Click here to switch to the map view.

The map label for this gene is gabT [H]

Identifier: 117921529

GI number: 117921529

Start: 3707576

End: 3708853

Strand: Reverse

Name: gabT [H]

Synonym: Shewana3_3091

Alternate gene names: 117921529

Gene position: 3708853-3707576 (Counterclockwise)

Preceding gene: 117921530

Following gene: 117921526

Centisome position: 74.59

GC content: 53.36

Gene sequence:

>1278_bases
ATGAGCACAACCAATGATTCATTGATGGCACGTCGCCAAGCCGCAGTCGCAGGCGGTGTTGGTCAAATTCATCCTGTTTT
TACTGCTCGCGCCGAAAACGCGACCGTGTGGGATGTGGAAGGTCGAGAGTTTATCGACTTTGCGGGTGGTATTGCTGTGC
TTAACACTGGGCATTTACATCCTAAGGTGAAGGCGGCCGTTGCGGCGCAGCTTGAGGATTTCTCCCACACCTGTTTTATG
GTGCTTGGCTACGAAAGTTATATTCAAGTCTGTGAAAAACTGAATCAGTTAGTGCCGGGAGATTTTGCCAAGAAGACAGC
CTTATTCACCAGCGGCTCAGAGGCCGTTGAAAACGCGGTTAAAGTTGCTCGTGCATACACTAAGCGGGCGGGGGTGATTG
CCTTTACCTCGGGTTACCATGGTCGCACTATGGCGGCACTGGCGTTAACGGGAAAGGTCGCGCCTTACAGTAAAGGTATG
GGATTAATGTCGGCCAATGTGTTCCGCGCCGAGTTCCCCTGTGCGCTGCACGGCGTGTCCGATGATGATGCGATGGCCTC
TATCGAACGCATCTTTAAAAATGATGCTGAGCCGAGCAATATCGCGGCCATCATCCTCGAGCCTGTGCAGGGCGAGGGTG
GGTTTTATGCCGCATCGCCAGAGTTTATGCAACGTTTACGTGCGCTTTGCGACCGCGAAGGCATTATGCTGATCGCCGAT
GAAGTGCAAACGGGTGCGGGTCGCACAGGAACCTTCTTTGCTATGGAGCAAATGGGCGTGAGCGCCGATATCACCACCTT
TGCGAAATCTATTGCCGGTGGCTTCCCCCTTTCAGGTATTACGGGTAAAGCTGAAGTCATGGATGCCATCGGTCCCGGTG
GCCTTGGTGGCACCTACGGCGGTAATCCGCTGGCCTGTGCGGCAGCGCTCGCCGTACTCGAAGTGTTTGAAGAGGAAAAG
CTGCTTGAACGTGCCAATGCAATTGGCGAGCGGATTAAGTCGGCGCTAAATACTATGCAGGTTGAACATCCGCAAATTGC
CGATGTGCGTGGTCTAGGGGCGATGATCGCTATTGAATTGATGGAAGAGGGCAAACCCGCGCCTCAGTACTGTGCCCAAA
TTTTAGCCGAGGCAAGAAACCGAGGTTTGATCCTCCTGTCCTGTGGTACCTACGGTAACGTGCTGCGTATATTGGTGCCA
TTAACAGTTCCAGACGAGCAGCTTGCCGCAGGGCTGGGCATTCTTAAGTCCTGCTTCGATGCCGTGTTAAAAGGTTAA

Upstream 100 bases:

>100_bases
ATCAGTTTGGGATAGACCGCCAGTGGTAGCCCTTTGGGCATAGGCATTGTTATCGACATTTGTGTATAGCCAAGTTAGGC
ACGCGAGCAAGGAATACTAA

Downstream 100 bases:

>100_bases
CAGATATAAAAAATCCCGCTTAGGCGGGATTTTTTATGGCGTGGTTTAACGCTTAAGAGCCTTTTATCTCCATTAGGATT
TGCAGCGCTCGCTCACGTTT

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSTTNDSLMARRQAAVAGGVGQIHPVFTARAENATVWDVEGREFIDFAGGIAVLNTGHLHPKVKAAVAAQLEDFSHTCFM
VLGYESYIQVCEKLNQLVPGDFAKKTALFTSGSEAVENAVKVARAYTKRAGVIAFTSGYHGRTMAALALTGKVAPYSKGM
GLMSANVFRAEFPCALHGVSDDDAMASIERIFKNDAEPSNIAAIILEPVQGEGGFYAASPEFMQRLRALCDREGIMLIAD
EVQTGAGRTGTFFAMEQMGVSADITTFAKSIAGGFPLSGITGKAEVMDAIGPGGLGGTYGGNPLACAAALAVLEVFEEEK
LLERANAIGERIKSALNTMQVEHPQIADVRGLGAMIAIELMEEGKPAPQYCAQILAEARNRGLILLSCGTYGNVLRILVP
LTVPDEQLAAGLGILKSCFDAVLKG

Sequences:

>Translated_425_residues
MSTTNDSLMARRQAAVAGGVGQIHPVFTARAENATVWDVEGREFIDFAGGIAVLNTGHLHPKVKAAVAAQLEDFSHTCFM
VLGYESYIQVCEKLNQLVPGDFAKKTALFTSGSEAVENAVKVARAYTKRAGVIAFTSGYHGRTMAALALTGKVAPYSKGM
GLMSANVFRAEFPCALHGVSDDDAMASIERIFKNDAEPSNIAAIILEPVQGEGGFYAASPEFMQRLRALCDREGIMLIAD
EVQTGAGRTGTFFAMEQMGVSADITTFAKSIAGGFPLSGITGKAEVMDAIGPGGLGGTYGGNPLACAAALAVLEVFEEEK
LLERANAIGERIKSALNTMQVEHPQIADVRGLGAMIAIELMEEGKPAPQYCAQILAEARNRGLILLSCGTYGNVLRILVP
LTVPDEQLAAGLGILKSCFDAVLKG
>Mature_424_residues
STTNDSLMARRQAAVAGGVGQIHPVFTARAENATVWDVEGREFIDFAGGIAVLNTGHLHPKVKAAVAAQLEDFSHTCFMV
LGYESYIQVCEKLNQLVPGDFAKKTALFTSGSEAVENAVKVARAYTKRAGVIAFTSGYHGRTMAALALTGKVAPYSKGMG
LMSANVFRAEFPCALHGVSDDDAMASIERIFKNDAEPSNIAAIILEPVQGEGGFYAASPEFMQRLRALCDREGIMLIADE
VQTGAGRTGTFFAMEQMGVSADITTFAKSIAGGFPLSGITGKAEVMDAIGPGGLGGTYGGNPLACAAALAVLEVFEEEKL
LERANAIGERIKSALNTMQVEHPQIADVRGLGAMIAIELMEEGKPAPQYCAQILAEARNRGLILLSCGTYGNVLRILVPL
TVPDEQLAAGLGILKSCFDAVLKG

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=431, Percent_Identity=31.554524361949, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI13994255, Length=425, Percent_Identity=30.8235294117647, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI37574042, Length=402, Percent_Identity=28.8557213930348, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI284507298, Length=319, Percent_Identity=32.2884012539185, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI226442705, Length=402, Percent_Identity=28.6069651741293, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI226442709, Length=370, Percent_Identity=29.4594594594595, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI24119277, Length=394, Percent_Identity=27.4111675126904, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI188536080, Length=398, Percent_Identity=25.8793969849246, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI38679950, Length=398, Percent_Identity=25.8793969849246, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI38679946, Length=398, Percent_Identity=25.8793969849246, Blast_Score=108, Evalue=8e-24,
Organism=Escherichia coli, GI1789016, Length=421, Percent_Identity=69.833729216152, Blast_Score=620, Evalue=1e-179,
Organism=Escherichia coli, GI1787560, Length=418, Percent_Identity=52.8708133971292, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1789759, Length=394, Percent_Identity=35.2791878172589, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI1788044, Length=396, Percent_Identity=35.6060606060606, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI145693181, Length=418, Percent_Identity=34.2105263157895, Blast_Score=178, Evalue=5e-46,
Organism=Escherichia coli, GI1786991, Length=350, Percent_Identity=34, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1786349, Length=320, Percent_Identity=32.1875, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32564660, Length=420, Percent_Identity=32.6190476190476, Blast_Score=197, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI25144271, Length=411, Percent_Identity=30.9002433090024, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71992977, Length=431, Percent_Identity=29.4663573085847, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI25144274, Length=320, Percent_Identity=29.6875, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17541228, Length=440, Percent_Identity=25.2272727272727, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71981843, Length=161, Percent_Identity=29.1925465838509, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=412, Percent_Identity=30.5825242718447, Blast_Score=192, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6324432, Length=405, Percent_Identity=30.6172839506173, Blast_Score=190, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324386, Length=371, Percent_Identity=24.7978436657682, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6321456, Length=246, Percent_Identity=28.4552845528455, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357415, Length=407, Percent_Identity=30.958230958231, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI28574759, Length=444, Percent_Identity=29.954954954955, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI161085790, Length=460, Percent_Identity=29.5652173913043, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21356575, Length=421, Percent_Identity=28.5035629453682, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI281366494, Length=399, Percent_Identity=26.3157894736842, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24667139, Length=399, Percent_Identity=26.3157894736842, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24667143, Length=399, Percent_Identity=26.3157894736842, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 44815; Mature: 44684

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTNDSLMARRQAAVAGGVGQIHPVFTARAENATVWDVEGREFIDFAGGIAVLNTGHLH
CCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCHHHHHCCCEEEEECCCCC
PKVKAAVAAQLEDFSHTCFMVLGYESYIQVCEKLNQLVPGDFAKKTALFTSGSEAVENAV
HHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHEECCCHHHHHHHH
KVARAYTKRAGVIAFTSGYHGRTMAALALTGKVAPYSKGMGLMSANVFRAEFPCALHGVS
HHHHHHHHCCCEEEEECCCCCCCEEEHEEECCCCCCCCCCCHHCCCCCCEECCEEECCCC
DDDAMASIERIFKNDAEPSNIAAIILEPVQGEGGFYAASPEFMQRLRALCDREGIMLIAD
CHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEECCHHHHHHHHHHHCCCCEEEEEE
EVQTGAGRTGTFFAMEQMGVSADITTFAKSIAGGFPLSGITGKAEVMDAIGPGGLGGTYG
CCCCCCCCCCCEEEHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCC
GNPLACAAALAVLEVFEEEKLLERANAIGERIKSALNTMQVEHPQIADVRGLGAMIAIEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHH
MEEGKPAPQYCAQILAEARNRGLILLSCGTYGNVLRILVPLTVPDEQLAAGLGILKSCFD
HHCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
AVLKG
HHHCC
>Mature Secondary Structure 
STTNDSLMARRQAAVAGGVGQIHPVFTARAENATVWDVEGREFIDFAGGIAVLNTGHLH
CCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCHHHHHCCCEEEEECCCCC
PKVKAAVAAQLEDFSHTCFMVLGYESYIQVCEKLNQLVPGDFAKKTALFTSGSEAVENAV
HHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHEECCCHHHHHHHH
KVARAYTKRAGVIAFTSGYHGRTMAALALTGKVAPYSKGMGLMSANVFRAEFPCALHGVS
HHHHHHHHCCCEEEEECCCCCCCEEEHEEECCCCCCCCCCCHHCCCCCCEECCEEECCCC
DDDAMASIERIFKNDAEPSNIAAIILEPVQGEGGFYAASPEFMQRLRALCDREGIMLIAD
CHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEECCHHHHHHHHHHHCCCCEEEEEE
EVQTGAGRTGTFFAMEQMGVSADITTFAKSIAGGFPLSGITGKAEVMDAIGPGGLGGTYG
CCCCCCCCCCCEEEHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCC
GNPLACAAALAVLEVFEEEKLLERANAIGERIKSALNTMQVEHPQIADVRGLGAMIAIEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHH
MEEGKPAPQYCAQILAEARNRGLILLSCGTYGNVLRILVPLTVPDEQLAAGLGILKSCFD
HHCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
AVLKG
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]