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The map label for this gene is trxC [H]

Identifier: 117918908

GI number: 117918908

Start: 527814

End: 528236

Strand: Reverse

Name: trxC [H]

Synonym: Shewana3_0452

Alternate gene names: 117918908

Gene position: 528236-527814 (Counterclockwise)

Preceding gene: 117918911

Following gene: 117918906

Centisome position: 10.62

GC content: 53.43

Gene sequence:

>423_bases
ATGATTATTGCCTGCCCCCACTGTGACACCTTAAACCGCGTGCCCCAAGAGCGGTTAACTGAGCAGCCGACCTGCGGCAA
ATGTAAACAAAATCTGTTTGCGGCGGCGCCCATTGAGCTCACGAGCGCCAATTTTATCAATCATGCTCACAAGTCAGAGT
TGCCACTCGTTGTCGATTTTTGGGCGAGCTGGTGCGGCCCCTGCAAAAGCTTTGCGCCCACCTTTTCGGCGGCGGCAAAA
GCATGGGAACCACAATTTCGCTTTGGCAAGATTAATACCGAGGAGCAACAGGCACTGGCGGCACAATTTGGGATCCGCTC
TATCCCTACGCTGATGATTTTCAAACAGGGGCATGTTATCGCCCAGCAAGCGGGCGCCTTACCCAAGCCGGCACTCGACC
AATGGCTGCATAGTTATTGTTAA

Upstream 100 bases:

>100_bases
ATCCATTTTGTGGCGCAGGTTTAGATACGCCTTTACCTCCCTTTAAATTTGCCGCAGCGCCCCCATATCTACAGCATGCA
TTGAGCTAAGGAGCCATTCC

Downstream 100 bases:

>100_bases
AGTCTTTCGCCCATAAAAATACCCAGCTTTGCTGGGTATTTTATTTGAATGGTTCAGAGGCGTTTACACTTCCCAGAAGG
TGTGGGCAATAATGCCCAGT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MIIACPHCDTLNRVPQERLTEQPTCGKCKQNLFAAAPIELTSANFINHAHKSELPLVVDFWASWCGPCKSFAPTFSAAAK
AWEPQFRFGKINTEEQQALAAQFGIRSIPTLMIFKQGHVIAQQAGALPKPALDQWLHSYC

Sequences:

>Translated_140_residues
MIIACPHCDTLNRVPQERLTEQPTCGKCKQNLFAAAPIELTSANFINHAHKSELPLVVDFWASWCGPCKSFAPTFSAAAK
AWEPQFRFGKINTEEQQALAAQFGIRSIPTLMIFKQGHVIAQQAGALPKPALDQWLHSYC
>Mature_140_residues
MIIACPHCDTLNRVPQERLTEQPTCGKCKQNLFAAAPIELTSANFINHAHKSELPLVVDFWASWCGPCKSFAPTFSAAAK
AWEPQFRFGKINTEEQQALAAQFGIRSIPTLMIFKQGHVIAQQAGALPKPALDQWLHSYC

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788936, Length=137, Percent_Identity=44.5255474452555, Blast_Score=143, Evalue=4e-36,
Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=39.6039603960396, Blast_Score=91, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI212646193, Length=95, Percent_Identity=31.5789473684211, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=87, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=88, Percent_Identity=36.3636363636364, Blast_Score=65, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319925, Length=90, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=32.9896907216495, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921434, Length=77, Percent_Identity=38.961038961039, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 15538; Mature: 15538

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
5.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIACPHCDTLNRVPQERLTEQPTCGKCKQNLFAAAPIELTSANFINHAHKSELPLVVDF
CEEECCCCCHHHCCCHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHH
WASWCGPCKSFAPTFSAAAKAWEPQFRFGKINTEEQQALAAQFGIRSIPTLMIFKQGHVI
HHHHHCHHHHHCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCHHCCCCEEEEECCCHH
AQQAGALPKPALDQWLHSYC
HHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MIIACPHCDTLNRVPQERLTEQPTCGKCKQNLFAAAPIELTSANFINHAHKSELPLVVDF
CEEECCCCCHHHCCCHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHH
WASWCGPCKSFAPTFSAAAKAWEPQFRFGKINTEEQQALAAQFGIRSIPTLMIFKQGHVI
HHHHHCHHHHHCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCHHCCCCEEEEECCCHH
AQQAGALPKPALDQWLHSYC
HHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]