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The map label for this gene is ndk [H]

Identifier: 117920715

GI number: 117920715

Start: 2736146

End: 2736577

Strand: Reverse

Name: ndk [H]

Synonym: Shewana3_2272

Alternate gene names: 117920715

Gene position: 2736577-2736146 (Counterclockwise)

Preceding gene: 117920716

Following gene: 117920714

Centisome position: 55.04

GC content: 46.53

Gene sequence:

>432_bases
ATGGCGATCGAACGCACATTTTCTATCATTAAGCCTGATGCTGTTGCTAAAAACCACATCGGTGCAATCTACAACCGTTT
TGAAACTGCTGGTCTGAAGATCGTTGCAGCTAAAATGTTACACCTGACTAAAGAACAAGCTGAAGGTTTCTATGCTGAGC
ATAGCGAGCGTGGCTTCTTCGGTGCTCTGGTTGCTTTCATGACTTCTGGCCCAATCATGGTTCAAGTTTTAGAAGGCGAA
AACGCTGTTTTAGCTCACCGCGAAATTTTAGGTGCAACTAACCCAGCTCAAGCGGCTCCAGGTACTATCCGTGCCGATTT
CGCTGAAAGCATCGACGAAAACGCTGCTCACGGTTCTGACGCTTTAGAATCTGCTGCGCGTGAAATTGCTTACTTCTTCA
GTGCTGAAGAACTGTGTCCACGTACTCGTTAA

Upstream 100 bases:

>100_bases
CAATATCTCAGACTTATTTGCTTTAAAGATAGGATTTGGTTTTTAAATTTCGTATAATCCGCGCGAATTTTTTCAAACTT
GCTGACAAAGGAAGCTTGTT

Downstream 100 bases:

>100_bases
TCTGAGTGTGAGACCGAAGAAGGGAGCCTAAGGGCTCCTTTTTTATTGGCGATATTCGACTAACCACGCCTGATACAAGG
TTTTTAATGCTAATAACCTG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MAIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIVAAKMLHLTKEQAEGFYAEHSERGFFGALVAFMTSGPIMVQVLEGE
NAVLAHREILGATNPAQAAPGTIRADFAESIDENAAHGSDALESAAREIAYFFSAEELCPRTR

Sequences:

>Translated_143_residues
MAIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIVAAKMLHLTKEQAEGFYAEHSERGFFGALVAFMTSGPIMVQVLEGE
NAVLAHREILGATNPAQAAPGTIRADFAESIDENAAHGSDALESAAREIAYFFSAEELCPRTR
>Mature_142_residues
AIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIVAAKMLHLTKEQAEGFYAEHSERGFFGALVAFMTSGPIMVQVLEGEN
AVLAHREILGATNPAQAAPGTIRADFAESIDENAAHGSDALESAAREIAYFFSAEELCPRTR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=48.8888888888889, Blast_Score=138, Evalue=1e-33,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=45.5882352941176, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=45.5882352941176, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=45.5882352941176, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=45.5882352941176, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=45.5882352941176, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI4557797, Length=139, Percent_Identity=43.8848920863309, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI38045913, Length=139, Percent_Identity=43.8848920863309, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=41.1764705882353, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=37.410071942446, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=37.410071942446, Blast_Score=93, Evalue=6e-20,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=39.7058823529412, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=35.5555555555556, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=33.5766423357664, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=30.4347826086957, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788866, Length=143, Percent_Identity=72.027972027972, Blast_Score=213, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=45.9259259259259, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=47.7941176470588, Blast_Score=135, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45549037, Length=139, Percent_Identity=49.6402877697842, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=35.0746268656716, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15468; Mature: 15336

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIVAAKMLHLTKEQAEGFYAEHSERGFF
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHCCCCCHH
GALVAFMTSGPIMVQVLEGENAVLAHREILGATNPAQAAPGTIRADFAESIDENAAHGSD
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCHH
ALESAAREIAYFFSAEELCPRTR
HHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIVAAKMLHLTKEQAEGFYAEHSERGFF
CCCHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHCCCCCHH
GALVAFMTSGPIMVQVLEGENAVLAHREILGATNPAQAAPGTIRADFAESIDENAAHGSD
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCHH
ALESAAREIAYFFSAEELCPRTR
HHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA