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The map label for this gene is dxr [H]

Identifier: 117921250

GI number: 117921250

Start: 3356445

End: 3357635

Strand: Reverse

Name: dxr [H]

Synonym: Shewana3_2809

Alternate gene names: 117921250

Gene position: 3357635-3356445 (Counterclockwise)

Preceding gene: 117921251

Following gene: 117921249

Centisome position: 67.53

GC content: 49.79

Gene sequence:

>1191_bases
ATGCAAAATATGGTGATTTTGGGCGCAACCGGGTCGATTGGTGCCAGCACTTTAAGTGTAATTTCGGCTAATCCCGATGC
TTATCGTGTTTACGCTTTAGTGGCGAATGCGAGTGTCGATAAGATGCTCGCCCTGTGTGTGACCCATCGCCCCCAAGTCG
CCCATATGGTCGATAGTCAGGCCGCATTAGCGCTACAAGCTAAGCTTCCCCCTGAGCTTAATATCCAAGTCACAAGTGGC
GAGGATGAACTCATCGCCTTAGTCACAGCCACCGAAGTGGATACTGTGATGGCCGCTATCGTCGGCGCAGCGGGGTTAGT
GCCCACCTTAGCCGCTGTCAAAGCGGGTAAGCGAGTATTACTTGCCAATAAAGAGGCCTTGGTGATGTCAGGTGAACTCT
TTATTGAGGCCACGAAAGCATCGGGCGCTACTTTGTTGCCGGTCGATAGTGAGCACAATGCAATTTTCCAATGCTTACCC
GAAGAGGTGCAGGCTAATTTAGGCCGCTGTGATTTAGCCGCATCGGGCATTTCACATATTTTACTGACAGGCTCTGGCGG
CCCCTTTTTAACCGCTGAGCTTGCCAGCCTTGCGTCTATGACGCCAGCGCAGGCCTGTAAACATCCAAACTGGTCGATGG
GCCCGAAAATTTCAGTCGACTCCGCCACTATGATGAATAAAGGCTTGGAGTTTATTGAAGCTCGTTGGTTGTTTAATACT
CAGAAAGACCAATTAAAGGTGGTTATCCATCCGCAGAGTGTTATCCATTCGATGGTGCAATACCGGGATGGTAGCGTGAT
CGCGCAAATGGGTAACCCGGATATGCGTACACCGATTGCACATTGTATGTCCTATCCACAAAGAATTCGCTCTGGCGTTG
AACCTTTGGATTTTTTCAAAGTCGGACAGTTAAGCTTTTGTGAGCCAGACTTTAATCGCTTCCCCTGTTTGGCGTTAGCG
ATCGCCGCTTGTGCCCAAGGTCAAGAAGCGACTACGGTACTCAATGCCGCCAATGAAATCGCCGTTGAGGCATTTTTACA
GGGGCAGATTGGTTTTACCCATATCGCCAAGGTGAATGAAGCCTGTTTATCCTCTGTGCCTAAACGGGCGATGACCAGCA
TCGATGATATTATCGCCCTGGATGCACAAACGCGGATTTATGCCCGCGAACAGTTAGCGAAATTTGCTTAA

Upstream 100 bases:

>100_bases
ATTCTGCCTGGGCATGGTGGCGTGCTCGATCGCATCGACAGCCTCACTGCGGCCCTGCCGGTGTTTACCTTAATCTACAT
TGCATTTTGGATGTAACGCT

Downstream 100 bases:

>100_bases
TCCCTCATTGGGTTAGGGATAAGCGGATTTGACGATGACATAAGGAGTGGAATGTTAGATTTTTTGTGGAACTTAGGTTC
GTTTATCGTTGCGCTTGGGC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MQNMVILGATGSIGASTLSVISANPDAYRVYALVANASVDKMLALCVTHRPQVAHMVDSQAALALQAKLPPELNIQVTSG
EDELIALVTATEVDTVMAAIVGAAGLVPTLAAVKAGKRVLLANKEALVMSGELFIEATKASGATLLPVDSEHNAIFQCLP
EEVQANLGRCDLAASGISHILLTGSGGPFLTAELASLASMTPAQACKHPNWSMGPKISVDSATMMNKGLEFIEARWLFNT
QKDQLKVVIHPQSVIHSMVQYRDGSVIAQMGNPDMRTPIAHCMSYPQRIRSGVEPLDFFKVGQLSFCEPDFNRFPCLALA
IAACAQGQEATTVLNAANEIAVEAFLQGQIGFTHIAKVNEACLSSVPKRAMTSIDDIIALDAQTRIYAREQLAKFA

Sequences:

>Translated_396_residues
MQNMVILGATGSIGASTLSVISANPDAYRVYALVANASVDKMLALCVTHRPQVAHMVDSQAALALQAKLPPELNIQVTSG
EDELIALVTATEVDTVMAAIVGAAGLVPTLAAVKAGKRVLLANKEALVMSGELFIEATKASGATLLPVDSEHNAIFQCLP
EEVQANLGRCDLAASGISHILLTGSGGPFLTAELASLASMTPAQACKHPNWSMGPKISVDSATMMNKGLEFIEARWLFNT
QKDQLKVVIHPQSVIHSMVQYRDGSVIAQMGNPDMRTPIAHCMSYPQRIRSGVEPLDFFKVGQLSFCEPDFNRFPCLALA
IAACAQGQEATTVLNAANEIAVEAFLQGQIGFTHIAKVNEACLSSVPKRAMTSIDDIIALDAQTRIYAREQLAKFA
>Mature_396_residues
MQNMVILGATGSIGASTLSVISANPDAYRVYALVANASVDKMLALCVTHRPQVAHMVDSQAALALQAKLPPELNIQVTSG
EDELIALVTATEVDTVMAAIVGAAGLVPTLAAVKAGKRVLLANKEALVMSGELFIEATKASGATLLPVDSEHNAIFQCLP
EEVQANLGRCDLAASGISHILLTGSGGPFLTAELASLASMTPAQACKHPNWSMGPKISVDSATMMNKGLEFIEARWLFNT
QKDQLKVVIHPQSVIHSMVQYRDGSVIAQMGNPDMRTPIAHCMSYPQRIRSGVEPLDFFKVGQLSFCEPDFNRFPCLALA
IAACAQGQEATTVLNAANEIAVEAFLQGQIGFTHIAKVNEACLSSVPKRAMTSIDDIIALDAQTRIYAREQLAKFA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=397, Percent_Identity=57.1788413098237, Blast_Score=445, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42099; Mature: 42099

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNMVILGATGSIGASTLSVISANPDAYRVYALVANASVDKMLALCVTHRPQVAHMVDSQ
CCCEEEEECCCCCCCCEEEEEECCCCCEEEEEEEECCCHHHHHHHHHCCCCHHHHHHCCC
AALALQAKLPPELNIQVTSGEDELIALVTATEVDTVMAAIVGAAGLVPTLAAVKAGKRVL
CEEEEEECCCCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
LANKEALVMSGELFIEATKASGATLLPVDSEHNAIFQCLPEEVQANLGRCDLAASGISHI
EECCCEEEEECEEEEEEECCCCCEEEEECCCCCHHHHCCCHHHHCCCCCCHHHHCCCEEE
LLTGSGGPFLTAELASLASMTPAQACKHPNWSMGPKISVDSATMMNKGLEFIEARWLFNT
EEECCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCEEECCHHHHHHHCHHHHHHHHEECC
QKDQLKVVIHPQSVIHSMVQYRDGSVIAQMGNPDMRTPIAHCMSYPQRIRSGVEPLDFFK
CCCCEEEEECCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHC
VGQLSFCEPDFNRFPCLALAIAACAQGQEATTVLNAANEIAVEAFLQGQIGFTHIAKVNE
CCCCEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ACLSSVPKRAMTSIDDIIALDAQTRIYAREQLAKFA
HHHHHCCHHHHHHHHHHEEECCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNMVILGATGSIGASTLSVISANPDAYRVYALVANASVDKMLALCVTHRPQVAHMVDSQ
CCCEEEEECCCCCCCCEEEEEECCCCCEEEEEEEECCCHHHHHHHHHCCCCHHHHHHCCC
AALALQAKLPPELNIQVTSGEDELIALVTATEVDTVMAAIVGAAGLVPTLAAVKAGKRVL
CEEEEEECCCCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
LANKEALVMSGELFIEATKASGATLLPVDSEHNAIFQCLPEEVQANLGRCDLAASGISHI
EECCCEEEEECEEEEEEECCCCCEEEEECCCCCHHHHCCCHHHHCCCCCCHHHHCCCEEE
LLTGSGGPFLTAELASLASMTPAQACKHPNWSMGPKISVDSATMMNKGLEFIEARWLFNT
EEECCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCEEECCHHHHHHHCHHHHHHHHEECC
QKDQLKVVIHPQSVIHSMVQYRDGSVIAQMGNPDMRTPIAHCMSYPQRIRSGVEPLDFFK
CCCCEEEEECCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHC
VGQLSFCEPDFNRFPCLALAIAACAQGQEATTVLNAANEIAVEAFLQGQIGFTHIAKVNE
CCCCEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ACLSSVPKRAMTSIDDIIALDAQTRIYAREQLAKFA
HHHHHCCHHHHHHHHHHEEECCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]