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The map label for this gene is qor [C]

Identifier: 117918863

GI number: 117918863

Start: 465040

End: 466062

Strand: Reverse

Name: qor [C]

Synonym: Shewana3_0406

Alternate gene names: 117918863

Gene position: 466062-465040 (Counterclockwise)

Preceding gene: 117918865

Following gene: 117918862

Centisome position: 9.37

GC content: 50.44

Gene sequence:

>1023_bases
ATGAAAGCCATAGGTTATCAAACCGCGGGAGCCGTCGATGCACCCAATGCATTACAAAACATCACCTTACCCGAACCTAC
ACCGCAAGGTTTTGACCTGTTAGTTGAGGTAAAAGCCATATCCGTTAATCCCGTCGATACCAAAATCCGCACATCGAGCT
CAGCTCCAACAGGGGAATATAAAATCCTCGGTTGGGATGCGGTCGGAGTCGTTAAAGCCGTGGGTGAAAAGGTGAGCCTG
TTTAAGGTGGGCGATGAAGTCTGGTATGCCGGCGATATTAGCCGCAGCGGCAGTTATGCCGAGTATCAGTTAGTCGATGA
GCGCATTGTGGGCCATAAACCGCAAACCTTAAGCAATGCCCAGGCTGCAGCCCTCCCCCTAACCAGTATTACGGCTTGGG
AGCTATTGTTTGATCGCTTAGGCTTACCTCAGGATGGCTCGGCCACGAATGCGCGAATTTTGATTATCGGTGCCGCTGGA
GGTGTAGGTTCTATCATCACCCAACTTGCGGTCAAGCTGACTGGCGCCGAGGTAATTGGCACAGCATCACGCCCCGAATC
TGCCGCTTGGGTGAAAAAGTTAGGCGCGAATCAGGTTATCAATCACCAACAGCCACTCTCGCAGGAACTGGCGAAGTGGG
ATATTGCCGATGTCACCCATGTGATTAGCCTAACCCAAACCGATAAGCACTTTGACGAAATCGTAAAAGTCCTCAGACCC
CAAGGTAAACTGGCACTCATTGACGATCCCGTCGGTCCACTGGACGTGATGAAGCTTAAACTTAAAAGCCTGTCGCTACA
TTGGGAGCTCATGTTTACCCGCAGCCTCTTTCAAACCGAAGACATGATTGCTCAGCATCATCTGCTCAATCGTATCGCCG
AGCTGATTGATGCAGGCACAGTTCAAAGTACCTTTGGCGAACACTATGGCGCCATTAATGCGCAAAACTTGCTTAAAGCC
CATGCACCAATAGAGTCGGGTAAGGCCATAGGTAAAATCGTGCTCGAAGGATTTAGCCAATGA

Upstream 100 bases:

>100_bases
GAAAAAATTACAAAGTTTACCCCGTTTATCTAGGCTTTAATATTCCACACAATAGTTGCCATTGACAAGTACAGGCACCA
GCCGCAAGCGAGGAATCAAG

Downstream 100 bases:

>100_bases
AAGTGACAGTTTTTGCGCAAATTCAAGCTCGTTCTGGCCAAGGCAAAGCCTTGTCTCACGTCCTTAAGCAGCTGGTTAAA
GCAACCCTGACCGAGGCCGG

Product: alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKAIGYQTAGAVDAPNALQNITLPEPTPQGFDLLVEVKAISVNPVDTKIRTSSSAPTGEYKILGWDAVGVVKAVGEKVSL
FKVGDEVWYAGDISRSGSYAEYQLVDERIVGHKPQTLSNAQAAALPLTSITAWELLFDRLGLPQDGSATNARILIIGAAG
GVGSIITQLAVKLTGAEVIGTASRPESAAWVKKLGANQVINHQQPLSQELAKWDIADVTHVISLTQTDKHFDEIVKVLRP
QGKLALIDDPVGPLDVMKLKLKSLSLHWELMFTRSLFQTEDMIAQHHLLNRIAELIDAGTVQSTFGEHYGAINAQNLLKA
HAPIESGKAIGKIVLEGFSQ

Sequences:

>Translated_340_residues
MKAIGYQTAGAVDAPNALQNITLPEPTPQGFDLLVEVKAISVNPVDTKIRTSSSAPTGEYKILGWDAVGVVKAVGEKVSL
FKVGDEVWYAGDISRSGSYAEYQLVDERIVGHKPQTLSNAQAAALPLTSITAWELLFDRLGLPQDGSATNARILIIGAAG
GVGSIITQLAVKLTGAEVIGTASRPESAAWVKKLGANQVINHQQPLSQELAKWDIADVTHVISLTQTDKHFDEIVKVLRP
QGKLALIDDPVGPLDVMKLKLKSLSLHWELMFTRSLFQTEDMIAQHHLLNRIAELIDAGTVQSTFGEHYGAINAQNLLKA
HAPIESGKAIGKIVLEGFSQ
>Mature_340_residues
MKAIGYQTAGAVDAPNALQNITLPEPTPQGFDLLVEVKAISVNPVDTKIRTSSSAPTGEYKILGWDAVGVVKAVGEKVSL
FKVGDEVWYAGDISRSGSYAEYQLVDERIVGHKPQTLSNAQAAALPLTSITAWELLFDRLGLPQDGSATNARILIIGAAG
GVGSIITQLAVKLTGAEVIGTASRPESAAWVKKLGANQVINHQQPLSQELAKWDIADVTHVISLTQTDKHFDEIVKVLRP
QGKLALIDDPVGPLDVMKLKLKSLSLHWELMFTRSLFQTEDMIAQHHLLNRIAELIDAGTVQSTFGEHYGAINAQNLLKA
HAPIESGKAIGKIVLEGFSQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=348, Percent_Identity=29.0229885057471, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI194239674, Length=181, Percent_Identity=37.0165745856354, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI13236495, Length=181, Percent_Identity=37.0165745856354, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI194239676, Length=181, Percent_Identity=37.0165745856354, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI28557745, Length=344, Percent_Identity=27.3255813953488, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI24308257, Length=309, Percent_Identity=24.5954692556634, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI22538446, Length=348, Percent_Identity=28.1609195402299, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI22538444, Length=348, Percent_Identity=28.1609195402299, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1790485, Length=328, Percent_Identity=28.9634146341463, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17507255, Length=240, Percent_Identity=33.75, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71987554, Length=319, Percent_Identity=26.9592476489028, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36547; Mature: 36547

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIGYQTAGAVDAPNALQNITLPEPTPQGFDLLVEVKAISVNPVDTKIRTSSSAPTGEY
CCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCEEEEEEEEEEECCCCCEEECCCCCCCCCE
KILGWDAVGVVKAVGEKVSLFKVGDEVWYAGDISRSGSYAEYQLVDERIVGHKPQTLSNA
EEEECCHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
QAAALPLTSITAWELLFDRLGLPQDGSATNARILIIGAAGGVGSIITQLAVKLTGAEVIG
CHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEE
TASRPESAAWVKKLGANQVINHQQPLSQELAKWDIADVTHVISLTQTDKHFDEIVKVLRP
CCCCCCHHHHHHHHCCHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHCC
QGKLALIDDPVGPLDVMKLKLKSLSLHWELMFTRSLFQTEDMIAQHHLLNRIAELIDAGT
CCCEEEEECCCCCHHHHHHHHHHHEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VQSTFGEHYGAINAQNLLKAHAPIESGKAIGKIVLEGFSQ
HHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MKAIGYQTAGAVDAPNALQNITLPEPTPQGFDLLVEVKAISVNPVDTKIRTSSSAPTGEY
CCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCEEEEEEEEEEECCCCCEEECCCCCCCCCE
KILGWDAVGVVKAVGEKVSLFKVGDEVWYAGDISRSGSYAEYQLVDERIVGHKPQTLSNA
EEEECCHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
QAAALPLTSITAWELLFDRLGLPQDGSATNARILIIGAAGGVGSIITQLAVKLTGAEVIG
CHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEE
TASRPESAAWVKKLGANQVINHQQPLSQELAKWDIADVTHVISLTQTDKHFDEIVKVLRP
CCCCCCHHHHHHHHCCHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHCC
QGKLALIDDPVGPLDVMKLKLKSLSLHWELMFTRSLFQTEDMIAQHHLLNRIAELIDAGT
CCCEEEEECCCCCHHHHHHHHHHHEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VQSTFGEHYGAINAQNLLKAHAPIESGKAIGKIVLEGFSQ
HHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA