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The map label for this gene is rmlA2 [C]

Identifier: 117921642

GI number: 117921642

Start: 3846952

End: 3847617

Strand: Reverse

Name: rmlA2 [C]

Synonym: Shewana3_3204

Alternate gene names: 117921642

Gene position: 3847617-3846952 (Counterclockwise)

Preceding gene: 117921643

Following gene: 117921641

Centisome position: 77.38

GC content: 52.7

Gene sequence:

>666_bases
ATGAAGGCGATGATCCTTGCGGCTGGCAGGGGAGAGCGTTTACGCCCCTTGACCGACACGCTACCAAAACCTTTAGTGCC
CGTCTTAGGCAAACCGCTGATTGTGTACCATATCGAGAAGTTGGCCGCGGCAGGGATTGTCGATATCGTGATAAATCATG
CTTGGCTTGGGCATAAGCTGGTCGAAACCTTAGGGGATGGTCACGCCTTTGGGGTCAAGATCCAATATAGCGCCGAAGCA
TCGGCCCTCGAAACCGGTGGCGGAATTAAACAAGCCTTGCCTTTGCTAACTGACGACTCGGATGCGCCGTTTTTAGTGCT
CAATGGTGATGTGTTTATCGATGCCTTGCCGACGATTGTTCCCTTAGCGGATACTGCTCTGGCGCATTTATGGTTGGTGC
CAAATCCCGAGCAACATCCGAACGGTGATTTTGCCTTGGAGCAGGGCCTTGTACGTGAGCAGGGTGAGCAAAAATATACT
TTCTCTGGCATGGGTTTATATCGCCCATCATTTTTTAATGGCACGCCGGATGGGGCTTTTGCCCTTGGGCCTTTGCTGCG
GGCTAAAATGGCCGATGGCTTGATCTCCGGGGCACACTTTAATGGACTTTGGTGTGATGTTGGGACGATTGCGCGTCTGC
AAGCATTGGAGTCCGCGCTGGCGTAA

Upstream 100 bases:

>100_bases
GCCTTTATCCAGCGCTCACGCCATTTTCCGCTTGGGTGCAATCGCGCGTTGTACCTGCGTTTGCGGCTAAGGGAAAGGAT
ACTCAGCAGGGAGACAAGCA

Downstream 100 bases:

>100_bases
TGGCAAGGCATATCGCCTAACGCTCAATGTTTAGCGCCTTGAGTGAACGGTTTCACTCGCGATGTCGATTGAGTGACTGA
ATAAATTATCAAATTGGGAA

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MKAMILAAGRGERLRPLTDTLPKPLVPVLGKPLIVYHIEKLAAAGIVDIVINHAWLGHKLVETLGDGHAFGVKIQYSAEA
SALETGGGIKQALPLLTDDSDAPFLVLNGDVFIDALPTIVPLADTALAHLWLVPNPEQHPNGDFALEQGLVREQGEQKYT
FSGMGLYRPSFFNGTPDGAFALGPLLRAKMADGLISGAHFNGLWCDVGTIARLQALESALA

Sequences:

>Translated_221_residues
MKAMILAAGRGERLRPLTDTLPKPLVPVLGKPLIVYHIEKLAAAGIVDIVINHAWLGHKLVETLGDGHAFGVKIQYSAEA
SALETGGGIKQALPLLTDDSDAPFLVLNGDVFIDALPTIVPLADTALAHLWLVPNPEQHPNGDFALEQGLVREQGEQKYT
FSGMGLYRPSFFNGTPDGAFALGPLLRAKMADGLISGAHFNGLWCDVGTIARLQALESALA
>Mature_221_residues
MKAMILAAGRGERLRPLTDTLPKPLVPVLGKPLIVYHIEKLAAAGIVDIVINHAWLGHKLVETLGDGHAFGVKIQYSAEA
SALETGGGIKQALPLLTDDSDAPFLVLNGDVFIDALPTIVPLADTALAHLWLVPNPEQHPNGDFALEQGLVREQGEQKYT
FSGMGLYRPSFFNGTPDGAFALGPLLRAKMADGLISGAHFNGLWCDVGTIARLQALESALA

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=115, Percent_Identity=40.8695652173913, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI11761619, Length=115, Percent_Identity=40.8695652173913, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI31881779, Length=244, Percent_Identity=29.5081967213115, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI45447090, Length=244, Percent_Identity=29.5081967213115, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=115, Percent_Identity=40.8695652173913, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=115, Percent_Identity=45.2173913043478, Blast_Score=89, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21355443, Length=114, Percent_Identity=35.9649122807018, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24644084, Length=114, Percent_Identity=35.9649122807018, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24653912, Length=121, Percent_Identity=37.1900826446281, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 23504; Mature: 23504

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMILAAGRGERLRPLTDTLPKPLVPVLGKPLIVYHIEKLAAAGIVDIVINHAWLGHKL
CCEEEEECCCCCCCCCHHHHCCCCCHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
VETLGDGHAFGVKIQYSAEASALETGGGIKQALPLLTDDSDAPFLVLNGDVFIDALPTIV
HHHHCCCCEEEEEEEECCCCCHHHCCCCHHHHCCCEECCCCCCEEEEECCEEEECHHHHH
PLADTALAHLWLVPNPEQHPNGDFALEQGLVREQGEQKYTFSGMGLYRPSFFNGTPDGAF
HHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHH
ALGPLLRAKMADGLISGAHFNGLWCDVGTIARLQALESALA
HHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAMILAAGRGERLRPLTDTLPKPLVPVLGKPLIVYHIEKLAAAGIVDIVINHAWLGHKL
CCEEEEECCCCCCCCCHHHHCCCCCHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
VETLGDGHAFGVKIQYSAEASALETGGGIKQALPLLTDDSDAPFLVLNGDVFIDALPTIV
HHHHCCCCEEEEEEEECCCCCHHHCCCCHHHHCCCEECCCCCCEEEEECCEEEECHHHHH
PLADTALAHLWLVPNPEQHPNGDFALEQGLVREQGEQKYTFSGMGLYRPSFFNGTPDGAF
HHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHH
ALGPLLRAKMADGLISGAHFNGLWCDVGTIARLQALESALA
HHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA