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The map label for this gene is arsC [H]

Identifier: 117920788

GI number: 117920788

Start: 2821787

End: 2822263

Strand: Direct

Name: arsC [H]

Synonym: Shewana3_2345

Alternate gene names: 117920788

Gene position: 2821787-2822263 (Clockwise)

Preceding gene: 117920787

Following gene: 117920795

Centisome position: 56.75

GC content: 47.38

Gene sequence:

>477_bases
ATGGCAAATATCACAGACAACCATCTTGAAAAACAAAGCGTTGAAACACACAGCAGCATTAGGATTTACCATAATCCGGC
CTGTGGCACCTCGCGTAACACTTTAGGCCTTATCCGCAATACAGGGGTTGAACCAACCATTATCCTCTACCTTGAGACGC
CACCGAGCCGACAAACTCTGCTGCAACTGATTGCGGAGATGGGGATTTCGGTGCGCAGTTTACTGCGGCAAAATGTCGAG
CCCTTTGCAGCATTAGGCTTAAGTGAAGATAAGTTTAGCGACAGTGAATTAATCGATTTTATGCTTGAGTACCCCATCCT
AATCAATCGTCCCATAGTCGTTACGCCATTGGGCACTCGCCTGTGCCGCCCCTCGGAACAGGTGTTGGATATTTTACCTA
ATCCCCAACAGGGCGCTTTTACCAAGGAAGACGGTGAAGTAGTGATTGATGCTAATGGACAAAGAGTCGCTCAATAA

Upstream 100 bases:

>100_bases
ATCATCCATTTAGTGCCTATGGATAAATGTATAAGCGATTATTTATCAGAGAGAAGCTATCAGAGAAAAGTTATCAGAGA
GAAGTTATCAGAGACATGTT

Downstream 100 bases:

>100_bases
CGTTCCGTGTATAGATTGCGCTTTAAATGGCTCTAGAATCGAAAATGCCTGCAAAACTATCAGCTTTACAGGCATTTTTT
ACCTAATGAACACATTCATA

Product: arsenate reductase

Products: NA

Alternate protein names: Arsenical pump modifier [H]

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MANITDNHLEKQSVETHSSIRIYHNPACGTSRNTLGLIRNTGVEPTIILYLETPPSRQTLLQLIAEMGISVRSLLRQNVE
PFAALGLSEDKFSDSELIDFMLEYPILINRPIVVTPLGTRLCRPSEQVLDILPNPQQGAFTKEDGEVVIDANGQRVAQ

Sequences:

>Translated_158_residues
MANITDNHLEKQSVETHSSIRIYHNPACGTSRNTLGLIRNTGVEPTIILYLETPPSRQTLLQLIAEMGISVRSLLRQNVE
PFAALGLSEDKFSDSELIDFMLEYPILINRPIVVTPLGTRLCRPSEQVLDILPNPQQGAFTKEDGEVVIDANGQRVAQ
>Mature_157_residues
ANITDNHLEKQSVETHSSIRIYHNPACGTSRNTLGLIRNTGVEPTIILYLETPPSRQTLLQLIAEMGISVRSLLRQNVEP
FAALGLSEDKFSDSELIDFMLEYPILINRPIVVTPLGTRLCRPSEQVLDILPNPQQGAFTKEDGEVVIDANGQRVAQ

Specific function: Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance [H]

COG id: COG1393

COG function: function code P; Arsenate reductase and related proteins, glutaredoxin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArsC family [H]

Homologues:

Organism=Escherichia coli, GI1789918, Length=139, Percent_Identity=74.1007194244604, Blast_Score=221, Evalue=1e-59,
Organism=Escherichia coli, GI1788841, Length=116, Percent_Identity=43.9655172413793, Blast_Score=102, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006659
- InterPro:   IPR006660
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF03960 ArsC [H]

EC number: =1.20.4.1 [H]

Molecular weight: Translated: 17535; Mature: 17404

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANITDNHLEKQSVETHSSIRIYHNPACGTSRNTLGLIRNTGVEPTIILYLETPPSRQTL
CCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHH
LQLIAEMGISVRSLLRQNVEPFAALGLSEDKFSDSELIDFMLEYPILINRPIVVTPLGTR
HHHHHHCCHHHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHCCEEECCCEEEEECCHH
LCRPSEQVLDILPNPQQGAFTKEDGEVVIDANGQRVAQ
HCCCHHHHHHHCCCCCCCCEECCCCCEEEECCCCCCCC
>Mature Secondary Structure 
ANITDNHLEKQSVETHSSIRIYHNPACGTSRNTLGLIRNTGVEPTIILYLETPPSRQTL
CCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHH
LQLIAEMGISVRSLLRQNVEPFAALGLSEDKFSDSELIDFMLEYPILINRPIVVTPLGTR
HHHHHHCCHHHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHCCEEECCCEEEEECCHH
LCRPSEQVLDILPNPQQGAFTKEDGEVVIDANGQRVAQ
HCCCHHHHHHHCCCCCCCCEECCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3021763; 1703401; 1704144 [H]