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The map label for this gene is msrAB [H]

Identifier: 117920836

GI number: 117920836

Start: 2871948

End: 2872853

Strand: Reverse

Name: msrAB [H]

Synonym: Shewana3_2393

Alternate gene names: 117920836

Gene position: 2872853-2871948 (Counterclockwise)

Preceding gene: 117920839

Following gene: 117920834

Centisome position: 57.78

GC content: 49.67

Gene sequence:

>906_bases
ATGAACAAACTGACTGATTTTGAACGCTATGTCATAGAAGAAAAGGGCACTGAACGTCCCTTTAGCGGTGAGTACTATAA
ACATGACGCCAAAGGCGTGTATTTGTGCAAAAAATGCCATGCGCCTTTGTATCGCTCAGAAGATAAGTTTAATGCTCACT
GTGGTTGGCCTGCCTTCGATGATGAAATTCCGGGGGCGGTGAGTCGTCATGTCGACGCCGATGGTCGTCGTACCGAAATC
GTCTGTAGTCAGTGTGGCGGTCATCTTGGCCATGTGTTTGAAGGGGAATATTTAACGCCGAAGAATATTCGTCACTGCGT
TAATTCTGTCTCTATGGTGTTTCAAGCGGCCGATGAGGTGACAACATCGACGCATAAAACGGCCTTTGCGACCTTTGGGG
CGGGCTGTTTTTGGTGTGTTGAAGCGATTTTTAAGAGCCTTAAGGGCGTGCTGAATGTCAGATCTGGTTACTCGGGCGGC
GAGGCGAGCGATGCCGATTATAAGTCGGTGTGTTCGGGATTAACTGGGCATGCTGAAGTGGTGCACATCGAGTTTGACCC
CGCGCAAATCAGCTTTACAACGCTGCTGCAGGTGTTATTTGAGAGTCACGACCCCACTACGCTCAACCGTCAAGGCAACG
ATAAAGGGCCGCAGTATCGCTCCGTCGTCTTTACCCACGATGCGGCGCAGATTGAAGAGACCAACACCATGATTGCCAAA
TTAACCGAGGCAAAGGTATTTGATGCGCCGATAGTGACCCAAGTGGTGGCCTTTGAGTCATTTTATCCCGCTGAGGATTA
CCATAATGACTATTTCGCCTTGCATGGCGAGCAGCCCTATTGCCAAATTGTGGTGCGGCCAAAGGTTGAAAAGATCAGAG
CCCTCTTTGCTGAGCTACAAGCATAG

Upstream 100 bases:

>100_bases
GGCTACTATGCCAAAAAGCCAATTCAGGCCGAGGCGCAATAAACCTGAGGAATAAACGGTCTTATGCAGGCGAATACCTT
AGGAGCTAAAGGAGACTTTT

Downstream 100 bases:

>100_bases
GCTTAATGTGCGAGCAAAATGACGGATAAAAAACGCCACCAATTAGGGTGGCGTTTTCGTTAATTGCTTGCCTGATAGGC
TGAAGACTCAGTGTATTAGC

Product: bifunctional methionine sulfoxide reductase B/A protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MNKLTDFERYVIEEKGTERPFSGEYYKHDAKGVYLCKKCHAPLYRSEDKFNAHCGWPAFDDEIPGAVSRHVDADGRRTEI
VCSQCGGHLGHVFEGEYLTPKNIRHCVNSVSMVFQAADEVTTSTHKTAFATFGAGCFWCVEAIFKSLKGVLNVRSGYSGG
EASDADYKSVCSGLTGHAEVVHIEFDPAQISFTTLLQVLFESHDPTTLNRQGNDKGPQYRSVVFTHDAAQIEETNTMIAK
LTEAKVFDAPIVTQVVAFESFYPAEDYHNDYFALHGEQPYCQIVVRPKVEKIRALFAELQA

Sequences:

>Translated_301_residues
MNKLTDFERYVIEEKGTERPFSGEYYKHDAKGVYLCKKCHAPLYRSEDKFNAHCGWPAFDDEIPGAVSRHVDADGRRTEI
VCSQCGGHLGHVFEGEYLTPKNIRHCVNSVSMVFQAADEVTTSTHKTAFATFGAGCFWCVEAIFKSLKGVLNVRSGYSGG
EASDADYKSVCSGLTGHAEVVHIEFDPAQISFTTLLQVLFESHDPTTLNRQGNDKGPQYRSVVFTHDAAQIEETNTMIAK
LTEAKVFDAPIVTQVVAFESFYPAEDYHNDYFALHGEQPYCQIVVRPKVEKIRALFAELQA
>Mature_301_residues
MNKLTDFERYVIEEKGTERPFSGEYYKHDAKGVYLCKKCHAPLYRSEDKFNAHCGWPAFDDEIPGAVSRHVDADGRRTEI
VCSQCGGHLGHVFEGEYLTPKNIRHCVNSVSMVFQAADEVTTSTHKTAFATFGAGCFWCVEAIFKSLKGVLNVRSGYSGG
EASDADYKSVCSGLTGHAEVVHIEFDPAQISFTTLLQVLFESHDPTTLNRQGNDKGPQYRSVVFTHDAAQIEETNTMIAK
LTEAKVFDAPIVTQVVAFESFYPAEDYHNDYFALHGEQPYCQIVVRPKVEKIRALFAELQA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=151, Percent_Identity=45.0331125827815, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI208609995, Length=151, Percent_Identity=45.0331125827815, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI301336164, Length=133, Percent_Identity=39.0977443609023, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI301336162, Length=133, Percent_Identity=39.0977443609023, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI73089054, Length=133, Percent_Identity=39.0977443609023, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI37620216, Length=133, Percent_Identity=39.0977443609023, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI117606353, Length=124, Percent_Identity=41.9354838709677, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI208609993, Length=103, Percent_Identity=43.6893203883495, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1790665, Length=176, Percent_Identity=39.2045454545455, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788077, Length=115, Percent_Identity=38.2608695652174, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17553450, Length=112, Percent_Identity=41.0714285714286, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI115532676, Length=112, Percent_Identity=41.0714285714286, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=31.0344827586207, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319816, Length=120, Percent_Identity=49.1666666666667, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=36.3057324840764, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24645799, Length=125, Percent_Identity=47.2, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45553335, Length=125, Percent_Identity=47.2, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21356369, Length=125, Percent_Identity=47.2, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24645801, Length=136, Percent_Identity=43.3823529411765, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24645804, Length=136, Percent_Identity=43.3823529411765, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI221378664, Length=134, Percent_Identity=45.5223880597015, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI221378662, Length=141, Percent_Identity=43.2624113475177, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24664627, Length=149, Percent_Identity=35.5704697986577, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24664631, Length=150, Percent_Identity=37.3333333333333, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI45553131, Length=142, Percent_Identity=33.8028169014084, Blast_Score=81, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.12; =1.8.4.11 [H]

Molecular weight: Translated: 33628; Mature: 33628

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKLTDFERYVIEEKGTERPFSGEYYKHDAKGVYLCKKCHAPLYRSEDKFNAHCGWPAFD
CCCCHHHHHHHHHCCCCCCCCCCCCEEECCCCEEEHHHHCCCCCCCCCCCCCCCCCCCCC
DEIPGAVSRHVDADGRRTEIVCSQCGGHLGHVFEGEYLTPKNIRHCVNSVSMVFQAADEV
CCCCCHHHHCCCCCCCHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHH
TTSTHKTAFATFGAGCFWCVEAIFKSLKGVLNVRSGYSGGEASDADYKSVCSGLTGHAEV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCEEE
VHIEFDPAQISFTTLLQVLFESHDPTTLNRQGNDKGPQYRSVVFTHDAAQIEETNTMIAK
EEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHH
LTEAKVFDAPIVTQVVAFESFYPAEDYHNDYFALHGEQPYCQIVVRPKVEKIRALFAELQ
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHC
A
C
>Mature Secondary Structure
MNKLTDFERYVIEEKGTERPFSGEYYKHDAKGVYLCKKCHAPLYRSEDKFNAHCGWPAFD
CCCCHHHHHHHHHCCCCCCCCCCCCEEECCCCEEEHHHHCCCCCCCCCCCCCCCCCCCCC
DEIPGAVSRHVDADGRRTEIVCSQCGGHLGHVFEGEYLTPKNIRHCVNSVSMVFQAADEV
CCCCCHHHHCCCCCCCHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHH
TTSTHKTAFATFGAGCFWCVEAIFKSLKGVLNVRSGYSGGEASDADYKSVCSGLTGHAEV
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCEEE
VHIEFDPAQISFTTLLQVLFESHDPTTLNRQGNDKGPQYRSVVFTHDAAQIEETNTMIAK
EEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHH
LTEAKVFDAPIVTQVVAFESFYPAEDYHNDYFALHGEQPYCQIVVRPKVEKIRALFAELQ
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]