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The map label for this gene is ppiA [H]

Identifier: 117921376

GI number: 117921376

Start: 3526850

End: 3527485

Strand: Direct

Name: ppiA [H]

Synonym: Shewana3_2936

Alternate gene names: 117921376

Gene position: 3526850-3527485 (Clockwise)

Preceding gene: 117921366

Following gene: 117921378

Centisome position: 70.93

GC content: 49.53

Gene sequence:

>636_bases
ATGAAAAGAATCACGGGACTTTTACTCGCCAGCAGTTTGAGCTTAGCCCTTGGCGCCTGCGGCGGCAGTGGCGACGATGA
ATTAACACCAACGATCCCGACTCCCGATCCGACCCCACCGAGCTTAAGCGCCGATGTCTGTTATTTAATGAGCACCACAA
AGGGAGATTTGACCTTAGCCATCGACCTCACCCATATGCCGATCACGGGTAAGAACTTTAAACAATATGTCGATAAGTCA
TTCTATAACGGTACTTTATTCCACAGAACCATCAACAACTTTGTGATCCAAGGCGGTGGTTTCACCACGGGATTACAAAG
CAAGCCGACCAGCGCGCCGATTAAAAACGAGGCCGCCGTCGGCATCAGCAACAAACGCGGCACTATCGCAATGGCGCGAA
CCACAGTGCCAGACTCAGCGACATCACAGTTCTTTATCAATGTGTTAGATAATCCTCAGCTCGATGCTTCGGCGAGCAGC
TATGGTTATGCCGTGTTTGGTAAAGTTGTCGAAGGAATGGATGTGGTCGATCAGATAAGCATTGTGCCAACCAAAACCAG
CAATGGTTTTAGCGACACACCTGTGAATGAAATTTTGATCAATAGCGTGATGGAAACGACCTGTCCCGCCGCCTAG

Upstream 100 bases:

>100_bases
AAACAAAAACAACACCTAATCGCAACATTTACCTACAGCTACTTACATCATTCAAAGTGGCAGGAATAAATGGCGAACGA
TGCAAAATAAGGAAATTGAT

Downstream 100 bases:

>100_bases
CAAAAATAACAAAGCACTGTAGATACAGTGCTTTTATATTATTAGCACCGAAAGGGGATTATTCGTCCCCTTGAATTTTA
CCCACCAACAACATAGGCGC

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MKRITGLLLASSLSLALGACGGSGDDELTPTIPTPDPTPPSLSADVCYLMSTTKGDLTLAIDLTHMPITGKNFKQYVDKS
FYNGTLFHRTINNFVIQGGGFTTGLQSKPTSAPIKNEAAVGISNKRGTIAMARTTVPDSATSQFFINVLDNPQLDASASS
YGYAVFGKVVEGMDVVDQISIVPTKTSNGFSDTPVNEILINSVMETTCPAA

Sequences:

>Translated_211_residues
MKRITGLLLASSLSLALGACGGSGDDELTPTIPTPDPTPPSLSADVCYLMSTTKGDLTLAIDLTHMPITGKNFKQYVDKS
FYNGTLFHRTINNFVIQGGGFTTGLQSKPTSAPIKNEAAVGISNKRGTIAMARTTVPDSATSQFFINVLDNPQLDASASS
YGYAVFGKVVEGMDVVDQISIVPTKTSNGFSDTPVNEILINSVMETTCPAA
>Mature_211_residues
MKRITGLLLASSLSLALGACGGSGDDELTPTIPTPDPTPPSLSADVCYLMSTTKGDLTLAIDLTHMPITGKNFKQYVDKS
FYNGTLFHRTINNFVIQGGGFTTGLQSKPTSAPIKNEAAVGISNKRGTIAMARTTVPDSATSQFFINVLDNPQLDASASS
YGYAVFGKVVEGMDVVDQISIVPTKTSNGFSDTPVNEILINSVMETTCPAA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This protein is not essential for growth. Presumably plays a role in signal transduction [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547215, Length=156, Percent_Identity=36.5384615384615, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI22547212, Length=156, Percent_Identity=36.5384615384615, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI7657473, Length=156, Percent_Identity=36.5384615384615, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI7706339, Length=178, Percent_Identity=30.3370786516854, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI19557636, Length=158, Percent_Identity=30.379746835443, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1789763, Length=165, Percent_Identity=50.9090909090909, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI1786736, Length=157, Percent_Identity=50.9554140127389, Blast_Score=155, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71980590, Length=136, Percent_Identity=30.8823529411765, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71980594, Length=136, Percent_Identity=30.8823529411765, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=162, Percent_Identity=32.7160493827161, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71997782, Length=152, Percent_Identity=32.8947368421053, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=141, Percent_Identity=36.8794326241135, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922912, Length=158, Percent_Identity=33.5443037974684, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17986117, Length=153, Percent_Identity=30.718954248366, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922376, Length=157, Percent_Identity=28.6624203821656, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 22189; Mature: 22189

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRITGLLLASSLSLALGACGGSGDDELTPTIPTPDPTPPSLSADVCYLMSTTKGDLTLA
CCHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
IDLTHMPITGKNFKQYVDKSFYNGTLFHRTINNFVIQGGGFTTGLQSKPTSAPIKNEAAV
EEEEECCCCCCHHHHHHHHHHCCCCHHEEECCCEEEECCCEECCCCCCCCCCCCCCCEEE
GISNKRGTIAMARTTVPDSATSQFFINVLDNPQLDASASSYGYAVFGKVVEGMDVVDQIS
EECCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCHHHHHHEE
IVPTKTSNGFSDTPVNEILINSVMETTCPAA
EEECCCCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKRITGLLLASSLSLALGACGGSGDDELTPTIPTPDPTPPSLSADVCYLMSTTKGDLTLA
CCHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
IDLTHMPITGKNFKQYVDKSFYNGTLFHRTINNFVIQGGGFTTGLQSKPTSAPIKNEAAV
EEEEECCCCCCHHHHHHHHHHCCCCHHEEECCCEEEECCCEECCCCCCCCCCCCCCCEEE
GISNKRGTIAMARTTVPDSATSQFFINVLDNPQLDASASSYGYAVFGKVVEGMDVVDQIS
EECCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCHHHHHHEE
IVPTKTSNGFSDTPVNEILINSVMETTCPAA
EEECCCCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 8581173 [H]