Click here to switch to the map view.

The map label for this gene is panC

Identifier: 117921846

GI number: 117921846

Start: 4077644

End: 4078489

Strand: Direct

Name: panC

Synonym: Shewana3_3409

Alternate gene names: 117921846

Gene position: 4077644-4078489 (Clockwise)

Preceding gene: 117921845

Following gene: 117921847

Centisome position: 82.01

GC content: 53.07

Gene sequence:

>846_bases
ATGATCACTAGCGCCCATATCGATGATATTCGTACTCAAGTGCGGGCATGGCATGCCAAGGGCGAGACCGTCGCCTTTGT
GCCTACCATGGGCAATCTCCATCAGGGACACATCACCTTAGTGAAAGAAGCGGCGAAGAAATGCGACCATGTAGTCGTGT
CAATCTTCGTTAATCCCATGCAGTTTGGGCAGAACGAAGATCTCGATGCCTACCCGCGCACCTTAGAGGCCGACAGCCAA
GCGCTGACGGCCGCGGGCGCCGAGCTGCTATTTACCCCAACGCCTACGGTTATTTATCCAAAAGGCTTGGCGCAGCAAAC
CTATGTTGAAGTACCGGGAATTTCCGATGTACTCTGCGGTGCCAGTCGTCCCGGTCATTTCCGTGGCGTTGCGACTGTAG
TCTGCAAACTGTTCAACATAGTGCAGCCCGATGTGGCGTTCTTTGGCAACAAGGATTATCAACAACTCTTAGTGATCCGC
ACTATGGTTGAAGACTTGTCACTGCCGATTGAAATTATCGGTGTGGATACCATTCGTGAAGCCTCAGGCTTAGCCATGAG
TTCACGCAATGGCTACCTGACGGCGGAAGAAAAAGCCGCGGCGCCGGCGCTGAAAAAAGCTATCGATGCCATGGCACAAG
GCATTAAGCAAGGCGTGAGCATCGAACAAGTCACCGCGGAAGCCAAAGCGAGCCTTATCGCCGCAGGCTTTACCCCAGAT
TATTTAGAAGTTTGCCATGCCACTACCCTGGCCAATGCGGAAACTACGGACCAAGCACTGGTGATTTTGGCCGCCGCTTA
CTTAGGTAAGGCGCGTCTTATCGATAACCTGCGCTTCGACCGCTAA

Upstream 100 bases:

>100_bases
AGTGCTGATCACACGTTCAACTAAGCGTGCTTGCACTCATTGAGCTAAATAGTGCTAAGCACACAGACGACTATTTCAAG
TTTTAGCAAGGTAAGAGTTA

Downstream 100 bases:

>100_bases
GCGTTTTAGCGCAAGAAAAAGGAGCTTAGGCTCCTTTTTTGTTTGCGCAGCTCTGTACAGACTCGCCTCAATCCATTGAG
CGTCAAAAAAATTCCATCGT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MITSAHIDDIRTQVRAWHAKGETVAFVPTMGNLHQGHITLVKEAAKKCDHVVVSIFVNPMQFGQNEDLDAYPRTLEADSQ
ALTAAGAELLFTPTPTVIYPKGLAQQTYVEVPGISDVLCGASRPGHFRGVATVVCKLFNIVQPDVAFFGNKDYQQLLVIR
TMVEDLSLPIEIIGVDTIREASGLAMSSRNGYLTAEEKAAAPALKKAIDAMAQGIKQGVSIEQVTAEAKASLIAAGFTPD
YLEVCHATTLANAETTDQALVILAAAYLGKARLIDNLRFDR

Sequences:

>Translated_281_residues
MITSAHIDDIRTQVRAWHAKGETVAFVPTMGNLHQGHITLVKEAAKKCDHVVVSIFVNPMQFGQNEDLDAYPRTLEADSQ
ALTAAGAELLFTPTPTVIYPKGLAQQTYVEVPGISDVLCGASRPGHFRGVATVVCKLFNIVQPDVAFFGNKDYQQLLVIR
TMVEDLSLPIEIIGVDTIREASGLAMSSRNGYLTAEEKAAAPALKKAIDAMAQGIKQGVSIEQVTAEAKASLIAAGFTPD
YLEVCHATTLANAETTDQALVILAAAYLGKARLIDNLRFDR
>Mature_281_residues
MITSAHIDDIRTQVRAWHAKGETVAFVPTMGNLHQGHITLVKEAAKKCDHVVVSIFVNPMQFGQNEDLDAYPRTLEADSQ
ALTAAGAELLFTPTPTVIYPKGLAQQTYVEVPGISDVLCGASRPGHFRGVATVVCKLFNIVQPDVAFFGNKDYQQLLVIR
TMVEDLSLPIEIIGVDTIREASGLAMSSRNGYLTAEEKAAAPALKKAIDAMAQGIKQGVSIEQVTAEAKASLIAAGFTPD
YLEVCHATTLANAETTDQALVILAAAYLGKARLIDNLRFDR

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=268, Percent_Identity=51.865671641791, Blast_Score=283, Evalue=9e-78,
Organism=Saccharomyces cerevisiae, GI6322046, Length=283, Percent_Identity=39.2226148409894, Blast_Score=187, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_SHESA (A0L0R3)

Other databases:

- EMBL:   CP000469
- RefSeq:   YP_871038.1
- ProteinModelPortal:   A0L0R3
- SMR:   A0L0R3
- STRING:   A0L0R3
- GeneID:   4476752
- GenomeReviews:   CP000469_GR
- KEGG:   shn:Shewana3_3409
- NMPDR:   fig|94122.5.peg.3410
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   A0L0R3
- ProtClustDB:   PRK00380
- BioCyc:   SSP94122:SHEWANA3_3409-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30251; Mature: 30251

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 155-155 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITSAHIDDIRTQVRAWHAKGETVAFVPTMGNLHQGHITLVKEAAKKCDHVVVSIFVNPM
CCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHEEEHEEECHH
QFGQNEDLDAYPRTLEADSQALTAAGAELLFTPTPTVIYPKGLAQQTYVEVPGISDVLCG
HCCCCCCCCCCCCCCCCCCHHHHHCCCEEEECCCCCEEECCCCCCCCEEECCCCHHHHHC
ASRPGHFRGVATVVCKLFNIVQPDVAFFGNKDYQQLLVIRTMVEDLSLPIEIIGVDTIRE
CCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECHHHHH
ASGLAMSSRNGYLTAEEKAAAPALKKAIDAMAQGIKQGVSIEQVTAEAKASLIAAGFTPD
HCCCEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEECCCHH
YLEVCHATTLANAETTDQALVILAAAYLGKARLIDNLRFDR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MITSAHIDDIRTQVRAWHAKGETVAFVPTMGNLHQGHITLVKEAAKKCDHVVVSIFVNPM
CCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHEEEHEEECHH
QFGQNEDLDAYPRTLEADSQALTAAGAELLFTPTPTVIYPKGLAQQTYVEVPGISDVLCG
HCCCCCCCCCCCCCCCCCCHHHHHCCCEEEECCCCCEEECCCCCCCCEEECCCCHHHHHC
ASRPGHFRGVATVVCKLFNIVQPDVAFFGNKDYQQLLVIRTMVEDLSLPIEIIGVDTIRE
CCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECHHHHH
ASGLAMSSRNGYLTAEEKAAAPALKKAIDAMAQGIKQGVSIEQVTAEAKASLIAAGFTPD
HCCCEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEECCCHH
YLEVCHATTLANAETTDQALVILAAAYLGKARLIDNLRFDR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA