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The map label for this gene is ung [H]

Identifier: 117921659

GI number: 117921659

Start: 3863883

End: 3864548

Strand: Reverse

Name: ung [H]

Synonym: Shewana3_3221

Alternate gene names: 117921659

Gene position: 3864548-3863883 (Counterclockwise)

Preceding gene: 117921660

Following gene: 117921657

Centisome position: 77.72

GC content: 50.0

Gene sequence:

>666_bases
GTGACTGTGGCAACTTGGCAGGAATTTATCGATTATCAACGTGCTCAACCCTATTACCAGCAGTTGATTGCATTTGTGAA
TCAAGAGCGTGCGTCGGGTAAGGTGATCTATCCCCCCAAGGAGGATGTGTTCAACGCCTTTAAGACAACTCCTTTGGAAA
AGGTGCGTGTGGTACTTATCGGTCAAGATCCCTACCATGGTCCCGACCAAGCCCACGGCCTGTGTTTCTCGGTTAAGCGA
GGCATTAAACCGCCGCCATCGCTGGCCAATATGTATAAAGAGTTAGTGAACGATATTCCCGGTTTTCAAATCCCTAACCA
TGGCGATTTAACTCAATGGGCAGAGCAGGGGATCTTAATGCTCAATACCGTGCTGACGGTGGAGCAAGGACAAGCTCATT
CCCACGCTAATGCGGGCTGGGAAACCTTTACCACTGAGGCGTTAAAGCTGCTTAATGCGCAGGAGCAGCCGATTATTTTT
GTACTATGGGGCAGCCATGCCATCAAAAAAGGGGCGGTGATTACTGCGCCACAGCATCAAATACTGTCGGGACCCCATCC
GTCACCGCTGTCAGCTTATCGCGGCTTCTTTGGTTGTGGGCATTTTTCTAAAGTGAACCAACTGCTGATGGCAAGGGGCG
AAGTACCGATCCAATGGCAGGTTTAA

Upstream 100 bases:

>100_bases
GCTTGCGATATCTCAAGACTGGGGAATAAAAAACTGAGTTGGCTTGTCATGTCGCGCTATCACTTTTAAGCTAACGGCAT
TCTAACCAGAGGAAAAGATT

Downstream 100 bases:

>100_bases
GTTCGCTTTGATAAAGAACGTTAAAAATAAAAAGGCCTTGCTAAGCAAGGCCTTTTTATTGGTTTATCGCAGCCAATTAG
TGGTTGCGATCAACGGAGAT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MTVATWQEFIDYQRAQPYYQQLIAFVNQERASGKVIYPPKEDVFNAFKTTPLEKVRVVLIGQDPYHGPDQAHGLCFSVKR
GIKPPPSLANMYKELVNDIPGFQIPNHGDLTQWAEQGILMLNTVLTVEQGQAHSHANAGWETFTTEALKLLNAQEQPIIF
VLWGSHAIKKGAVITAPQHQILSGPHPSPLSAYRGFFGCGHFSKVNQLLMARGEVPIQWQV

Sequences:

>Translated_221_residues
MTVATWQEFIDYQRAQPYYQQLIAFVNQERASGKVIYPPKEDVFNAFKTTPLEKVRVVLIGQDPYHGPDQAHGLCFSVKR
GIKPPPSLANMYKELVNDIPGFQIPNHGDLTQWAEQGILMLNTVLTVEQGQAHSHANAGWETFTTEALKLLNAQEQPIIF
VLWGSHAIKKGAVITAPQHQILSGPHPSPLSAYRGFFGCGHFSKVNQLLMARGEVPIQWQV
>Mature_220_residues
TVATWQEFIDYQRAQPYYQQLIAFVNQERASGKVIYPPKEDVFNAFKTTPLEKVRVVLIGQDPYHGPDQAHGLCFSVKRG
IKPPPSLANMYKELVNDIPGFQIPNHGDLTQWAEQGILMLNTVLTVEQGQAHSHANAGWETFTTEALKLLNAQEQPIIFV
LWGSHAIKKGAVITAPQHQILSGPHPSPLSAYRGFFGCGHFSKVNQLLMARGEVPIQWQV

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=216, Percent_Identity=50.9259259259259, Blast_Score=238, Evalue=2e-63,
Organism=Homo sapiens, GI6224979, Length=216, Percent_Identity=50.9259259259259, Blast_Score=238, Evalue=3e-63,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=60, Blast_Score=279, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI17556304, Length=220, Percent_Identity=45.4545454545455, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323620, Length=222, Percent_Identity=45.945945945946, Blast_Score=191, Evalue=6e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24727; Mature: 24595

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVATWQEFIDYQRAQPYYQQLIAFVNQERASGKVIYPPKEDVFNAFKTTPLEKVRVVLI
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCCHHHEEEEEE
GQDPYHGPDQAHGLCFSVKRGIKPPPSLANMYKELVNDIPGFQIPNHGDLTQWAEQGILM
CCCCCCCCCHHCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCEEE
LNTVLTVEQGQAHSHANAGWETFTTEALKLLNAQEQPIIFVLWGSHAIKKGAVITAPQHQ
EHHEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHCCEEEECCCHH
ILSGPHPSPLSAYRGFFGCGHFSKVNQLLMARGEVPIQWQV
HCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECC
>Mature Secondary Structure 
TVATWQEFIDYQRAQPYYQQLIAFVNQERASGKVIYPPKEDVFNAFKTTPLEKVRVVLI
CCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCCHHHEEEEEE
GQDPYHGPDQAHGLCFSVKRGIKPPPSLANMYKELVNDIPGFQIPNHGDLTQWAEQGILM
CCCCCCCCCHHCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCEEE
LNTVLTVEQGQAHSHANAGWETFTTEALKLLNAQEQPIIFVLWGSHAIKKGAVITAPQHQ
EHHEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHCCEEEECCCHH
ILSGPHPSPLSAYRGFFGCGHFSKVNQLLMARGEVPIQWQV
HCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]