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The map label for this gene is msrA2 [H]

Identifier: 117676262

GI number: 117676262

Start: 215086

End: 215586

Strand: Reverse

Name: msrA2 [H]

Synonym: Shewana3_4325

Alternate gene names: 117676262

Gene position: 215586-215086 (Counterclockwise)

Preceding gene: 117676263

Following gene: 117676261

Centisome position: 77.29

GC content: 46.11

Gene sequence:

>501_bases
ATGGCAATTGAACGCGCAGTATTAGCCGGTGGCTGCTTTTGGGGCATGCAGGATCTTATCCGCAAACGTCCCGGTATCAC
TTCAACCCGAGTAGGTTATACCGGTGGTGAAGTGGCTAATGCTACCTACCGCAATCATGGTAACCATGCTGAAGGCATTG
AAATAATGTTCGATAATGAAATCACCAGCTATCGACAAATTTTAGAGTTTTTCTTTCAGATTCATGACCCTAGTACAGTA
AATAGACAAGGTAATGACAAGGGCACATCTTATCGCTCAGCCATTTATTATACCTCTGAGGCACAGCATGCTGAGGCAGT
AAAAACCATTGCTGACGTGGATGCTTCGGGATTATGGCCTGGAAAAGTAGTGACTGAAGTCGAACCTGCAAGTGATTTTT
GGGAAGCGGAGGCTATGCATCAGGACTATTTGGAACTCCGACCAAATGGCTATACCTGCCACTTCCCCAGACCAGACTGG
AAGTTGCCCTCATCTCAATGA

Upstream 100 bases:

>100_bases
GTTATTGTATTAACTCAGCGTCATTACGTTTTATTCCTAGGGAAGAAATGGCAAGTAAAGGTTACGCAGAGTATTTAGAC
CAAGTAGAGGACATTTAATT

Downstream 100 bases:

>100_bases
GTTTGCAGCAGCCCACACAGACTTGCAATTTGCATACGACAACCACCCTTAATACAATCGGCTTAGGCGGTGGTTGTCAC
TGGTGCACCGAAGGCGTATT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MAIERAVLAGGCFWGMQDLIRKRPGITSTRVGYTGGEVANATYRNHGNHAEGIEIMFDNEITSYRQILEFFFQIHDPSTV
NRQGNDKGTSYRSAIYYTSEAQHAEAVKTIADVDASGLWPGKVVTEVEPASDFWEAEAMHQDYLELRPNGYTCHFPRPDW
KLPSSQ

Sequences:

>Translated_166_residues
MAIERAVLAGGCFWGMQDLIRKRPGITSTRVGYTGGEVANATYRNHGNHAEGIEIMFDNEITSYRQILEFFFQIHDPSTV
NRQGNDKGTSYRSAIYYTSEAQHAEAVKTIADVDASGLWPGKVVTEVEPASDFWEAEAMHQDYLELRPNGYTCHFPRPDW
KLPSSQ
>Mature_165_residues
AIERAVLAGGCFWGMQDLIRKRPGITSTRVGYTGGEVANATYRNHGNHAEGIEIMFDNEITSYRQILEFFFQIHDPSTVN
RQGNDKGTSYRSAIYYTSEAQHAEAVKTIADVDASGLWPGKVVTEVEPASDFWEAEAMHQDYLELRPNGYTCHFPRPDWK
LPSSQ

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=37.1794871794872, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI208609995, Length=158, Percent_Identity=36.7088607594937, Blast_Score=104, Evalue=3e-23,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=38.3177570093458, Blast_Score=77, Evalue=6e-15,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=41.8300653594771, Blast_Score=117, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17533973, Length=141, Percent_Identity=34.7517730496454, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=165, Percent_Identity=35.7575757575758, Blast_Score=108, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24664627, Length=141, Percent_Identity=32.6241134751773, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=33.0882352941176, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24664631, Length=141, Percent_Identity=31.2056737588652, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 18706; Mature: 18575

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERAVLAGGCFWGMQDLIRKRPGITSTRVGYTGGEVANATYRNHGNHAEGIEIMFDNE
CCCCHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCEEEEECCC
ITSYRQILEFFFQIHDPSTVNRQGNDKGTSYRSAIYYTSEAQHAEAVKTIADVDASGLWP
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCC
GKVVTEVEPASDFWEAEAMHQDYLELRPNGYTCHFPRPDWKLPSSQ
CCEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure 
AIERAVLAGGCFWGMQDLIRKRPGITSTRVGYTGGEVANATYRNHGNHAEGIEIMFDNE
CCCHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCEEEEECCC
ITSYRQILEFFFQIHDPSTVNRQGNDKGTSYRSAIYYTSEAQHAEAVKTIADVDASGLWP
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCC
GKVVTEVEPASDFWEAEAMHQDYLELRPNGYTCHFPRPDWKLPSSQ
CCEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12835416 [H]