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The map label for this gene is cyp18 [H]

Identifier: 117919237

GI number: 117919237

Start: 906609

End: 907196

Strand: Reverse

Name: cyp18 [H]

Synonym: Shewana3_0785

Alternate gene names: 117919237

Gene position: 907196-906609 (Counterclockwise)

Preceding gene: 117919238

Following gene: 117919236

Centisome position: 18.25

GC content: 48.64

Gene sequence:

>588_bases
ATGTTTCGTTGGATATCTGCACTCTTAGTTCTGTGTGCCAGCTATAGCAGCTGGGCGGCAATCGACATTCAACCCGATAC
CTTGTATCCCCAAGTCGAGTTTGATACCAGCCTAGGTAAGATTGTGGTCGAACTCGATAGAACCCGCGCACCGATTACCG
TCGATAACTTCCTGACCTATGTGGTCAAAGGCGAGTACAACAACACGATTTTCCATCGTATTATCAGTGACTTTGTCGTT
CAAGGTGGCGGACTAAACCCACAGTTAGAAGAGTTACCCGCGGGTAAGCCTATCGTTAACGAGTCTGGCAACGGCTTATC
CAACAGCATGGGCACTATTGCGATGGCGCGCGACAATGATCCTCATTCGGCTACCCGCCAGTTTTACTTCAACGTGGCGG
ATAACACTAAGCTGGATCCATCCAAACGTCGTTGGGGTTATGCGGTATTTGGTGAAGTGATTGAGGGCAAACAAGTGCTG
GAAGCCATGGCCGTGGTCGAGACCACGACCAATGCAAAACTCAATTGGCCCGATGTGCCAGTGACACCTATCATATTGAA
AACAGCTAAATTACTGCCGAAAAAATAA

Upstream 100 bases:

>100_bases
GTTACTCGGCCAACTCACAGGGGAAATTTTGAATGACCCTGAGTTAAACCAGTTCCTGCAACAATAATAGTGCTAATCGA
TAATTAATAAGGAAATCATA

Downstream 100 bases:

>100_bases
TCGAAAAAAATTTGAGCAAAAGCCCTAATCCTCTGTCTATACTCAAAAGGCAACAGAAAGGAGGCAAGGGTGACGATTGA
AGAATTTATCGATAATAAAG

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MFRWISALLVLCASYSSWAAIDIQPDTLYPQVEFDTSLGKIVVELDRTRAPITVDNFLTYVVKGEYNNTIFHRIISDFVV
QGGGLNPQLEELPAGKPIVNESGNGLSNSMGTIAMARDNDPHSATRQFYFNVADNTKLDPSKRRWGYAVFGEVIEGKQVL
EAMAVVETTTNAKLNWPDVPVTPIILKTAKLLPKK

Sequences:

>Translated_195_residues
MFRWISALLVLCASYSSWAAIDIQPDTLYPQVEFDTSLGKIVVELDRTRAPITVDNFLTYVVKGEYNNTIFHRIISDFVV
QGGGLNPQLEELPAGKPIVNESGNGLSNSMGTIAMARDNDPHSATRQFYFNVADNTKLDPSKRRWGYAVFGEVIEGKQVL
EAMAVVETTTNAKLNWPDVPVTPIILKTAKLLPKK
>Mature_195_residues
MFRWISALLVLCASYSSWAAIDIQPDTLYPQVEFDTSLGKIVVELDRTRAPITVDNFLTYVVKGEYNNTIFHRIISDFVV
QGGGLNPQLEELPAGKPIVNESGNGLSNSMGTIAMARDNDPHSATRQFYFNVADNTKLDPSKRRWGYAVFGEVIEGKQVL
EAMAVVETTTNAKLNWPDVPVTPIILKTAKLLPKK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=156, Percent_Identity=33.974358974359, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1789763, Length=195, Percent_Identity=44.6153846153846, Blast_Score=160, Evalue=5e-41,
Organism=Escherichia coli, GI1786736, Length=160, Percent_Identity=45, Blast_Score=139, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17539496, Length=153, Percent_Identity=31.3725490196078, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17986117, Length=162, Percent_Identity=32.0987654320988, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922376, Length=165, Percent_Identity=28.4848484848485, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21645; Mature: 21645

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRWISALLVLCASYSSWAAIDIQPDTLYPQVEFDTSLGKIVVELDRTRAPITVDNFLTY
CHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEECCCCCEEEEEECCCCCCEEHHCEEEE
VVKGEYNNTIFHRIISDFVVQGGGLNPQLEELPAGKPIVNESGNGLSNSMGTIAMARDND
EEECCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEECCCCCCCCCCCCEEEEECCCC
PHSATRQFYFNVADNTKLDPSKRRWGYAVFGEVIEGKQVLEAMAVVETTTNAKLNWPDVP
CCCCEEEEEEEECCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCC
VTPIILKTAKLLPKK
CCHHHHHHHHHCCCC
>Mature Secondary Structure
MFRWISALLVLCASYSSWAAIDIQPDTLYPQVEFDTSLGKIVVELDRTRAPITVDNFLTY
CHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEECCCCCEEEEEECCCCCCEEHHCEEEE
VVKGEYNNTIFHRIISDFVVQGGGLNPQLEELPAGKPIVNESGNGLSNSMGTIAMARDND
EEECCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEECCCCCCCCCCCCEEEEECCCC
PHSATRQFYFNVADNTKLDPSKRRWGYAVFGEVIEGKQVLEAMAVVETTTNAKLNWPDVP
CCCCEEEEEEEECCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCC
VTPIILKTAKLLPKK
CCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]