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The map label for this gene is zitB [H]

Identifier: 117920674

GI number: 117920674

Start: 2682753

End: 2684003

Strand: Reverse

Name: zitB [H]

Synonym: Shewana3_2231

Alternate gene names: 117920674

Gene position: 2684003-2682753 (Counterclockwise)

Preceding gene: 117920676

Following gene: 117920673

Centisome position: 53.98

GC content: 48.92

Gene sequence:

>1251_bases
ATGAAAACAACATCTTCAACCGAGAAACCGATGCAGAGTACTGGGCTTGGGCATTCTGTCGCGCAGTGGCAACATTCCCA
TGGATTTTCTAACCAAAATACCGCTGGCGAAAAAAATACCCGTTATGTGTTGTATCTCACCGTGATTACCATGGTGGCCG
AGATTGTGGCGGGGACCATTTATGGATCTATGGCCTTGCTGGCCGATGGTTGGCATATGGGTACCCACGCCGCCGCCTTT
ATGATCACCTTATTTGCCTATTCCTATGCCCGTAAGCATGCCAATGATCCGGCCTTTGCCTTTGGGACTGGTAAGGTGAG
TGTGCTTGGCGGTTACACCAGTGCCATCGCTTTAGGCTTAGTGGCCTTAGTGATGTTAATTGAATCGGGCATGCGCTTGA
TTAATCCTGAGGATATTCACTTTAATGAAGCGATTTTTGTCGCCCTGATTGGCTTAAGCGTGAACGTATTAAGTGTGTTC
CTGTTGAAGGATCATCACTCCCACGACCATGGACATTCACACGGCCACTCGCATGGACATTCGCACAGTCACTCTCACGG
CCATGATCACGACGATGAAGATGATGACCATAAGGATCATCAAGATAATCATTGCTGCCATGGGAACGATCATCATGCTG
CTGACCATGACCATGACCATGACCATGACCATGACCATGACCATGACCATGACCATGACCATGACCATGACCATGACCAT
GACCATGACCATGACCATGACGACCATTCACACAGCCAGGCACAGGGTCATTCTCATGGGCATTCACACGGGCATTCGGG
CCATGATCACAATCTAAGGGCGGCTTATTTCCACGTATTAGCCGATGCGTTAACCTCAGTGCTGGCGATTGCGGCACTGT
TGTTCGGTAAATATATGGGCTTAACTTGGCTCGATCCGATTATGGGGATTGTTGGCGCGATTATTATCAGCCGCTGGTCA
TGGGGTCTTATCCAACAGACCAGTCCGATTTTGTTGGACGGTGGGGTAAAAGCCTCGCTACAGTGCAAAGTGCGTGAGAC
GATCGAGGCAGTACCGGATCATCAAGTCGCCGATTTACATATTTGGCGCGTGAGTGCCGATCACCATGCTATGATGGTGT
CCATTGTGTCTCACTCACCGAAAGAAGCCAGTTATTTTAATCAGTTACTGACTAAGTTCCCTGAGTTATCTCATATTACC
ATTGAGCTGCATACTTGCCGTCAACGTGAGTGTGTGGCTAAGGAAGCCTAA

Upstream 100 bases:

>100_bases
TGGCGACAGAAGTCATCAATCACCACAGCGGGTTTGCTCTTGCTGCATGAATTTACGCACTCATTTATGCAAGCTAGGGA
AAATCGCTTAGGAAAAAATA

Downstream 100 bases:

>100_bases
TGACAGTTGCACACCCGCATGATGCTTTATCAGCCGCGTCCGCCCATTCTACGGATCAGGCCCTGAACCATGTGATTATT
GAGTTTTATGAAAAATTATC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKTTSSTEKPMQSTGLGHSVAQWQHSHGFSNQNTAGEKNTRYVLYLTVITMVAEIVAGTIYGSMALLADGWHMGTHAAAF
MITLFAYSYARKHANDPAFAFGTGKVSVLGGYTSAIALGLVALVMLIESGMRLINPEDIHFNEAIFVALIGLSVNVLSVF
LLKDHHSHDHGHSHGHSHGHSHSHSHGHDHDDEDDDHKDHQDNHCCHGNDHHAADHDHDHDHDHDHDHDHDHDHDHDHDH
DHDHDHDDHSHSQAQGHSHGHSHGHSGHDHNLRAAYFHVLADALTSVLAIAALLFGKYMGLTWLDPIMGIVGAIIISRWS
WGLIQQTSPILLDGGVKASLQCKVRETIEAVPDHQVADLHIWRVSADHHAMMVSIVSHSPKEASYFNQLLTKFPELSHIT
IELHTCRQRECVAKEA

Sequences:

>Translated_416_residues
MKTTSSTEKPMQSTGLGHSVAQWQHSHGFSNQNTAGEKNTRYVLYLTVITMVAEIVAGTIYGSMALLADGWHMGTHAAAF
MITLFAYSYARKHANDPAFAFGTGKVSVLGGYTSAIALGLVALVMLIESGMRLINPEDIHFNEAIFVALIGLSVNVLSVF
LLKDHHSHDHGHSHGHSHGHSHSHSHGHDHDDEDDDHKDHQDNHCCHGNDHHAADHDHDHDHDHDHDHDHDHDHDHDHDH
DHDHDHDDHSHSQAQGHSHGHSHGHSGHDHNLRAAYFHVLADALTSVLAIAALLFGKYMGLTWLDPIMGIVGAIIISRWS
WGLIQQTSPILLDGGVKASLQCKVRETIEAVPDHQVADLHIWRVSADHHAMMVSIVSHSPKEASYFNQLLTKFPELSHIT
IELHTCRQRECVAKEA
>Mature_416_residues
MKTTSSTEKPMQSTGLGHSVAQWQHSHGFSNQNTAGEKNTRYVLYLTVITMVAEIVAGTIYGSMALLADGWHMGTHAAAF
MITLFAYSYARKHANDPAFAFGTGKVSVLGGYTSAIALGLVALVMLIESGMRLINPEDIHFNEAIFVALIGLSVNVLSVF
LLKDHHSHDHGHSHGHSHGHSHSHSHGHDHDDEDDDHKDHQDNHCCHGNDHHAADHDHDHDHDHDHDHDHDHDHDHDHDH
DHDHDHDDHSHSQAQGHSHGHSHGHSGHDHNLRAAYFHVLADALTSVLAIAALLFGKYMGLTWLDPIMGIVGAIIISRWS
WGLIQQTSPILLDGGVKASLQCKVRETIEAVPDHQVADLHIWRVSADHHAMMVSIVSHSPKEASYFNQLLTKFPELSHIT
IELHTCRQRECVAKEA

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI222080086, Length=361, Percent_Identity=24.6537396121884, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI40255009, Length=361, Percent_Identity=24.6537396121884, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI20070323, Length=148, Percent_Identity=28.3783783783784, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI52352803, Length=379, Percent_Identity=23.4828496042216, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786966, Length=131, Percent_Identity=32.824427480916, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI32564488, Length=114, Percent_Identity=35.0877192982456, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323899, Length=351, Percent_Identity=28.2051282051282, Blast_Score=106, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6324892, Length=347, Percent_Identity=22.1902017291066, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574430, Length=333, Percent_Identity=27.027027027027, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24584409, Length=331, Percent_Identity=26.5861027190332, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585900, Length=399, Percent_Identity=20.0501253132832, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585898, Length=399, Percent_Identity=20.0501253132832, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585896, Length=399, Percent_Identity=20.0501253132832, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921672, Length=399, Percent_Identity=20.0501253132832, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24656728, Length=336, Percent_Identity=25, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656724, Length=336, Percent_Identity=25, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656720, Length=336, Percent_Identity=25, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656715, Length=336, Percent_Identity=25, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357035, Length=336, Percent_Identity=25, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 46123; Mature: 46123

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTSSTEKPMQSTGLGHSVAQWQHSHGFSNQNTAGEKNTRYVLYLTVITMVAEIVAGTI
CCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHH
YGSMALLADGWHMGTHAAAFMITLFAYSYARKHANDPAFAFGTGKVSVLGGYTSAIALGL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCHHHHHHHHH
VALVMLIESGMRLINPEDIHFNEAIFVALIGLSVNVLSVFLLKDHHSHDHGHSHGHSHGH
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
SHSHSHGHDHDDEDDDHKDHQDNHCCHGNDHHAADHDHDHDHDHDHDHDHDHDHDHDHDH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DHDHDHDDHSHSQAQGHSHGHSHGHSGHDHNLRAAYFHVLADALTSVLAIAALLFGKYMG
CCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTWLDPIMGIVGAIIISRWSWGLIQQTSPILLDGGVKASLQCKVRETIEAVPDHQVADLH
HHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEECCCCEEEEEHHHHHHHHCCCCCEEEEE
IWRVSADHHAMMVSIVSHSPKEASYFNQLLTKFPELSHITIELHTCRQRECVAKEA
EEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHCCC
>Mature Secondary Structure
MKTTSSTEKPMQSTGLGHSVAQWQHSHGFSNQNTAGEKNTRYVLYLTVITMVAEIVAGTI
CCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHH
YGSMALLADGWHMGTHAAAFMITLFAYSYARKHANDPAFAFGTGKVSVLGGYTSAIALGL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCHHHHHHHHH
VALVMLIESGMRLINPEDIHFNEAIFVALIGLSVNVLSVFLLKDHHSHDHGHSHGHSHGH
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
SHSHSHGHDHDDEDDDHKDHQDNHCCHGNDHHAADHDHDHDHDHDHDHDHDHDHDHDHDH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DHDHDHDDHSHSQAQGHSHGHSHGHSGHDHNLRAAYFHVLADALTSVLAIAALLFGKYMG
CCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTWLDPIMGIVGAIIISRWSWGLIQQTSPILLDGGVKASLQCKVRETIEAVPDHQVADLH
HHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEECCCCEEEEEHHHHHHHHCCCCCEEEEE
IWRVSADHHAMMVSIVSHSPKEASYFNQLLTKFPELSHITIELHTCRQRECVAKEA
EEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]