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The map label for this gene is lrp [H]

Identifier: 117920493

GI number: 117920493

Start: 2457090

End: 2457596

Strand: Direct

Name: lrp [H]

Synonym: Shewana3_2049

Alternate gene names: 117920493

Gene position: 2457090-2457596 (Clockwise)

Preceding gene: 117920490

Following gene: 117920494

Centisome position: 49.42

GC content: 41.81

Gene sequence:

>507_bases
ATGGCATATAATAAAAAGAGTCCTGTAAAAGACTTGGATCGCATCGATCGCAACATTCTTAATGAATTACAAATTGATGG
ACGCATTTCAAATGTGGAACTGTCTAAAAGAGTAGGATTAAGTCCCACTCCGTGTTTAGAAAGAGTGAAACGACTCGAAA
AGCAAGGATATATCAACGGCTATACCGCCTTGGTAAATCCTCATTTCTTGGGTGCATCCCTACTGGTATTCGTGGAAATC
ACCTTGAGCCGTGATACTCCCGAAGTATTTGATAAGTTTAATCGCGCTGTGCAACTGTTAGATGATATTCAAGAGTGTCA
TCTGGTTTCTGGTGACTTTGACTACTTATTGAAGACACGTGTTTCTGATATGTCAGCTTATCGCCGTTTACTCGGTGAGA
CGCTGCTGAAATTACCTTCAGTGTCCGATACCCGTACTTACGTGGTGATGGAAGAAGTGAAACACACGAGTCGTGTCGCG
ATAAACCATCTGCTCTCCGATATTTAA

Upstream 100 bases:

>100_bases
AGGGATATCTAGTATAGTATCGGCGACGCAGTTTATGCTGCTGAACTTTAGACATACGTAGAATAAAATGTTGTTTTAGT
GATAAAGCAAGGTTAAATAA

Downstream 100 bases:

>100_bases
TACCCTGAACGTTTACAATAAGGGGCCTCGGCCCCTTATTTATTCCTACGATCACCGTTTCGAACTCAAAAATGACCTTG
CTTAGCCCTTAGGTTTGCCA

Product: leucine-responsive transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MAYNKKSPVKDLDRIDRNILNELQIDGRISNVELSKRVGLSPTPCLERVKRLEKQGYINGYTALVNPHFLGASLLVFVEI
TLSRDTPEVFDKFNRAVQLLDDIQECHLVSGDFDYLLKTRVSDMSAYRRLLGETLLKLPSVSDTRTYVVMEEVKHTSRVA
INHLLSDI

Sequences:

>Translated_168_residues
MAYNKKSPVKDLDRIDRNILNELQIDGRISNVELSKRVGLSPTPCLERVKRLEKQGYINGYTALVNPHFLGASLLVFVEI
TLSRDTPEVFDKFNRAVQLLDDIQECHLVSGDFDYLLKTRVSDMSAYRRLLGETLLKLPSVSDTRTYVVMEEVKHTSRVA
INHLLSDI
>Mature_167_residues
AYNKKSPVKDLDRIDRNILNELQIDGRISNVELSKRVGLSPTPCLERVKRLEKQGYINGYTALVNPHFLGASLLVFVEIT
LSRDTPEVFDKFNRAVQLLDDIQECHLVSGDFDYLLKTRVSDMSAYRRLLGETLLKLPSVSDTRTYVVMEEVKHTSRVAI
NHLLSDI

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=161, Percent_Identity=79.5031055900621, Blast_Score=267, Evalue=3e-73,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=33.112582781457, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1790182, Length=142, Percent_Identity=26.7605633802817, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 19177; Mature: 19046

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYNKKSPVKDLDRIDRNILNELQIDGRISNVELSKRVGLSPTPCLERVKRLEKQGYING
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCCCCCHHHHHHHHHHHCCCCCC
YTALVNPHFLGASLLVFVEITLSRDTPEVFDKFNRAVQLLDDIQECHLVSGDFDYLLKTR
HHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VSDMSAYRRLLGETLLKLPSVSDTRTYVVMEEVKHTSRVAINHLLSDI
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AYNKKSPVKDLDRIDRNILNELQIDGRISNVELSKRVGLSPTPCLERVKRLEKQGYING
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCCCCCHHHHHHHHHHHCCCCCC
YTALVNPHFLGASLLVFVEITLSRDTPEVFDKFNRAVQLLDDIQECHLVSGDFDYLLKTR
HHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VSDMSAYRRLLGETLLKLPSVSDTRTYVVMEEVKHTSRVAINHLLSDI
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]