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The map label for this gene is gltP [H]

Identifier: 117918600

GI number: 117918600

Start: 163107

End: 164336

Strand: Reverse

Name: gltP [H]

Synonym: Shewana3_0142

Alternate gene names: 117918600

Gene position: 164336-163107 (Counterclockwise)

Preceding gene: 117918602

Following gene: 117918599

Centisome position: 3.31

GC content: 51.63

Gene sequence:

>1230_bases
ATGAAGAGCAAGAGTTTATTAGGCAACATTGGTGTGCAAGTGGTTATTGCCATGATTATTGGCGCACTGGTTGGTTTTAC
CATGGGCGAAAGTGCGAGCATCTTCGCACCACTGGGCACCATTTTTATCCATTTAGTCAAAATGCTAGTGATCCCACTGG
TGCTGGTGTCTATCATCAGCGGCGCCGCCAGCCTAGGCGATAGCCCCTCGGCGGGTAAGATTGGTGTCGGCACCTTCGGT
TTCTTTATTGTCACCTCGGGGATTGCCGTTGCCTTAGCATTAGTCATGGGCAATATGTTTACCCCCGGCGCGGGTGTCGA
CTTTACCGCCCATAGTAGTAGCGGCCTGATGGAAGTCACCGCCGAACATGGCGCACTGCCTGGGGTAATGGATACCTTTA
TTGGCATGATCCCAACCAACGTGTTCGAATCGCTGACTGGCGGGAATATCCTTCAAATTCTGGTGTTTAGTATATTTTTC
GGTATCGCACTGACCAAGGTCAAAGGCGATGGCGCTAAGCCCATCATGGCAGCGTTAAATACCGTCGTCGACGCCTTTGT
GTGGATGATTAACTGTGTGATGGTGATTGCGCCCATTGGGGTGTTTGGCTTGATGGCCGATTCCGTCGGCACCTTCGGTT
TCGATGCCTTAGAAGTGGTGTTTAAGTTGTTTGCCGTGTTTGTGGCCGCGATTCTGATCTACGGTTTTGTGTTCTTCCCC
TTAGTGGTGCAGCTGTTTTCTAGGGTATCGGCACGCCAATTTATTTCGGCGATGAAAAAACCTCAGGTGATGGCACTGTC
GACGGCTTCATCCATGGCGACGCTGCCGGTGAATATGGAAACCTGCGAAGAAGATCTTAAGGTTTCTAAGGCTACAACCG
CCTTTGTGCTGCCTTTAGGTGCCACCATCAATATGAGCGGCAACGCGATTTACTATGGTTTAGTCGCCATGTTCTTCGCG
CAGATGTACAACGTCGATCTGTCGATGACGGCCTATGCCGCAATTATCTTTACCTCAACCTTAGGCGCCATTGGCCAAGC
GGGTGTGCCCGGTCCATCATTTTTAGTGGTTGCCGTGCTACTGGCCGCCGGTATTCCCATTGACGGTTTACCATTGTTAT
TCGCCCTCGACCGGGTGTTTGACATGATCCGCACCGCGCTCAACATCACGGGTGACGCCGCCTGCGCCGTGATTATGGAT
AAGTACACCGCAGAGCCAAGCTCGAACTAA

Upstream 100 bases:

>100_bases
GTCAGGGCTGAGCTTTTACGCCAAAAGCGAGGGCAAGCCTGTAAATAGATAACTAGTCTTAAGACACAAAATGCCGCGGT
AACTGGGGAGTTTCGCAAGA

Downstream 100 bases:

>100_bases
CTGTGCGAATACATTGATATACCAAGGCTTGAATAGGCTTGCTTATTCAAGCCTTTTTTATGGTTTAAACTTCGAGATAC
CGCATCTTATCCCACTGATT

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MKSKSLLGNIGVQVVIAMIIGALVGFTMGESASIFAPLGTIFIHLVKMLVIPLVLVSIISGAASLGDSPSAGKIGVGTFG
FFIVTSGIAVALALVMGNMFTPGAGVDFTAHSSSGLMEVTAEHGALPGVMDTFIGMIPTNVFESLTGGNILQILVFSIFF
GIALTKVKGDGAKPIMAALNTVVDAFVWMINCVMVIAPIGVFGLMADSVGTFGFDALEVVFKLFAVFVAAILIYGFVFFP
LVVQLFSRVSARQFISAMKKPQVMALSTASSMATLPVNMETCEEDLKVSKATTAFVLPLGATINMSGNAIYYGLVAMFFA
QMYNVDLSMTAYAAIIFTSTLGAIGQAGVPGPSFLVVAVLLAAGIPIDGLPLLFALDRVFDMIRTALNITGDAACAVIMD
KYTAEPSSN

Sequences:

>Translated_409_residues
MKSKSLLGNIGVQVVIAMIIGALVGFTMGESASIFAPLGTIFIHLVKMLVIPLVLVSIISGAASLGDSPSAGKIGVGTFG
FFIVTSGIAVALALVMGNMFTPGAGVDFTAHSSSGLMEVTAEHGALPGVMDTFIGMIPTNVFESLTGGNILQILVFSIFF
GIALTKVKGDGAKPIMAALNTVVDAFVWMINCVMVIAPIGVFGLMADSVGTFGFDALEVVFKLFAVFVAAILIYGFVFFP
LVVQLFSRVSARQFISAMKKPQVMALSTASSMATLPVNMETCEEDLKVSKATTAFVLPLGATINMSGNAIYYGLVAMFFA
QMYNVDLSMTAYAAIIFTSTLGAIGQAGVPGPSFLVVAVLLAAGIPIDGLPLLFALDRVFDMIRTALNITGDAACAVIMD
KYTAEPSSN
>Mature_409_residues
MKSKSLLGNIGVQVVIAMIIGALVGFTMGESASIFAPLGTIFIHLVKMLVIPLVLVSIISGAASLGDSPSAGKIGVGTFG
FFIVTSGIAVALALVMGNMFTPGAGVDFTAHSSSGLMEVTAEHGALPGVMDTFIGMIPTNVFESLTGGNILQILVFSIFF
GIALTKVKGDGAKPIMAALNTVVDAFVWMINCVMVIAPIGVFGLMADSVGTFGFDALEVVFKLFAVFVAAILIYGFVFFP
LVVQLFSRVSARQFISAMKKPQVMALSTASSMATLPVNMETCEEDLKVSKATTAFVLPLGATINMSGNAIYYGLVAMFFA
QMYNVDLSMTAYAAIIFTSTLGAIGQAGVPGPSFLVVAVLLAAGIPIDGLPLLFALDRVFDMIRTALNITGDAACAVIMD
KYTAEPSSN

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=454, Percent_Identity=28.4140969162996, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI21314632, Length=414, Percent_Identity=29.4685990338164, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI5032093, Length=393, Percent_Identity=30.2798982188295, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI66773030, Length=465, Percent_Identity=28.1720430107527, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI4827012, Length=445, Percent_Identity=26.5168539325843, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI223468566, Length=272, Percent_Identity=31.6176470588235, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI40254478, Length=413, Percent_Identity=27.1186440677966, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI223468564, Length=266, Percent_Identity=31.9548872180451, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI262359914, Length=372, Percent_Identity=27.6881720430108, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI194239697, Length=454, Percent_Identity=26.6519823788546, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI301601644, Length=168, Percent_Identity=35.7142857142857, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1790514, Length=415, Percent_Identity=32.7710843373494, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1789947, Length=411, Percent_Identity=29.1970802919708, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1788024, Length=401, Percent_Identity=26.1845386533666, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1789473, Length=377, Percent_Identity=27.8514588859416, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71996953, Length=447, Percent_Identity=27.9642058165548, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI193206654, Length=406, Percent_Identity=29.3103448275862, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71983106, Length=450, Percent_Identity=28, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71983099, Length=450, Percent_Identity=28, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI193206505, Length=402, Percent_Identity=28.3582089552239, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17541374, Length=408, Percent_Identity=29.9019607843137, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17537407, Length=413, Percent_Identity=26.8765133171913, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24583025, Length=447, Percent_Identity=24.6085011185682, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17137668, Length=447, Percent_Identity=24.6085011185682, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24583023, Length=447, Percent_Identity=24.6085011185682, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI281360483, Length=447, Percent_Identity=26.8456375838926, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137666, Length=447, Percent_Identity=26.8456375838926, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281360481, Length=447, Percent_Identity=26.8456375838926, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 42563; Mature: 42563

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure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HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]