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The map label for this gene is ipk

Identifier: 118475816

GI number: 118475816

Start: 48101

End: 48979

Strand: Direct

Name: ipk

Synonym: BALH_0040

Alternate gene names: 118475816

Gene position: 48101-48979 (Clockwise)

Preceding gene: 118475815

Following gene: 118475817

Centisome position: 0.91

GC content: 38.34

Gene sequence:

>879_bases
GTGAATAGATTGAAGCTACTAGTGAAAGCACCAGCAAAGATTAATCTGTCGTTAGATGTACTGGGAAAAAGACAAGACGG
ATATCATGAAGTGAAAATGATTATGACAACAATCGATTTAGCGGATCGTTTAGAACTAATGGAATTAGCAGAAGACCGTA
TTGAAATTTTATCCCATAATCGGTATGTCCCAGACGACCAAAGAAATCTGGCTTATCAAGCAGCGAAATTATTAAAAGAG
AAGTTTAATGTGAAAAAAGGTGTATCTATTACTATTGAAAAAACGATTCCAGTAGCAGCTGGATTAGCGGGTGGAAGTAG
TGATGCAGCAGCGACATTACGTGGTCTTAATAAATTATGGAATTTAGGCCTTACGATTGATCAATTAGCAGAGCTTGGCG
CAGAAATTGGATCAGATGTATCGTTTTGTGTATATGGTGGGACAGCAATTGCCACTGGAAGAGGAGAGCAGATTGAGCAC
ATAAAAACTCCACCTTCTTGTTGGGTTATTTTAGCAAAGCCTCATATTGGTGTATCTACTGCTGATGTATATGGAAATTT
AAAGTTAAATCGAGTTACACATCCAAATGTAGATAAAATGGTGGATGTCATAAACGCTGGAGACTACAAAGGGATTTGCG
ATACTGTTGGTAACGTTTTAGAAGATGTAACGTTTGCTATGCATCCTGAAGTTGCACGTATTAAAGCACAAATGAAGCGA
TTTGGAGCAGATGCTGTATTAATGAGTGGAAGTGGTCCAACTGTATTCGGCCTAGTGCACCATGATTCGCGAATGCATCG
TATATATAACGGATTAAAAGGATTTTGTGAACAAGTATACGCAGTACGTTTATTAGGAGAGCGAGAAACGCTTGAATAA

Upstream 100 bases:

>100_bases
GTTTCATTCTGAATGCTTTTCGTTATAATTAGGGAAGTGTCATCGTCTTACTATAAATTTATGGTAAAATAAACGATAAA
AGATTGAGTACATAGAGTGG

Downstream 100 bases:

>100_bases
AGACGTATAATACGTTATGATTTGTTTAGAATATTCGTGATTTGAGGTGAGAGTATGAAAATTAGACGAAGTACAAGATT
AGTCGATATGACTTATTACT

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MNRLKLLVKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELMELAEDRIEILSHNRYVPDDQRNLAYQAAKLLKE
KFNVKKGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDQLAELGAEIGSDVSFCVYGGTAIATGRGEQIEH
IKTPPSCWVILAKPHIGVSTADVYGNLKLNRVTHPNVDKMVDVINAGDYKGICDTVGNVLEDVTFAMHPEVARIKAQMKR
FGADAVLMSGSGPTVFGLVHHDSRMHRIYNGLKGFCEQVYAVRLLGERETLE

Sequences:

>Translated_292_residues
MNRLKLLVKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELMELAEDRIEILSHNRYVPDDQRNLAYQAAKLLKE
KFNVKKGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDQLAELGAEIGSDVSFCVYGGTAIATGRGEQIEH
IKTPPSCWVILAKPHIGVSTADVYGNLKLNRVTHPNVDKMVDVINAGDYKGICDTVGNVLEDVTFAMHPEVARIKAQMKR
FGADAVLMSGSGPTVFGLVHHDSRMHRIYNGLKGFCEQVYAVRLLGERETLE
>Mature_292_residues
MNRLKLLVKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELMELAEDRIEILSHNRYVPDDQRNLAYQAAKLLKE
KFNVKKGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLWNLGLTIDQLAELGAEIGSDVSFCVYGGTAIATGRGEQIEH
IKTPPSCWVILAKPHIGVSTADVYGNLKLNRVTHPNVDKMVDVINAGDYKGICDTVGNVLEDVTFAMHPEVARIKAQMKR
FGADAVLMSGSGPTVFGLVHHDSRMHRIYNGLKGFCEQVYAVRLLGERETLE

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

Organism=Escherichia coli, GI1787459, Length=215, Percent_Identity=33.0232558139535, Blast_Score=108, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_BACAH (A0R8B7)

Other databases:

- EMBL:   CP000485
- RefSeq:   YP_892967.1
- ProteinModelPortal:   A0R8B7
- SMR:   A0R8B7
- STRING:   A0R8B7
- EnsemblBacteria:   EBBACT00000068402
- GeneID:   4545237
- GenomeReviews:   CP000485_GR
- KEGG:   btl:BALH_0040
- eggNOG:   COG1947
- GeneTree:   EBGT00050000000875
- HOGENOM:   HBG734593
- OMA:   RIYNGLR
- ProtClustDB:   PRK00128
- BioCyc:   BTHU412694:BALH_0040-MONOMER
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 31976; Mature: 31976

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: ACT_SITE 13-13 ACT_SITE 139-139

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLKLLVKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELMELAEDRIEILSHN
CCCEEEEEECCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RYVPDDQRNLAYQAAKLLKEKFNVKKGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLW
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHHHH
NLGLTIDQLAELGAEIGSDVSFCVYGGTAIATGRGEQIEHIKTPPSCWVILAKPHIGVST
HCCCCHHHHHHHHHHHCCCCEEEEECCEEEECCCCCCHHHCCCCCCEEEEEECCCCCCEE
ADVYGNLKLNRVTHPNVDKMVDVINAGDYKGICDTVGNVLEDVTFAMHPEVARIKAQMKR
HHEEECEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
FGADAVLMSGSGPTVFGLVHHDSRMHRIYNGLKGFCEQVYAVRLLGERETLE
CCCCEEEEECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNRLKLLVKAPAKINLSLDVLGKRQDGYHEVKMIMTTIDLADRLELMELAEDRIEILSHN
CCCEEEEEECCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RYVPDDQRNLAYQAAKLLKEKFNVKKGVSITIEKTIPVAAGLAGGSSDAAATLRGLNKLW
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHHHH
NLGLTIDQLAELGAEIGSDVSFCVYGGTAIATGRGEQIEHIKTPPSCWVILAKPHIGVST
HCCCCHHHHHHHHHHHCCCCEEEEECCEEEECCCCCCHHHCCCCCCEEEEEECCCCCCEE
ADVYGNLKLNRVTHPNVDKMVDVINAGDYKGICDTVGNVLEDVTFAMHPEVARIKAQMKR
HHEEECEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
FGADAVLMSGSGPTVFGLVHHDSRMHRIYNGLKGFCEQVYAVRLLGERETLE
CCCCEEEEECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA