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The map label for this gene is gcvR [H]

Identifier: 117920102

GI number: 117920102

Start: 1945555

End: 1946106

Strand: Reverse

Name: gcvR [H]

Synonym: Shewana3_1655

Alternate gene names: 117920102

Gene position: 1946106-1945555 (Counterclockwise)

Preceding gene: 117920107

Following gene: 117920101

Centisome position: 39.14

GC content: 47.28

Gene sequence:

>552_bases
ATGACCAATTTCCTGGTCGTAACCGCAATGGGCGTAGACCGTCCTGGACTCGTAAGTAAACTAGCTCGGCTTGCCAGCGA
CTGTGACTGCGATATCGTCGACAGCCGTATGGCATTATTTGGTAACGAATTTACCTTAATCATGATGTTGTCAGGTTCGT
GGGCATCCATAACGAAAATTGAAAGCCTGCTCCCGAGTCTCAGTGTTGAATTAGAACTGATGACAGTGATGAAGCGCACC
TCTAAACATACGCCGCAAAACTACCTTTCACGCCTTGAAGTGCGCTTTACCGGTAAGGATCAGCGCGGCACCATGAAGCT
TATCACCCAGTTCCTCGCCGACCGTTCCTTAGACTTAGCCGCAGTACGCTCTTTCTCTGAAGAACTCGACAACGGTGAGC
AAACCCAGACGATTTCGTTAACCATCAATATTCCTGAAAAAGTTGAACTAGAAAAGCTCGAAAAGAGTATCTATCAACTC
TCTGAAGAAATGGCACTGGATTGCACCATTAGACGCATGGAAGGCACCACCTCAAGAAGCGATAGAGGATAA

Upstream 100 bases:

>100_bases
CTCAAATTGAATTAGTTATGGTAGCATTACATCCCGCACAAAAACTCGGCACTCAGTCTCGAGTTTTCGCTCTATGATAT
CGAAAAAGTGAGGACAATTC

Downstream 100 bases:

>100_bases
TTGATGAACACATTAACCGCTGGCGCGAAAGCGCCGCTATTTACCCTTCAAGATCAACAGGGTAATGCTGTTTCTCTACA
AGAATGCTTAACGCGCGGCC

Product: glycine cleavage system transcriptional repressor

Products: NA

Alternate protein names: Gcv operon repressor [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MTNFLVVTAMGVDRPGLVSKLARLASDCDCDIVDSRMALFGNEFTLIMMLSGSWASITKIESLLPSLSVELELMTVMKRT
SKHTPQNYLSRLEVRFTGKDQRGTMKLITQFLADRSLDLAAVRSFSEELDNGEQTQTISLTINIPEKVELEKLEKSIYQL
SEEMALDCTIRRMEGTTSRSDRG

Sequences:

>Translated_183_residues
MTNFLVVTAMGVDRPGLVSKLARLASDCDCDIVDSRMALFGNEFTLIMMLSGSWASITKIESLLPSLSVELELMTVMKRT
SKHTPQNYLSRLEVRFTGKDQRGTMKLITQFLADRSLDLAAVRSFSEELDNGEQTQTISLTINIPEKVELEKLEKSIYQL
SEEMALDCTIRRMEGTTSRSDRG
>Mature_182_residues
TNFLVVTAMGVDRPGLVSKLARLASDCDCDIVDSRMALFGNEFTLIMMLSGSWASITKIESLLPSLSVELELMTVMKRTS
KHTPQNYLSRLEVRFTGKDQRGTMKLITQFLADRSLDLAAVRSFSEELDNGEQTQTISLTINIPEKVELEKLEKSIYQLS
EEMALDCTIRRMEGTTSRSDRG

Specific function: Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how gcvR acts as a repressor. It does not seem to bind DNA. It could interact with gcvA and suppress its activato

COG id: COG2716

COG function: function code E; Glycine cleavage system regulatory protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082113, Length=163, Percent_Identity=35.5828220858896, Blast_Score=110, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR016867 [H]

Pfam domain/function: PF01842 ACT [H]

EC number: NA

Molecular weight: Translated: 20551; Mature: 20420

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNFLVVTAMGVDRPGLVSKLARLASDCDCDIVDSRMALFGNEFTLIMMLSGSWASITKI
CCCEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHH
ESLLPSLSVELELMTVMKRTSKHTPQNYLSRLEVRFTGKDQRGTMKLITQFLADRSLDLA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEEECCCCCCCHHHHHHHHHHCCCCHHH
AVRSFSEELDNGEQTQTISLTINIPEKVELEKLEKSIYQLSEEMALDCTIRRMEGTTSRS
HHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCC
DRG
CCC
>Mature Secondary Structure 
TNFLVVTAMGVDRPGLVSKLARLASDCDCDIVDSRMALFGNEFTLIMMLSGSWASITKI
CCEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHH
ESLLPSLSVELELMTVMKRTSKHTPQNYLSRLEVRFTGKDQRGTMKLITQFLADRSLDLA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEEECCCCCCCHHHHHHHHHHCCCCHHH
AVRSFSEELDNGEQTQTISLTINIPEKVELEKLEKSIYQLSEEMALDCTIRRMEGTTSRS
HHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCC
DRG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537378; 9205837; 9278503; 2016588 [H]