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The map label for this gene is ilvY [H]

Identifier: 117918811

GI number: 117918811

Start: 389048

End: 389920

Strand: Reverse

Name: ilvY [H]

Synonym: Shewana3_0354

Alternate gene names: 117918811

Gene position: 389920-389048 (Counterclockwise)

Preceding gene: 117918821

Following gene: 117918809

Centisome position: 7.84

GC content: 54.87

Gene sequence:

>873_bases
ATGGACATACGCACCCTCAAATTGTACCTACACTTATGTGACAGTTTGCACTTCGCCAAGACGGCGGAGCAGATGCACGT
CAGTCCCTCGACCTTAAGTCGCGCCTTGCAACGGCTCGAAGAAGAAGTGAACGCCAAGTTATTCGAACGGGATAATCGCA
GCGTGACCTTAACCCATGCGGGGCGCGAGTTTAAATTGTTCGCCGAGCAGACCCTGCACCATTGGCGCAACCTGCGGCAC
AGTATCGATCTCAAGCAGGATGTACTGCGCGGCACCTTAAATCTCTATTGCTCGGTGACCGCCGCCTACAGCCATTTACC
GCAATTGCTGGAACGTTTTCGGCAGGAGCATCCCTTTGTTGAGATAGCCCTCACCACAGGGGATGCTGCCAATGCACTGG
CCGAAGTGCAACAAAATCGCGCCGACATTGCCATTGCCGCGCTGCCGGATCCCTTCCCTGCCACCTTGCATTTCGCCAAG
ATTGACGATGTGCCTTTGTCCTTAATCGCGCCAACCATGCGCTGCGCGGTGCAGCAACAGATAAGCCAAGCCCCCATCGA
CTGGTCGCGGGTGCCCTTTATCATTCCCGACCATGGCCCAGGGCGACGCCGCGCCGATAATTGGTTCAAACAGATGGGAA
TAAGCCCCAATATTTATGCGCAGGTGTCGGGGCAAGAAGCGATTGCGTCCATGGTGGCGCTCGGGTGTGGTGTGAGTATC
ACCCCAGAGGTAGTGATCAATAACAGTCCGGTACGGGATAGGATCCAGCTATTAGCCTCCCCCGTGAACATTGCCCCCTT
TGAGCTGGGTTGTTGTTGCAAGGTCAAACGCTTGGACGATCCGATAGTGAATGCGTTTTTAGAAGCGATCTAA

Upstream 100 bases:

>100_bases
ATCGTTGCTTAAAATGATATATTCGAAACCTCATATTGCGTTTTATGCAATGTCATTTTCGGTTACAACAGCCTTGATAA
GCGGCCAATAGGACGAGGTT

Downstream 100 bases:

>100_bases
ATTTTAGTAGCAATATAAAAAACGGGACTGAGTCCCGTTTTTTTATGATGTTGATAAGATTAGGTATCTGGCGACATCAA
CTTATCGTTGCCATCGATAC

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MDIRTLKLYLHLCDSLHFAKTAEQMHVSPSTLSRALQRLEEEVNAKLFERDNRSVTLTHAGREFKLFAEQTLHHWRNLRH
SIDLKQDVLRGTLNLYCSVTAAYSHLPQLLERFRQEHPFVEIALTTGDAANALAEVQQNRADIAIAALPDPFPATLHFAK
IDDVPLSLIAPTMRCAVQQQISQAPIDWSRVPFIIPDHGPGRRRADNWFKQMGISPNIYAQVSGQEAIASMVALGCGVSI
TPEVVINNSPVRDRIQLLASPVNIAPFELGCCCKVKRLDDPIVNAFLEAI

Sequences:

>Translated_290_residues
MDIRTLKLYLHLCDSLHFAKTAEQMHVSPSTLSRALQRLEEEVNAKLFERDNRSVTLTHAGREFKLFAEQTLHHWRNLRH
SIDLKQDVLRGTLNLYCSVTAAYSHLPQLLERFRQEHPFVEIALTTGDAANALAEVQQNRADIAIAALPDPFPATLHFAK
IDDVPLSLIAPTMRCAVQQQISQAPIDWSRVPFIIPDHGPGRRRADNWFKQMGISPNIYAQVSGQEAIASMVALGCGVSI
TPEVVINNSPVRDRIQLLASPVNIAPFELGCCCKVKRLDDPIVNAFLEAI
>Mature_290_residues
MDIRTLKLYLHLCDSLHFAKTAEQMHVSPSTLSRALQRLEEEVNAKLFERDNRSVTLTHAGREFKLFAEQTLHHWRNLRH
SIDLKQDVLRGTLNLYCSVTAAYSHLPQLLERFRQEHPFVEIALTTGDAANALAEVQQNRADIAIAALPDPFPATLHFAK
IDDVPLSLIAPTMRCAVQQQISQAPIDWSRVPFIIPDHGPGRRRADNWFKQMGISPNIYAQVSGQEAIASMVALGCGVSI
TPEVVINNSPVRDRIQLLASPVNIAPFELGCCCKVKRLDDPIVNAFLEAI

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=289, Percent_Identity=53.9792387543253, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI1790399, Length=258, Percent_Identity=24.4186046511628, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788296, Length=236, Percent_Identity=27.1186440677966, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787601, Length=245, Percent_Identity=23.265306122449, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787806, Length=263, Percent_Identity=21.6730038022814, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788887, Length=253, Percent_Identity=26.4822134387352, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI2367136, Length=259, Percent_Identity=22.3938223938224, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787879, Length=250, Percent_Identity=25.2, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI145693105, Length=144, Percent_Identity=25.6944444444444, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789639, Length=265, Percent_Identity=23.7735849056604, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788706, Length=158, Percent_Identity=32.9113924050633, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787530, Length=264, Percent_Identity=23.4848484848485, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI157672245, Length=235, Percent_Identity=20.4255319148936, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788297, Length=248, Percent_Identity=24.1935483870968, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788748, Length=247, Percent_Identity=23.4817813765182, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32442; Mature: 32442

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRTLKLYLHLCDSLHFAKTAEQMHVSPSTLSRALQRLEEEVNAKLFERDNRSVTLTHA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
GREFKLFAEQTLHHWRNLRHSIDLKQDVLRGTLNLYCSVTAAYSHLPQLLERFRQEHPFV
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
EIALTTGDAANALAEVQQNRADIAIAALPDPFPATLHFAKIDDVPLSLIAPTMRCAVQQQ
EEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
ISQAPIDWSRVPFIIPDHGPGRRRADNWFKQMGISPNIYAQVSGQEAIASMVALGCGVSI
HHHCCCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCCC
TPEVVINNSPVRDRIQLLASPVNIAPFELGCCCKVKRLDDPIVNAFLEAI
CCEEEECCCCHHHHHHHHHCCCCCCCCCCCCEEEHHHCCCHHHHHHHHHC
>Mature Secondary Structure
MDIRTLKLYLHLCDSLHFAKTAEQMHVSPSTLSRALQRLEEEVNAKLFERDNRSVTLTHA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
GREFKLFAEQTLHHWRNLRHSIDLKQDVLRGTLNLYCSVTAAYSHLPQLLERFRQEHPFV
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
EIALTTGDAANALAEVQQNRADIAIAALPDPFPATLHFAKIDDVPLSLIAPTMRCAVQQQ
EEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
ISQAPIDWSRVPFIIPDHGPGRRRADNWFKQMGISPNIYAQVSGQEAIASMVALGCGVSI
HHHCCCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCCC
TPEVVINNSPVRDRIQLLASPVNIAPFELGCCCKVKRLDDPIVNAFLEAI
CCEEEECCCCHHHHHHHHHCCCCCCCCCCCCEEEHHHCCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3003115; 1379743; 9278503; 3550695 [H]