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The map label for this gene is mmgC [H]

Identifier: 117920119

GI number: 117920119

Start: 1964658

End: 1965827

Strand: Reverse

Name: mmgC [H]

Synonym: Shewana3_1672

Alternate gene names: 117920119

Gene position: 1965827-1964658 (Counterclockwise)

Preceding gene: 117920120

Following gene: 117920118

Centisome position: 39.54

GC content: 51.11

Gene sequence:

>1170_bases
ATGAACTCACTCTACACCAGTCTCAATTTTGGCCTAGGCGAAGAAGTCGATATGCTGCGCGATGCGGTGCAAGATTTCGC
TAAACACGAAATCGCCCCTATTGCCGCTAAAGTCGACCACGACAACGCCTTTCCTAACGAAATTTGGCCCGTACTCGGTG
GAATGGGACTCTTAGGTGTTACTGTGCCTGAGGAATACGGCGGTGCAAATATGGGCTATCTTGCCCACGTGGTCGCCATG
GAAGAGATCTCCCGCGCCTCGGCCTCAATCGGATTAAGTTACGGCGCCCACTCTAACCTGTGCGTAAACCAAATTAACCG
CAACGGTAATGCAGAGCAAAAAGCCAAGTATTTACCAAAGCTGGTCAGCGGTGAACATATCGGCGCACTGGCGATGAGTG
AGCCCAATGCAGGCTCAGATGTGGTTTCGATGAAGCTGCATGCCCGTAAAGAAGGCGACCGTTACATCCTTAATGGCAAC
AAGATGTGGATCACCAACGGTCCCGATGCCAATACCTATGTGATTTATGCCAAAACCGACTTAACCAAAGGCGCACACGG
TATCACCGCCTTTATCGTTGAGCGTGGTTTTAAAGGTTTCAGCCAAGCGCAAAAACTCGACAAACTGGGGATGCGCGGTT
CAAACACCTGTGAACTGGTGTTTGAAGATGTCGAAGTACCAGAGGAAAACATTCTCGGCGGCCTCAACAATGGCGTTAAA
GTGCTGATGAGTGGCTTAGATTACGAGCGCGTCGTGCTCTCAGGCGGCCCGCTTGGGATCATGAACGCCTGTATGGACAT
CGTCGTGCCTTATATCCACGAGCGTGAGCAATTTGGTAAATCCATCGGTGAATTCCAATTAGTCCAAGGCAAATTAGCCG
ATATGTACACAGGTATGAACGCCGCTAAAGCCTATGTGTATAGCGTAGCGAAATCCTGCGATCGCGGTGAAACCACCCGT
AAAGACGCCGCAGGCGCCATCCTTTACAGCGCGGAGCTGGCGACCAAAATGGCTCTGGATGCCATTCAATTACTCGGCGG
TAACGGTTACGTCAATGAGTATGCGACTGGCCGCTTACTGCGCGATGCCAAACTCTATGAGATTGGCGCTGGCACCTCAG
AAATTCGCCGTATGCTGATTGGCCGCGAGCTCTTTAACGAATCGAAATAA

Upstream 100 bases:

>100_bases
GCGTGACAGGGATATATCACGCACTGTAAGACGGTTTTAAAGACTCAAGCACCTAATAATCATAAAAATATAAATTAGAA
CCTAAGATAGGACACAAGCA

Downstream 100 bases:

>100_bases
GCAGCCTAGGGCGAACGGCGCATGACGAGCTTTAGCCTTTCATGCTCCTCGCCCACCGAGCCAACTGATACTGAGTTACC
GCTTTATAAGGACAATCAAA

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MNSLYTSLNFGLGEEVDMLRDAVQDFAKHEIAPIAAKVDHDNAFPNEIWPVLGGMGLLGVTVPEEYGGANMGYLAHVVAM
EEISRASASIGLSYGAHSNLCVNQINRNGNAEQKAKYLPKLVSGEHIGALAMSEPNAGSDVVSMKLHARKEGDRYILNGN
KMWITNGPDANTYVIYAKTDLTKGAHGITAFIVERGFKGFSQAQKLDKLGMRGSNTCELVFEDVEVPEENILGGLNNGVK
VLMSGLDYERVVLSGGPLGIMNACMDIVVPYIHEREQFGKSIGEFQLVQGKLADMYTGMNAAKAYVYSVAKSCDRGETTR
KDAAGAILYSAELATKMALDAIQLLGGNGYVNEYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFNESK

Sequences:

>Translated_389_residues
MNSLYTSLNFGLGEEVDMLRDAVQDFAKHEIAPIAAKVDHDNAFPNEIWPVLGGMGLLGVTVPEEYGGANMGYLAHVVAM
EEISRASASIGLSYGAHSNLCVNQINRNGNAEQKAKYLPKLVSGEHIGALAMSEPNAGSDVVSMKLHARKEGDRYILNGN
KMWITNGPDANTYVIYAKTDLTKGAHGITAFIVERGFKGFSQAQKLDKLGMRGSNTCELVFEDVEVPEENILGGLNNGVK
VLMSGLDYERVVLSGGPLGIMNACMDIVVPYIHEREQFGKSIGEFQLVQGKLADMYTGMNAAKAYVYSVAKSCDRGETTR
KDAAGAILYSAELATKMALDAIQLLGGNGYVNEYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFNESK
>Mature_389_residues
MNSLYTSLNFGLGEEVDMLRDAVQDFAKHEIAPIAAKVDHDNAFPNEIWPVLGGMGLLGVTVPEEYGGANMGYLAHVVAM
EEISRASASIGLSYGAHSNLCVNQINRNGNAEQKAKYLPKLVSGEHIGALAMSEPNAGSDVVSMKLHARKEGDRYILNGN
KMWITNGPDANTYVIYAKTDLTKGAHGITAFIVERGFKGFSQAQKLDKLGMRGSNTCELVFEDVEVPEENILGGLNNGVK
VLMSGLDYERVVLSGGPLGIMNACMDIVVPYIHEREQFGKSIGEFQLVQGKLADMYTGMNAAKAYVYSVAKSCDRGETTR
KDAAGAILYSAELATKMALDAIQLLGGNGYVNEYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFNESK

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=64.8936170212766, Blast_Score=515, Evalue=1e-146,
Organism=Homo sapiens, GI226958414, Length=339, Percent_Identity=67.8466076696165, Blast_Score=491, Evalue=1e-139,
Organism=Homo sapiens, GI4557233, Length=386, Percent_Identity=40.9326424870466, Blast_Score=291, Evalue=1e-78,
Organism=Homo sapiens, GI4501859, Length=371, Percent_Identity=36.3881401617251, Blast_Score=262, Evalue=5e-70,
Organism=Homo sapiens, GI21361497, Length=380, Percent_Identity=38.1578947368421, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=35.3246753246753, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=35.3246753246753, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI4501857, Length=376, Percent_Identity=34.0425531914894, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI76496475, Length=376, Percent_Identity=34.3085106382979, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4557235, Length=376, Percent_Identity=34.3085106382979, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI7656849, Length=383, Percent_Identity=31.5926892950392, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI4503943, Length=369, Percent_Identity=29.810298102981, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI7669494, Length=365, Percent_Identity=30.4109589041096, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI48976061, Length=284, Percent_Identity=25, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI211971008, Length=284, Percent_Identity=25, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38505218, Length=292, Percent_Identity=22.9452054794521, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786223, Length=383, Percent_Identity=28.1984334203655, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI87081958, Length=384, Percent_Identity=30.46875, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI87082384, Length=259, Percent_Identity=26.2548262548263, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87081702, Length=341, Percent_Identity=25.5131964809384, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=63.6842105263158, Blast_Score=513, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17506239, Length=378, Percent_Identity=34.3915343915344, Blast_Score=248, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=37.2703412073491, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=33.9622641509434, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=35.6020942408377, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17570075, Length=386, Percent_Identity=32.6424870466321, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71990804, Length=276, Percent_Identity=39.4927536231884, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17533517, Length=379, Percent_Identity=31.1345646437995, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71985184, Length=353, Percent_Identity=34.8441926345609, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=37.6623376623377, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17505929, Length=366, Percent_Identity=31.4207650273224, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=30.2452316076294, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=33.2116788321168, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71985192, Length=313, Percent_Identity=33.8658146964856, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17534353, Length=375, Percent_Identity=29.0666666666667, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17531909, Length=246, Percent_Identity=30.8943089430894, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21355753, Length=384, Percent_Identity=60.9375, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI21356377, Length=376, Percent_Identity=40.4255319148936, Blast_Score=291, Evalue=7e-79,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=37.5, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24666513, Length=379, Percent_Identity=34.8284960422164, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24660351, Length=387, Percent_Identity=35.9173126614987, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI281363737, Length=359, Percent_Identity=33.4261838440111, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI19920834, Length=389, Percent_Identity=29.5629820051414, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42123; Mature: 42123

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSLYTSLNFGLGEEVDMLRDAVQDFAKHEIAPIAAKVDHDNAFPNEIWPVLGGMGLLGV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCHHHHHHHCCCCEEEE
TVPEEYGGANMGYLAHVVAMEEISRASASIGLSYGAHSNLCVNQINRNGNAEQKAKYLPK
ECCHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCCCHHHHHHHHHH
LVSGEHIGALAMSEPNAGSDVVSMKLHARKEGDRYILNGNKMWITNGPDANTYVIYAKTD
HHCCCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEECCCEEEEECCCCCCEEEEEEECC
LTKGAHGITAFIVERGFKGFSQAQKLDKLGMRGSNTCELVFEDVEVPEENILGGLNNGVK
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHCCCCCCCHH
VLMSGLDYERVVLSGGPLGIMNACMDIVVPYIHEREQFGKSIGEFQLVQGKLADMYTGMN
HHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCH
AAKAYVYSVAKSCDRGETTRKDAAGAILYSAELATKMALDAIQLLGGNGYVNEYATGRLL
HHHHHHHHHHHHCCCCCCCHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHCHHH
RDAKLYEIGAGTSEIRRMLIGRELFNESK
HCCEEEEECCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNSLYTSLNFGLGEEVDMLRDAVQDFAKHEIAPIAAKVDHDNAFPNEIWPVLGGMGLLGV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCHHHHHHHCCCCEEEE
TVPEEYGGANMGYLAHVVAMEEISRASASIGLSYGAHSNLCVNQINRNGNAEQKAKYLPK
ECCHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCCCHHHHHHHHHH
LVSGEHIGALAMSEPNAGSDVVSMKLHARKEGDRYILNGNKMWITNGPDANTYVIYAKTD
HHCCCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEECCCEEEEECCCCCCEEEEEEECC
LTKGAHGITAFIVERGFKGFSQAQKLDKLGMRGSNTCELVFEDVEVPEENILGGLNNGVK
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHCCCCCCCHH
VLMSGLDYERVVLSGGPLGIMNACMDIVVPYIHEREQFGKSIGEFQLVQGKLADMYTGMN
HHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCH
AAKAYVYSVAKSCDRGETTRKDAAGAILYSAELATKMALDAIQLLGGNGYVNEYATGRLL
HHHHHHHHHHHHCCCCCCCHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHCHHH
RDAKLYEIGAGTSEIRRMLIGRELFNESK
HCCEEEEECCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]