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The map label for this gene is neuA [H]

Identifier: 117919757

GI number: 117919757

Start: 1524119

End: 1524835

Strand: Reverse

Name: neuA [H]

Synonym: Shewana3_1309

Alternate gene names: 117919757

Gene position: 1524835-1524119 (Counterclockwise)

Preceding gene: 117919758

Following gene: 117919756

Centisome position: 30.67

GC content: 47.98

Gene sequence:

>717_bases
ATGAAAATTGCCATAATTCCAGCCAGAGGCGGCAGTAAAAGAATACCAGGGAAAAATATTCGTCTGTTCCATGACAAACC
CATTATTGTGTGGTCCATCGAGGCGGCACTTGCCAGCGGTTGCTTTGATAAAGTCATTGTTTCTACTGATGATCCAAATA
TTACCGACATTGCGATTCAGGCCGGTGCAGAAGCCCCCTTTATGCGACCAGCTGAATTATCAGACGATATGACAGGAACC
ATGGCGGTGATCCGCCATGCCATCCACTGGCTAAATGGCACCTTGTCTCGGCAAAGTGGGGATATGGAGCTTACCCATGT
GTGTTGTATATATGCCACGGCCCCCTTCATCAGCGCCGAAGACATCAAAATTGGCTTGCAGAAGCTGACTAGTGGTGAAA
ACGACTACGCCCTGGCCGTCACCAATTTTGAATTTCCCATTCAACGTGCAGTGATACTCAATGCACAACATCAGCTTGAA
ATGTTACAACCCAACCACTTCATGACCCGCTCACAGGATCTGCCAATTGCATACCACGATGCAGGACAATTTTGCTGGGG
AACCACTGCAGCCTGGCTGCAACAGAAGGCCATCTTCACCAGCCCAACAGCACCGGTGTTTATTCCCAGTTATAGAGTGC
AGGATGTTGATACCGAAGACGATTGGATAAGAGCTGAACTCATGTTCAAAGCCATTTATACTATGCAGGGTGTGTGA

Upstream 100 bases:

>100_bases
GGCTGACTGCCTAGAATATGAATTACCCTTACAATTACAACAGCAGGCCACAGATCAAATCTGAAGCCTTGCTATTTGCA
GAATTGCAGAGAGTCCAGTT

Downstream 100 bases:

>100_bases
GGCCAATGGTGGATAATTTACAGGCAGCGTTATCAGACAGCCAGACCGTTGTTTTTCGCACAGACTCAAGCCGGAGCATA
GGTTATGGACATGTTATGCG

Product: acylneuraminate cytidylyltransferase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase; CMP-sialic acid synthase [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKIAIIPARGGSKRIPGKNIRLFHDKPIIVWSIEAALASGCFDKVIVSTDDPNITDIAIQAGAEAPFMRPAELSDDMTGT
MAVIRHAIHWLNGTLSRQSGDMELTHVCCIYATAPFISAEDIKIGLQKLTSGENDYALAVTNFEFPIQRAVILNAQHQLE
MLQPNHFMTRSQDLPIAYHDAGQFCWGTTAAWLQQKAIFTSPTAPVFIPSYRVQDVDTEDDWIRAELMFKAIYTMQGV

Sequences:

>Translated_238_residues
MKIAIIPARGGSKRIPGKNIRLFHDKPIIVWSIEAALASGCFDKVIVSTDDPNITDIAIQAGAEAPFMRPAELSDDMTGT
MAVIRHAIHWLNGTLSRQSGDMELTHVCCIYATAPFISAEDIKIGLQKLTSGENDYALAVTNFEFPIQRAVILNAQHQLE
MLQPNHFMTRSQDLPIAYHDAGQFCWGTTAAWLQQKAIFTSPTAPVFIPSYRVQDVDTEDDWIRAELMFKAIYTMQGV
>Mature_238_residues
MKIAIIPARGGSKRIPGKNIRLFHDKPIIVWSIEAALASGCFDKVIVSTDDPNITDIAIQAGAEAPFMRPAELSDDMTGT
MAVIRHAIHWLNGTLSRQSGDMELTHVCCIYATAPFISAEDIKIGLQKLTSGENDYALAVTNFEFPIQRAVILNAQHQLE
MLQPNHFMTRSQDLPIAYHDAGQFCWGTTAAWLQQKAIFTSPTAPVFIPSYRVQDVDTEDDWIRAELMFKAIYTMQGV

Specific function: Activates Kdo (A Required 8-Carbon Sugar) For Incorporation Into Bacterial Lipopolysaccharide In Gram-Negative Bacteria (By Similarity). [C]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=120, Percent_Identity=37.5, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 26453; Mature: 26453

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIIPARGGSKRIPGKNIRLFHDKPIIVWSIEAALASGCFDKVIVSTDDPNITDIAIQ
CEEEEEECCCCCCCCCCCCEEEEECCCEEEEEEHHHHHCCCCCEEEEECCCCCEEEEEEE
AGAEAPFMRPAELSDDMTGTMAVIRHAIHWLNGTLSRQSGDMELTHVCCIYATAPFISAE
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCCCCC
DIKIGLQKLTSGENDYALAVTNFEFPIQRAVILNAQHQLEMLQPNHFMTRSQDLPIAYHD
HHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCHHHHEEECCCCCCCCCCCCCEEEEC
AGQFCWGTTAAWLQQKAIFTSPTAPVFIPSYRVQDVDTEDDWIRAELMFKAIYTMQGV
CCCCCCCCHHHHHHHHHEEECCCCCEEECCEEEEECCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIAIIPARGGSKRIPGKNIRLFHDKPIIVWSIEAALASGCFDKVIVSTDDPNITDIAIQ
CEEEEEECCCCCCCCCCCCEEEEECCCEEEEEEHHHHHCCCCCEEEEECCCCCEEEEEEE
AGAEAPFMRPAELSDDMTGTMAVIRHAIHWLNGTLSRQSGDMELTHVCCIYATAPFISAE
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCCCCC
DIKIGLQKLTSGENDYALAVTNFEFPIQRAVILNAQHQLEMLQPNHFMTRSQDLPIAYHD
HHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCHHHHEEECCCCCCCCCCCCCEEEEC
AGQFCWGTTAAWLQQKAIFTSPTAPVFIPSYRVQDVDTEDDWIRAELMFKAIYTMQGV
CCCCCCCCHHHHHHHHHEEECCCCCEEECCEEEEECCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]