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The map label for this gene is gmr [H]

Identifier: 117920751

GI number: 117920751

Start: 2773278

End: 2775536

Strand: Reverse

Name: gmr [H]

Synonym: Shewana3_2308

Alternate gene names: 117920751

Gene position: 2775536-2773278 (Counterclockwise)

Preceding gene: 117920752

Following gene: 117920748

Centisome position: 55.82

GC content: 47.9

Gene sequence:

>2259_bases
ATGGACGAAGGAATTGCGGTTACGGGCACTATCGGCGAGATTAATGCTCAGTTTAATCAAAGTGTTAGCTTAGAATGTTA
TAACGGCATCTTGTCTATGCTGCTCAATGGCGCGCCATTAGCAGAAATCCTCCATGCTCTAGTCTTAAAAATTGAAGATC
AGCGTTTAGGCACGCATGCCTCCGTATTGCTACTCAGCGAAGACGGCAAAAAGCTGCTCACGGGCGCCGCGCCCCATTTA
CCCGTCAGTTATAACCAAGTCATTCATGGGGTCGAAATTGGTCCTGGGGTTGGCTCCTGCGGTACCGCGGCGTTTACGGG
GCAGCGGGTGATTGTCGATGACATTGAACATCATCCCTATTGGGCGCCGTACAAAGAGTTTGCATTAACCCACGGGCTGA
GGGCCTGTTGGTCTGAGCCTATCAAAGATACTCAAGGCAAGGTCCTCGGCACCTTTGCCATGTATTATGAAACCGTAAAA
GTACCGACGGCCGCGGATTTAACCTTGATTTCTGAGGCGGCAAGGCTGGCGAGTTTAGCGGTAGAGCGCAGTCGGTCACT
CGAGTTTCAGCGCCTTGCGGTGAAAATATTTGATCGCCTACCTCTGTCGTTAGTCATCACCAATGCCAGCCATTCCGTGC
TCTATGCAAACGATGCGTTTACCCAGATGGTTTATCCTAAAACCACTGATATTCATGATTTTTGCCCTGAACACTTTTTC
TCTCCCTCTGAGCCCCACGAAATCGATTCCCTGTTTCAACATCTGTCCGAGGGGAAAATGTGGCAGGGTGAGTTGATTGG
CCTGCGTAATAACGGTGAAACCTTTTACCTCGATTTAACCGTGACCGTGTTTCGCGAGCCCCATAGCAACGAGAATAGTT
TTGCTTGGTTATTTTCCGATATCAGTGAGCGTAAAAAGGCGGCGCAGTTAATTAAGTATCAAGCCAACAATGATCCCCTC
ACTGGCTTGGCAAACCGTAATGCCTTGTTTAGACAAATCCAAGAGCTGATATCCGCCGACAGCTTAACCCCTGGTTTTAG
CTTTATGCTGATGGATTTAGATAACTTTAAACAAGTGAACGATACCTATGGTCACGACAAAGGGGATGCGCTGCTGGTGC
AGGTCGTGGAGCAGATTAAGACCTGTTTGAATGAGCAAGCGGTATTTGCCCGTTTAGGGGGCGATGAGTTTGCGCTGTTG
CTTCCGGGCCTTGTGACACAAAGAGAATTGTCACAGCTTGCTGATAAGATTAATAAACGTGTGTATCAACGTTATGAATT
GTCCCATGATAAGGGCGTATATAGCTCGGTGAGTATTGGGATCGCGCGCTTTCCCGAGGATGCGTTGGATCTGGAGCAGC
TGTTGAACTGCGCCGATCAGGCCATGTATATCTCCAAGGCGGATGGCCGTAACCGTTACCATTTTTTCACCGAGCAAATG
CAGCAAAATGCCGAGCGCATTGCGAATTTGCATACACTGCTGAAACAAGCCTTAGAACAAGAAGCCTTCGAGCTATATTT
TCAGCCGATTGTGGATGCGACAACAGGGCTTGTTCAGCGCGCCGAAGTGCTACTGCGTTGGCAGCACGAGGGGCAGTTTA
TTTCCCCCGATGAGTTTATTCCCATCGCCGAGAACAGCGGTTTAATCGTTAACATTGGTCGCTATGTACGCAAAGCCGTG
ATGCAAACCATCATCGATATGCAAGTTCTAGGCTGGCCAATCAATTTAGCGGTGAACGTGTCGACCTTTGAGTTTTGGTC
CCACGAGTTGCAGGATGCGTTTTGTGACTCCTTTGCCGATATTATCGAAGAGCTGGGGTTAATTGAGTTTCCCTACGAGC
TTATCACCTTAGAAATCACTGAATCGCTGTTGATGAAACAGCATGTGCATTTAATCCAAGTGCTGAACGAGTTACGCGGA
CGAGGCATTAAAATCTCCCTCGATGACTTTGGTACCGGTTATTCTTCCTTATCCTATTTGGCGAATTTTCCTATCGATCA
AATCAAAATCGATAAGAGTTTTATCGATAGGTTAGATGAAGGGGAGCGCCATCTCGCATTGATAGAGGCGATTGTGCGCT
TAAGTCATGCGCTGAATTTGAGTGTGACGGCAGAAGGGGTCGAAACCCAGGCGCAGCTTAAGGTGATGATGGAAAACCAT
ATTCAAGAAATTCAAGGCTATATCTTTTATAAGCCCATGCCCAAGGCGGCATTTTTTGAGTTACTTGCCGAGCAGGCTGC
GGCTCATCACCATTCATAA

Upstream 100 bases:

>100_bases
TGCTTTAGTGCGACTAAATACCTAAAATTCACCCCTGATTTACAAAGATTGTTCATCTTAGTAAGGTCGTTAACTTAAGC
GCTAAATGACTAAGGGATGT

Downstream 100 bases:

>100_bases
TGAGTTCAAACCAACCTCAAAAAAGAAGCGCGCTATATAGGCGCGCTTTTCAGTTTATTTAGCCTATCACTCGGTCTATC
ACTTAGCCGCTAACTGGCCG

Product: diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 752; Mature: 752

Protein sequence:

>752_residues
MDEGIAVTGTIGEINAQFNQSVSLECYNGILSMLLNGAPLAEILHALVLKIEDQRLGTHASVLLLSEDGKKLLTGAAPHL
PVSYNQVIHGVEIGPGVGSCGTAAFTGQRVIVDDIEHHPYWAPYKEFALTHGLRACWSEPIKDTQGKVLGTFAMYYETVK
VPTAADLTLISEAARLASLAVERSRSLEFQRLAVKIFDRLPLSLVITNASHSVLYANDAFTQMVYPKTTDIHDFCPEHFF
SPSEPHEIDSLFQHLSEGKMWQGELIGLRNNGETFYLDLTVTVFREPHSNENSFAWLFSDISERKKAAQLIKYQANNDPL
TGLANRNALFRQIQELISADSLTPGFSFMLMDLDNFKQVNDTYGHDKGDALLVQVVEQIKTCLNEQAVFARLGGDEFALL
LPGLVTQRELSQLADKINKRVYQRYELSHDKGVYSSVSIGIARFPEDALDLEQLLNCADQAMYISKADGRNRYHFFTEQM
QQNAERIANLHTLLKQALEQEAFELYFQPIVDATTGLVQRAEVLLRWQHEGQFISPDEFIPIAENSGLIVNIGRYVRKAV
MQTIIDMQVLGWPINLAVNVSTFEFWSHELQDAFCDSFADIIEELGLIEFPYELITLEITESLLMKQHVHLIQVLNELRG
RGIKISLDDFGTGYSSLSYLANFPIDQIKIDKSFIDRLDEGERHLALIEAIVRLSHALNLSVTAEGVETQAQLKVMMENH
IQEIQGYIFYKPMPKAAFFELLAEQAAAHHHS

Sequences:

>Translated_752_residues
MDEGIAVTGTIGEINAQFNQSVSLECYNGILSMLLNGAPLAEILHALVLKIEDQRLGTHASVLLLSEDGKKLLTGAAPHL
PVSYNQVIHGVEIGPGVGSCGTAAFTGQRVIVDDIEHHPYWAPYKEFALTHGLRACWSEPIKDTQGKVLGTFAMYYETVK
VPTAADLTLISEAARLASLAVERSRSLEFQRLAVKIFDRLPLSLVITNASHSVLYANDAFTQMVYPKTTDIHDFCPEHFF
SPSEPHEIDSLFQHLSEGKMWQGELIGLRNNGETFYLDLTVTVFREPHSNENSFAWLFSDISERKKAAQLIKYQANNDPL
TGLANRNALFRQIQELISADSLTPGFSFMLMDLDNFKQVNDTYGHDKGDALLVQVVEQIKTCLNEQAVFARLGGDEFALL
LPGLVTQRELSQLADKINKRVYQRYELSHDKGVYSSVSIGIARFPEDALDLEQLLNCADQAMYISKADGRNRYHFFTEQM
QQNAERIANLHTLLKQALEQEAFELYFQPIVDATTGLVQRAEVLLRWQHEGQFISPDEFIPIAENSGLIVNIGRYVRKAV
MQTIIDMQVLGWPINLAVNVSTFEFWSHELQDAFCDSFADIIEELGLIEFPYELITLEITESLLMKQHVHLIQVLNELRG
RGIKISLDDFGTGYSSLSYLANFPIDQIKIDKSFIDRLDEGERHLALIEAIVRLSHALNLSVTAEGVETQAQLKVMMENH
IQEIQGYIFYKPMPKAAFFELLAEQAAAHHHS
>Mature_752_residues
MDEGIAVTGTIGEINAQFNQSVSLECYNGILSMLLNGAPLAEILHALVLKIEDQRLGTHASVLLLSEDGKKLLTGAAPHL
PVSYNQVIHGVEIGPGVGSCGTAAFTGQRVIVDDIEHHPYWAPYKEFALTHGLRACWSEPIKDTQGKVLGTFAMYYETVK
VPTAADLTLISEAARLASLAVERSRSLEFQRLAVKIFDRLPLSLVITNASHSVLYANDAFTQMVYPKTTDIHDFCPEHFF
SPSEPHEIDSLFQHLSEGKMWQGELIGLRNNGETFYLDLTVTVFREPHSNENSFAWLFSDISERKKAAQLIKYQANNDPL
TGLANRNALFRQIQELISADSLTPGFSFMLMDLDNFKQVNDTYGHDKGDALLVQVVEQIKTCLNEQAVFARLGGDEFALL
LPGLVTQRELSQLADKINKRVYQRYELSHDKGVYSSVSIGIARFPEDALDLEQLLNCADQAMYISKADGRNRYHFFTEQM
QQNAERIANLHTLLKQALEQEAFELYFQPIVDATTGLVQRAEVLLRWQHEGQFISPDEFIPIAENSGLIVNIGRYVRKAV
MQTIIDMQVLGWPINLAVNVSTFEFWSHELQDAFCDSFADIIEELGLIEFPYELITLEITESLLMKQHVHLIQVLNELRG
RGIKISLDDFGTGYSSLSYLANFPIDQIKIDKSFIDRLDEGERHLALIEAIVRLSHALNLSVTAEGVETQAQLKVMMENH
IQEIQGYIFYKPMPKAAFFELLAEQAAAHHHS

Specific function: Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC/ymaD and adrA (yaic). Activity of this protein is antag

COG id: COG5001

COG function: function code T; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=443, Percent_Identity=39.2776523702032, Blast_Score=273, Evalue=3e-74,
Organism=Escherichia coli, GI87081921, Length=435, Percent_Identity=33.3333333333333, Blast_Score=215, Evalue=8e-57,
Organism=Escherichia coli, GI226510982, Length=426, Percent_Identity=28.8732394366197, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI87081845, Length=248, Percent_Identity=37.5, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1786507, Length=245, Percent_Identity=35.9183673469388, Blast_Score=140, Evalue=4e-34,
Organism=Escherichia coli, GI1790496, Length=255, Percent_Identity=32.9411764705882, Blast_Score=133, Evalue=5e-32,
Organism=Escherichia coli, GI87081980, Length=255, Percent_Identity=34.9019607843137, Blast_Score=126, Evalue=5e-30,
Organism=Escherichia coli, GI1788502, Length=275, Percent_Identity=30.1818181818182, Blast_Score=122, Evalue=1e-28,
Organism=Escherichia coli, GI87081743, Length=261, Percent_Identity=31.0344827586207, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1787055, Length=249, Percent_Identity=31.7269076305221, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI87082096, Length=434, Percent_Identity=25.1152073732719, Blast_Score=103, Evalue=6e-23,
Organism=Escherichia coli, GI1787262, Length=171, Percent_Identity=35.672514619883, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI87082007, Length=165, Percent_Identity=35.1515151515151, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87081881, Length=178, Percent_Identity=34.8314606741573, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87081977, Length=164, Percent_Identity=37.1951219512195, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1788381, Length=194, Percent_Identity=32.4742268041237, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1787802, Length=168, Percent_Identity=34.5238095238095, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1788849, Length=242, Percent_Identity=30.9917355371901, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1788956, Length=161, Percent_Identity=34.1614906832298, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI145693134, Length=169, Percent_Identity=31.9526627218935, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1787816, Length=173, Percent_Identity=34.1040462427746, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786584, Length=187, Percent_Identity=27.807486631016, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1789650, Length=470, Percent_Identity=20.6382978723404, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788085, Length=170, Percent_Identity=28.8235294117647, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87081974, Length=163, Percent_Identity=28.2208588957055, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787410, Length=119, Percent_Identity=30.2521008403361, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1787056, Length=127, Percent_Identity=33.8582677165354, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR000014
- InterPro:   IPR013767 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF00989 PAS [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 84535; Mature: 84535

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50113 PAC ; PS50883 EAL ; PS50887 GGDEF ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEGIAVTGTIGEINAQFNQSVSLECYNGILSMLLNGAPLAEILHALVLKIEDQRLGTHA
CCCCEEEEEEHHHCCCCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHCCCCE
SVLLLSEDGKKLLTGAAPHLPVSYNQVIHGVEIGPGVGSCGTAAFTGQRVIVDDIEHHPY
EEEEECCCCCCHHCCCCCCCCCCHHHHEECCEECCCCCCCCCHHHCCCEEEEECCCCCCC
WAPYKEFALTHGLRACWSEPIKDTQGKVLGTFAMYYETVKVPTAADLTLISEAARLASLA
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VERSRSLEFQRLAVKIFDRLPLSLVITNASHSVLYANDAFTQMVYPKTTDIHDFCPEHFF
HHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCHHHEECCCCCCHHHHCHHHCC
SPSEPHEIDSLFQHLSEGKMWQGELIGLRNNGETFYLDLTVTVFREPHSNENSFAWLFSD
CCCCCHHHHHHHHHHHCCCEECCEEEEEECCCCEEEEEEEEEEEECCCCCCCCEEHHHHH
ISERKKAAQLIKYQANNDPLTGLANRNALFRQIQELISADSLTPGFSFMLMDLDNFKQVN
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECHHHHHHH
DTYGHDKGDALLVQVVEQIKTCLNEQAVFARLGGDEFALLLPGLVTQRELSQLADKINKR
HHCCCCCCHHHHHHHHHHHHHHHCCHHHEECCCCCCEEEHHCCHHHHHHHHHHHHHHHHH
VYQRYELSHDKGVYSSVSIGIARFPEDALDLEQLLNCADQAMYISKADGRNRYHFFTEQM
HHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHH
QQNAERIANLHTLLKQALEQEAFELYFQPIVDATTGLVQRAEVLLRWQHEGQFISPDEFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEECCCCCE
PIAENSGLIVNIGRYVRKAVMQTIIDMQVLGWPINLAVNVSTFEFWSHELQDAFCDSFAD
EEECCCCEEEEHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHH
IIEELGLIEFPYELITLEITESLLMKQHVHLIQVLNELRGRGIKISLDDFGTGYSSLSYL
HHHHCCCEECCHHHEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
ANFPIDQIKIDKSFIDRLDEGERHLALIEAIVRLSHALNLSVTAEGVETQAQLKVMMENH
HCCCHHHEEECHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHH
IQEIQGYIFYKPMPKAAFFELLAEQAAAHHHS
HHHHCCEEEECCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDEGIAVTGTIGEINAQFNQSVSLECYNGILSMLLNGAPLAEILHALVLKIEDQRLGTHA
CCCCEEEEEEHHHCCCCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHCCCCE
SVLLLSEDGKKLLTGAAPHLPVSYNQVIHGVEIGPGVGSCGTAAFTGQRVIVDDIEHHPY
EEEEECCCCCCHHCCCCCCCCCCHHHHEECCEECCCCCCCCCHHHCCCEEEEECCCCCCC
WAPYKEFALTHGLRACWSEPIKDTQGKVLGTFAMYYETVKVPTAADLTLISEAARLASLA
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VERSRSLEFQRLAVKIFDRLPLSLVITNASHSVLYANDAFTQMVYPKTTDIHDFCPEHFF
HHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCHHHEECCCCCCHHHHCHHHCC
SPSEPHEIDSLFQHLSEGKMWQGELIGLRNNGETFYLDLTVTVFREPHSNENSFAWLFSD
CCCCCHHHHHHHHHHHCCCEECCEEEEEECCCCEEEEEEEEEEEECCCCCCCCEEHHHHH
ISERKKAAQLIKYQANNDPLTGLANRNALFRQIQELISADSLTPGFSFMLMDLDNFKQVN
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECHHHHHHH
DTYGHDKGDALLVQVVEQIKTCLNEQAVFARLGGDEFALLLPGLVTQRELSQLADKINKR
HHCCCCCCHHHHHHHHHHHHHHHCCHHHEECCCCCCEEEHHCCHHHHHHHHHHHHHHHHH
VYQRYELSHDKGVYSSVSIGIARFPEDALDLEQLLNCADQAMYISKADGRNRYHFFTEQM
HHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHH
QQNAERIANLHTLLKQALEQEAFELYFQPIVDATTGLVQRAEVLLRWQHEGQFISPDEFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEECCCCCE
PIAENSGLIVNIGRYVRKAVMQTIIDMQVLGWPINLAVNVSTFEFWSHELQDAFCDSFAD
EEECCCCEEEEHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHH
IIEELGLIEFPYELITLEITESLLMKQHVHLIQVLNELRGRGIKISLDDFGTGYSSLSYL
HHHHCCCEECCHHHEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
ANFPIDQIKIDKSFIDRLDEGERHLALIEAIVRLSHALNLSVTAEGVETQAQLKVMMENH
HCCCHHHEEECHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHH
IQEIQGYIFYKPMPKAAFFELLAEQAAAHHHS
HHHHCCEEEECCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]