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The map label for this gene is acsA [H]

Identifier: 117920966

GI number: 117920966

Start: 3019358

End: 3021310

Strand: Direct

Name: acsA [H]

Synonym: Shewana3_2523

Alternate gene names: 117920966

Gene position: 3019358-3021310 (Clockwise)

Preceding gene: 117920964

Following gene: 117920967

Centisome position: 60.72

GC content: 52.23

Gene sequence:

>1953_bases
ATGAGCTCGCAGTCTCTCTACAAAGTCTCCGGCAATATCGCTGCCAATGCACTTGTAAATAACGATCAATATAAAAAAAT
GTACCAAGAGTCGATTGTCAATCCAGAGGGTTTCTGGAGAGAGCACGGCAAACGGATCGATTGGATAAAGCCATACACTA
AAATCAAAAAAACCACTTTTGACGATCATAACTTATCGATTAACTGGTTCTACGACGGCACCCTAAACGCCTCAGCCAAC
TGCTTAGATCGCCATCTAGCAGAGCACAGCGACCGCGTTGCCATTATTTGGGAAGGCGATAACGCCAGCGAACAACGTCA
AATCACCTACGGTGAGCTGCACACTCAAGTGTGTAAGTTTGCCAACGCCCTACGCAGCCAAGGCGTGCGTCGTGGGGATA
TTGTGACCATTTATATGCCAATGGTGCCAGAAGCGGCGGTGGCAATGCTGGCCTGTGCCCGCATCGGTGCCGTGCATTCG
GTGGTCTTTGGTGGCTTCTCACCCGATTCTATCGCTTCAAGGGTTATCGACGGTAAATCTAAAGTGGTTATCACCGCCGA
TGAAGGTATGCGTGGTGGCCGCGCGATCCCACTCAAACGCAACATCGACGATGCGCTAAAGCATCCCGATGTCACCAGCG
TTGAGAAGGTGATTGTACTTAAACGTACTGGCGGCAAGGTTGACTGGGTCGAAGGCCGCGATGTGTGGTGGCATTCTCTG
GTTGAAACCGCATCCGAGCACTGCGCCATTGAAGAAATGGGCGCCGAAGATCCGCTCTTCTTACTTTATACCTCTGGTTC
AACTGGTAATCCCAAGGGCGTATTGCACACCACCGGCGGATATATGGTGTATGCCTCTATGACCCACGAGTATGTGTTCG
ATTACAAACCCGGTGAGATTTACTGGTGTACCGCCGACGTGGGTTGGATCACGGGTCATTCCTACATGGTGTACGGCCCA
CTGGCGAACGGTGCGACCGTGCTTATCCACGAAGGGATCCCTAATTACCCAAGCCCTGCGCGTTTAGGCGAGATGATTGA
CCGTCACAAGGTGAATATTCTCTATACGGCACCGACACTTATCCGTGCACTGATGGCCGAAGGTAAACAGCATTTTGACA
AGTATGATGGCAGCTCGCTGCGCATCATGGGCTCAGTGGGTGAACCCATCAACCCAGAAGCTTGGCGCTGGTACCACGAG
GTCATCGGTCATGAGCATTGCCCGATTGTCGATACTTGGTGGCAAACCGAAACCGGCGGCATTTTGATTACGCCATTACC
AGGTGCAACCGATACCAAACCCGGCTCGGCGACTCGTCCCTTCTTTGGGGTACAACCGGCGCTCGTGGACAACATGGGTA
ACATTTTAGAAGGTGCAACCGAAGGTAACTTAGTGCTGCTCGACTCATGGCCAGGCCAAATGCGTACCGTATATGGCGAC
CATGAACGCTTCGTGCTGACCTACTTCAAAACCTTCCGTGGCATGTACTTTACCGGTGACGGCGCGCGCCGCGATGAAGA
CGGTTACTACTGGATCACCGGCCGTGTGGACGATGTGATTAACGTCTCCGGCCACAGATTAGGTACAGCAGAGGTAGAAA
GTGCACTGGTGTCACACGAACTGGTCGCTGAAGCCGCTGTTGTGGGCTATCCCCATGATATTAAAGGCCAAGGTATTTAC
GCCTATGTGACGTTAACCCGCGGCACAGAAGAGAGTGAAGAGCTTCGCCAAGAGCTGCGCCAATGGGTTCGCAAAGAAAT
TGGCGCTCTGGCCACACCGGATCTTATCCAGTGGGCGACAGGATTACCTAAGACACGTTCAGGCAAAATCATGCGCCGTT
TCCTGCGTAAGATCGCCGCGAACGAAGTGACCAACTTAGGTGATGCATCAACACTGGCCGATCCAGCCGTGATTGAGACC
TTGATTGAAACTCGCTTGAATCGTAACGAGTAA

Upstream 100 bases:

>100_bases
AAATATAAAGGAAATTTTAAAACTAGACCAAGGTCTAATGGAGTTGCCTGCCCCTTGCATACCATACTCAGACTACGCAA
TTTTTAGAAAGGGAAGCCCT

Downstream 100 bases:

>100_bases
TCGTTATCCCGCGCTTAATCGTGATTTATCACGGTTAAGCGCAGCTTTAGCTCCTGTACGTTTGAACCTTGCTCCGTCGA
GTATAGGTTCCTTTAAATGA

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MSSQSLYKVSGNIAANALVNNDQYKKMYQESIVNPEGFWREHGKRIDWIKPYTKIKKTTFDDHNLSINWFYDGTLNASAN
CLDRHLAEHSDRVAIIWEGDNASEQRQITYGELHTQVCKFANALRSQGVRRGDIVTIYMPMVPEAAVAMLACARIGAVHS
VVFGGFSPDSIASRVIDGKSKVVITADEGMRGGRAIPLKRNIDDALKHPDVTSVEKVIVLKRTGGKVDWVEGRDVWWHSL
VETASEHCAIEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYASMTHEYVFDYKPGEIYWCTADVGWITGHSYMVYGP
LANGATVLIHEGIPNYPSPARLGEMIDRHKVNILYTAPTLIRALMAEGKQHFDKYDGSSLRIMGSVGEPINPEAWRWYHE
VIGHEHCPIVDTWWQTETGGILITPLPGATDTKPGSATRPFFGVQPALVDNMGNILEGATEGNLVLLDSWPGQMRTVYGD
HERFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVSHELVAEAAVVGYPHDIKGQGIY
AYVTLTRGTEESEELRQELRQWVRKEIGALATPDLIQWATGLPKTRSGKIMRRFLRKIAANEVTNLGDASTLADPAVIET
LIETRLNRNE

Sequences:

>Translated_650_residues
MSSQSLYKVSGNIAANALVNNDQYKKMYQESIVNPEGFWREHGKRIDWIKPYTKIKKTTFDDHNLSINWFYDGTLNASAN
CLDRHLAEHSDRVAIIWEGDNASEQRQITYGELHTQVCKFANALRSQGVRRGDIVTIYMPMVPEAAVAMLACARIGAVHS
VVFGGFSPDSIASRVIDGKSKVVITADEGMRGGRAIPLKRNIDDALKHPDVTSVEKVIVLKRTGGKVDWVEGRDVWWHSL
VETASEHCAIEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYASMTHEYVFDYKPGEIYWCTADVGWITGHSYMVYGP
LANGATVLIHEGIPNYPSPARLGEMIDRHKVNILYTAPTLIRALMAEGKQHFDKYDGSSLRIMGSVGEPINPEAWRWYHE
VIGHEHCPIVDTWWQTETGGILITPLPGATDTKPGSATRPFFGVQPALVDNMGNILEGATEGNLVLLDSWPGQMRTVYGD
HERFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVSHELVAEAAVVGYPHDIKGQGIY
AYVTLTRGTEESEELRQELRQWVRKEIGALATPDLIQWATGLPKTRSGKIMRRFLRKIAANEVTNLGDASTLADPAVIET
LIETRLNRNE
>Mature_649_residues
SSQSLYKVSGNIAANALVNNDQYKKMYQESIVNPEGFWREHGKRIDWIKPYTKIKKTTFDDHNLSINWFYDGTLNASANC
LDRHLAEHSDRVAIIWEGDNASEQRQITYGELHTQVCKFANALRSQGVRRGDIVTIYMPMVPEAAVAMLACARIGAVHSV
VFGGFSPDSIASRVIDGKSKVVITADEGMRGGRAIPLKRNIDDALKHPDVTSVEKVIVLKRTGGKVDWVEGRDVWWHSLV
ETASEHCAIEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYASMTHEYVFDYKPGEIYWCTADVGWITGHSYMVYGPL
ANGATVLIHEGIPNYPSPARLGEMIDRHKVNILYTAPTLIRALMAEGKQHFDKYDGSSLRIMGSVGEPINPEAWRWYHEV
IGHEHCPIVDTWWQTETGGILITPLPGATDTKPGSATRPFFGVQPALVDNMGNILEGATEGNLVLLDSWPGQMRTVYGDH
ERFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVSHELVAEAAVVGYPHDIKGQGIYA
YVTLTRGTEESEELRQELRQWVRKEIGALATPDLIQWATGLPKTRSGKIMRRFLRKIAANEVTNLGDASTLADPAVIETL
IETRLNRNE

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=654, Percent_Identity=52.7522935779816, Blast_Score=682, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=668, Percent_Identity=52.0958083832335, Blast_Score=680, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=624, Percent_Identity=50.1602564102564, Blast_Score=637, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=633, Percent_Identity=36.1769352290679, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI42544132, Length=564, Percent_Identity=29.2553191489362, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI122937307, Length=552, Percent_Identity=28.6231884057971, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI38505220, Length=540, Percent_Identity=29.8148148148148, Blast_Score=196, Evalue=7e-50,
Organism=Homo sapiens, GI115511026, Length=534, Percent_Identity=28.4644194756554, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI31982927, Length=648, Percent_Identity=24.3827160493827, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI58082049, Length=525, Percent_Identity=26.4761904761905, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI157311624, Length=525, Percent_Identity=25.9047619047619, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI157311622, Length=525, Percent_Identity=25.9047619047619, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI195947378, Length=442, Percent_Identity=25.7918552036199, Blast_Score=116, Evalue=9e-26,
Organism=Homo sapiens, GI42544134, Length=383, Percent_Identity=25.3263707571802, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI187761345, Length=500, Percent_Identity=26, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI187761343, Length=500, Percent_Identity=26, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI156151445, Length=572, Percent_Identity=23.4265734265734, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1790505, Length=645, Percent_Identity=70.2325581395349, Blast_Score=984, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=632, Percent_Identity=37.5, Blast_Score=407, Evalue=1e-114,
Organism=Escherichia coli, GI1788107, Length=593, Percent_Identity=23.9460370994941, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI221142682, Length=532, Percent_Identity=21.9924812030075, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI145693145, Length=551, Percent_Identity=23.5934664246824, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1786810, Length=569, Percent_Identity=21.6168717047452, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789201, Length=368, Percent_Identity=23.6413043478261, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71983001, Length=641, Percent_Identity=50.5460218408736, Blast_Score=631, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71982997, Length=641, Percent_Identity=50.5460218408736, Blast_Score=631, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=656, Percent_Identity=22.8658536585366, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17558820, Length=521, Percent_Identity=23.6084452975048, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI32563687, Length=551, Percent_Identity=23.4119782214156, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71985884, Length=590, Percent_Identity=21.3559322033898, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17538037, Length=142, Percent_Identity=31.6901408450704, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17557194, Length=132, Percent_Identity=32.5757575757576, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323182, Length=642, Percent_Identity=49.8442367601246, Blast_Score=630, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319264, Length=641, Percent_Identity=46.3338533541342, Blast_Score=572, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6319699, Length=374, Percent_Identity=22.192513368984, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24667955, Length=664, Percent_Identity=53.0120481927711, Blast_Score=686, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=56.9395017793594, Blast_Score=636, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=57.8846153846154, Blast_Score=596, Evalue=1e-170,
Organism=Drosophila melanogaster, GI21355225, Length=646, Percent_Identity=34.984520123839, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI18859661, Length=556, Percent_Identity=23.5611510791367, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21355181, Length=525, Percent_Identity=22.8571428571429, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21358303, Length=559, Percent_Identity=20.0357781753131, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581924, Length=530, Percent_Identity=22.2641509433962, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24656500, Length=545, Percent_Identity=21.8348623853211, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72412; Mature: 72281

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQSLYKVSGNIAANALVNNDQYKKMYQESIVNPEGFWREHGKRIDWIKPYTKIKKTTF
CCCCCEEEECCCEEEEEEECCHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHCCC
DDHNLSINWFYDGTLNASANCLDRHLAEHSDRVAIIWEGDNASEQRQITYGELHTQVCKF
CCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHH
ANALRSQGVRRGDIVTIYMPMVPEAAVAMLACARIGAVHSVVFGGFSPDSIASRVIDGKS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
KVVITADEGMRGGRAIPLKRNIDDALKHPDVTSVEKVIVLKRTGGKVDWVEGRDVWWHSL
EEEEEECCCCCCCEEECCCCCCHHHHCCCCCCCCEEEEEEEECCCEEEEECCCHHHHHHH
VETASEHCAIEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYASMTHEYVFDYKPGEI
HHHHHHHCCHHHCCCCCCEEEEEECCCCCCCCEEEEECCCEEEEEEECEEEEEEECCCEE
YWCTADVGWITGHSYMVYGPLANGATVLIHEGIPNYPSPARLGEMIDRHKVNILYTAPTL
EEEECCCCEEECCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECHHH
IRALMAEGKQHFDKYDGSSLRIMGSVGEPINPEAWRWYHEVIGHEHCPIVDTWWQTETGG
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCC
ILITPLPGATDTKPGSATRPFFGVQPALVDNMGNILEGATEGNLVLLDSWPGQMRTVYGD
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEECC
HERFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVSHE
CCHHHHEEHHHHCCEEEECCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHH
LVAEAAVVGYPHDIKGQGIYAYVTLTRGTEESEELRQELRQWVRKEIGALATPDLIQWAT
HHHHHHHCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHC
GLPKTRSGKIMRRFLRKIAANEVTNLGDASTLADPAVIETLIETRLNRNE
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SSQSLYKVSGNIAANALVNNDQYKKMYQESIVNPEGFWREHGKRIDWIKPYTKIKKTTF
CCCCEEEECCCEEEEEEECCHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHCCC
DDHNLSINWFYDGTLNASANCLDRHLAEHSDRVAIIWEGDNASEQRQITYGELHTQVCKF
CCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHH
ANALRSQGVRRGDIVTIYMPMVPEAAVAMLACARIGAVHSVVFGGFSPDSIASRVIDGKS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
KVVITADEGMRGGRAIPLKRNIDDALKHPDVTSVEKVIVLKRTGGKVDWVEGRDVWWHSL
EEEEEECCCCCCCEEECCCCCCHHHHCCCCCCCCEEEEEEEECCCEEEEECCCHHHHHHH
VETASEHCAIEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYASMTHEYVFDYKPGEI
HHHHHHHCCHHHCCCCCCEEEEEECCCCCCCCEEEEECCCEEEEEEECEEEEEEECCCEE
YWCTADVGWITGHSYMVYGPLANGATVLIHEGIPNYPSPARLGEMIDRHKVNILYTAPTL
EEEECCCCEEECCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECHHH
IRALMAEGKQHFDKYDGSSLRIMGSVGEPINPEAWRWYHEVIGHEHCPIVDTWWQTETGG
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCC
ILITPLPGATDTKPGSATRPFFGVQPALVDNMGNILEGATEGNLVLLDSWPGQMRTVYGD
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEECC
HERFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVSHE
CCHHHHEEHHHHCCEEEECCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHH
LVAEAAVVGYPHDIKGQGIYAYVTLTRGTEESEELRQELRQWVRKEIGALATPDLIQWAT
HHHHHHHCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHC
GLPKTRSGKIMRRFLRKIAANEVTNLGDASTLADPAVIETLIETRLNRNE
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA