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The map label for this gene is msrA [H]

Identifier: 117676272

GI number: 117676272

Start: 223573

End: 224061

Strand: Reverse

Name: msrA [H]

Synonym: Shewana3_4335

Alternate gene names: 117676272

Gene position: 224061-223573 (Counterclockwise)

Preceding gene: 117676275

Following gene: 117676271

Centisome position: 80.33

GC content: 47.44

Gene sequence:

>489_bases
ATGAAACTAGATTATGTGATCGTTGCCGGAGGGTGTTTTTGGGGTCTCGAAGACCTCCTTAGGAGTCTGGACGGTGTGAC
GTCAACGAAGGTGGGCTACTCTGGCGGAGATTTTGATGATCCTACCTACGCCGATATTATAACAGGGAAAACGGGGCACG
CCGAAGCGGTTCGCGTGGAATACGACCAAGACGAAATATCTCTCGAAGAGATTCTACATTACTTTTTCAAAATCCATGAT
CCGACTACGAAGAATCGCCAAGGAAATGATGTTGGCACTTCGTATCGCTCGGCAGCGTTCTATCGTGACGATGCACAGAA
AGCGATTATCGAAAACGTGATTGATGAGGTCAATGAGATCGGTCGCTTCGAGAATGAAGTGGTCACGACCGTCACCCTGG
AAACAGAATTCTACGACGCTGAGGCATATCACCAAAACTATTTGCAGAGGAATCCCAGCGGATACTCTTGCCATTTTGAA
AGAGACTAA

Upstream 100 bases:

>100_bases
CCAATAGGTCATGTTATACGAACTATTGAACATATTATATCTATTTTACATGCTGTAAAGTCAGTCTAATCAGTAAGTGG
ATGAAAACTAAGGAGGCTTT

Downstream 100 bases:

>100_bases
ATCATGAACCAAATGAACGAGGAAAAAATGAAAGCACTTAAGAATGTTGTTATTTATACGAAAGACCATTGTCCATTTTG
CGCACGCGTGAAGAATTACC

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MKLDYVIVAGGCFWGLEDLLRSLDGVTSTKVGYSGGDFDDPTYADIITGKTGHAEAVRVEYDQDEISLEEILHYFFKIHD
PTTKNRQGNDVGTSYRSAAFYRDDAQKAIIENVIDEVNEIGRFENEVVTTVTLETEFYDAEAYHQNYLQRNPSGYSCHFE
RD

Sequences:

>Translated_162_residues
MKLDYVIVAGGCFWGLEDLLRSLDGVTSTKVGYSGGDFDDPTYADIITGKTGHAEAVRVEYDQDEISLEEILHYFFKIHD
PTTKNRQGNDVGTSYRSAAFYRDDAQKAIIENVIDEVNEIGRFENEVVTTVTLETEFYDAEAYHQNYLQRNPSGYSCHFE
RD
>Mature_162_residues
MKLDYVIVAGGCFWGLEDLLRSLDGVTSTKVGYSGGDFDDPTYADIITGKTGHAEAVRVEYDQDEISLEEILHYFFKIHD
PTTKNRQGNDVGTSYRSAAFYRDDAQKAIIENVIDEVNEIGRFENEVVTTVTLETEFYDAEAYHQNYLQRNPSGYSCHFE
RD

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=154, Percent_Identity=43.5064935064935, Blast_Score=123, Evalue=6e-29,
Organism=Homo sapiens, GI6912516, Length=149, Percent_Identity=44.9664429530201, Blast_Score=123, Evalue=6e-29,
Organism=Homo sapiens, GI208609993, Length=110, Percent_Identity=44.5454545454545, Blast_Score=83, Evalue=8e-17,
Organism=Escherichia coli, GI1790665, Length=154, Percent_Identity=43.5064935064935, Blast_Score=125, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=140, Percent_Identity=31.4285714285714, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320881, Length=167, Percent_Identity=39.5209580838323, Blast_Score=121, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24664627, Length=141, Percent_Identity=36.8794326241135, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=36.8794326241135, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24664631, Length=141, Percent_Identity=36.1702127659575, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 18429; Mature: 18429

Theoretical pI: Translated: 4.21; Mature: 4.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDYVIVAGGCFWGLEDLLRSLDGVTSTKVGYSGGDFDDPTYADIITGKTGHAEAVRVE
CCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCEEEEEE
YDQDEISLEEILHYFFKIHDPTTKNRQGNDVGTSYRSAAFYRDDAQKAIIENVIDEVNEI
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRFENEVVTTVTLETEFYDAEAYHQNYLQRNPSGYSCHFERD
HCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCEEEECCC
>Mature Secondary Structure
MKLDYVIVAGGCFWGLEDLLRSLDGVTSTKVGYSGGDFDDPTYADIITGKTGHAEAVRVE
CCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHEECCCCCCCEEEEEE
YDQDEISLEEILHYFFKIHDPTTKNRQGNDVGTSYRSAAFYRDDAQKAIIENVIDEVNEI
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRFENEVVTTVTLETEFYDAEAYHQNYLQRNPSGYSCHFERD
HCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA