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The map label for this gene is glmU [H]

Identifier: 118475820

GI number: 118475820

Start: 51132

End: 52529

Strand: Direct

Name: glmU [H]

Synonym: BALH_0044

Alternate gene names: 118475820

Gene position: 51132-52529 (Clockwise)

Preceding gene: 162382789

Following gene: 118475821

Centisome position: 0.97

GC content: 38.41

Gene sequence:

>1398_bases
TTGCGATGGAGGGTCTATATGTCAAACAGATTTGCAGTGATTCTAGCTGCAGGTAAAGGCACACGTATGAAGTCTAAGCT
ATACAAAGTGCTTCATCCTGTATGTGGAAAACCTATGGTACAACATGTTGTCGATCAAGTATCTCAATTAGGGTTGCAGA
AACTTGTAACAGTCGTAGGACATGGTGCTGAAATGGTACAAGAACAGCTAGGAAACGTAAGTGAGTTTGCATTACAAGCA
GAACAACTTGGTACAGCGCATGCTGTAGATCAAGCTGCAGGTGTACTTGCAAATGAAGAAGGAACAACTTTAGTTATTTG
TGGTGATACGCCGCTAATAACTGCTGAAACGATGGAAGCATTACTTCAGCAACATAAAGAAGCAGGGGCAATGGCAACGG
TGTTAACAGCTTACATAGAAGAACCTGCTGGATATGGTCGTATCGTTCGTAATGAGAATGGTCATGTTGAAAAGATTGTT
GAGCATAAGGATGCAAATGAGAAAGAATTAGCTATTAAAGAAATCAATACAGGTACGTATTGTTTTGATAATAAAGCTTT
ATTCGCTTCACTTTCTAAAGTTTCAAATGATAACGTACAAGGTGAATATTACCTGCCAGATGTTATTGAGATTTTAAAAA
ATGAAGGTCATATTGTATCGGCTTATCAAACAGAGCACTTCGATGAAACGTTAGGTGTTAACGACAGAGTCGCTCTATCG
CAAGCGGAAATTATTATGAAAAACCGTATCAACCGAAAGAACATGGTAAATGGTGTTACAATTATTGATCCAAGTAACAC
GTATATTTCTGCTGATGCAATTATCGGTAGTGATACAGTTCTTCATCCAGGAACAATTATTGAGGGGAACACTGTAATTG
GTTCTGATTGTGAAATTGGACCGCATACAGTAATTCGCGATAGTGAAATTGGAGATCGTACGACAATTCGTCAATCTACT
GTACATGATAGTAAGCTTGGTACAGAAGTATCGGTTGGTCCATTTGCACATATTCGCCCAGATTCAGTTATTGGAGATGA
AGTACGCGTTGGAAACTTCGTGGAAATCAAAAAAACTGTTTTTGGTAATAGAAGTAAAGCTTCACACTTAAGTTATATCG
GGGATGCGCAAGTTGGAGAAGACGTGAATCTTGGTTGTGGTTCAATTACGGTGAACTATGACGGTAAGAATAAATTCAAA
ACTGTGATTGGTAACGGGGTATTTATTGGATGTAATTCAAACCTTGTTGCTCCTGTAACAGTTGAAGATGGTGCTTATGT
GGCAGCAGGCTCTACAATTACAGAGAATGTTCCATCAAAAGCATTATCTGTAGCACGTGCACGTCAAGTTAACAAAGAAG
ACTATGTTGATCAATTGCTGAATAAGAAAAAATCATAA

Upstream 100 bases:

>100_bases
AGTAAAACATCTTATAAGAATTATGGTAAAATTTAATAGTTAAAATGTGTTTCTTGAAATATATGATGATTTAGGATAAT
ATCGTTAATGGATAAATAGG

Downstream 100 bases:

>100_bases
TGTGGAGGGTTAATCTAGATGTCGACTCAATATCTAAATTCTAATTTGAAAGTATTCTCTTTAAACTCTAATAAGGAACT
TGCTGAGCAAATTGCAAAGC

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MRWRVYMSNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEMVQEQLGNVSEFALQA
EQLGTAHAVDQAAGVLANEEGTTLVICGDTPLITAETMEALLQQHKEAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIV
EHKDANEKELAIKEINTGTYCFDNKALFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEHFDETLGVNDRVALS
QAEIIMKNRINRKNMVNGVTIIDPSNTYISADAIIGSDTVLHPGTIIEGNTVIGSDCEIGPHTVIRDSEIGDRTTIRQST
VHDSKLGTEVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTVFGNRSKASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFK
TVIGNGVFIGCNSNLVAPVTVEDGAYVAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS

Sequences:

>Translated_465_residues
MRWRVYMSNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEMVQEQLGNVSEFALQA
EQLGTAHAVDQAAGVLANEEGTTLVICGDTPLITAETMEALLQQHKEAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIV
EHKDANEKELAIKEINTGTYCFDNKALFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEHFDETLGVNDRVALS
QAEIIMKNRINRKNMVNGVTIIDPSNTYISADAIIGSDTVLHPGTIIEGNTVIGSDCEIGPHTVIRDSEIGDRTTIRQST
VHDSKLGTEVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTVFGNRSKASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFK
TVIGNGVFIGCNSNLVAPVTVEDGAYVAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS
>Mature_465_residues
MRWRVYMSNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVGHGAEMVQEQLGNVSEFALQA
EQLGTAHAVDQAAGVLANEEGTTLVICGDTPLITAETMEALLQQHKEAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIV
EHKDANEKELAIKEINTGTYCFDNKALFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEHFDETLGVNDRVALS
QAEIIMKNRINRKNMVNGVTIIDPSNTYISADAIIGSDTVLHPGTIIEGNTVIGSDCEIGPHTVIRDSEIGDRTTIRQST
VHDSKLGTEVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTVFGNRSKASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFK
TVIGNGVFIGCNSNLVAPVTVEDGAYVAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=359, Percent_Identity=23.9554317548747, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI11761619, Length=340, Percent_Identity=24.1176470588235, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790168, Length=445, Percent_Identity=44.4943820224719, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI133931050, Length=357, Percent_Identity=25.2100840336134, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320148, Length=359, Percent_Identity=24.2339832869081, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21355443, Length=362, Percent_Identity=23.7569060773481, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24644084, Length=362, Percent_Identity=23.7569060773481, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep; PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 50316; Mature: 50316

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWRVYMSNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVG
CEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
HGAEMVQEQLGNVSEFALQAEQLGTAHAVDQAAGVLANEEGTTLVICGDTPLITAETMEA
CCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCEEECCCCCEEEEECCCCEEEHHHHHH
LLQQHKEAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDANEKELAIKEINTGTY
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHCCCCCHHEEEEECCCCEE
CFDNKALFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEHFDETLGVNDRVALS
EECCHHHHHHHHHHCCCCCCCEEECHHHHHHHHCCCCEEEEEEHHCHHHHCCCCCCEEHH
QAEIIMKNRINRKNMVNGVTIIDPSNTYISADAIIGSDTVLHPGTIIEGNTVIGSDCEIG
HHHHHHHHCCCCCHHCCCEEEECCCCCEEEECEEECCCCEECCCEEEECCEEECCCCCCC
PHTVIRDSEIGDRTTIRQSTVHDSKLGTEVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTV
CCEEEECCCCCCCHHHHHHHCCHHHCCCEEECCCCCCCCCCCCCCCCEECCCEEEEHHHH
FGNRSKASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFKTVIGNGVFIGCNSNLVAPVT
CCCCCCCCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEECCCEEEEECCCEEEEEE
VEDGAYVAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS
ECCCCEEEECCCHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MRWRVYMSNRFAVILAAGKGTRMKSKLYKVLHPVCGKPMVQHVVDQVSQLGLQKLVTVVG
CEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
HGAEMVQEQLGNVSEFALQAEQLGTAHAVDQAAGVLANEEGTTLVICGDTPLITAETMEA
CCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCEEECCCCCEEEEECCCCEEEHHHHHH
LLQQHKEAGAMATVLTAYIEEPAGYGRIVRNENGHVEKIVEHKDANEKELAIKEINTGTY
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHCCCCCHHEEEEECCCCEE
CFDNKALFASLSKVSNDNVQGEYYLPDVIEILKNEGHIVSAYQTEHFDETLGVNDRVALS
EECCHHHHHHHHHHCCCCCCCEEECHHHHHHHHCCCCEEEEEEHHCHHHHCCCCCCEEHH
QAEIIMKNRINRKNMVNGVTIIDPSNTYISADAIIGSDTVLHPGTIIEGNTVIGSDCEIG
HHHHHHHHCCCCCHHCCCEEEECCCCCEEEECEEECCCCEECCCEEEECCEEECCCCCCC
PHTVIRDSEIGDRTTIRQSTVHDSKLGTEVSVGPFAHIRPDSVIGDEVRVGNFVEIKKTV
CCEEEECCCCCCCHHHHHHHCCHHHCCCEEECCCCCCCCCCCCCCCCEECCCEEEEHHHH
FGNRSKASHLSYIGDAQVGEDVNLGCGSITVNYDGKNKFKTVIGNGVFIGCNSNLVAPVT
CCCCCCCCHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEECCCEEEEECCCEEEEEE
VEDGAYVAAGSTITENVPSKALSVARARQVNKEDYVDQLLNKKKS
ECCCCEEEECCCHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA