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The map label for this gene is nadC [H]

Identifier: 117918879

GI number: 117918879

Start: 481358

End: 482239

Strand: Reverse

Name: nadC [H]

Synonym: Shewana3_0422

Alternate gene names: 117918879

Gene position: 482239-481358 (Counterclockwise)

Preceding gene: 117918889

Following gene: 117918878

Centisome position: 9.7

GC content: 48.19

Gene sequence:

>882_bases
ATGCTAGAAAACGATATTCGCCACGCCGTAAAAACCGCCCTCAATGAAGACCTTGGTGGAACAGAGATCAATGAGCACAG
CAAAGCCATTGCCTACGGCGATATTACCGCCCAACTTATTCCTGCTGATAAATATGCAGAAGCAACCTTAATCACCCGTG
AAGAAGGCGTTTTTTGCGGAAAAGCTTGGGCCGAACAAGTCTTTAATCAATTAGGTGGCGATGTCGCCCTGCACTGGCAT
GTTGATGATGGCGATCTCGTGTTGCCAAACCAAGTCTTATGTGAATTATCAGGCCCTGCCCGCACCCTGCTGACGGGCGA
GCGCACGGCAATGAACTTTATTCAGACTTTGTCAGGAGTGGCGACGCTGACAAAACACTATGTCGATAAGTTAGCGGGCA
CTCACACACGACTACTCGATACTCGCAAAACCATCCCAGGACTCCGCACGGCTCAAAAATACGCAGTCACCTGTGGCGGC
GGTAAAAACCATCGAATTGGTTTGTTTGATGCCTTCTTAATTAAAGAAAATCACATTATGGCCTGCGGTGGCATACGCCA
AGCAGTGGATGCAGCGCGCAGTTTACATCCTAATAAACCCGTAGAAGTCGAAGTCGAATCCCTAGAAGAACTGGCATTAG
CGCTAGATTCAGGCACAGATATCATTATGTTAGATAACTTCGATATCACCATGATGGTCGAAGCCGTCGAGCTGAATAAT
CAATACAAGGCTAAAGGCAGCGGTGCAAAACTCGAAGTCTCAGGCAATGTCACCTTAGATACCTTGGCAGAATTTGCCAA
AACTGGGGTTGACTATATCTCCGTTGGCGCCCTCACCAAGCATGTTCGCGCCTTAGATCTATCAATGCGGCTGAAAGGCT
AG

Upstream 100 bases:

>100_bases
TCTAGCACCTAGCGGCGCAGCCATGATAATCTTAAGCCAAATGCAAGCAAGCAATTTCAAGCACGCCATCTGTGGCATGC
AAGAATGCAAGGACCCAATC

Downstream 100 bases:

>100_bases
AAAAAGCAGAGCGGGCTGCGCCCTTATAGATTCTAGGTACTAGGTTCTAGTAGCAGCCCATAAGCCGTCATCCTCGCGAA
CGACTGCATGGATGCAGGAG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MLENDIRHAVKTALNEDLGGTEINEHSKAIAYGDITAQLIPADKYAEATLITREEGVFCGKAWAEQVFNQLGGDVALHWH
VDDGDLVLPNQVLCELSGPARTLLTGERTAMNFIQTLSGVATLTKHYVDKLAGTHTRLLDTRKTIPGLRTAQKYAVTCGG
GKNHRIGLFDAFLIKENHIMACGGIRQAVDAARSLHPNKPVEVEVESLEELALALDSGTDIIMLDNFDITMMVEAVELNN
QYKAKGSGAKLEVSGNVTLDTLAEFAKTGVDYISVGALTKHVRALDLSMRLKG

Sequences:

>Translated_293_residues
MLENDIRHAVKTALNEDLGGTEINEHSKAIAYGDITAQLIPADKYAEATLITREEGVFCGKAWAEQVFNQLGGDVALHWH
VDDGDLVLPNQVLCELSGPARTLLTGERTAMNFIQTLSGVATLTKHYVDKLAGTHTRLLDTRKTIPGLRTAQKYAVTCGG
GKNHRIGLFDAFLIKENHIMACGGIRQAVDAARSLHPNKPVEVEVESLEELALALDSGTDIIMLDNFDITMMVEAVELNN
QYKAKGSGAKLEVSGNVTLDTLAEFAKTGVDYISVGALTKHVRALDLSMRLKG
>Mature_293_residues
MLENDIRHAVKTALNEDLGGTEINEHSKAIAYGDITAQLIPADKYAEATLITREEGVFCGKAWAEQVFNQLGGDVALHWH
VDDGDLVLPNQVLCELSGPARTLLTGERTAMNFIQTLSGVATLTKHYVDKLAGTHTRLLDTRKTIPGLRTAQKYAVTCGG
GKNHRIGLFDAFLIKENHIMACGGIRQAVDAARSLHPNKPVEVEVESLEELALALDSGTDIIMLDNFDITMMVEAVELNN
QYKAKGSGAKLEVSGNVTLDTLAEFAKTGVDYISVGALTKHVRALDLSMRLKG

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=258, Percent_Identity=35.2713178294574, Blast_Score=146, Evalue=2e-35,
Organism=Escherichia coli, GI1786299, Length=289, Percent_Identity=64.3598615916955, Blast_Score=335, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6321162, Length=257, Percent_Identity=35.0194552529183, Blast_Score=142, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31752; Mature: 31752

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLENDIRHAVKTALNEDLGGTEINEHSKAIAYGDITAQLIPADKYAEATLITREEGVFCG
CCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCEEEEEECCCCCCCEEEEEECCCCEEH
KAWAEQVFNQLGGDVALHWHVDDGDLVLPNQVLCELSGPARTLLTGERTAMNFIQTLSGV
HHHHHHHHHHCCCCEEEEEEECCCCEECCCHHEEECCCCCCEEECCCHHHHHHHHHHHHH
ATLTKHYVDKLAGTHTRLLDTRKTIPGLRTAQKYAVTCGGGKNHRIGLFDAFLIKENHIM
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCEE
ACGGIRQAVDAARSLHPNKPVEVEVESLEELALALDSGTDIIMLDNFDITMMVEAVELNN
EECCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHCCCCCEEEEECCCEEEEEEEEECCC
QYKAKGSGAKLEVSGNVTLDTLAEFAKTGVDYISVGALTKHVRALDLSMRLKG
CEECCCCCCEEEEECCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHEEEEEECC
>Mature Secondary Structure
MLENDIRHAVKTALNEDLGGTEINEHSKAIAYGDITAQLIPADKYAEATLITREEGVFCG
CCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCEEEEEECCCCCCCEEEEEECCCCEEH
KAWAEQVFNQLGGDVALHWHVDDGDLVLPNQVLCELSGPARTLLTGERTAMNFIQTLSGV
HHHHHHHHHHCCCCEEEEEEECCCCEECCCHHEEECCCCCCEEECCCHHHHHHHHHHHHH
ATLTKHYVDKLAGTHTRLLDTRKTIPGLRTAQKYAVTCGGGKNHRIGLFDAFLIKENHIM
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCEE
ACGGIRQAVDAARSLHPNKPVEVEVESLEELALALDSGTDIIMLDNFDITMMVEAVELNN
EECCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHCCCCCEEEEECCCEEEEEEEEECCC
QYKAKGSGAKLEVSGNVTLDTLAEFAKTGVDYISVGALTKHVRALDLSMRLKG
CEECCCCCCEEEEECCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419294; 11677609; 9016724 [H]