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The map label for this gene is moeA [H]

Identifier: 117918589

GI number: 117918589

Start: 146271

End: 147605

Strand: Reverse

Name: moeA [H]

Synonym: Shewana3_0131

Alternate gene names: 117918589

Gene position: 147605-146271 (Counterclockwise)

Preceding gene: 117918591

Following gene: 117918588

Centisome position: 2.97

GC content: 53.48

Gene sequence:

>1335_bases
ATGCAGATCATAGCCAAGCAAGCACAGCGTGGCATAATAGCCCCCATATTTGCCCAATCTTTTGCCCATAAGGAAGACCC
GATGTCCGTGAAAGCCGATCCTTGTTCGCAACCTAGCTTAATGCATCCAGATCAAGCCATTCCCCTTCTGCTTGAGCAGG
TTAGCCCAGTGTCAGACACAGAAGTCGTTACTCTTCCCCACGCGCTTGGCCGCGTTTTAGCGGAGGATTTGGCTTCTTGT
ATCGATTTACCGCCCTTCGATAACTCTTCGATGGACGGCTACGCCTTTCGCTTTGCCGATTTAGCGACTGACACCAATCA
AACCACGCTGACACTGATTGGCAGCTCATTTGCGGGCCATGGTTTTGAAGGTGAAATCCCCCCTCACTCCTGCGTGCGCA
TTATGACGGGCGCGCCAGTGCCTGCGGGTTATGACACAGTGCAAATGCAGGAAGAGACCCAAGCACAGGGCAACCAAATC
CAAATCAATCACCCTAAGGCTAAGGGCGCCAATGTTCGCTGCCGTGGTGAAGAATTGCTGCAAGGCACAAAAGTGCTGAA
AGCGGGCATCGAAATTAAAGCCGCTGAACTGGGAGTACTCGCCACCATTGGCGTGAGTCAGGTGCGGGTTTACCGCCAAC
TCAAAGTCGCGTTTTTCTCCACTGGGGATGAACTGCGCCCCGTGGGCAGCGACTTAGCACCGGGACAAATTTACGATTCA
AATCGTTATTCCATCCAAGGCTTACTCAGCCGCGCCAATGTGGAATGGTTGGATTTAGGCGTGATAGCCGACGACCCAGA
GGCCATTCGCCACGCATTTCGCCATGCCGCGAGCCAAGCGGATATGGTGTTAACCTCGGGCGGCGTCTCGGTCGGTGAAG
CAGATTTTACTAAGCAAATCCTTGATGAAGAAGGCAAAATCACCTTCTGGAAACTCGCCATTAAACCGGGCAAACCCTTT
GCCATGGGACGCATAGGCAAGGCGGTATTCTGCGGCTTACCGGGCAATCCCGTGTCTTCCATGGTGACCTTCTACAAGTT
GGTGTGGCCCATTCTGAATAAGATGCAGGGCTTAACCCCGAAGGCGCCACTGATGCTTTCCGCCACTCTGACAACTCCCG
TGCGTAAACAGCCCGGCCGTGTCGAATATCAGCGCGGCATTTTATCCCGCAATGCACAGGGCGAGTTGGAAGTGGCCATC
ACGGGCAGCCAAGGTTCGGGCATGTTGACCTCTATGAGTCTGGCGAATTGTTTCGTACTGCTGGAGCAATTCCAAGGTGA
CACCCCAGTGGGCACGCAAGTGACGGTTGAACCTTTTAATTCAGTGCTCTGCTAA

Upstream 100 bases:

>100_bases
TTTAGCGCCGCCTGAGCTGTAGTGCAAAATCACAAAGTAGAAGGATTCACCTTAGGCAACACTTAAGGGGGAAACTGTCT
GACAAATCACATAAACTCCT

Downstream 100 bases:

>100_bases
GGTACGCCTCGATGAATGAACAACTAGAGATCCTCAGCGACGGCGAACTCACCCGCTACAGTCGCCAAATCTCAATCAAG
GCGATGGATATCGACGGCCA

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MQIIAKQAQRGIIAPIFAQSFAHKEDPMSVKADPCSQPSLMHPDQAIPLLLEQVSPVSDTEVVTLPHALGRVLAEDLASC
IDLPPFDNSSMDGYAFRFADLATDTNQTTLTLIGSSFAGHGFEGEIPPHSCVRIMTGAPVPAGYDTVQMQEETQAQGNQI
QINHPKAKGANVRCRGEELLQGTKVLKAGIEIKAAELGVLATIGVSQVRVYRQLKVAFFSTGDELRPVGSDLAPGQIYDS
NRYSIQGLLSRANVEWLDLGVIADDPEAIRHAFRHAASQADMVLTSGGVSVGEADFTKQILDEEGKITFWKLAIKPGKPF
AMGRIGKAVFCGLPGNPVSSMVTFYKLVWPILNKMQGLTPKAPLMLSATLTTPVRKQPGRVEYQRGILSRNAQGELEVAI
TGSQGSGMLTSMSLANCFVLLEQFQGDTPVGTQVTVEPFNSVLC

Sequences:

>Translated_444_residues
MQIIAKQAQRGIIAPIFAQSFAHKEDPMSVKADPCSQPSLMHPDQAIPLLLEQVSPVSDTEVVTLPHALGRVLAEDLASC
IDLPPFDNSSMDGYAFRFADLATDTNQTTLTLIGSSFAGHGFEGEIPPHSCVRIMTGAPVPAGYDTVQMQEETQAQGNQI
QINHPKAKGANVRCRGEELLQGTKVLKAGIEIKAAELGVLATIGVSQVRVYRQLKVAFFSTGDELRPVGSDLAPGQIYDS
NRYSIQGLLSRANVEWLDLGVIADDPEAIRHAFRHAASQADMVLTSGGVSVGEADFTKQILDEEGKITFWKLAIKPGKPF
AMGRIGKAVFCGLPGNPVSSMVTFYKLVWPILNKMQGLTPKAPLMLSATLTTPVRKQPGRVEYQRGILSRNAQGELEVAI
TGSQGSGMLTSMSLANCFVLLEQFQGDTPVGTQVTVEPFNSVLC
>Mature_444_residues
MQIIAKQAQRGIIAPIFAQSFAHKEDPMSVKADPCSQPSLMHPDQAIPLLLEQVSPVSDTEVVTLPHALGRVLAEDLASC
IDLPPFDNSSMDGYAFRFADLATDTNQTTLTLIGSSFAGHGFEGEIPPHSCVRIMTGAPVPAGYDTVQMQEETQAQGNQI
QINHPKAKGANVRCRGEELLQGTKVLKAGIEIKAAELGVLATIGVSQVRVYRQLKVAFFSTGDELRPVGSDLAPGQIYDS
NRYSIQGLLSRANVEWLDLGVIADDPEAIRHAFRHAASQADMVLTSGGVSVGEADFTKQILDEEGKITFWKLAIKPGKPF
AMGRIGKAVFCGLPGNPVSSMVTFYKLVWPILNKMQGLTPKAPLMLSATLTTPVRKQPGRVEYQRGILSRNAQGELEVAI
TGSQGSGMLTSMSLANCFVLLEQFQGDTPVGTQVTVEPFNSVLC

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=393, Percent_Identity=36.6412213740458, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI66932975, Length=393, Percent_Identity=36.6412213740458, Blast_Score=221, Evalue=8e-58,
Organism=Escherichia coli, GI1787049, Length=405, Percent_Identity=49.6296296296296, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI25147659, Length=305, Percent_Identity=32.1311475409836, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17562606, Length=318, Percent_Identity=28.9308176100629, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17136978, Length=375, Percent_Identity=29.3333333333333, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24638841, Length=375, Percent_Identity=29.3333333333333, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 47760; Mature: 47760

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIIAKQAQRGIIAPIFAQSFAHKEDPMSVKADPCSQPSLMHPDQAIPLLLEQVSPVSDT
CCCCHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
EVVTLPHALGRVLAEDLASCIDLPPFDNSSMDGYAFRFADLATDTNQTTLTLIGSSFAGH
EEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHCCCCCCEEEEEEECCCCCC
GFEGEIPPHSCVRIMTGAPVPAGYDTVQMQEETQAQGNQIQINHPKAKGANVRCRGEELL
CCCCCCCHHHHEEEEECCCCCCCCCCEEECHHHHCCCCEEEEECCCCCCCCEEECHHHHH
QGTKVLKAGIEIKAAELGVLATIGVSQVRVYRQLKVAFFSTGDELRPVGSDLAPGQIYDS
HHHHHHHCCCEEEECCCCEEEECCHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCEEECC
NRYSIQGLLSRANVEWLDLGVIADDPEAIRHAFRHAASQADMVLTSGGVSVGEADFTKQI
CCHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHH
LDEEGKITFWKLAIKPGKPFAMGRIGKAVFCGLPGNPVSSMVTFYKLVWPILNKMQGLTP
HCCCCCEEEEEEEECCCCCHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCC
KAPLMLSATLTTPVRKQPGRVEYQRGILSRNAQGELEVAITGSQGSGMLTSMSLANCFVL
CCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHH
LEQFQGDTPVGTQVTVEPFNSVLC
HHHHCCCCCCCCEEEECCHHCCCC
>Mature Secondary Structure
MQIIAKQAQRGIIAPIFAQSFAHKEDPMSVKADPCSQPSLMHPDQAIPLLLEQVSPVSDT
CCCCHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
EVVTLPHALGRVLAEDLASCIDLPPFDNSSMDGYAFRFADLATDTNQTTLTLIGSSFAGH
EEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHCCCCCCEEEEEEECCCCCC
GFEGEIPPHSCVRIMTGAPVPAGYDTVQMQEETQAQGNQIQINHPKAKGANVRCRGEELL
CCCCCCCHHHHEEEEECCCCCCCCCCEEECHHHHCCCCEEEEECCCCCCCCEEECHHHHH
QGTKVLKAGIEIKAAELGVLATIGVSQVRVYRQLKVAFFSTGDELRPVGSDLAPGQIYDS
HHHHHHHCCCEEEECCCCEEEECCHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCEEECC
NRYSIQGLLSRANVEWLDLGVIADDPEAIRHAFRHAASQADMVLTSGGVSVGEADFTKQI
CCHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHH
LDEEGKITFWKLAIKPGKPFAMGRIGKAVFCGLPGNPVSSMVTFYKLVWPILNKMQGLTP
HCCCCCEEEEEEEECCCCCHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCC
KAPLMLSATLTTPVRKQPGRVEYQRGILSRNAQGELEVAITGSQGSGMLTSMSLANCFVL
CCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHH
LEQFQGDTPVGTQVTVEPFNSVLC
HHHHCCCCCCCCEEEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]