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The map label for this gene is folK [H]

Identifier: 117921518

GI number: 117921518

Start: 3693760

End: 3694269

Strand: Reverse

Name: folK [H]

Synonym: Shewana3_3080

Alternate gene names: 117921518

Gene position: 3694269-3693760 (Counterclockwise)

Preceding gene: 117921519

Following gene: 117921517

Centisome position: 74.3

GC content: 45.49

Gene sequence:

>510_bases
ATGGGTATGGCACGTATATACATTAGTTTAGGCAGTAATATAGAACCTTCTCGCTATCTAAAGGCGGGCTTGCAGTCATT
ACGAGAGCACTTTGGTCCACTGCAACTTTCCTCTATGTATGAGAGTGAAGCCGTAGGGTTTGATGGCACTAACTTTTTAA
ACATGGTGGCCTGTGCACAAACGAGCTTGAATATTGCTGAGGTAGTTGCGCAGTTTAAGCAAATCGAGCAAAATCACGGC
CGGTTGGTGGGGGCCAAAAAGTTTAGTCCAAGAACCTTAGATATTGACCTATTGCTTTATGATGATGTCGTTTGTCAGAC
CCCAGTGGTACTTCCCCGCGCCGAAATTGTCACTAATGCTTTTGTGCTTTGGCCTTTAGCGGAAATCGTCCCCAATTTGG
TTCACCCATTGCAGCAGAAAACCTATGCCGTAATGTGGGATGAATATGATAAAGCGTCGCAAAAGCTGTGGCCGGTAGCC
TTTGAATGGCCTCATGGGCTCACTTTTTAA

Upstream 100 bases:

>100_bases
GCCGTGCCTTCGGCCTCTGCCGTTGGGGTTGAGATTGAACGCTCACGCTAATTGGTTCTCTAGATTCGGGTTTTAGCTTA
GTTAGGCAGACGGTTCGGAC

Downstream 100 bases:

>100_bases
TTGATTGATAGGATTGTCATGGATACGTTTCAGGTAATTATTTTAGCGTTAATTCAAGGATTAACCGAGTTCCTCCCCAT
TTCTAGTTCGGCGCACCTTA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MGMARIYISLGSNIEPSRYLKAGLQSLREHFGPLQLSSMYESEAVGFDGTNFLNMVACAQTSLNIAEVVAQFKQIEQNHG
RLVGAKKFSPRTLDIDLLLYDDVVCQTPVVLPRAEIVTNAFVLWPLAEIVPNLVHPLQQKTYAVMWDEYDKASQKLWPVA
FEWPHGLTF

Sequences:

>Translated_169_residues
MGMARIYISLGSNIEPSRYLKAGLQSLREHFGPLQLSSMYESEAVGFDGTNFLNMVACAQTSLNIAEVVAQFKQIEQNHG
RLVGAKKFSPRTLDIDLLLYDDVVCQTPVVLPRAEIVTNAFVLWPLAEIVPNLVHPLQQKTYAVMWDEYDKASQKLWPVA
FEWPHGLTF
>Mature_168_residues
GMARIYISLGSNIEPSRYLKAGLQSLREHFGPLQLSSMYESEAVGFDGTNFLNMVACAQTSLNIAEVVAQFKQIEQNHGR
LVGAKKFSPRTLDIDLLLYDDVVCQTPVVLPRAEIVTNAFVLWPLAEIVPNLVHPLQQKTYAVMWDEYDKASQKLWPVAF
EWPHGLTF

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=160, Percent_Identity=33.125, Blast_Score=80, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19055; Mature: 18924

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMARIYISLGSNIEPSRYLKAGLQSLREHFGPLQLSSMYESEAVGFDGTNFLNMVACAQ
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHH
TSLNIAEVVAQFKQIEQNHGRLVGAKKFSPRTLDIDLLLYDDVVCQTPVVLPRAEIVTNA
CCCCHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEEEEECCHHHCCCCCCCHHHHHHHH
FVLWPLAEIVPNLVHPLQQKTYAVMWDEYDKASQKLWPVAFEWPHGLTF
HHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHCCCCEEEECCCCCCC
>Mature Secondary Structure 
GMARIYISLGSNIEPSRYLKAGLQSLREHFGPLQLSSMYESEAVGFDGTNFLNMVACAQ
CCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHH
TSLNIAEVVAQFKQIEQNHGRLVGAKKFSPRTLDIDLLLYDDVVCQTPVVLPRAEIVTNA
CCCCHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEEEEECCHHHCCCCCCCHHHHHHHH
FVLWPLAEIVPNLVHPLQQKTYAVMWDEYDKASQKLWPVAFEWPHGLTF
HHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]