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The map label for this gene is spoVC [H]

Identifier: 118475822

GI number: 118475822

Start: 53502

End: 54134

Strand: Direct

Name: spoVC [H]

Synonym: BALH_0046

Alternate gene names: 118475822

Gene position: 53502-54134 (Clockwise)

Preceding gene: 118475821

Following gene: 118475823

Centisome position: 1.02

GC content: 34.44

Gene sequence:

>633_bases
TTGGATAGAATGAGACGTAACCAAGATTGGTTACGTCTTTTCGTATCGAAAAAAGAAAGTAGTGGTACAAGAATGAAATT
GATAGTAGGACTTGGGAACCCAGGTAGAGAATATGAATTAACAAGGCATAATATTGGATTTATGGCGATTGATGAACTTG
CAAAGCGTTGGAATATTTCTTTGAACGAACAAAAGTTTAAAGGCTTATTTGGTGCAGGATTTGTTAATGGAGAAAAAGTA
ATCTTATTAAAGCCACTTACATATATGAATTTATCTGGGGAAAGTATTCGTCCGCTAATGGATTACTATAAAATTGATGT
AGAGGACTTCGTTGTTCTGTACGATGATTTAGATATCCCTGTAGGTAAATTACGCCTTCGTATGAAAGGTAGTGCTGGTG
GACATAATGGTGTGAAATCAACAATTTCACATTTAGGAACACAAGAGTTTCAACGTATCCGCATGGGAATTGATCGTCCG
AAAAATGGAATGAAGGTAGTAGATTATGTATTAGGACGTTTTACATCGGAAGAAATTCCTGATGTAAATCATTCTATTGA
AAAAGCAGCAGATGCATGTGAAGAATGGTTAAATAAACCTTTTCTTCAAATCATGAATACTTTCAATAGTTAA

Upstream 100 bases:

>100_bases
GAAAATCGACAAAGTACATGAACTTTCAGTTGCTCCACTAATCGGAGAAGCAATCATTCGTGTATACGAAGAAGAATCTG
TAAGTGTATTATTCAATTAA

Downstream 100 bases:

>100_bases
GGGTATGATTAGGAATATTTTATTCTGTTTTTACCCATACTAGCAGTAATTGTATTTTTAGGAGGCTAGTATGGAAGGGT
ATTATTATTGCAGACATTGC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MDRMRRNQDWLRLFVSKKESSGTRMKLIVGLGNPGREYELTRHNIGFMAIDELAKRWNISLNEQKFKGLFGAGFVNGEKV
ILLKPLTYMNLSGESIRPLMDYYKIDVEDFVVLYDDLDIPVGKLRLRMKGSAGGHNGVKSTISHLGTQEFQRIRMGIDRP
KNGMKVVDYVLGRFTSEEIPDVNHSIEKAADACEEWLNKPFLQIMNTFNS

Sequences:

>Translated_210_residues
MDRMRRNQDWLRLFVSKKESSGTRMKLIVGLGNPGREYELTRHNIGFMAIDELAKRWNISLNEQKFKGLFGAGFVNGEKV
ILLKPLTYMNLSGESIRPLMDYYKIDVEDFVVLYDDLDIPVGKLRLRMKGSAGGHNGVKSTISHLGTQEFQRIRMGIDRP
KNGMKVVDYVLGRFTSEEIPDVNHSIEKAADACEEWLNKPFLQIMNTFNS
>Mature_210_residues
MDRMRRNQDWLRLFVSKKESSGTRMKLIVGLGNPGREYELTRHNIGFMAIDELAKRWNISLNEQKFKGLFGAGFVNGEKV
ILLKPLTYMNLSGESIRPLMDYYKIDVEDFVVLYDDLDIPVGKLRLRMKGSAGGHNGVKSTISHLGTQEFQRIRMGIDRP
KNGMKVVDYVLGRFTSEEIPDVNHSIEKAADACEEWLNKPFLQIMNTFNS

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=32.1428571428571, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1787455, Length=188, Percent_Identity=39.3617021276596, Blast_Score=122, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321983, Length=182, Percent_Identity=29.6703296703297, Blast_Score=75, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 24076; Mature: 24076

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRMRRNQDWLRLFVSKKESSGTRMKLIVGLGNPGREYELTRHNIGFMAIDELAKRWNIS
CCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEHHCCCCHHHHHHHHHHHCCC
LNEQKFKGLFGAGFVNGEKVILLKPLTYMNLSGESIRPLMDYYKIDVEDFVVLYDDLDIP
CCHHHHHHHHCCCEECCCEEEEECCCEEECCCCCCHHHHHHHHHCCHHHEEEEEECCCCC
VGKLRLRMKGSAGGHNGVKSTISHLGTQEFQRIRMGIDRPKNGMKVVDYVLGRFTSEEIP
CCCEEEEEECCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCC
DVNHSIEKAADACEEWLNKPFLQIMNTFNS
CCHHHHHHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MDRMRRNQDWLRLFVSKKESSGTRMKLIVGLGNPGREYELTRHNIGFMAIDELAKRWNIS
CCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEHHCCCCHHHHHHHHHHHCCC
LNEQKFKGLFGAGFVNGEKVILLKPLTYMNLSGESIRPLMDYYKIDVEDFVVLYDDLDIP
CCHHHHHHHHCCCEECCCEEEEECCCEEECCCCCCHHHHHHHHHCCHHHEEEEEECCCCC
VGKLRLRMKGSAGGHNGVKSTISHLGTQEFQRIRMGIDRPKNGMKVVDYVLGRFTSEEIP
CCCEEEEEECCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCC
DVNHSIEKAADACEEWLNKPFLQIMNTFNS
CCHHHHHHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]