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The map label for this gene is hutH [H]

Identifier: 117918792

GI number: 117918792

Start: 370271

End: 371836

Strand: Reverse

Name: hutH [H]

Synonym: Shewana3_0335

Alternate gene names: 117918792

Gene position: 371836-370271 (Counterclockwise)

Preceding gene: 117918793

Following gene: 117918791

Centisome position: 7.48

GC content: 54.09

Gene sequence:

>1566_bases
ATGAGCCACGCAGTTACTCACACGACAACCACTGAGCAGCCAATCGAATTTGGCCGTCAGTTACTCACATTAGAGCAAGT
CGTCGCCGTTGCTAAGGGTGCTAAAGTCAAACTCTGTGATGATGCCGATTACCAAGCTTATATCCAAAAGGGCGCCCGCT
TTATCGACAGCCTGCTACACGAAGAAGGTGTGGTCTACGGCGTCACCACCGGCTATGGCGACTCTTGCACTGTCAACGTG
AGTCTCGACTTAGTCCATGAGCTGCCACTGCACTTATCCCGCTTCCATGGCTGTGGCCTCGGCGAAGTCTTGAGCGTGAT
GCAGGCGCGCGCCGTGATGGCTTGCCGTTTAAACTCACTCGCCATCGGTAAATCCGGCGTAACCTATGAGTTATTAAAAC
GCATCGAAACCTTGCTTAATCTCAATATAGTGCCGGTGATCCCAGAGGAAGGTTCGGTCGGTGCCAGCGGTGACTTAACG
CCACTGTCTTACTTGGCCGCCGCGCTAGTTGGCGAGCGCGAAGTGATTTATAACGGCGAGCGCAGAGCCACCCAAGAGGT
TTACCGTGAGCTGAACATCACGCCCCATGTGCTGCGCCCCAAGGAAGGTTTAGCCCTGATGAATGGCACGGCAGTGATGA
CGGCATTAGCCTGTTTAGCCTTTGATCGCGCACAATATTTAGCGCGTTTAGCCAGCCGCATTACCGCCATGGCATCGTTA
ACCCTCAAAGGTAACTCGAACCATTTCGACGATATTCTGTTTGCCGCCAAACCCCATCCGGGACAAAACCAAATCGCGAC
CTGGATTAGGGAAGATTTGAACCACCATGTTCACCCGCGCAATTCCGACAGATTGCAGGACAGATATTCCATCCGCTGCG
CGCCGCACATCATTGGCGTATTGCAGGATGCACTGCCCTTTATGCGCCAATTTATCGAAACCGAAGTCAACAGCGCCAAC
GACAACCCCATAGTCGATGGTGAAGGCGAGCATATTCTCCACGGCGGCCATTTTTACGGTGGACACATTGCCTTTGCGAT
GGATTCCTTAAAAAACACTGTGGCCAACATCGCCGATCTTATCGACCGCCAAATGGCACTAGTGATGGATCCTAAGTTTA
ACAACGGTTTACCCGCTAACCTTTCGGGTTCTACTGGCGCGCGCCGTGCCATCAACCATGGCTTTAAGGCGGTACAGATC
GGGGTTTCGGCATGGACCGCAGAGGCGCTCAAACACACTATGCCTGCGAGCGTGTTCTCTCGCTCAACCGAATGCCATAA
CCAAGATAAAGTCAGCATGGGTACTATCGCCGCCCGTGACTGTATGCGCGTGTTGCAGCTGACAGAACAAGTCGCCGCTG
CTGCCCTGCTCGCCATGACCCAAGGCATTGGTCTGCGCATCACACAGAACGAGTTAGACGAAGCTTCGCTGACGCCATCG
CTGGCCACCACGCTCGCCCAAGTGCGCGCCGATTTTGAGCCATTAGTCGAAGACAGACCGCTCGAAGCCGTACTGCGCCA
AACCGTAGCGAAAATCCAAGCGGGCGAATGGGAAGTGTGCCGATGA

Upstream 100 bases:

>100_bases
TTTGGCGGGACGATAGCAAGGTTAACCGCGCGACATCCGCCCCACAAACGACAGCAGCACTCCCGGAGCTGGAGCGCACT
ACAGACAGGACAGAGCATTT

Downstream 100 bases:

>100_bases
AAGCCTTGCTCAGCATAGAAATGGACATGCAGATCCCCTTCCACGATGTGGATTCGATGGGGATCACTTGGCATGGTAAT
TACCTGCGTTATTTCGAGAT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MSHAVTHTTTTEQPIEFGRQLLTLEQVVAVAKGAKVKLCDDADYQAYIQKGARFIDSLLHEEGVVYGVTTGYGDSCTVNV
SLDLVHELPLHLSRFHGCGLGEVLSVMQARAVMACRLNSLAIGKSGVTYELLKRIETLLNLNIVPVIPEEGSVGASGDLT
PLSYLAAALVGEREVIYNGERRATQEVYRELNITPHVLRPKEGLALMNGTAVMTALACLAFDRAQYLARLASRITAMASL
TLKGNSNHFDDILFAAKPHPGQNQIATWIREDLNHHVHPRNSDRLQDRYSIRCAPHIIGVLQDALPFMRQFIETEVNSAN
DNPIVDGEGEHILHGGHFYGGHIAFAMDSLKNTVANIADLIDRQMALVMDPKFNNGLPANLSGSTGARRAINHGFKAVQI
GVSAWTAEALKHTMPASVFSRSTECHNQDKVSMGTIAARDCMRVLQLTEQVAAAALLAMTQGIGLRITQNELDEASLTPS
LATTLAQVRADFEPLVEDRPLEAVLRQTVAKIQAGEWEVCR

Sequences:

>Translated_521_residues
MSHAVTHTTTTEQPIEFGRQLLTLEQVVAVAKGAKVKLCDDADYQAYIQKGARFIDSLLHEEGVVYGVTTGYGDSCTVNV
SLDLVHELPLHLSRFHGCGLGEVLSVMQARAVMACRLNSLAIGKSGVTYELLKRIETLLNLNIVPVIPEEGSVGASGDLT
PLSYLAAALVGEREVIYNGERRATQEVYRELNITPHVLRPKEGLALMNGTAVMTALACLAFDRAQYLARLASRITAMASL
TLKGNSNHFDDILFAAKPHPGQNQIATWIREDLNHHVHPRNSDRLQDRYSIRCAPHIIGVLQDALPFMRQFIETEVNSAN
DNPIVDGEGEHILHGGHFYGGHIAFAMDSLKNTVANIADLIDRQMALVMDPKFNNGLPANLSGSTGARRAINHGFKAVQI
GVSAWTAEALKHTMPASVFSRSTECHNQDKVSMGTIAARDCMRVLQLTEQVAAAALLAMTQGIGLRITQNELDEASLTPS
LATTLAQVRADFEPLVEDRPLEAVLRQTVAKIQAGEWEVCR
>Mature_520_residues
SHAVTHTTTTEQPIEFGRQLLTLEQVVAVAKGAKVKLCDDADYQAYIQKGARFIDSLLHEEGVVYGVTTGYGDSCTVNVS
LDLVHELPLHLSRFHGCGLGEVLSVMQARAVMACRLNSLAIGKSGVTYELLKRIETLLNLNIVPVIPEEGSVGASGDLTP
LSYLAAALVGEREVIYNGERRATQEVYRELNITPHVLRPKEGLALMNGTAVMTALACLAFDRAQYLARLASRITAMASLT
LKGNSNHFDDILFAAKPHPGQNQIATWIREDLNHHVHPRNSDRLQDRYSIRCAPHIIGVLQDALPFMRQFIETEVNSAND
NPIVDGEGEHILHGGHFYGGHIAFAMDSLKNTVANIADLIDRQMALVMDPKFNNGLPANLSGSTGARRAINHGFKAVQIG
VSAWTAEALKHTMPASVFSRSTECHNQDKVSMGTIAARDCMRVLQLTEQVAAAALLAMTQGIGLRITQNELDEASLTPSL
ATTLAQVRADFEPLVEDRPLEAVLRQTVAKIQAGEWEVCR

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=497, Percent_Identity=37.4245472837022, Blast_Score=299, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI17567831, Length=480, Percent_Identity=36.0416666666667, Blast_Score=257, Evalue=9e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 56820; Mature: 56689

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHAVTHTTTTEQPIEFGRQLLTLEQVVAVAKGAKVKLCDDADYQAYIQKGARFIDSLLH
CCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHH
EEGVVYGVTTGYGDSCTVNVSLDLVHELPLHLSRFHGCGLGEVLSVMQARAVMACRLNSL
HCCEEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHH
AIGKSGVTYELLKRIETLLNLNIVPVIPEEGSVGASGDLTPLSYLAAALVGEREVIYNGE
EECCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCC
RRATQEVYRELNITPHVLRPKEGLALMNGTAVMTALACLAFDRAQYLARLASRITAMASL
HHHHHHHHHHCCCCCCEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
TLKGNSNHFDDILFAAKPHPGQNQIATWIREDLNHHVHPRNSDRLQDRYSIRCAPHIIGV
EEECCCCCCHHEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEHHHHHHHH
LQDALPFMRQFIETEVNSANDNPIVDGEGEHILHGGHFYGGHIAFAMDSLKNTVANIADL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCEECCHHHHHHHHHHHHHHHHHHH
IDRQMALVMDPKFNNGLPANLSGSTGARRAINHGFKAVQIGVSAWTAEALKHTMPASVFS
HHHHHHEEECCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCHHHHH
RSTECHNQDKVSMGTIAARDCMRVLQLTEQVAAAALLAMTQGIGLRITQNELDEASLTPS
CCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHCCHH
LATTLAQVRADFEPLVEDRPLEAVLRQTVAKIQAGEWEVCR
HHHHHHHHHHCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SHAVTHTTTTEQPIEFGRQLLTLEQVVAVAKGAKVKLCDDADYQAYIQKGARFIDSLLH
CCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHH
EEGVVYGVTTGYGDSCTVNVSLDLVHELPLHLSRFHGCGLGEVLSVMQARAVMACRLNSL
HCCEEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHH
AIGKSGVTYELLKRIETLLNLNIVPVIPEEGSVGASGDLTPLSYLAAALVGEREVIYNGE
EECCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCC
RRATQEVYRELNITPHVLRPKEGLALMNGTAVMTALACLAFDRAQYLARLASRITAMASL
HHHHHHHHHHCCCCCCEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
TLKGNSNHFDDILFAAKPHPGQNQIATWIREDLNHHVHPRNSDRLQDRYSIRCAPHIIGV
EEECCCCCCHHEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEHHHHHHHH
LQDALPFMRQFIETEVNSANDNPIVDGEGEHILHGGHFYGGHIAFAMDSLKNTVANIADL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCEECCHHHHHHHHHHHHHHHHHHH
IDRQMALVMDPKFNNGLPANLSGSTGARRAINHGFKAVQIGVSAWTAEALKHTMPASVFS
HHHHHHEEECCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCHHHHH
RSTECHNQDKVSMGTIAARDCMRVLQLTEQVAAAALLAMTQGIGLRITQNELDEASLTPS
CCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHCCHH
LATTLAQVRADFEPLVEDRPLEAVLRQTVAKIQAGEWEVCR
HHHHHHHHHHCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA