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The map label for this gene is copA [H]

Identifier: 117920556

GI number: 117920556

Start: 2535414

End: 2537825

Strand: Direct

Name: copA [H]

Synonym: Shewana3_2112

Alternate gene names: 117920556

Gene position: 2535414-2537825 (Clockwise)

Preceding gene: 117920555

Following gene: 117920557

Centisome position: 50.99

GC content: 50.25

Gene sequence:

>2412_bases
ATGAATATTGCTATGACACATCCAAGTTGTTTTCACTGTAATGAGCCCGTGCTTACGGGCACTCAGTTTGTCACCCGTAT
CAATGATCGCGATGAACTCATGTGTTGCCCTGGCTGCCAAGCGGTATCCCAAGCCATTGTGGATGCAGGTTTATTAAGCT
ATTACAAGTTTCGAACCGAGCCCGGCAGTAAACAGACGGCACTGGTACCTGATGAATTAAATCAGTTTAGTGCCTACGAT
TTGCCCGAAGTACAGCAGGACTTTGTCCACTCAGAGGAAAATAGTGACTCTGTTTCGCTGTCCATCGATGGCATTACTTG
TGCGGCCTGTGCGTGGTTAATCGAGCATAAAGTGAAACAACTGCCTGGCGTCAGCCAAGTGATGGTCAACTCCACCACCC
AAAGGGCGATGATCAGCTGGGATAAACAGCAAGTTAAACTCAGTGATATTCTTGGGCAAATTAGCCGTATCGGTTATCAA
GCCGCGCCCTATCAAGTGGATGAGCAAGAACTGACCGCCAAGCAAAATAGCCGCAAATTCTTATTGCGCTTAGGCTTGGC
GGGTTTTGCGACTATGCAAGTGATGATGTTCGCCCTCGCCCTCTATACCGGTTACTTTACCGATTTGGATGTGCAATATC
GGGATTATTTCCGCTGGGTGAGCATGATTTTCGCCACGCCCGTGGTGCTGTATTCGGCGCAGCCCTTCTATTTCAGCGCC
ATTCGTACCCTGCTCAGTGGCAAACTCAATATGGATGTGTCGGTCTCTATCGCCATTGGCGGCGCCTATATTGCCAGTTG
CTTTGCCACCGTTAACGGCACGGGTGAAGTCTATTTTGAATCCGTTTCCATGTTTACCTTCTTCCTGCTGCTGGGGCGTT
ATTTCGAGCAGAAGGCAAGACAAAAGGCCTCCGTTAGCTCCAGCAATCTCCACAAATTAGTACCTCTTACGGCACATTTG
GTCACGGCCCAGGGGCAAGAAGAGATCCCCGCTAAGAAATTACGCCTTGGGGACATTATCCTCATTAAACCCGGCGAGAT
GGTTGCCGCCGACGGCATCGTAGTTGACGGCCATACCAGCATCAATGAAGCCATGCTCACCGGTGAGCAAATGCCGATTG
AAAAGCCCGTCGATAGCCAAGTGTTTGCTGGCACCATTAACCTAGACCAGCCTATCAAGGTAAAAGTCACCGCCCTTGGG
CAAGATCAATTGGTTGCCGAGATTATTCGTCTGCAGGAATTAGCCTCAAACACTAAACCTGCCGTCGCTATGTTGGCCGA
TAAATTGTCGCGTTATTTCTCAGGCACTATCTTAACCATTGCGACAATCACCTATCTGGTATGGCTGCAAATCTCCCCCG
AAGATGCCTTTTGGGTCACCTTGTCGGTATTAGTGGCCACCTGCCCTTGTGCCCTTGCGCTGGCGACCCCGACAGCCGTC
ACCTGTGCGACAGCTATTTTTACTCGCCTTGGGATCATTACCCGTAAGGCGGGCGTCTTTGAAAAACTGCCACAAATTAA
GCATGTGGTATTTGATAAAACTGGCACTCTCACCTGCGGCACCCTATCGATAGCCAAAGTTGAGTGCCATAAAGATTTCA
CCCAAGAACAAGCACTGGCGATTGCTGCGGCGTTAGAATCAGGCTCACGCCACCCCATCGCTGCGGCCTTTGCCAGCTTT
AGCCAAACCGATGTGATTGCCGAGCAAGTTCACCATGAAGTGGGTTTTGGGGTGAAAGGCTTGATTAATGGCACCGAATA
CCGCATTGGTAACGCAAGCTTCACGGGTGCTACCGCCAAGCCCAAGCTTGCAAATCAGCTGATTTGGCTCGCCCGCAGCC
ATAATGGCCAGCTTGAAGTCATCGCCACTATTGAGATCCAAGATAATATCCGTGTCGATAGCAAAGAAACCGTCGATATT
TTGAAGCAGCAAGGTTGCCAGGTCAGTATTGCCAGTGGCGATAGCTCTGGGCATGTGCATCAATTGGCGAAAGAACTCGG
GATTAACGATGTCCACAGTGGACTGACTCCAGCCGATAAACTGGCACTGGTGACCAAACTACAACAATCGACACCAGTTG
CGATGTTCGGCGATGGCATTAATGATGCACCAGTCTTGGCGGGCGCCGATTTGTCGGTGGCTATGGGGAGCGGCAGCGCG
ATTGCGAAAAACAGCGCCGATCTCATTCTGCTTGGCGATCACCTCTCTCGCTTCACCCAAGCGGTCAAGGTTGCTAAACT
GACCACACAAATTATTCGTCAAAACCTCGCTTGGGCCTTAGGCTATAACGCGCTGATTTTACCGCTGGCGGTAACTGGGC
ATGTTGCGCCTTATATTGCCGCCCTTGGCATGTCGGCAAGCTCTTTGATTGTTGTGGGTAACAGTTTGAGATTATTACGA
ATTAAATTATAA

Upstream 100 bases:

>100_bases
TGGGAAGTCCGTCTGGAAGGTTTTGATGGCAAATGGCGTATTCATCAACGTGTCGAACTCAAAGACAACGTCCAATTGTG
GTTGAACTAATTGTGGTTGA

Downstream 100 bases:

>100_bases
CAACAAAAAGGCTTAGGTTATGAGCATCATTTATGTACTAATTCCTATCGCGATGATCTTTGTGTTGATCGCCGTAGCCG
TGTTCTTTTGGGCAGTAAAA

Product: heavy metal translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 803; Mature: 803

Protein sequence:

>803_residues
MNIAMTHPSCFHCNEPVLTGTQFVTRINDRDELMCCPGCQAVSQAIVDAGLLSYYKFRTEPGSKQTALVPDELNQFSAYD
LPEVQQDFVHSEENSDSVSLSIDGITCAACAWLIEHKVKQLPGVSQVMVNSTTQRAMISWDKQQVKLSDILGQISRIGYQ
AAPYQVDEQELTAKQNSRKFLLRLGLAGFATMQVMMFALALYTGYFTDLDVQYRDYFRWVSMIFATPVVLYSAQPFYFSA
IRTLLSGKLNMDVSVSIAIGGAYIASCFATVNGTGEVYFESVSMFTFFLLLGRYFEQKARQKASVSSSNLHKLVPLTAHL
VTAQGQEEIPAKKLRLGDIILIKPGEMVAADGIVVDGHTSINEAMLTGEQMPIEKPVDSQVFAGTINLDQPIKVKVTALG
QDQLVAEIIRLQELASNTKPAVAMLADKLSRYFSGTILTIATITYLVWLQISPEDAFWVTLSVLVATCPCALALATPTAV
TCATAIFTRLGIITRKAGVFEKLPQIKHVVFDKTGTLTCGTLSIAKVECHKDFTQEQALAIAAALESGSRHPIAAAFASF
SQTDVIAEQVHHEVGFGVKGLINGTEYRIGNASFTGATAKPKLANQLIWLARSHNGQLEVIATIEIQDNIRVDSKETVDI
LKQQGCQVSIASGDSSGHVHQLAKELGINDVHSGLTPADKLALVTKLQQSTPVAMFGDGINDAPVLAGADLSVAMGSGSA
IAKNSADLILLGDHLSRFTQAVKVAKLTTQIIRQNLAWALGYNALILPLAVTGHVAPYIAALGMSASSLIVVGNSLRLLR
IKL

Sequences:

>Translated_803_residues
MNIAMTHPSCFHCNEPVLTGTQFVTRINDRDELMCCPGCQAVSQAIVDAGLLSYYKFRTEPGSKQTALVPDELNQFSAYD
LPEVQQDFVHSEENSDSVSLSIDGITCAACAWLIEHKVKQLPGVSQVMVNSTTQRAMISWDKQQVKLSDILGQISRIGYQ
AAPYQVDEQELTAKQNSRKFLLRLGLAGFATMQVMMFALALYTGYFTDLDVQYRDYFRWVSMIFATPVVLYSAQPFYFSA
IRTLLSGKLNMDVSVSIAIGGAYIASCFATVNGTGEVYFESVSMFTFFLLLGRYFEQKARQKASVSSSNLHKLVPLTAHL
VTAQGQEEIPAKKLRLGDIILIKPGEMVAADGIVVDGHTSINEAMLTGEQMPIEKPVDSQVFAGTINLDQPIKVKVTALG
QDQLVAEIIRLQELASNTKPAVAMLADKLSRYFSGTILTIATITYLVWLQISPEDAFWVTLSVLVATCPCALALATPTAV
TCATAIFTRLGIITRKAGVFEKLPQIKHVVFDKTGTLTCGTLSIAKVECHKDFTQEQALAIAAALESGSRHPIAAAFASF
SQTDVIAEQVHHEVGFGVKGLINGTEYRIGNASFTGATAKPKLANQLIWLARSHNGQLEVIATIEIQDNIRVDSKETVDI
LKQQGCQVSIASGDSSGHVHQLAKELGINDVHSGLTPADKLALVTKLQQSTPVAMFGDGINDAPVLAGADLSVAMGSGSA
IAKNSADLILLGDHLSRFTQAVKVAKLTTQIIRQNLAWALGYNALILPLAVTGHVAPYIAALGMSASSLIVVGNSLRLLR
IKL
>Mature_803_residues
MNIAMTHPSCFHCNEPVLTGTQFVTRINDRDELMCCPGCQAVSQAIVDAGLLSYYKFRTEPGSKQTALVPDELNQFSAYD
LPEVQQDFVHSEENSDSVSLSIDGITCAACAWLIEHKVKQLPGVSQVMVNSTTQRAMISWDKQQVKLSDILGQISRIGYQ
AAPYQVDEQELTAKQNSRKFLLRLGLAGFATMQVMMFALALYTGYFTDLDVQYRDYFRWVSMIFATPVVLYSAQPFYFSA
IRTLLSGKLNMDVSVSIAIGGAYIASCFATVNGTGEVYFESVSMFTFFLLLGRYFEQKARQKASVSSSNLHKLVPLTAHL
VTAQGQEEIPAKKLRLGDIILIKPGEMVAADGIVVDGHTSINEAMLTGEQMPIEKPVDSQVFAGTINLDQPIKVKVTALG
QDQLVAEIIRLQELASNTKPAVAMLADKLSRYFSGTILTIATITYLVWLQISPEDAFWVTLSVLVATCPCALALATPTAV
TCATAIFTRLGIITRKAGVFEKLPQIKHVVFDKTGTLTCGTLSIAKVECHKDFTQEQALAIAAALESGSRHPIAAAFASF
SQTDVIAEQVHHEVGFGVKGLINGTEYRIGNASFTGATAKPKLANQLIWLARSHNGQLEVIATIEIQDNIRVDSKETVDI
LKQQGCQVSIASGDSSGHVHQLAKELGINDVHSGLTPADKLALVTKLQQSTPVAMFGDGINDAPVLAGADLSVAMGSGSA
IAKNSADLILLGDHLSRFTQAVKVAKLTTQIIRQNLAWALGYNALILPLAVTGHVAPYIAALGMSASSLIVVGNSLRLLR
IKL

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=806, Percent_Identity=28.6600496277916, Blast_Score=298, Evalue=1e-80,
Organism=Homo sapiens, GI115529486, Length=818, Percent_Identity=26.161369193154, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI55743073, Length=591, Percent_Identity=28.087986463621, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI118498343, Length=160, Percent_Identity=31.25, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1786691, Length=836, Percent_Identity=29.5454545454545, Blast_Score=304, Evalue=1e-83,
Organism=Escherichia coli, GI1789879, Length=719, Percent_Identity=31.1543810848401, Blast_Score=290, Evalue=3e-79,
Organism=Escherichia coli, GI1786914, Length=539, Percent_Identity=24.860853432282, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17556548, Length=798, Percent_Identity=26.4411027568922, Blast_Score=239, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI17557486, Length=94, Percent_Identity=39.3617021276596, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17557770, Length=186, Percent_Identity=26.3440860215054, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32566766, Length=186, Percent_Identity=26.3440860215054, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319772, Length=666, Percent_Identity=30.7807807807808, Blast_Score=270, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6320475, Length=735, Percent_Identity=28.0272108843537, Blast_Score=266, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6321271, Length=271, Percent_Identity=23.2472324723247, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221329854, Length=526, Percent_Identity=30.0380228136882, Blast_Score=208, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR001366
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 86798; Mature: 86798

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAMTHPSCFHCNEPVLTGTQFVTRINDRDELMCCPGCQAVSQAIVDAGLLSYYKFRTE
CCEEECCCCCCCCCCCCCCCHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHEECC
PGSKQTALVPDELNQFSAYDLPEVQQDFVHSEENSDSVSLSIDGITCAACAWLIEHKVKQ
CCCCCEEECHHHHCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHH
LPGVSQVMVNSTTQRAMISWDKQQVKLSDILGQISRIGYQAAPYQVDEQELTAKQNSRKF
CCCHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHE
LLRLGLAGFATMQVMMFALALYTGYFTDLDVQYRDYFRWVSMIFATPVVLYSAQPFYFSA
EEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCHHHHH
IRTLLSGKLNMDVSVSIAIGGAYIASCFATVNGTGEVYFESVSMFTFFLLLGRYFEQKAR
HHHHHCCCCCCCEEEEEEECHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
QKASVSSSNLHKLVPLTAHLVTAQGQEEIPAKKLRLGDIILIKPGEMVAADGIVVDGHTS
HHHCCCCCCCHHHHHHHHEEEECCCCCCCCHHHEEECCEEEECCCCEEEECCEEECCCCC
INEAMLTGEQMPIEKPVDSQVFAGTINLDQPIKVKVTALGQDQLVAEIIRLQELASNTKP
HHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCC
AVAMLADKLSRYFSGTILTIATITYLVWLQISPEDAFWVTLSVLVATCPCALALATPTAV
HHHHHHHHHHHHHCCHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHCCHHHHHCCCHHH
TCATAIFTRLGIITRKAGVFEKLPQIKHVVFDKTGTLTCGTLSIAKVECHKDFTQEQALA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEECCEEEEEEHHHHHHHHHHHHH
IAAALESGSRHPIAAAFASFSQTDVIAEQVHHEVGFGVKGLINGTEYRIGNASFTGATAK
HHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCEEECCCEEEECCCEECCCCCC
PKLANQLIWLARSHNGQLEVIATIEIQDNIRVDSKETVDILKQQGCQVSIASGDSSGHVH
CHHHHHEEEEEECCCCCEEEEEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHH
QLAKELGINDVHSGLTPADKLALVTKLQQSTPVAMFGDGINDAPVLAGADLSVAMGSGSA
HHHHHCCCCHHHCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCCEEEECCCCE
IAKNSADLILLGDHLSRFTQAVKVAKLTTQIIRQNLAWALGYNALILPLAVTGHVAPYIA
EECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHH
ALGMSASSLIVVGNSLRLLRIKL
HHCCCCCEEEEECCCEEEEEEEC
>Mature Secondary Structure
MNIAMTHPSCFHCNEPVLTGTQFVTRINDRDELMCCPGCQAVSQAIVDAGLLSYYKFRTE
CCEEECCCCCCCCCCCCCCCHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHEECC
PGSKQTALVPDELNQFSAYDLPEVQQDFVHSEENSDSVSLSIDGITCAACAWLIEHKVKQ
CCCCCEEECHHHHCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHH
LPGVSQVMVNSTTQRAMISWDKQQVKLSDILGQISRIGYQAAPYQVDEQELTAKQNSRKF
CCCHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHE
LLRLGLAGFATMQVMMFALALYTGYFTDLDVQYRDYFRWVSMIFATPVVLYSAQPFYFSA
EEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCHHHHH
IRTLLSGKLNMDVSVSIAIGGAYIASCFATVNGTGEVYFESVSMFTFFLLLGRYFEQKAR
HHHHHCCCCCCCEEEEEEECHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
QKASVSSSNLHKLVPLTAHLVTAQGQEEIPAKKLRLGDIILIKPGEMVAADGIVVDGHTS
HHHCCCCCCCHHHHHHHHEEEECCCCCCCCHHHEEECCEEEECCCCEEEECCEEECCCCC
INEAMLTGEQMPIEKPVDSQVFAGTINLDQPIKVKVTALGQDQLVAEIIRLQELASNTKP
HHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCC
AVAMLADKLSRYFSGTILTIATITYLVWLQISPEDAFWVTLSVLVATCPCALALATPTAV
HHHHHHHHHHHHHCCHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHCCHHHHHCCCHHH
TCATAIFTRLGIITRKAGVFEKLPQIKHVVFDKTGTLTCGTLSIAKVECHKDFTQEQALA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEECCEEEEEEHHHHHHHHHHHHH
IAAALESGSRHPIAAAFASFSQTDVIAEQVHHEVGFGVKGLINGTEYRIGNASFTGATAK
HHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCEEECCCEEEECCCEECCCCCC
PKLANQLIWLARSHNGQLEVIATIEIQDNIRVDSKETVDILKQQGCQVSIASGDSSGHVH
CHHHHHEEEEEECCCCCEEEEEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHH
QLAKELGINDVHSGLTPADKLALVTKLQQSTPVAMFGDGINDAPVLAGADLSVAMGSGSA
HHHHHCCCCHHHCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCCEEEECCCCE
IAKNSADLILLGDHLSRFTQAVKVAKLTTQIIRQNLAWALGYNALILPLAVTGHVAPYIA
EECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHH
ALGMSASSLIVVGNSLRLLRIKL
HHCCCCCEEEEECCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA