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The map label for this gene is trxA [H]

Identifier: 117918866

GI number: 117918866

Start: 468768

End: 469094

Strand: Reverse

Name: trxA [H]

Synonym: Shewana3_0409

Alternate gene names: 117918866

Gene position: 469094-468768 (Counterclockwise)

Preceding gene: 117918869

Following gene: 117918865

Centisome position: 9.43

GC content: 42.51

Gene sequence:

>327_bases
ATGAGCGATAAAATTATATACCTGAGCGACGACAGCTTCGAAAACGACGTATTAAAGGCCGATTTACCAGTATTGGTAGA
CTTTTGGGCTGAATGGTGTGGTCCATGTAAAATGATCGCTCCAATCCTTGACGACGTTGCCGAAGAGTACGCAGGTCGTG
TGACTATCGCTAAATTAAACGTTGACCAAAACAACGTTTCTCCAGCGAAATATGGCGTTCGTGGTATCCCAACTTTACTG
TTATTCAAGAACGGTGAATTAGCGGCGACTAAAGTTGGCGCACTATCTAAAACTCAATTAAAAGAGTTCATCGACGCACA
AATCTAA

Upstream 100 bases:

>100_bases
GCCACATTGTAAAAAGGTAACTTGAAAAGCTATTTTTCAGCCCCAATATACATGGTAAGCCATTAACAAACCAGCAATGG
CAACCAAACTGGAGAACATC

Downstream 100 bases:

>100_bases
TTTGTTGTCGCTATGAGTGACCTCCGGCACAAGCTTTAATTAATTGTGCCGGAATACCCCTAAATTTCTGGACGCCCCGC
TTTGTTAGTGCTACTTTAAT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSDKIIYLSDDSFENDVLKADLPVLVDFWAEWCGPCKMIAPILDDVAEEYAGRVTIAKLNVDQNNVSPAKYGVRGIPTLL
LFKNGELAATKVGALSKTQLKEFIDAQI

Sequences:

>Translated_108_residues
MSDKIIYLSDDSFENDVLKADLPVLVDFWAEWCGPCKMIAPILDDVAEEYAGRVTIAKLNVDQNNVSPAKYGVRGIPTLL
LFKNGELAATKVGALSKTQLKEFIDAQI
>Mature_107_residues
SDKIIYLSDDSFENDVLKADLPVLVDFWAEWCGPCKMIAPILDDVAEEYAGRVTIAKLNVDQNNVSPAKYGVRGIPTLLL
FKNGELAATKVGALSKTQLKEFIDAQI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=36.9565217391304, Blast_Score=79, Evalue=8e-16,
Organism=Homo sapiens, GI5031973, Length=100, Percent_Identity=34, Blast_Score=72, Evalue=7e-14,
Organism=Homo sapiens, GI21361657, Length=92, Percent_Identity=41.304347826087, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=75.9259259259259, Blast_Score=178, Evalue=6e-47,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=41.304347826087, Blast_Score=95, Evalue=9e-22,
Organism=Escherichia coli, GI87081747, Length=64, Percent_Identity=42.1875, Blast_Score=66, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=40.2061855670103, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=49.2957746478873, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17556044, Length=86, Percent_Identity=34.8837209302326, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115532254, Length=113, Percent_Identity=32.7433628318584, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115532252, Length=113, Percent_Identity=32.7433628318584, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=100, Percent_Identity=37, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=90, Percent_Identity=32.2222222222222, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=88, Percent_Identity=35.2272727272727, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=71, Percent_Identity=50.7042253521127, Blast_Score=72, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=39.5348837209302, Blast_Score=69, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24639826, Length=87, Percent_Identity=42.5287356321839, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=35.4166666666667, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24664269, Length=87, Percent_Identity=37.9310344827586, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921434, Length=88, Percent_Identity=38.6363636363636, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17648013, Length=85, Percent_Identity=37.6470588235294, Blast_Score=66, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583090, Length=85, Percent_Identity=37.6470588235294, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11889; Mature: 11758

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKIIYLSDDSFENDVLKADLPVLVDFWAEWCGPCKMIAPILDDVAEEYAGRVTIAKLN
CCCCEEEEECCCCCCCEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEE
VDQNNVSPAKYGVRGIPTLLLFKNGELAATKVGALSKTQLKEFIDAQI
CCCCCCCHHHCCCCCCCEEEEEECCCEEEHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SDKIIYLSDDSFENDVLKADLPVLVDFWAEWCGPCKMIAPILDDVAEEYAGRVTIAKLN
CCCEEEEECCCCCCCEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEE
VDQNNVSPAKYGVRGIPTLLLFKNGELAATKVGALSKTQLKEFIDAQI
CCCCCCCHHHCCCCCCCEEEEEECCCEEEHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]