVRKGGKTFS
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKRKDVKRMTKEHDNTRSIAFTYKLILSIIAFFLIFMVAMVLGAADTSIKDVWLALTSSA
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
KGDKISIIREIRLPREVAAIFVGAGLAVSGAIMQGLTRNPLADPGLLGLSGGANAALALT
CCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCEEEEEE
LAFNPSISYLYLTLACFIGAAVGAIMVFGIGMVKKGGLSPLRIVLAGAAVSAFLLAISEG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
VGIYFKISQDVSLWTAGGVIGTTWSQLKVIIPVISISIFIAILLAKKLTVLSFSEEVAIG
CEEEEEEECCCEEEECCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHC
LGQKIIVIKTILFIIIILLAGASVALVGNMAFIGLMVPHMVRPIVGPDYRFVIPMSAIAG
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCC
ASFMLLADTIGRTINAPYETPVAAIVAIVGLPFFLFIVRKGGKTFS
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]