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The map label for this gene is 117918937

Identifier: 117918937

GI number: 117918937

Start: 564442

End: 566502

Strand: Reverse

Name: 117918937

Synonym: Shewana3_0482

Alternate gene names: NA

Gene position: 566502-564442 (Counterclockwise)

Preceding gene: 117918940

Following gene: 117918934

Centisome position: 11.39

GC content: 49.3

Gene sequence:

>2061_bases
ATGCAAAAATTTCCATTTACGAGTCAGTTATGCAGTGCTGCCATTGCCGCCGCACTGCTGCTGACGGGTTGCACTACGGC
GGATGTTCGCAACGAACAGCCTCAAGTTGCCGCGACGCAGCAAACCGAGGCGCCGCTCATTCCCATCGAAAACTTCTTTA
ACGAGCAAAGTATTCGCCATCTAAAAATGTCCGACGATGGCAAATGGCTCGCCTTTGTAAAGGAATACCAAGGGGCCAGC
AATATCTATCTGATGGCGGATAAGAGTGACCTCGCTAGCGCCACGCCATTGACCACATCGGTAGAACCTATCCGCGCCTT
CGAATGGTCCGCCAAGGGCAATGACTTATTCTTTATGAAGGACAAAGGCGGTAATGAGAACACCCAGATTTACAAGCTGA
GCTTTGAAGAACACGCGGGTAAAATCACCGCCAAAGAGCAGCGCTTAACCCATAAGGACGACGTGCAATACAGCGTGCTC
GAGCAGGTAAAAGACAATCCTGATTTACTGGTTGTTCAAGCCAACCACGACGATTCGAGCCGCATGGATATTTATCTGCT
CAATATCAACGATGGCAAGTTAACCCCAATCCTGAAGAACGAGCTGAGCTTTACTCAGGTGAAGTTTAATAAACAGGGGC
AACCTGTAATTGCCAGCAGCAGTAATCTCGATAACACCAATGCCTTATATGTACAGATCGACGGCAACTGGCGCAAGATC
ATTCAAAGTGCCAAGGGCGAGAGCATCGATATTCTAAAAGTGAACGATGATAAGAAGCTCGCCTATATCAGCGCCAATAT
CGGCGATCGCGATAAACAGGAATTGCTGAAAGTCGATCTGATGACGGGTAAATATGAAACCATTCACAGGGATCCCGACA
ACGAGGCCGACGTATTTGCGGTACAGTTTAGCGATGCGGGTGAGCCCTTGGCAGTTGGTTACTACGGTGGACGTTTACGG
GTTTATCCCTTAGATGCCGAGTTTACCCGCCATTGGGATGTGATTAATCGTCATTTTAATCAAGATGTTGAAATCACAAT
TGGCGAGATGAACGAGAAAACCAATCTGTGGCAAATTCATGTCGCCAGCGACAGAGCCGCAGGCGCTGACTATCAATACA
ATGCCGCCACTGGGGATATCCATCTATTAGTGGACATTCCAGCCAGCATTCCTGCGGATCAACTCTCGCCACGCCAATCT
ATCGTGTATACCGCGCGGGATGGGGTGAAAATCCAAGCCTATTTAACGCTACCGAAAGGTAAACAGACTCAGCTACCGAC
CATTATCCTGCCCCATGGCGGCCCTTGGGCACGGGATTTTTGGACACTCGACTCGGGTTATTTCCACGCGATTGCCCAGT
TCTATGCCAACCGTGGTTATGCCGTGTTGCAACCTAACTTCCGCGCCTCGACGGGTTTTGGTAAGAAATTCTTAAACCTA
GGTAACAATAACTGGGGGATTGGCAGCATGCAGCACGATCTCACCGACGGGGCCAATTACTTAGTCGAACAAGGTATTGC
CGATAAACAACGTTTAGGGATCTTCGGCGCCTCCTACGGTGGTTATGCGGCACTGTCTGGTGCGACCTTTACACCTGACT
TGTACCAAGCGGTGATCGCTTACGTGGGGCCATCGAGCCTAGTGACGCTGATGAATTCCTTCCCCGACTACTGGCGCCCC
TACTTAGGCCAATGGTTTGAGTCGGTGGGCGATCCGCAAATTGCCGAGCAGAAGCAAGATATGGAAAAGCGCTCGCCAAT
TAACTATGTCGATAATATCAAGGCGCCATTGATGCTGATCCAAGGGGCGAACGATCCACGCGTCACCCAAATTGAGTCGG
ATAATATCGCCAAGAAGATGTATCAAAAGTCTTTGCCCGTTAAGTACGTACTAGCAAAAGATGAAGGACATGGCTTTAGT
AAACGTGCCAACAAACTGGCATCGATTGTCGCCACCGAACAGTTTTTTGCTGAGCATTTAGGCGGGCGTGTCGATACGAA
TGTGAACCCCGACATTCTAAAACACTTAGACAGCCTGAACGTCGATATCAGTAAACTCTAA

Upstream 100 bases:

>100_bases
TTCGACAAAAAATATTACAAAGAAATATAATTTTATTGTTTTACGATAATTAATCTTCGTATTAGCATAATATCAATTTT
CCTAAACTAAGGTTACGACA

Downstream 100 bases:

>100_bases
CGCGCTAAGGGCAAGCTAAGGCTTGCCCTTTTTGTTGTGTCTTTATCACTCTGCGACCACGGCATCGATAGCCGCGGGTA
AGCGGATCTCAACTCGAGTC

Product: peptidase S9 prolyl oligopeptidase

Products: NA

Alternate protein names: AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase [H]

Number of amino acids: Translated: 686; Mature: 686

Protein sequence:

>686_residues
MQKFPFTSQLCSAAIAAALLLTGCTTADVRNEQPQVAATQQTEAPLIPIENFFNEQSIRHLKMSDDGKWLAFVKEYQGAS
NIYLMADKSDLASATPLTTSVEPIRAFEWSAKGNDLFFMKDKGGNENTQIYKLSFEEHAGKITAKEQRLTHKDDVQYSVL
EQVKDNPDLLVVQANHDDSSRMDIYLLNINDGKLTPILKNELSFTQVKFNKQGQPVIASSSNLDNTNALYVQIDGNWRKI
IQSAKGESIDILKVNDDKKLAYISANIGDRDKQELLKVDLMTGKYETIHRDPDNEADVFAVQFSDAGEPLAVGYYGGRLR
VYPLDAEFTRHWDVINRHFNQDVEITIGEMNEKTNLWQIHVASDRAAGADYQYNAATGDIHLLVDIPASIPADQLSPRQS
IVYTARDGVKIQAYLTLPKGKQTQLPTIILPHGGPWARDFWTLDSGYFHAIAQFYANRGYAVLQPNFRASTGFGKKFLNL
GNNNWGIGSMQHDLTDGANYLVEQGIADKQRLGIFGASYGGYAALSGATFTPDLYQAVIAYVGPSSLVTLMNSFPDYWRP
YLGQWFESVGDPQIAEQKQDMEKRSPINYVDNIKAPLMLIQGANDPRVTQIESDNIAKKMYQKSLPVKYVLAKDEGHGFS
KRANKLASIVATEQFFAEHLGGRVDTNVNPDILKHLDSLNVDISKL

Sequences:

>Translated_686_residues
MQKFPFTSQLCSAAIAAALLLTGCTTADVRNEQPQVAATQQTEAPLIPIENFFNEQSIRHLKMSDDGKWLAFVKEYQGAS
NIYLMADKSDLASATPLTTSVEPIRAFEWSAKGNDLFFMKDKGGNENTQIYKLSFEEHAGKITAKEQRLTHKDDVQYSVL
EQVKDNPDLLVVQANHDDSSRMDIYLLNINDGKLTPILKNELSFTQVKFNKQGQPVIASSSNLDNTNALYVQIDGNWRKI
IQSAKGESIDILKVNDDKKLAYISANIGDRDKQELLKVDLMTGKYETIHRDPDNEADVFAVQFSDAGEPLAVGYYGGRLR
VYPLDAEFTRHWDVINRHFNQDVEITIGEMNEKTNLWQIHVASDRAAGADYQYNAATGDIHLLVDIPASIPADQLSPRQS
IVYTARDGVKIQAYLTLPKGKQTQLPTIILPHGGPWARDFWTLDSGYFHAIAQFYANRGYAVLQPNFRASTGFGKKFLNL
GNNNWGIGSMQHDLTDGANYLVEQGIADKQRLGIFGASYGGYAALSGATFTPDLYQAVIAYVGPSSLVTLMNSFPDYWRP
YLGQWFESVGDPQIAEQKQDMEKRSPINYVDNIKAPLMLIQGANDPRVTQIESDNIAKKMYQKSLPVKYVLAKDEGHGFS
KRANKLASIVATEQFFAEHLGGRVDTNVNPDILKHLDSLNVDISKL
>Mature_686_residues
MQKFPFTSQLCSAAIAAALLLTGCTTADVRNEQPQVAATQQTEAPLIPIENFFNEQSIRHLKMSDDGKWLAFVKEYQGAS
NIYLMADKSDLASATPLTTSVEPIRAFEWSAKGNDLFFMKDKGGNENTQIYKLSFEEHAGKITAKEQRLTHKDDVQYSVL
EQVKDNPDLLVVQANHDDSSRMDIYLLNINDGKLTPILKNELSFTQVKFNKQGQPVIASSSNLDNTNALYVQIDGNWRKI
IQSAKGESIDILKVNDDKKLAYISANIGDRDKQELLKVDLMTGKYETIHRDPDNEADVFAVQFSDAGEPLAVGYYGGRLR
VYPLDAEFTRHWDVINRHFNQDVEITIGEMNEKTNLWQIHVASDRAAGADYQYNAATGDIHLLVDIPASIPADQLSPRQS
IVYTARDGVKIQAYLTLPKGKQTQLPTIILPHGGPWARDFWTLDSGYFHAIAQFYANRGYAVLQPNFRASTGFGKKFLNL
GNNNWGIGSMQHDLTDGANYLVEQGIADKQRLGIFGASYGGYAALSGATFTPDLYQAVIAYVGPSSLVTLMNSFPDYWRP
YLGQWFESVGDPQIAEQKQDMEKRSPINYVDNIKAPLMLIQGANDPRVTQIESDNIAKKMYQKSLPVKYVLAKDEGHGFS
KRANKLASIVATEQFFAEHLGGRVDTNVNPDILKHLDSLNVDISKL

Specific function: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9C family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=289, Percent_Identity=27.681660899654, Blast_Score=91, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI25144537, Length=671, Percent_Identity=27.4217585692996, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI25144540, Length=362, Percent_Identity=34.2541436464088, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI25144543, Length=578, Percent_Identity=25.2595155709343, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17552908, Length=297, Percent_Identity=29.96632996633, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI25149159, Length=226, Percent_Identity=30.0884955752212, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR001375
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9 [H]

EC number: =3.4.19.1 [H]

Molecular weight: Translated: 76544; Mature: 76544

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKFPFTSQLCSAAIAAALLLTGCTTADVRNEQPQVAATQQTEAPLIPIENFFNEQSIRH
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCHHHHCCCCCEEE
LKMSDDGKWLAFVKEYQGASNIYLMADKSDLASATPLTTSVEPIRAFEWSAKGNDLFFMK
EEECCCCCEEEEEHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEE
DKGGNENTQIYKLSFEEHAGKITAKEQRLTHKDDVQYSVLEQVKDNPDLLVVQANHDDSS
CCCCCCCCEEEEEEEHHCCCCEEEHHHHCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCC
RMDIYLLNINDGKLTPILKNELSFTQVKFNKQGQPVIASSSNLDNTNALYVQIDGNWRKI
CEEEEEEEECCCEECCCHHCCCCEEEEEECCCCCEEEECCCCCCCCCEEEEEECCCHHHH
IQSAKGESIDILKVNDDKKLAYISANIGDRDKQELLKVDLMTGKYETIHRDPDNEADVFA
HHHCCCCEEEEEEECCCCEEEEEECCCCCCCHHHHHEEEEECCCCCEECCCCCCCCCEEE
VQFSDAGEPLAVGYYGGRLRVYPLDAEFTRHWDVINRHFNQDVEITIGEMNEKTNLWQIH
EEECCCCCEEEEEEECCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEE
VASDRAAGADYQYNAATGDIHLLVDIPASIPADQLSPRQSIVYTARDGVKIQAYLTLPKG
EECCCCCCCCEEEECCCCCEEEEEECCCCCCHHHCCCCCEEEEEECCCEEEEEEEECCCC
KQTQLPTIILPHGGPWARDFWTLDSGYFHAIAQFYANRGYAVLQPNFRASTGFGKKFLNL
CCCCCCEEEEECCCCCCCCEEECCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHC
GNNNWGIGSMQHDLTDGANYLVEQGIADKQRLGIFGASYGGYAALSGATFTPDLYQAVIA
CCCCCCCCCCHHHHCCHHHHHHHCCCCCCHHCEEEECCCCCCEEECCCCCCHHHHHHHHH
YVGPSSLVTLMNSFPDYWRPYLGQWFESVGDPQIAEQKQDMEKRSPINYVDNIKAPLMLI
HCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHCCCCCEEEE
QGANDPRVTQIESDNIAKKMYQKSLPVKYVLAKDEGHGFSKRANKLASIVATEQFFAEHL
ECCCCCCEEEECCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
GGRVDTNVNPDILKHLDSLNVDISKL
CCEECCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQKFPFTSQLCSAAIAAALLLTGCTTADVRNEQPQVAATQQTEAPLIPIENFFNEQSIRH
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCHHHHCCCCCEEE
LKMSDDGKWLAFVKEYQGASNIYLMADKSDLASATPLTTSVEPIRAFEWSAKGNDLFFMK
EEECCCCCEEEEEHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEE
DKGGNENTQIYKLSFEEHAGKITAKEQRLTHKDDVQYSVLEQVKDNPDLLVVQANHDDSS
CCCCCCCCEEEEEEEHHCCCCEEEHHHHCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCC
RMDIYLLNINDGKLTPILKNELSFTQVKFNKQGQPVIASSSNLDNTNALYVQIDGNWRKI
CEEEEEEEECCCEECCCHHCCCCEEEEEECCCCCEEEECCCCCCCCCEEEEEECCCHHHH
IQSAKGESIDILKVNDDKKLAYISANIGDRDKQELLKVDLMTGKYETIHRDPDNEADVFA
HHHCCCCEEEEEEECCCCEEEEEECCCCCCCHHHHHEEEEECCCCCEECCCCCCCCCEEE
VQFSDAGEPLAVGYYGGRLRVYPLDAEFTRHWDVINRHFNQDVEITIGEMNEKTNLWQIH
EEECCCCCEEEEEEECCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEE
VASDRAAGADYQYNAATGDIHLLVDIPASIPADQLSPRQSIVYTARDGVKIQAYLTLPKG
EECCCCCCCCEEEECCCCCEEEEEECCCCCCHHHCCCCCEEEEEECCCEEEEEEEECCCC
KQTQLPTIILPHGGPWARDFWTLDSGYFHAIAQFYANRGYAVLQPNFRASTGFGKKFLNL
CCCCCCEEEEECCCCCCCCEEECCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHC
GNNNWGIGSMQHDLTDGANYLVEQGIADKQRLGIFGASYGGYAALSGATFTPDLYQAVIA
CCCCCCCCCCHHHHCCHHHHHHHCCCCCCHHCEEEECCCCCCEEECCCCCCHHHHHHHHH
YVGPSSLVTLMNSFPDYWRPYLGQWFESVGDPQIAEQKQDMEKRSPINYVDNIKAPLMLI
HCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHCCCCCEEEE
QGANDPRVTQIESDNIAKKMYQKSLPVKYVLAKDEGHGFSKRANKLASIVATEQFFAEHL
ECCCCCCEEEECCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
GGRVDTNVNPDILKHLDSLNVDISKL
CCEECCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966; 12037315 [H]