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The map label for this gene is phhA [H]

Identifier: 117921222

GI number: 117921222

Start: 3320366

End: 3321181

Strand: Reverse

Name: phhA [H]

Synonym: Shewana3_2781

Alternate gene names: 117921222

Gene position: 3321181-3320366 (Counterclockwise)

Preceding gene: 117921229

Following gene: 117921221

Centisome position: 66.79

GC content: 48.65

Gene sequence:

>816_bases
ATGACTAAAGAGATAGCACACACTGCGCCCTATGTTGCGCGAAGTGCAGATGATTCAGGGTATATCCATTACCCGCAGGA
AGAACATGATATTTGGAGCCAATTATATGCTCGCCAAGCGGTGAAGCTACCGGGGCGTGCCTGTAAGGAATATCTTCAAG
GGCTTGCTGCCTTGGCGATGCCGAAGGACCGCATTCCACAATTGGCGGAGATAGACAAAGTATTGCAAGCCACTACTGGA
TGGAAAACCGCTGCCGTGCCGGCCTTGATTTCCTTTGGCCGCTTCTTTGAGTTATTGGCCAACAAGGAATTTCCGGTTGC
GACCTTTATCCGCCGTAAGGAAGAGTTTGATTACCTGCAAGAGCCGGATATTTTCCATGAGATCTTTGGCCATTGCCCCT
TGCTGACCAATCCTTCTTTCGCCCATTTTTCCCATATCTATGGTCAATTGGGCTTAAATGCCAGCAAAGAAGACCGCGTC
TTTTTAGCGCGCCTGTATTGGTTTACCGTCGAATTTGGCTTACTCAAACCTCAAGATGGCGAATTGTGTATCTACGGCGG
CGGTATTTTAAGCTCTCCCGGCGAAACCTTGTATGCCATGGAAAGCCAAGTGCCGGAGCGTAAGCCCTTCGATCTCTTAG
ATGTGCTGCGCACGCCTTACCGTATCGATATTATGCAGCCGATTTATTATGTGATTGAACATATTGATATGCTGGATGAA
ATCGCCAAGATGGACATCATGGCCTATGTGGCTAAGGCGCGTCAGTTAGGCTTATTTGCCCCTAAGTATCCGCCCAAGAC
CAAGAAAGCCAGCTAA

Upstream 100 bases:

>100_bases
GCGTCACATTATCGCGTAAACAATAAACTGTGAGGGAGTTAACAAAAATCGAGGCTTAGATCACTATGGAGGCATTAGCG
TCAGCCATGAAGTGAATTTT

Downstream 100 bases:

>100_bases
TGGCTGACCGTTAAAAACGAATTGAATAAAGCGTAATAAGGGCAACGGATTGATCTCCCTAATGTTGCCAAGAGGAGTAT
GTATGACAGCGTTAACCCAA

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTKEIAHTAPYVARSADDSGYIHYPQEEHDIWSQLYARQAVKLPGRACKEYLQGLAALAMPKDRIPQLAEIDKVLQATTG
WKTAAVPALISFGRFFELLANKEFPVATFIRRKEEFDYLQEPDIFHEIFGHCPLLTNPSFAHFSHIYGQLGLNASKEDRV
FLARLYWFTVEFGLLKPQDGELCIYGGGILSSPGETLYAMESQVPERKPFDLLDVLRTPYRIDIMQPIYYVIEHIDMLDE
IAKMDIMAYVAKARQLGLFAPKYPPKTKKAS

Sequences:

>Translated_271_residues
MTKEIAHTAPYVARSADDSGYIHYPQEEHDIWSQLYARQAVKLPGRACKEYLQGLAALAMPKDRIPQLAEIDKVLQATTG
WKTAAVPALISFGRFFELLANKEFPVATFIRRKEEFDYLQEPDIFHEIFGHCPLLTNPSFAHFSHIYGQLGLNASKEDRV
FLARLYWFTVEFGLLKPQDGELCIYGGGILSSPGETLYAMESQVPERKPFDLLDVLRTPYRIDIMQPIYYVIEHIDMLDE
IAKMDIMAYVAKARQLGLFAPKYPPKTKKAS
>Mature_270_residues
TKEIAHTAPYVARSADDSGYIHYPQEEHDIWSQLYARQAVKLPGRACKEYLQGLAALAMPKDRIPQLAEIDKVLQATTGW
KTAAVPALISFGRFFELLANKEFPVATFIRRKEEFDYLQEPDIFHEIFGHCPLLTNPSFAHFSHIYGQLGLNASKEDRVF
LARLYWFTVEFGLLKPQDGELCIYGGGILSSPGETLYAMESQVPERKPFDLLDVLRTPYRIDIMQPIYYVIEHIDMLDEI
AKMDIMAYVAKARQLGLFAPKYPPKTKKAS

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=258, Percent_Identity=34.8837209302326, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI88900505, Length=258, Percent_Identity=34.8837209302326, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI88900501, Length=258, Percent_Identity=34.8837209302326, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4759248, Length=251, Percent_Identity=34.6613545816733, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI4557819, Length=252, Percent_Identity=34.1269841269841, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI31795563, Length=223, Percent_Identity=34.9775784753363, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71980736, Length=233, Percent_Identity=36.480686695279, Blast_Score=143, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17531391, Length=218, Percent_Identity=38.9908256880734, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI115533973, Length=237, Percent_Identity=30.8016877637131, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI115532103, Length=237, Percent_Identity=30.379746835443, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71980731, Length=156, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI17136774, Length=238, Percent_Identity=35.2941176470588, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17136776, Length=235, Percent_Identity=35.7446808510638, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI62472054, Length=224, Percent_Identity=33.9285714285714, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24660393, Length=224, Percent_Identity=33.9285714285714, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24654994, Length=250, Percent_Identity=32.8, Blast_Score=106, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 30925; Mature: 30794

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKEIAHTAPYVARSADDSGYIHYPQEEHDIWSQLYARQAVKLPGRACKEYLQGLAALAM
CCCCHHHHCCHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
PKDRIPQLAEIDKVLQATTGWKTAAVPALISFGRFFELLANKEFPVATFIRRKEEFDYLQ
CHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
EPDIFHEIFGHCPLLTNPSFAHFSHIYGQLGLNASKEDRVFLARLYWFTVEFGLLKPQDG
CCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
ELCIYGGGILSSPGETLYAMESQVPERKPFDLLDVLRTPYRIDIMQPIYYVIEHIDMLDE
CEEEECCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHH
IAKMDIMAYVAKARQLGLFAPKYPPKTKKAS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TKEIAHTAPYVARSADDSGYIHYPQEEHDIWSQLYARQAVKLPGRACKEYLQGLAALAM
CCCHHHHCCHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
PKDRIPQLAEIDKVLQATTGWKTAAVPALISFGRFFELLANKEFPVATFIRRKEEFDYLQ
CHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
EPDIFHEIFGHCPLLTNPSFAHFSHIYGQLGLNASKEDRVFLARLYWFTVEFGLLKPQDG
CCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
ELCIYGGGILSSPGETLYAMESQVPERKPFDLLDVLRTPYRIDIMQPIYYVIEHIDMLDE
CEEEECCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHH
IAKMDIMAYVAKARQLGLFAPKYPPKTKKAS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8108417; 10984043 [H]