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The map label for this gene is aarA [H]

Identifier: 117921729

GI number: 117921729

Start: 3939266

End: 3940843

Strand: Reverse

Name: aarA [H]

Synonym: Shewana3_3291

Alternate gene names: 117921729

Gene position: 3940843-3939266 (Counterclockwise)

Preceding gene: 117921730

Following gene: 117921724

Centisome position: 79.26

GC content: 47.66

Gene sequence:

>1578_bases
ATGCGTGTGGCGTTAATCTTAAAAAAACTCCAGTTGATCTATGTGCCCTTTATACTGCTCTGCCTGCTATTTGTCTCAGG
CTACAGCTTGCTCCATTGGTTGTTGATTATCGAGTTCCAACTGCTGAGGATTGACGAATCGATTATCAATTTCTGGCTGC
CGCTGATATTGCCTTGGCCCTTGCTGTTTTTCTATTTAAGGCCGAGGCTCAAGTTATTCCGCTTTACCAAGAGCAATAGC
CGTTTTATCTATTTTGTGATTGCCGTGCTTTTGCTGGCCGTGCCCACTATCGTGGTGCAGGAATACCTTAATAGTGCAAC
AGGCAAGTTGACTCAACTTGAGTCCATCAATGCACTATTACACCAGCCGCAAACTAAGTATTACCAATTAAATCAGTTTT
ATATTGATAAAAAACACATAGGTGTGCAGCGTAATATTGAGCCCATAGGTAAGGGCAACAGTGAGCTGCGCATGAGCCTG
TATATTGCGATGCCGATTTTCGCTAAACGTAATGAGAGTTGGCGGGTCGGTGCTAAGGCCTTGGCATGGTATGGCAAAGT
TTATGAGAAAACGATCAGTAATCGACTCGAACAGCAGGAGAAAGAATCGCTATTTCAGGAGTTTATTCATCAGAGTGAGC
AGGAATTTAATGCCTTAAACCCGGATGATTTTGTCTATCTGGACCGTATAGGCCCGTCAAGCCGCTACACTCAGCTACTC
ACCGCTGCTCAAAAAAGCACTGTCTACTTCGAGGGTTACCAAACCGTCTTAATGCCTGTGAATCAACCCTTCGAGGCGCG
TAATGGCCATAAACTGGCGTGGATTATTGCTTGGTTAAGCTTTGGGGCCATTCTGTGGTTGTTGATGAGTCTGATGCTAA
AACTGGATGAGACGCAGGCGTCTAAGCCCATGGCTGCACAGCTGAGTATGGAAAAACCTAAGGCAGAGCTCTATGGCTTT
TTGGCCGAATTTAAACCTCGGCAGGGCTTTGTTATCACACCTATCTTGCTCTATATCAACACCTTGATATTTGTATTGAT
GGCCTTTGTCAGCCAGCACGTTATCGCCTTACCAAACAGTGTGTTACTCGATTGGGGGGCTAACCTTCGGCAGTTGGTGC
TTGAGCAACAAGTTTGGCGTTTAATCAGCAATGTGTTTTTGCACGGCGGCCTGATGCATTTGGTCTTTAACTTATACGGG
CTGTTTTTTGCGGGGATGTTTTTGGAGCCACTGCTGGGCAAATGGCGTTTACTCTGGGTCTATCTGTGCTGTGGTTTAGT
GGCGAGTATGGCCAGCATAGGCTGGTATGAGGCGACGATCAGCATAGGTGCCTCGGGCGCTATCATGGGGCTATTTGGGG
TGTTGATCATCTGGATATGGTTGGGTTTATTGCCCTTGGCGGACAATATGCCGCTCGCCCTGAATCTGACCCTATTCGTT
ACTGCCAGTCTTGTGATGGGACTCTTTGGCGGGGTGGATAATGCCGCGCACCTGGGTGGTTTGGGCAGTGGGCTGCTGCT
TGGGGGCTTGCTACGCCCAAACAAGGTGCAGTCGCAGGCCAATAAAAAGCCGAGGTAA

Upstream 100 bases:

>100_bases
GATTGATTGGCTTCACTAAAAACCAAGCAATCACCCCGCTAAGGGTGCGTTGTGTGGCGATACGCCGTATCATTGGCGGG
ATTTTTCTCTCAAGGATGAT

Downstream 100 bases:

>100_bases
ATCCTCGGCTAATGGGTTTTCCTATTGAATGTAAGCGGTATTTAGGCGTGCTCAAACATCAGGAAGAGGTACACGATAAA
CAGCACTATATGGGTCGCCC

Product: rhomboid family protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MRVALILKKLQLIYVPFILLCLLFVSGYSLLHWLLIIEFQLLRIDESIINFWLPLILPWPLLFFYLRPRLKLFRFTKSNS
RFIYFVIAVLLLAVPTIVVQEYLNSATGKLTQLESINALLHQPQTKYYQLNQFYIDKKHIGVQRNIEPIGKGNSELRMSL
YIAMPIFAKRNESWRVGAKALAWYGKVYEKTISNRLEQQEKESLFQEFIHQSEQEFNALNPDDFVYLDRIGPSSRYTQLL
TAAQKSTVYFEGYQTVLMPVNQPFEARNGHKLAWIIAWLSFGAILWLLMSLMLKLDETQASKPMAAQLSMEKPKAELYGF
LAEFKPRQGFVITPILLYINTLIFVLMAFVSQHVIALPNSVLLDWGANLRQLVLEQQVWRLISNVFLHGGLMHLVFNLYG
LFFAGMFLEPLLGKWRLLWVYLCCGLVASMASIGWYEATISIGASGAIMGLFGVLIIWIWLGLLPLADNMPLALNLTLFV
TASLVMGLFGGVDNAAHLGGLGSGLLLGGLLRPNKVQSQANKKPR

Sequences:

>Translated_525_residues
MRVALILKKLQLIYVPFILLCLLFVSGYSLLHWLLIIEFQLLRIDESIINFWLPLILPWPLLFFYLRPRLKLFRFTKSNS
RFIYFVIAVLLLAVPTIVVQEYLNSATGKLTQLESINALLHQPQTKYYQLNQFYIDKKHIGVQRNIEPIGKGNSELRMSL
YIAMPIFAKRNESWRVGAKALAWYGKVYEKTISNRLEQQEKESLFQEFIHQSEQEFNALNPDDFVYLDRIGPSSRYTQLL
TAAQKSTVYFEGYQTVLMPVNQPFEARNGHKLAWIIAWLSFGAILWLLMSLMLKLDETQASKPMAAQLSMEKPKAELYGF
LAEFKPRQGFVITPILLYINTLIFVLMAFVSQHVIALPNSVLLDWGANLRQLVLEQQVWRLISNVFLHGGLMHLVFNLYG
LFFAGMFLEPLLGKWRLLWVYLCCGLVASMASIGWYEATISIGASGAIMGLFGVLIIWIWLGLLPLADNMPLALNLTLFV
TASLVMGLFGGVDNAAHLGGLGSGLLLGGLLRPNKVQSQANKKPR
>Mature_525_residues
MRVALILKKLQLIYVPFILLCLLFVSGYSLLHWLLIIEFQLLRIDESIINFWLPLILPWPLLFFYLRPRLKLFRFTKSNS
RFIYFVIAVLLLAVPTIVVQEYLNSATGKLTQLESINALLHQPQTKYYQLNQFYIDKKHIGVQRNIEPIGKGNSELRMSL
YIAMPIFAKRNESWRVGAKALAWYGKVYEKTISNRLEQQEKESLFQEFIHQSEQEFNALNPDDFVYLDRIGPSSRYTQLL
TAAQKSTVYFEGYQTVLMPVNQPFEARNGHKLAWIIAWLSFGAILWLLMSLMLKLDETQASKPMAAQLSMEKPKAELYGF
LAEFKPRQGFVITPILLYINTLIFVLMAFVSQHVIALPNSVLLDWGANLRQLVLEQQVWRLISNVFLHGGLMHLVFNLYG
LFFAGMFLEPLLGKWRLLWVYLCCGLVASMASIGWYEATISIGASGAIMGLFGVLIIWIWLGLLPLADNMPLALNLTLFV
TASLVMGLFGGVDNAAHLGGLGSGLLLGGLLRPNKVQSQANKKPR

Specific function: Rhomboid serine protease that catalyzes intramembrane proteolysis. Mediates quorum-sensing and the subsequent regulation of target genes via activation of the Tat protein export system. Catalyzes the proteolytic activation of tatA by removal of its N- ter

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S54 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764 [H]

Pfam domain/function: PF01694 Rhomboid [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 59815; Mature: 59815

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVALILKKLQLIYVPFILLCLLFVSGYSLLHWLLIIEFQLLRIDESIINFWLPLILPWP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLFFYLRPRLKLFRFTKSNSRFIYFVIAVLLLAVPTIVVQEYLNSATGKLTQLESINALL
HHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
HQPQTKYYQLNQFYIDKKHIGVQRNIEPIGKGNSELRMSLYIAMPIFAKRNESWRVGAKA
CCCCCHHEEHHHEEEEHHHCCCCCCCCCCCCCCCCEEEEEEEEEHHHHCCCCCCHHHHHH
LAWYGKVYEKTISNRLEQQEKESLFQEFIHQSEQEFNALNPDDFVYLDRIGPSSRYTQLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHH
TAAQKSTVYFEGYQTVLMPVNQPFEARNGHKLAWIIAWLSFGAILWLLMSLMLKLDETQA
HHHHHCCEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SKPMAAQLSMEKPKAELYGFLAEFKPRQGFVITPILLYINTLIFVLMAFVSQHVIALPNS
CCCHHHHHCCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
VLLDWGANLRQLVLEQQVWRLISNVFLHGGLMHLVFNLYGLFFAGMFLEPLLGKWRLLWV
HEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLCCGLVASMASIGWYEATISIGASGAIMGLFGVLIIWIWLGLLPLADNMPLALNLTLFV
HHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHH
TASLVMGLFGGVDNAAHLGGLGSGLLLGGLLRPNKVQSQANKKPR
HHHHHHHHHCCCCCHHHHCCCCCHHHHHCCCCCHHHHHHCCCCCC
>Mature Secondary Structure
MRVALILKKLQLIYVPFILLCLLFVSGYSLLHWLLIIEFQLLRIDESIINFWLPLILPWP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLFFYLRPRLKLFRFTKSNSRFIYFVIAVLLLAVPTIVVQEYLNSATGKLTQLESINALL
HHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
HQPQTKYYQLNQFYIDKKHIGVQRNIEPIGKGNSELRMSLYIAMPIFAKRNESWRVGAKA
CCCCCHHEEHHHEEEEHHHCCCCCCCCCCCCCCCCEEEEEEEEEHHHHCCCCCCHHHHHH
LAWYGKVYEKTISNRLEQQEKESLFQEFIHQSEQEFNALNPDDFVYLDRIGPSSRYTQLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHH
TAAQKSTVYFEGYQTVLMPVNQPFEARNGHKLAWIIAWLSFGAILWLLMSLMLKLDETQA
HHHHHCCEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SKPMAAQLSMEKPKAELYGFLAEFKPRQGFVITPILLYINTLIFVLMAFVSQHVIALPNS
CCCHHHHHCCCCCHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
VLLDWGANLRQLVLEQQVWRLISNVFLHGGLMHLVFNLYGLFFAGMFLEPLLGKWRLLWV
HEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLCCGLVASMASIGWYEATISIGASGAIMGLFGVLIIWIWLGLLPLADNMPLALNLTLFV
HHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHH
TASLVMGLFGGVDNAAHLGGLGSGLLLGGLLRPNKVQSQANKKPR
HHHHHHHHHCCCCCHHHHCCCCCHHHHHCCCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8051030 [H]