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The map label for this gene is metC [H]

Identifier: 117920857

GI number: 117920857

Start: 2895136

End: 2896335

Strand: Direct

Name: metC [H]

Synonym: Shewana3_2414

Alternate gene names: 117920857

Gene position: 2895136-2896335 (Clockwise)

Preceding gene: 117920856

Following gene: 117920860

Centisome position: 58.23

GC content: 52.5

Gene sequence:

>1200_bases
ATGACAGATAAACATCAGCTAGCCACCCAAATCGTCAGCGTCGGTCGAGATAAAAAATGGACCAAGGGCGTGATTAACCC
GCCCGTATTTCGCGCATCCACTATCGTCTTCGACACCATGGAAGACATGCGTCACGCCGCTAAAAACAAAACCAATGGCG
AAATGTTTTATGGCCGCCGCGGCACCCCAACCCATTTTGCGTTTCAGGCGGCGATCAGTGAGCTCGAAGGTGGCGCAGGT
ACGGCGCTTTATCCCTCGGGTGCGGCAGCGATTAGCGCGGCTTTGTTATCGTTTTTACAGGCGGGCGATCACCTCTTGAT
GGTCGACAGTGTTTACGAGCCAACGCGAGATCTCTGTAGCCATATTCTGGCGGGCTTTAATATTGAGACCACCTATTACG
ATCCGCTAATTGGTGAAGGCATCCGCGAGCTTATTCGCCCCAATACTAAGGTGCTATTTTTAGAGTCTCCCGGCTCCATC
ACCATGGAAGTGCAGGACGTCCCAACCCTATGCCGTATCGCCCATGAACATGGATTGGTGACTATTCTCGACAACACTTG
GGCGTCGCCAATCAATAGCAAGCCCTTCGAGATGGGTGTCGATGTGTCGATTCAAGCCGCGACCAAATATATCGTCGGTC
ACTCTGATGTGATGATAGGCACCGCGACCGCCAACGAGAAGCACTGGCCGCAGCTGCGTGAGCGCAGTTATTTATTGGGG
CAAACCACCTCCCCCGACGATGTGTATCTCGCTACGCGCGGATTACGCACCCTAGGCGTGCGCATGGCGCAGCATGAGAA
AAATGCCCTTAAAGTAGCTAACTGGTTGAAAACGCGCCCCGAGGTTGATCATTTACGTCACCCCGCCTTTGATACCTGCC
CTGGACATGAATTCTTTAAACGCGACTTTAGCGCCGCCAACGGCCTGTTCTCCTTCGTGTTAAAGCAAGGGGATCAAGAA
GCGGTCACCGCCCTCGTTGAAAATATGCAGCATTTTAAAATGGGGTTTTCGTGGGGCGGTTATGAGAGTCTGATCCTAGG
GATTTTCGGGATTGAAAAAATCCGCAGTGCCACTCAGTGGGATGCACGCAAGCCGTTGATCCGTGTGCATATTGGCCTAG
AAGATCCCGATGATTTAATTGCCGATCTCAGCGCGGGCTTTGAGCGCTTTAATGCCGTACTCGCCACCAAGGCCAAATAA

Upstream 100 bases:

>100_bases
ACTCATCTGTTTGCCTCCTGCCATTTTCACGGGCAGATGCTAAGATGACGGCCATCACAATGGATAACAACATAAAAACT
GACTCGCCAAGGTAAGCCCT

Downstream 100 bases:

>100_bases
AGCTTAAACAACTTATATGTTAAACAACGAAGGCGGGAACTCTCCCGCCTTTATTTTGCCCCGCCTTCTTTGTGCCCCGC
CATCGTATTACTTCGGCTTC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTDKHQLATQIVSVGRDKKWTKGVINPPVFRASTIVFDTMEDMRHAAKNKTNGEMFYGRRGTPTHFAFQAAISELEGGAG
TALYPSGAAAISAALLSFLQAGDHLLMVDSVYEPTRDLCSHILAGFNIETTYYDPLIGEGIRELIRPNTKVLFLESPGSI
TMEVQDVPTLCRIAHEHGLVTILDNTWASPINSKPFEMGVDVSIQAATKYIVGHSDVMIGTATANEKHWPQLRERSYLLG
QTTSPDDVYLATRGLRTLGVRMAQHEKNALKVANWLKTRPEVDHLRHPAFDTCPGHEFFKRDFSAANGLFSFVLKQGDQE
AVTALVENMQHFKMGFSWGGYESLILGIFGIEKIRSATQWDARKPLIRVHIGLEDPDDLIADLSAGFERFNAVLATKAK

Sequences:

>Translated_399_residues
MTDKHQLATQIVSVGRDKKWTKGVINPPVFRASTIVFDTMEDMRHAAKNKTNGEMFYGRRGTPTHFAFQAAISELEGGAG
TALYPSGAAAISAALLSFLQAGDHLLMVDSVYEPTRDLCSHILAGFNIETTYYDPLIGEGIRELIRPNTKVLFLESPGSI
TMEVQDVPTLCRIAHEHGLVTILDNTWASPINSKPFEMGVDVSIQAATKYIVGHSDVMIGTATANEKHWPQLRERSYLLG
QTTSPDDVYLATRGLRTLGVRMAQHEKNALKVANWLKTRPEVDHLRHPAFDTCPGHEFFKRDFSAANGLFSFVLKQGDQE
AVTALVENMQHFKMGFSWGGYESLILGIFGIEKIRSATQWDARKPLIRVHIGLEDPDDLIADLSAGFERFNAVLATKAK
>Mature_398_residues
TDKHQLATQIVSVGRDKKWTKGVINPPVFRASTIVFDTMEDMRHAAKNKTNGEMFYGRRGTPTHFAFQAAISELEGGAGT
ALYPSGAAAISAALLSFLQAGDHLLMVDSVYEPTRDLCSHILAGFNIETTYYDPLIGEGIRELIRPNTKVLFLESPGSIT
MEVQDVPTLCRIAHEHGLVTILDNTWASPINSKPFEMGVDVSIQAATKYIVGHSDVMIGTATANEKHWPQLRERSYLLGQ
TTSPDDVYLATRGLRTLGVRMAQHEKNALKVANWLKTRPEVDHLRHPAFDTCPGHEFFKRDFSAANGLFSFVLKQGDQEA
VTALVENMQHFKMGFSWGGYESLILGIFGIEKIRSATQWDARKPLIRVHIGLEDPDDLIADLSAGFERFNAVLATKAK

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=342, Percent_Identity=32.7485380116959, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI299473759, Length=342, Percent_Identity=29.5321637426901, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI25453487, Length=342, Percent_Identity=29.2397660818713, Blast_Score=148, Evalue=9e-36,
Organism=Escherichia coli, GI1789383, Length=395, Percent_Identity=52.6582278481013, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI1790375, Length=396, Percent_Identity=32.0707070707071, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71980708, Length=372, Percent_Identity=33.3333333333333, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17538055, Length=381, Percent_Identity=30.1837270341207, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17560056, Length=379, Percent_Identity=30.3430079155673, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI193202265, Length=85, Percent_Identity=37.6470588235294, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321170, Length=338, Percent_Identity=47.6331360946746, Blast_Score=334, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6319307, Length=351, Percent_Identity=30.1994301994302, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321904, Length=392, Percent_Identity=26.0204081632653, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6323333, Length=414, Percent_Identity=25.3623188405797, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6321254, Length=416, Percent_Identity=25.4807692307692, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI19922554, Length=391, Percent_Identity=31.9693094629156, Blast_Score=199, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44201; Mature: 44070

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKHQLATQIVSVGRDKKWTKGVINPPVFRASTIVFDTMEDMRHAAKNKTNGEMFYGRR
CCCHHHHHHHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCC
GTPTHFAFQAAISELEGGAGTALYPSGAAAISAALLSFLQAGDHLLMVDSVYEPTRDLCS
CCCHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHCCCCEEEECCHHCCHHHHHH
HILAGFNIETTYYDPLIGEGIRELIRPNTKVLFLESPGSITMEVQDVPTLCRIAHEHGLV
HHHHCCCCCEEECCCHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHCCEE
TILDNTWASPINSKPFEMGVDVSIQAATKYIVGHSDVMIGTATANEKHWPQLRERSYLLG
EEECCCCCCCCCCCCCCCCCCEEEHHHHHEEECCCCEEEEECCCCCCCCHHHHHCCEEEC
QTTSPDDVYLATRGLRTLGVRMAQHEKNALKVANWLKTRPEVDHLRHPAFDTCPGHEFFK
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHH
RDFSAANGLFSFVLKQGDQEAVTALVENMQHFKMGFSWGGYESLILGIFGIEKIRSATQW
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
DARKPLIRVHIGLEDPDDLIADLSAGFERFNAVLATKAK
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDKHQLATQIVSVGRDKKWTKGVINPPVFRASTIVFDTMEDMRHAAKNKTNGEMFYGRR
CCHHHHHHHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCC
GTPTHFAFQAAISELEGGAGTALYPSGAAAISAALLSFLQAGDHLLMVDSVYEPTRDLCS
CCCHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHCCCCEEEECCHHCCHHHHHH
HILAGFNIETTYYDPLIGEGIRELIRPNTKVLFLESPGSITMEVQDVPTLCRIAHEHGLV
HHHHCCCCCEEECCCHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHCCEE
TILDNTWASPINSKPFEMGVDVSIQAATKYIVGHSDVMIGTATANEKHWPQLRERSYLLG
EEECCCCCCCCCCCCCCCCCCEEEHHHHHEEECCCCEEEEECCCCCCCCHHHHHCCEEEC
QTTSPDDVYLATRGLRTLGVRMAQHEKNALKVANWLKTRPEVDHLRHPAFDTCPGHEFFK
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHH
RDFSAANGLFSFVLKQGDQEAVTALVENMQHFKMGFSWGGYESLILGIFGIEKIRSATQW
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
DARKPLIRVHIGLEDPDDLIADLSAGFERFNAVLATKAK
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659970; 11677609 [H]