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The map label for this gene is apt [H]

Identifier: 117920890

GI number: 117920890

Start: 2936003

End: 2936554

Strand: Reverse

Name: apt [H]

Synonym: Shewana3_2447

Alternate gene names: 117920890

Gene position: 2936554-2936003 (Counterclockwise)

Preceding gene: 117920891

Following gene: 117920889

Centisome position: 59.06

GC content: 44.75

Gene sequence:

>552_bases
ATGGCTATGAATACAGAAACCTTATCCTTGATAAAGCAAAGCATTAAAACGATTCCTAATTATCCTAAGGAAGGGATTCT
ATTTCGCGATGTGACCAGTCTGCTGGAAAATGCCGCGGCCTATAAAGCGACTATCGATTTATTAGTTGAGCAATATCGTA
ATAAAGGCTTTACCAAGATTGTGGGCACTGAAGCCCGTGGTTTCTTGTTTGGTGCGCCTTTAGCACTGGAATTAGGCATT
GGTTTTGTGCCTGTACGTAAGCCTGGTAAATTGCCACGCGCGACCATTAGCCAAAGCTATGAGCTGGAATATGGCCACGA
TAGCCTTGAAATCCATACCGATGCGATCACCGCGAATGATAAAGTATTAGTGGTTGACGATTTGCTGGCAACTGGTGGCA
CTATCGAAGCCACAGTCAAACTTATCCGCCAACTGGGTGGTGAAGTGCAAGATGCAGCCTTTGTGATTTCATTACCAGAT
CTCGGTGGCGAAGCCCGTTTAACTGCCTTAGGTCTTGAGTTGGTTAAACTTTGTGAGTTTGAAGGCGAATAA

Upstream 100 bases:

>100_bases
TAAGCTTTGTGCGAATTATTAAAGCTCGTCCACACTCGCTGTGGACGTTTTGTTTTTACCGCCAGCAGTTACGCATGGCG
AAACGATTAAGTTAAATTAA

Downstream 100 bases:

>100_bases
TTCTTCAGCCAAAGGCGCCTAGGGATAGTTTAATGGCATGTCGCTAATTGACATGTTATCTTGCAACTATCTCGGGGCGC
GATCCCCTTTTTTGTACCAA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MAMNTETLSLIKQSIKTIPNYPKEGILFRDVTSLLENAAAYKATIDLLVEQYRNKGFTKIVGTEARGFLFGAPLALELGI
GFVPVRKPGKLPRATISQSYELEYGHDSLEIHTDAITANDKVLVVDDLLATGGTIEATVKLIRQLGGEVQDAAFVISLPD
LGGEARLTALGLELVKLCEFEGE

Sequences:

>Translated_183_residues
MAMNTETLSLIKQSIKTIPNYPKEGILFRDVTSLLENAAAYKATIDLLVEQYRNKGFTKIVGTEARGFLFGAPLALELGI
GFVPVRKPGKLPRATISQSYELEYGHDSLEIHTDAITANDKVLVVDDLLATGGTIEATVKLIRQLGGEVQDAAFVISLPD
LGGEARLTALGLELVKLCEFEGE
>Mature_182_residues
AMNTETLSLIKQSIKTIPNYPKEGILFRDVTSLLENAAAYKATIDLLVEQYRNKGFTKIVGTEARGFLFGAPLALELGIG
FVPVRKPGKLPRATISQSYELEYGHDSLEIHTDAITANDKVLVVDDLLATGGTIEATVKLIRQLGGEVQDAAFVISLPDL
GGEARLTALGLELVKLCEFEGE

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=169, Percent_Identity=42.0118343195266, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI71773201, Length=133, Percent_Identity=45.1127819548872, Blast_Score=120, Evalue=9e-28,
Organism=Escherichia coli, GI1786675, Length=183, Percent_Identity=69.3989071038251, Blast_Score=253, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI17509087, Length=164, Percent_Identity=42.6829268292683, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=163, Percent_Identity=43.558282208589, Blast_Score=122, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320649, Length=173, Percent_Identity=36.4161849710983, Blast_Score=95, Evalue=7e-21,
Organism=Drosophila melanogaster, GI17136334, Length=173, Percent_Identity=43.9306358381503, Blast_Score=130, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19806; Mature: 19675

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMNTETLSLIKQSIKTIPNYPKEGILFRDVTSLLENAAAYKATIDLLVEQYRNKGFTKI
CCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VGTEARGFLFGAPLALELGIGFVPVRKPGKLPRATISQSYELEYGHDSLEIHTDAITAND
ECCCCCCEEEECCEEEECCCCEEECCCCCCCCHHHHCCCEEEEECCCCEEEEEEEEECCC
KVLVVDDLLATGGTIEATVKLIRQLGGEVQDAAFVISLPDLGGEARLTALGLELVKLCEF
CEEEEEHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHC
EGE
CCC
>Mature Secondary Structure 
AMNTETLSLIKQSIKTIPNYPKEGILFRDVTSLLENAAAYKATIDLLVEQYRNKGFTKI
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VGTEARGFLFGAPLALELGIGFVPVRKPGKLPRATISQSYELEYGHDSLEIHTDAITAND
ECCCCCCEEEECCEEEECCCCEEECCCCCCCCHHHHCCCEEEEECCCCEEEEEEEEECCC
KVLVVDDLLATGGTIEATVKLIRQLGGEVQDAAFVISLPDLGGEARLTALGLELVKLCEF
CEEEEEHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHC
EGE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA