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The map label for this gene is f1pep1 [H]

Identifier: 117920977

GI number: 117920977

Start: 3031577

End: 3033757

Strand: Reverse

Name: f1pep1 [H]

Synonym: Shewana3_2536

Alternate gene names: 117920977

Gene position: 3033757-3031577 (Counterclockwise)

Preceding gene: 117920978

Following gene: 117920976

Centisome position: 61.01

GC content: 47.96

Gene sequence:

>2181_bases
ATGGCATTAAGATTTCGCCTTGCCCAGCAAGGTTTATTAGTGGCCACATTGGGCATGGCGTTGGCCGCCTGCCAGAGTGG
CAATACGCCAGAAGAGGCCGCACAGCAGGTCAGCGCCAACAAATTGGTTTACCCTGAAACCCGAAAAGACAACTTAGTCG
AGACGATTCACGGTGTTGCAGTGGCGGACCCTTACCGTCACCTTGAAGAAAACACGCCAGAAACCGAAAGCTGGGTAAAA
GAACAACAGGCCTTTGGTCAAGCTTACTTGGCGAAGATCCCCAACAAACAAGCCGTGGTTGACCGTATCACAGAGCTGTG
GAACTACGAGAAAATCTCAGCTCCTTTCGAGAATGGCGATAACCAGTTTTATTACCGTAACGATGGTTTACAAGCGCAAT
CGGTACTGTATGTAAAAGGCAAAGACGGCGTTGAGAAACCTGTACTGGATCCAAATGGTTTTTCAGCCGATGGAACTGTG
GCGCTTTCCGGCGTATCAGTCAGTAATGACGGCAAGATTTTAGCCTATGGTGTGTCTCAGTCGGGCTCTGACTGGCAGCA
GTGGCAGTTTATCGATATTGCCACGGGTAAAAAGCTTAAAGATGAACTCAACTGGATTAAATTCTCCAGCGCGGTGTGGG
ATAAGGAAAACCAAGGTGTTTTCTATGCCCGTTACGATGCGCCCGCGGGCGGTGATTTACTGGCCGATGTGAATTTTAAT
CAAAAAGTGTATTACCACAAATTAGGCACAGATCAGCGCCAAGATTTATTGATTTACGAACGCCCACAAAATAAAGATTG
GGGCTTCGGTATCGATGTGTCTGAGCAGGGCGAATATTTACTGTTGTCAATTTCCCAAGGCACAGACAAACGTAATCGTT
TCTTCTATAAATCACTGTTTGAACCTAAAGCGCAGGTGGTGGAATTAATCCTTAACCTCGAAGCGGAATATGAGTTTTTA
GGCAATGATGGCGCCGTATTTTATTTCAAGACCGATTTAGATGCGCCAAACGGTAAAGTGATTGCCATCGATACCCGTAA
TAGTGATAAATCCCAGTGGCAAACCATTATTCCAGAATCGAAAGATCCTATTAATAAAGTGGCCATTATTAATGACCATT
TAGTCGTGAGTTATTTGCACGATGTATTGGGACAGTTATCGATTTTCAGCATGGGCGGACAAAAGCGTCAGGATGTCACT
TTACCTGGTAAAGGTAATGTTGCCGGACCTTTCGGCAAGGCGAGTAAAGACTATTTCTACTATGTCTTTAACAGCTATAT
TCAACCCGAAACCACCTATAAGTTCGATTTTAAAACGGCAGAATCGACAGTGGTCGCTAAGCCGCAGGTGTCGTTCAATC
CCGATGACTATGTGTCTGAGCAAGTGTTTTACACCAGCAAGGACGGTACTCGCGTCCCTATGATGGTGTCCTACAAGAAG
GGGCTGGTGAAGAATGGGCAAAACCCAACGCTTCTGTATGCCTATGGCGGCTTTGCGATTTCAATGACACCGCGTTTTAG
TCCTGCCAACATCGCTTGGTTAGATATGGGCGGCATTTACGCAGTACCAAGTTTGCGTGGCGGCGCGGATTACGGTGAAA
GCTGGCACCAAGCAGGGATGTTCGATAAGAAGCAAAATGTGTTTGATGACTATTTTGCGGCGGCCGAATATCTGATCAAC
GAAAAATACACTAACAGCACTAAGCTAGGTGCCTATGGTCGCAGTAACGGTGGTTTGTTGATGGGTGCTGCTGTCACCCA
ACGTCCTGAACTGTTTGCCGCTGTGTTACCGGCCGTGGGTGTGCTGGATATGCTGCGCTTCCACAAGTTCACCATTGGCT
GGGCTTGGACCAGTGAATACGGCAGTGCCGACAACGCGGAGCAATTCCCTGCGTTATTGGCTTACTCGCCTTACCATAAC
GTTAAAACGCAGGCCTATCCTGCGACTATGGTGATGACGGCCGATCACGATGACCGCGTGGTACCGCTACACAGCTTTAA
GTTTGCTGCCATGATGCAAGAGATGCAGCAGGGCGATAAACCCGTCATTATGCGCATTGAGTCCAATGCAGGGCACGGTG
CGGGCAAACCGACGGCGATGAAGATCGACGAGTTTGCTGACATTTACAGCTTCCTGTGGCAAAGCTTTGGGCTGACATTG
CCGCAAACTCTCGCAAAATAG

Upstream 100 bases:

>100_bases
AGCTCATCTTTTGCTGTGGCATTGCCATGAAAAATTTTGCTTGTATAGTACTTGCTGCAAAAGAGCGTTAAGCCAGACAT
CACCAAAAGGACGATAAAAG

Downstream 100 bases:

>100_bases
CGAACTATGTTAATGAAATGGGGTCGTTTGACCCCATTGTTATTTACAAATCCCTCAATTGCGCTGAAACCCGCGCTATC
CCTATCTATATCTTCGTCGG

Product: prolyl oligopeptidase

Products: NA

Alternate protein names: Post-proline cleaving enzyme; Proline-specific endopeptidase; PE; PSE [H]

Number of amino acids: Translated: 726; Mature: 725

Protein sequence:

>726_residues
MALRFRLAQQGLLVATLGMALAACQSGNTPEEAAQQVSANKLVYPETRKDNLVETIHGVAVADPYRHLEENTPETESWVK
EQQAFGQAYLAKIPNKQAVVDRITELWNYEKISAPFENGDNQFYYRNDGLQAQSVLYVKGKDGVEKPVLDPNGFSADGTV
ALSGVSVSNDGKILAYGVSQSGSDWQQWQFIDIATGKKLKDELNWIKFSSAVWDKENQGVFYARYDAPAGGDLLADVNFN
QKVYYHKLGTDQRQDLLIYERPQNKDWGFGIDVSEQGEYLLLSISQGTDKRNRFFYKSLFEPKAQVVELILNLEAEYEFL
GNDGAVFYFKTDLDAPNGKVIAIDTRNSDKSQWQTIIPESKDPINKVAIINDHLVVSYLHDVLGQLSIFSMGGQKRQDVT
LPGKGNVAGPFGKASKDYFYYVFNSYIQPETTYKFDFKTAESTVVAKPQVSFNPDDYVSEQVFYTSKDGTRVPMMVSYKK
GLVKNGQNPTLLYAYGGFAISMTPRFSPANIAWLDMGGIYAVPSLRGGADYGESWHQAGMFDKKQNVFDDYFAAAEYLIN
EKYTNSTKLGAYGRSNGGLLMGAAVTQRPELFAAVLPAVGVLDMLRFHKFTIGWAWTSEYGSADNAEQFPALLAYSPYHN
VKTQAYPATMVMTADHDDRVVPLHSFKFAAMMQEMQQGDKPVIMRIESNAGHGAGKPTAMKIDEFADIYSFLWQSFGLTL
PQTLAK

Sequences:

>Translated_726_residues
MALRFRLAQQGLLVATLGMALAACQSGNTPEEAAQQVSANKLVYPETRKDNLVETIHGVAVADPYRHLEENTPETESWVK
EQQAFGQAYLAKIPNKQAVVDRITELWNYEKISAPFENGDNQFYYRNDGLQAQSVLYVKGKDGVEKPVLDPNGFSADGTV
ALSGVSVSNDGKILAYGVSQSGSDWQQWQFIDIATGKKLKDELNWIKFSSAVWDKENQGVFYARYDAPAGGDLLADVNFN
QKVYYHKLGTDQRQDLLIYERPQNKDWGFGIDVSEQGEYLLLSISQGTDKRNRFFYKSLFEPKAQVVELILNLEAEYEFL
GNDGAVFYFKTDLDAPNGKVIAIDTRNSDKSQWQTIIPESKDPINKVAIINDHLVVSYLHDVLGQLSIFSMGGQKRQDVT
LPGKGNVAGPFGKASKDYFYYVFNSYIQPETTYKFDFKTAESTVVAKPQVSFNPDDYVSEQVFYTSKDGTRVPMMVSYKK
GLVKNGQNPTLLYAYGGFAISMTPRFSPANIAWLDMGGIYAVPSLRGGADYGESWHQAGMFDKKQNVFDDYFAAAEYLIN
EKYTNSTKLGAYGRSNGGLLMGAAVTQRPELFAAVLPAVGVLDMLRFHKFTIGWAWTSEYGSADNAEQFPALLAYSPYHN
VKTQAYPATMVMTADHDDRVVPLHSFKFAAMMQEMQQGDKPVIMRIESNAGHGAGKPTAMKIDEFADIYSFLWQSFGLTL
PQTLAK
>Mature_725_residues
ALRFRLAQQGLLVATLGMALAACQSGNTPEEAAQQVSANKLVYPETRKDNLVETIHGVAVADPYRHLEENTPETESWVKE
QQAFGQAYLAKIPNKQAVVDRITELWNYEKISAPFENGDNQFYYRNDGLQAQSVLYVKGKDGVEKPVLDPNGFSADGTVA
LSGVSVSNDGKILAYGVSQSGSDWQQWQFIDIATGKKLKDELNWIKFSSAVWDKENQGVFYARYDAPAGGDLLADVNFNQ
KVYYHKLGTDQRQDLLIYERPQNKDWGFGIDVSEQGEYLLLSISQGTDKRNRFFYKSLFEPKAQVVELILNLEAEYEFLG
NDGAVFYFKTDLDAPNGKVIAIDTRNSDKSQWQTIIPESKDPINKVAIINDHLVVSYLHDVLGQLSIFSMGGQKRQDVTL
PGKGNVAGPFGKASKDYFYYVFNSYIQPETTYKFDFKTAESTVVAKPQVSFNPDDYVSEQVFYTSKDGTRVPMMVSYKKG
LVKNGQNPTLLYAYGGFAISMTPRFSPANIAWLDMGGIYAVPSLRGGADYGESWHQAGMFDKKQNVFDDYFAAAEYLINE
KYTNSTKLGAYGRSNGGLLMGAAVTQRPELFAAVLPAVGVLDMLRFHKFTIGWAWTSEYGSADNAEQFPALLAYSPYHNV
KTQAYPATMVMTADHDDRVVPLHSFKFAAMMQEMQQGDKPVIMRIESNAGHGAGKPTAMKIDEFADIYSFLWQSFGLTLP
QTLAK

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=707, Percent_Identity=41.3012729844413, Blast_Score=547, Evalue=1e-155,
Organism=Homo sapiens, GI108860686, Length=199, Percent_Identity=30.1507537688442, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI284172420, Length=199, Percent_Identity=30.1507537688442, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI284172413, Length=199, Percent_Identity=30.1507537688442, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI70778815, Length=199, Percent_Identity=30.1507537688442, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI284172438, Length=199, Percent_Identity=30.1507537688442, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI284172431, Length=199, Percent_Identity=30.1507537688442, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI108860692, Length=198, Percent_Identity=29.7979797979798, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1788150, Length=695, Percent_Identity=25.7553956834532, Blast_Score=212, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24583414, Length=752, Percent_Identity=40.6914893617021, Blast_Score=540, Evalue=1e-153,
Organism=Drosophila melanogaster, GI221510989, Length=732, Percent_Identity=39.7540983606557, Blast_Score=510, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 81005; Mature: 80874

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALRFRLAQQGLLVATLGMALAACQSGNTPEEAAQQVSANKLVYPETRKDNLVETIHGVA
CCEEEEHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEECCCCCCCHHHHHHHCCE
VADPYRHLEENTPETESWVKEQQAFGQAYLAKIPNKQAVVDRITELWNYEKISAPFENGD
ECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCCCCCC
NQFYYRNDGLQAQSVLYVKGKDGVEKPVLDPNGFSADGTVALSGVSVSNDGKILAYGVSQ
CEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCC
SGSDWQQWQFIDIATGKKLKDELNWIKFSSAVWDKENQGVFYARYDAPAGGDLLADVNFN
CCCCCCCEEEEEECCCCHHHHHHCEEEECHHHCCCCCCCEEEEEECCCCCCCEEEECCCC
QKVYYHKLGTDQRQDLLIYERPQNKDWGFGIDVSEQGEYLLLSISQGTDKRNRFFYKSLF
CEEEEEECCCCCCCCEEEEECCCCCCCCCCCEECCCCCEEEEEECCCCCHHHHHHHHHHC
EPKAQVVELILNLEAEYEFLGNDGAVFYFKTDLDAPNGKVIAIDTRNSDKSQWQTIIPES
CCHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCCCCEEEEEECCCCCHHHHHEECCCC
KDPINKVAIINDHLVVSYLHDVLGQLSIFSMGGQKRQDVTLPGKGNVAGPFGKASKDYFY
CCCCCEEEEEECHHHHHHHHHHHHCEEEEECCCCCCCCEECCCCCCCCCCCCCCCCCEEE
YVFNSYIQPETTYKFDFKTAESTVVAKPQVSFNPDDYVSEQVFYTSKDGTRVPMMVSYKK
EEEECCCCCCCEEEEEEECCCCEEEECCCCCCCCCHHCCCEEEEECCCCCCCCEEEECHH
GLVKNGQNPTLLYAYGGFAISMTPRFSPANIAWLDMGGIYAVPSLRGGADYGESWHQAGM
HHHHCCCCCEEEEEECCEEEEECCCCCCCCEEEEECCCEEECCCCCCCCCCCHHHHHCCC
FDKKQNVFDDYFAAAEYLINEKYTNSTKLGAYGRSNGGLLMGAAVTQRPELFAAVLPAVG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHCCCHHHHHHHHHHHH
VLDMLRFHKFTIGWAWTSEYGSADNAEQFPALLAYSPYHNVKTQAYPATMVMTADHDDRV
HHHHHHHHEEEEEEEEECCCCCCCCHHHCCEEEEECCCCCCCCCCCCEEEEEEECCCCCE
VPLHSFKFAAMMQEMQQGDKPVIMRIESNAGHGAGKPTAMKIDEFADIYSFLWQSFGLTL
EEEHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCC
PQTLAK
HHHHCC
>Mature Secondary Structure 
ALRFRLAQQGLLVATLGMALAACQSGNTPEEAAQQVSANKLVYPETRKDNLVETIHGVA
CEEEEHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEECCCCCCCHHHHHHHCCE
VADPYRHLEENTPETESWVKEQQAFGQAYLAKIPNKQAVVDRITELWNYEKISAPFENGD
ECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCCCCCC
NQFYYRNDGLQAQSVLYVKGKDGVEKPVLDPNGFSADGTVALSGVSVSNDGKILAYGVSQ
CEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCC
SGSDWQQWQFIDIATGKKLKDELNWIKFSSAVWDKENQGVFYARYDAPAGGDLLADVNFN
CCCCCCCEEEEEECCCCHHHHHHCEEEECHHHCCCCCCCEEEEEECCCCCCCEEEECCCC
QKVYYHKLGTDQRQDLLIYERPQNKDWGFGIDVSEQGEYLLLSISQGTDKRNRFFYKSLF
CEEEEEECCCCCCCCEEEEECCCCCCCCCCCEECCCCCEEEEEECCCCCHHHHHHHHHHC
EPKAQVVELILNLEAEYEFLGNDGAVFYFKTDLDAPNGKVIAIDTRNSDKSQWQTIIPES
CCHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCCCCEEEEEECCCCCHHHHHEECCCC
KDPINKVAIINDHLVVSYLHDVLGQLSIFSMGGQKRQDVTLPGKGNVAGPFGKASKDYFY
CCCCCEEEEEECHHHHHHHHHHHHCEEEEECCCCCCCCEECCCCCCCCCCCCCCCCCEEE
YVFNSYIQPETTYKFDFKTAESTVVAKPQVSFNPDDYVSEQVFYTSKDGTRVPMMVSYKK
EEEECCCCCCCEEEEEEECCCCEEEECCCCCCCCCHHCCCEEEEECCCCCCCCEEEECHH
GLVKNGQNPTLLYAYGGFAISMTPRFSPANIAWLDMGGIYAVPSLRGGADYGESWHQAGM
HHHHCCCCCEEEEEECCEEEEECCCCCCCCEEEEECCCEEECCCCCCCCCCCHHHHHCCC
FDKKQNVFDDYFAAAEYLINEKYTNSTKLGAYGRSNGGLLMGAAVTQRPELFAAVLPAVG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHCCCHHHHHHHHHHHH
VLDMLRFHKFTIGWAWTSEYGSADNAEQFPALLAYSPYHNVKTQAYPATMVMTADHDDRV
HHHHHHHHEEEEEEEEECCCCCCCCHHHCCEEEEECCCCCCCCCCCCEEEEEEECCCCCE
VPLHSFKFAAMMQEMQQGDKPVIMRIESNAGHGAGKPTAMKIDEFADIYSFLWQSFGLTL
EEEHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCC
PQTLAK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1840588; 7764331 [H]