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The map label for this gene is deoA [H]

Identifier: 117919491

GI number: 117919491

Start: 1218945

End: 1220276

Strand: Direct

Name: deoA [H]

Synonym: Shewana3_1042

Alternate gene names: 117919491

Gene position: 1218945-1220276 (Clockwise)

Preceding gene: 117919490

Following gene: 117919492

Centisome position: 24.52

GC content: 50.08

Gene sequence:

>1332_bases
ATGTTTCTAGCTCAGGAAATTATACGTAAGAAACGCAATGGGTTAGCCTTAAGTACAGAAGAGATCCAGTTCTTCGTTAA
GGGCATAACCACTAATGCAGTGTCGGAAGGTCAGATCGCCGCACTAGGCATGGCTGTGTATTTTAATGACATGAATATGG
ATGAAAGAATCGCTTTGACCACGGCAATGCGCGATTCTGGCACTGTACTCAACTGGCAATCACTTGGTCTGAATGGCCCT
GTCATCGATAAACACAGTACAGGTGGTGTCGGTGATGTGATTAGTCTCATGCTCGGCCCCATGGCTGCGGCTTGCGGTGG
TTATGTGCCGATGATTTCGGGTCGCGGACTCGGACACACAGGCGGTACGCTCGATAAGTTCGACGCTATTCCCGGTTATC
AAACCGAACCTTCGAGTGAATTGTTCCGCAAAGTAGTTAAAGACGTTGGTGTGGCGATTATCGGCCAAACTGGCGATCTG
GTTCCCGCCGATAAACGTTTTTATTCCATCCGTGACAACACTGCGACCGTCGAATCCATCTCCCTCATCACCGCCTCAAT
TCTCTCTAAGAAATTAGCTTGTAGTCTCGATGCATTGGCGATGGACGTCAAAGTCGGTAGCGGCGCATTTATGCCAACTT
ACGAAGCCTCTGAAGAGCTTGCTCGCAGCATTGCGGCGGTAGCCAATGGCGCAGGTACTAAAACGACGGCCTTACTCACC
GACATGAACCAAGTGTTAGCCTCATGTGCGGGTAATGCGGTTGAAGTGAAAGAAGCCATCGATTTTTTAACCGGTGCTTA
CCGTAATCCTCGCCTCTACGCAGTGACTATGGGGCTATGTGCCGAGATGTTACTCCTGGGTGGTCTGGCGAGCGATGAAG
CCGATGCCCGTGCCAAGTTGAACCGCGTGCTAGACAACGGCCGTGCTGCCGAGATCTTTGGCAAGATGGTTTCAGGCCTC
GGTGGCCCCGTCGATTTTGTCGAAAACTACAGTAAGTACTTACCGCAATCACAAATTATTCGCCCTGTCTTTGCGGATAC
CCAAGGTTATGCTTACAGCATGGATACCCGCGAACTCGGTTTAGCCGTGGTTACCTTAGGTGGTGGTCGTCGCAAACCTG
GTGATGCACTCGACTACAGTGTTGGTTTGACGCAAGTCTGTGCCCTTGGCGATAAAATTGATGCTTCTACGCCGATTGCT
GTGATCCACGCGCAATCTGAAGAAGCCTTTGCGCAGGCAGAAGAAGCGGTGAAAAAAGCGATTCATATCGATGAAGTCGC
TCCAGAAAAAACACCTGAGATCTATGCTTATATTCGAGCTTCGGATCTTTAA

Upstream 100 bases:

>100_bases
TTCGATAGCATGTAATTGTAATATTGCTACAGTTTTGATGTTTCATTGCAAAGCTAAATAACGGATATGTTGTATTAGTA
TTTAGCTTGGAGGCAGTATC

Downstream 100 bases:

>100_bases
GGAAGAATTATGAAACGTACAGTTATAATGATGTTGGATTCCTTTGGCGTGGGCGCTGCTGGTGACGCCGCCAAGTTTGG
GGATCTAGGTTCTGACACAT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MFLAQEIIRKKRNGLALSTEEIQFFVKGITTNAVSEGQIAALGMAVYFNDMNMDERIALTTAMRDSGTVLNWQSLGLNGP
VIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYQTEPSSELFRKVVKDVGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLACSLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLT
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYAVTMGLCAEMLLLGGLASDEADARAKLNRVLDNGRAAEIFGKMVSGL
GGPVDFVENYSKYLPQSQIIRPVFADTQGYAYSMDTRELGLAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDASTPIA
VIHAQSEEAFAQAEEAVKKAIHIDEVAPEKTPEIYAYIRASDL

Sequences:

>Translated_443_residues
MFLAQEIIRKKRNGLALSTEEIQFFVKGITTNAVSEGQIAALGMAVYFNDMNMDERIALTTAMRDSGTVLNWQSLGLNGP
VIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYQTEPSSELFRKVVKDVGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLACSLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLT
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYAVTMGLCAEMLLLGGLASDEADARAKLNRVLDNGRAAEIFGKMVSGL
GGPVDFVENYSKYLPQSQIIRPVFADTQGYAYSMDTRELGLAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDASTPIA
VIHAQSEEAFAQAEEAVKKAIHIDEVAPEKTPEIYAYIRASDL
>Mature_443_residues
MFLAQEIIRKKRNGLALSTEEIQFFVKGITTNAVSEGQIAALGMAVYFNDMNMDERIALTTAMRDSGTVLNWQSLGLNGP
VIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYQTEPSSELFRKVVKDVGVAIIGQTGDL
VPADKRFYSIRDNTATVESISLITASILSKKLACSLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLT
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYAVTMGLCAEMLLLGGLASDEADARAKLNRVLDNGRAAEIFGKMVSGL
GGPVDFVENYSKYLPQSQIIRPVFADTQGYAYSMDTRELGLAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDASTPIA
VIHAQSEEAFAQAEEAVKKAIHIDEVAPEKTPEIYAYIRASDL

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=443, Percent_Identity=37.2460496613996, Blast_Score=261, Evalue=7e-70,
Organism=Homo sapiens, GI4503445, Length=443, Percent_Identity=37.2460496613996, Blast_Score=261, Evalue=7e-70,
Organism=Homo sapiens, GI166158922, Length=443, Percent_Identity=37.2460496613996, Blast_Score=261, Evalue=7e-70,
Organism=Escherichia coli, GI1790842, Length=438, Percent_Identity=67.8082191780822, Blast_Score=614, Evalue=1e-177,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 46887; Mature: 46887

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLAQEIIRKKRNGLALSTEEIQFFVKGITTNAVSEGQIAALGMAVYFNDMNMDERIALT
CCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCEEEEE
TAMRDSGTVLNWQSLGLNGPVIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHT
EEECCCCCEEEEHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
GGTLDKFDAIPGYQTEPSSELFRKVVKDVGVAIIGQTGDLVPADKRFYSIRDNTATVESI
CCCCHHHCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEECCCCCHHHHH
SLITASILSKKLACSLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLT
HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYAVTMGLCAEMLLLGGLASDEADARAKL
HHHHHHHHHCCCCEEHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCCCCHHHHHHH
NRVLDNGRAAEIFGKMVSGLGGPVDFVENYSKYLPQSQIIRPVFADTQGYAYSMDTRELG
HHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCEEECCCHHCC
LAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDASTPIAVIHAQSEEAFAQAEEAVKKA
EEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHH
IHIDEVAPEKTPEIYAYIRASDL
HHHHHCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MFLAQEIIRKKRNGLALSTEEIQFFVKGITTNAVSEGQIAALGMAVYFNDMNMDERIALT
CCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCEEEEE
TAMRDSGTVLNWQSLGLNGPVIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHT
EEECCCCCEEEEHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCC
GGTLDKFDAIPGYQTEPSSELFRKVVKDVGVAIIGQTGDLVPADKRFYSIRDNTATVESI
CCCCHHHCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEECCCCCHHHHH
SLITASILSKKLACSLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLT
HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYAVTMGLCAEMLLLGGLASDEADARAKL
HHHHHHHHHCCCCEEHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCCCCHHHHHHH
NRVLDNGRAAEIFGKMVSGLGGPVDFVENYSKYLPQSQIIRPVFADTQGYAYSMDTRELG
HHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCEEECCCHHCC
LAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDASTPIAVIHAQSEEAFAQAEEAVKKA
EEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHH
IHIDEVAPEKTPEIYAYIRASDL
HHHHHCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA